Incidental Mutation 'R2375:Odr4'
| ID |
248251 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Odr4
|
| Ensembl Gene |
ENSMUSG00000006010 |
| Gene Name |
odr4 GPCR localization factor homolog |
| Synonyms |
BC003331, 1810053E15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.783)
|
| Stock # |
R2375 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
150237056-150268831 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 150265985 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107544
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006167]
[ENSMUST00000006167]
[ENSMUST00000094477]
[ENSMUST00000097546]
[ENSMUST00000097546]
[ENSMUST00000097547]
[ENSMUST00000097547]
[ENSMUST00000111913]
[ENSMUST00000111913]
[ENSMUST00000119161]
[ENSMUST00000124973]
|
| AlphaFold |
Q4PJX1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000006167
|
| SMART Domains |
Protein: ENSMUSP00000006167
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000006167
|
| SMART Domains |
Protein: ENSMUSP00000006167
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094477
|
| SMART Domains |
Protein: ENSMUSP00000092050
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
383 |
2.8e-120 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097546
|
| SMART Domains |
Protein: ENSMUSP00000095152
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097546
|
| SMART Domains |
Protein: ENSMUSP00000095152
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097547
|
| SMART Domains |
Protein: ENSMUSP00000095153
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
209 |
1.2e-57 |
PFAM |
|
Pfam:ODR4-like
|
206 |
354 |
3.1e-43 |
PFAM |
|
transmembrane domain
|
392 |
414 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097547
|
| SMART Domains |
Protein: ENSMUSP00000095153
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
209 |
1.2e-57 |
PFAM |
|
Pfam:ODR4-like
|
206 |
354 |
3.1e-43 |
PFAM |
|
transmembrane domain
|
392 |
414 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111913
|
| SMART Domains |
Protein: ENSMUSP00000107544
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
386 |
7.1e-113 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111913
|
| SMART Domains |
Protein: ENSMUSP00000107544
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
386 |
7.1e-113 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119161
|
| SMART Domains |
Protein: ENSMUSP00000112606
Gene: ENSMUSG00000006005
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
49 |
370 |
N/A |
INTRINSIC |
|
coiled coil region
|
423 |
515 |
N/A |
INTRINSIC |
|
low complexity region
|
518 |
534 |
N/A |
INTRINSIC |
|
coiled coil region
|
539 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
795 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
826 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1019 |
N/A |
INTRINSIC |
|
Pfam:TPR_MLP1_2
|
1036 |
1167 |
9.1e-33 |
PFAM |
|
coiled coil region
|
1215 |
1421 |
N/A |
INTRINSIC |
|
coiled coil region
|
1473 |
1629 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
1630 |
1691 |
1.48e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1761 |
1777 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1814 |
1827 |
5.58e-5 |
PROSPERO |
|
internal_repeat_3
|
1819 |
1881 |
1.48e-5 |
PROSPERO |
|
internal_repeat_4
|
1875 |
1895 |
5.58e-5 |
PROSPERO |
|
internal_repeat_1
|
1893 |
1919 |
2.03e-6 |
PROSPERO |
|
low complexity region
|
1920 |
1933 |
N/A |
INTRINSIC |
|
low complexity region
|
1942 |
1981 |
N/A |
INTRINSIC |
|
low complexity region
|
1989 |
2014 |
N/A |
INTRINSIC |
|
internal_repeat_4
|
2017 |
2036 |
5.58e-5 |
PROSPERO |
|
low complexity region
|
2059 |
2078 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
2084 |
2135 |
3.95e-6 |
PROSPERO |
|
internal_repeat_5
|
2127 |
2140 |
