Incidental Mutation 'R2375:Zfp655'
| ID |
248258 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp655
|
| Ensembl Gene |
ENSMUSG00000007812 |
| Gene Name |
zinc finger protein 655 |
| Synonyms |
2700038I16Rik, 9030409O18Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.353)
|
| Stock # |
R2375 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
145168525-145184112 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 145181206 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 355
(T355A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128969
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167316]
[ENSMUST00000199322]
|
| AlphaFold |
Q9CZP3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167316
AA Change: T355A
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000128969
Gene: ENSMUSG00000007812
AA Change: T355A
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
243 |
265 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
299 |
328 |
1.38e2 |
SMART |
|
ZnF_C2H2
|
334 |
356 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
3.99e0 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
1.01e-1 |
SMART |
|
low complexity region
|
463 |
475 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
517 |
6.47e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199322
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2ml1 |
C |
T |
6: 128,557,349 (GRCm39) |
A115T |
probably benign |
Het |
| Arhgef7 |
A |
G |
8: 11,864,995 (GRCm39) |
N369S |
probably benign |
Het |
| Celsr3 |
G |
A |
9: 108,719,751 (GRCm39) |
R2450H |
probably benign |
Het |
| Cps1 |
G |
A |
1: 67,257,019 (GRCm39) |
M1312I |
probably benign |
Het |
| Fbn2 |
A |
C |
18: 58,169,038 (GRCm39) |
I2247S |
probably damaging |
Het |
| Gtf2ird2 |
T |
A |
5: 134,245,977 (GRCm39) |
L745Q |
probably benign |
Het |
| Lrr1 |
A |
G |
12: 69,221,697 (GRCm39) |
T280A |
probably benign |
Het |
| Mpig6b |
C |
T |
17: 35,283,359 (GRCm39) |
M226I |
probably benign |
Het |
| Myo1a |
A |
G |
10: 127,541,159 (GRCm39) |
D12G |
probably damaging |
Het |
| Odr4 |
A |
G |
1: 150,265,985 (GRCm39) |
|
probably null |
Het |
| Or6c1 |
A |
G |
10: 129,518,032 (GRCm39) |
F192S |
probably benign |
Het |
| Orc5 |
A |
G |
5: 22,751,550 (GRCm39) |
L71P |
probably damaging |
Het |
| Phc2 |
T |
C |
4: 128,616,818 (GRCm39) |
S364P |
probably benign |
Het |
| Ramp3 |
G |
T |
11: 6,626,643 (GRCm39) |
V117L |
probably benign |
Het |
| Rpap1 |
C |
A |
2: 119,600,888 (GRCm39) |
W836L |
possibly damaging |
Het |
| Syt13 |
G |
A |
2: 92,776,496 (GRCm39) |
G261D |
probably benign |
Het |
| Taf6 |
A |
T |
5: 138,180,463 (GRCm39) |
Y300* |
probably null |
Het |
| Thsd7a |
T |
C |
6: 12,337,361 (GRCm39) |
S1219G |
probably damaging |
Het |
| Tmco3 |
T |
C |
8: 13,342,059 (GRCm39) |
F111S |
possibly damaging |
Het |
| Upk1b |
C |
T |
16: 38,607,490 (GRCm39) |
G79E |
probably damaging |
Het |
| Zc3h7b |
G |
A |
15: 81,676,703 (GRCm39) |
V773M |
probably benign |
Het |
|
| Other mutations in Zfp655 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Zfp655
|
APN |
5 |
145,180,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01679:Zfp655
|
APN |
5 |
145,180,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02379:Zfp655
|
APN |
5 |
145,180,765 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02647:Zfp655
|
APN |
5 |
145,179,816 (GRCm39) |
missense |
probably benign |
|
|
R0104:Zfp655
|
UTSW |
5 |
145,180,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0104:Zfp655
|
UTSW |
5 |
145,180,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Zfp655
|
UTSW |
5 |
145,181,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zfp655
|
UTSW |
5 |
145,180,867 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1528:Zfp655
|
UTSW |
5 |
145,181,411 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2076:Zfp655
|
UTSW |
5 |
145,181,410 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2119:Zfp655
|
UTSW |
5 |
145,181,594 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2403:Zfp655
|
UTSW |
5 |
145,181,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4032:Zfp655
|
UTSW |
5 |
145,180,858 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4532:Zfp655
|
UTSW |
5 |
145,181,507 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4880:Zfp655
|
UTSW |
5 |
145,181,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5484:Zfp655
|
UTSW |
5 |
145,180,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5529:Zfp655
|
UTSW |
5 |
145,181,546 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6193:Zfp655
|
UTSW |
5 |
145,181,586 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6195:Zfp655
|
UTSW |
5 |
145,180,572 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7050:Zfp655
|
UTSW |
5 |
145,181,545 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7471:Zfp655
|
UTSW |
5 |
145,181,542 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7612:Zfp655
|
UTSW |
5 |
145,173,999 (GRCm39) |
missense |
unknown |
|
|
R7626:Zfp655
|
UTSW |
5 |
145,173,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7989:Zfp655
|
UTSW |
5 |
145,181,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8557:Zfp655
|
UTSW |
5 |
145,180,835 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8805:Zfp655
|
UTSW |
5 |
145,181,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Zfp655
|
UTSW |
5 |
145,181,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9664:Zfp655
|
UTSW |
5 |
145,180,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp655
|
UTSW |
5 |
145,180,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATCAGGCCTCAGCTCTTAC -3'
(R):5'- GCATGAGGTTTGGCTGAAAG -3'
Sequencing Primer
(F):5'- GTCAGAGCTCAAGTCTTAGTCGAC -3'
(R):5'- CCCACATTCGTTACATGAGTAGGG -3'
|
| Posted On |
2014-11-11 |
Incidental Mutation