5.58e-5 |
PROSPERO |
|
internal_repeat_1
|
2154 |
2179 |
2.03e-6 |
PROSPERO |
|
internal_repeat_2
|
2156 |
2212 |
3.95e-6 |
PROSPERO |
|
low complexity region
|
2239 |
2251 |
N/A |
INTRINSIC |
|
low complexity region
|
2263 |
2277 |
N/A |
INTRINSIC |
|
low complexity region
|
2292 |
2314 |
N/A |
INTRINSIC |
|
low complexity region
|
2346 |
2357 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124973
|
| SMART Domains |
Protein: ENSMUSP00000117616
Gene: ENSMUSG00000006005
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
14 |
N/A |
INTRINSIC |
|
low complexity region
|
24 |
77 |
N/A |
INTRINSIC |
|
coiled coil region
|
123 |
444 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
608 |
N/A |
INTRINSIC |
|
coiled coil region
|
613 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
856 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
900 |
N/A |
INTRINSIC |
|
low complexity region
|
1077 |
1093 |
N/A |
INTRINSIC |
|
Pfam:TPR_MLP1_2
|
1112 |
1240 |
5.1e-37 |
PFAM |
|
coiled coil region
|
1289 |
1495 |
N/A |
INTRINSIC |
|
low complexity region
|
1682 |
1698 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1703 |
1750 |
8.04e-5 |
PROSPERO |
|
internal_repeat_3
|
1704 |
1765 |
1.07e-5 |
PROSPERO |
|
low complexity region
|
1769 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1835 |
1851 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1857 |
1900 |
8.04e-5 |
PROSPERO |
|
internal_repeat_6
|
1887 |
1911 |
8.04e-5 |
PROSPERO |
|
internal_repeat_3
|
1893 |
1955 |
1.07e-5 |
PROSPERO |
|
internal_repeat_4
|
1949 |
1969 |
4.1e-5 |
PROSPERO |
|
internal_repeat_1
|
1967 |
1993 |
1.42e-6 |
PROSPERO |
|
low complexity region
|
1994 |
2007 |
N/A |
INTRINSIC |
|
low complexity region
|
2016 |
2055 |
N/A |
INTRINSIC |
|
low complexity region
|
2063 |
2088 |
N/A |
INTRINSIC |
|
internal_repeat_4
|
2091 |
2110 |
4.1e-5 |
PROSPERO |
|
internal_repeat_6
|
2108 |
2132 |
8.04e-5 |
PROSPERO |
|
low complexity region
|
2133 |
2152 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
2158 |
2209 |
2.78e-6 |
PROSPERO |
|
internal_repeat_1
|
2228 |
2253 |
1.42e-6 |
PROSPERO |
|
internal_repeat_2
|
2230 |
2286 |
2.78e-6 |
PROSPERO |
|
low complexity region
|
2313 |
2325 |
N/A |
INTRINSIC |
|
low complexity region
|
2337 |
2351 |
N/A |
INTRINSIC |
|
low complexity region
|
2366 |
2388 |
N/A |
INTRINSIC |
|
low complexity region
|
2420 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140112
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150615
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148389
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131701
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2ml1 |
C |
T |
6: 128,557,349 (GRCm39) |
A115T |
probably benign |
Het |
| Arhgef7 |
A |
G |
8: 11,864,995 (GRCm39) |
N369S |
probably benign |
Het |
| Celsr3 |
G |
A |
9: 108,719,751 (GRCm39) |
R2450H |
probably benign |
Het |
| Cps1 |
G |
A |
1: 67,257,019 (GRCm39) |
M1312I |
probably benign |
Het |
| Fbn2 |
A |
C |
18: 58,169,038 (GRCm39) |
I2247S |
probably damaging |
Het |
| Gtf2ird2 |
T |
A |
5: 134,245,977 (GRCm39) |
L745Q |
probably benign |
Het |
| Lrr1 |
A |
G |
12: 69,221,697 (GRCm39) |
T280A |
probably benign |
Het |
| Mpig6b |
C |
T |
17: 35,283,359 (GRCm39) |
M226I |
probably benign |
Het |
| Myo1a |
A |
G |
10: 127,541,159 (GRCm39) |
D12G |
probably damaging |
Het |
| Or6c1 |
A |
G |
10: 129,518,032 (GRCm39) |
F192S |
probably benign |
Het |
| Orc5 |
A |
G |
5: 22,751,550 (GRCm39) |
L71P |
probably damaging |
Het |
| Phc2 |
T |
C |
4: 128,616,818 (GRCm39) |
S364P |
probably benign |
Het |
| Ramp3 |
G |
T |
11: 6,626,643 (GRCm39) |
V117L |
probably benign |
Het |
| Rpap1 |
C |
A |
2: 119,600,888 (GRCm39) |
W836L |
possibly damaging |
Het |
| Syt13 |
G |
A |
2: 92,776,496 (GRCm39) |
G261D |
probably benign |
Het |
| Taf6 |
A |
T |
5: 138,180,463 (GRCm39) |
Y300* |
probably null |
Het |
| Thsd7a |
T |
C |
6: 12,337,361 (GRCm39) |
S1219G |
probably damaging |
Het |
| Tmco3 |
T |
C |
8: 13,342,059 (GRCm39) |
F111S |
possibly damaging |
Het |
| Upk1b |
C |
T |
16: 38,607,490 (GRCm39) |
G79E |
probably damaging |
Het |
| Zc3h7b |
G |
A |
15: 81,676,703 (GRCm39) |
V773M |
probably benign |
Het |
| Zfp655 |
A |
G |
5: 145,181,206 (GRCm39) |
T355A |
probably benign |
Het |
|
| Other mutations in Odr4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01876:Odr4
|
APN |
1 |
150,258,089 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02189:Odr4
|
APN |
1 |
150,247,784 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02257:Odr4
|
APN |
1 |
150,262,155 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02485:Odr4
|
APN |
1 |
150,239,240 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02585:Odr4
|
APN |
1 |
150,239,272 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02712:Odr4
|
APN |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02902:Odr4
|
APN |
1 |
150,260,179 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03014:Odr4
|
APN |
1 |
150,258,804 (GRCm39) |
splice site |
probably benign |
|
|
IGL03124:Odr4
|
APN |
1 |
150,262,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03181:Odr4
|
APN |
1 |
150,239,290 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03344:Odr4
|
APN |
1 |
150,239,295 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Odr4
|
UTSW |
1 |
150,262,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1796:Odr4
|
UTSW |
1 |
150,251,305 (GRCm39) |
missense |
probably benign |
|
|
R1902:Odr4
|
UTSW |
1 |
150,264,360 (GRCm39) |
splice site |
probably null |
|
|
R2149:Odr4
|
UTSW |
1 |
150,264,310 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2155:Odr4
|
UTSW |
1 |
150,258,086 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3786:Odr4
|
UTSW |
1 |
150,260,282 (GRCm39) |
missense |
probably benign |
0.21 |
|
R3948:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R4589:Odr4
|
UTSW |
1 |
150,260,238 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4590:Odr4
|
UTSW |
1 |
150,262,103 (GRCm39) |
splice site |
probably null |
|
|
R4815:Odr4
|
UTSW |
1 |
150,250,597 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5196:Odr4
|
UTSW |
1 |
150,258,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5437:Odr4
|
UTSW |
1 |
150,239,269 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5549:Odr4
|
UTSW |
1 |
150,247,909 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5677:Odr4
|
UTSW |
1 |
150,250,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Odr4
|
UTSW |
1 |
150,256,111 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6472:Odr4
|
UTSW |
1 |
150,257,273 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7108:Odr4
|
UTSW |
1 |
150,258,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7402:Odr4
|
UTSW |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7662:Odr4
|
UTSW |
1 |
150,258,045 (GRCm39) |
missense |
probably benign |
|
|
R7767:Odr4
|
UTSW |
1 |
150,247,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7810:Odr4
|
UTSW |
1 |
150,268,659 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R7916:Odr4
|
UTSW |
1 |
150,260,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Odr4
|
UTSW |
1 |
150,260,177 (GRCm39) |
splice site |
probably null |
|
|
R8435:Odr4
|
UTSW |
1 |
150,258,020 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9397:Odr4
|
UTSW |
1 |
150,238,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAGTTTCAACCAGATTTCCTACTC -3'
(R):5'- AGAGTTTTGGGAATGGGCCAC -3'
Sequencing Primer
(F):5'- ACCAGATTTCCTACTCTTTCAAATG -3'
(R):5'- GCTAAAACATCAGAAATCGCTTTTCC -3'
|
| Posted On |
2014-11-11 |
Incidental Mutation