Incidental Mutation 'R2379:Scart2'
ID 248386
Institutional Source Beutler Lab
Gene Symbol Scart2
Ensembl Gene ENSMUSG00000054672
Gene Name scavenger receptor family member expressed on T cells 2
Synonyms 5830411N06Rik
MMRRC Submission 040355-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2379 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 139827197-139880649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 139879682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 990 (D990V)
Ref Sequence ENSEMBL: ENSMUSP00000091520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]
AlphaFold B3F5L4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059882
SMART Domains Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000093984
AA Change: D990V

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672
AA Change: D990V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
SR 446 546 8.78e-30 SMART
SR 551 651 1.26e-53 SMART
SR 656 756 2.88e-16 SMART
SR 783 883 7.62e-48 SMART
transmembrane domain 903 925 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164583
AA Change: D1106V

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: D1106V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
Blast:SR 291 349 5e-12 BLAST
SR 354 452 1.65e-34 SMART
SR 456 556 4.53e-32 SMART
SR 562 662 8.78e-30 SMART
SR 667 767 1.26e-53 SMART
SR 772 872 2.88e-16 SMART
SR 899 999 7.62e-48 SMART
transmembrane domain 1019 1041 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211749
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency 93% (37/40)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 T C 11: 53,299,305 (GRCm39) probably benign Het
Anpep T C 7: 79,490,966 (GRCm39) T209A probably benign Het
Asb16 A G 11: 102,163,357 (GRCm39) T116A probably benign Het
Brd10 G T 19: 29,696,275 (GRCm39) Q1140K probably benign Het
Btc A T 5: 91,524,768 (GRCm39) probably benign Het
C4b T C 17: 34,954,717 (GRCm39) D860G possibly damaging Het
Cd177 G A 7: 24,457,468 (GRCm39) T191I possibly damaging Het
Cngb1 A G 8: 95,986,758 (GRCm39) L378P probably damaging Het
Ddx60 T C 8: 62,490,122 (GRCm39) F1697S probably damaging Het
Dop1a G A 9: 86,403,138 (GRCm39) S1446N probably damaging Het
Fn1 T A 1: 71,688,443 (GRCm39) K154* probably null Het
Gm10801 G T 2: 98,494,185 (GRCm39) S109I probably benign Het
Ifi204 T A 1: 173,583,559 (GRCm39) R220* probably null Het
Limk1 A G 5: 134,708,335 (GRCm39) probably benign Het
Mcm2 G A 6: 88,869,990 (GRCm39) R60C probably damaging Het
Mms22l T A 4: 24,496,929 (GRCm39) S8T possibly damaging Het
Mpp7 T A 18: 7,403,345 (GRCm39) R322* probably null Het
Mycbp2 T C 14: 103,412,386 (GRCm39) N2529S probably benign Het
Npr3 A G 15: 11,883,449 (GRCm39) F327L probably damaging Het
Or12j3 A T 7: 139,952,748 (GRCm39) Y258* probably null Het
Or14c41 T G 7: 86,235,400 (GRCm39) F306V probably benign Het
Or14c46 T C 7: 85,918,857 (GRCm39) T47A probably damaging Het
Or51f5 A T 7: 102,424,052 (GRCm39) H107L probably benign Het
Or5p1 T C 7: 107,916,499 (GRCm39) S133P probably benign Het
Or6c217 A T 10: 129,737,781 (GRCm39) V266E probably damaging Het
Or7e177 T C 9: 20,211,963 (GRCm39) S157P possibly damaging Het
Pld2 A T 11: 70,445,140 (GRCm39) Y580F probably benign Het
Sik3 A G 9: 46,066,707 (GRCm39) E162G probably damaging Het
Sla2 G A 2: 156,717,862 (GRCm39) R137C probably damaging Het
Spen T C 4: 141,244,238 (GRCm39) T266A unknown Het
Tnks1bp1 A G 2: 84,894,182 (GRCm39) S1370G probably benign Het
Usp28 A G 9: 48,914,395 (GRCm39) R99G probably null Het
Vmn2r13 T G 5: 109,319,644 (GRCm39) E445D probably benign Het
Vmn2r27 A G 6: 124,201,342 (GRCm39) I205T possibly damaging Het
Other mutations in Scart2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Scart2 APN 7 139,874,755 (GRCm39) missense probably damaging 0.99
IGL01101:Scart2 APN 7 139,876,017 (GRCm39) missense probably benign 0.35
IGL01120:Scart2 APN 7 139,876,472 (GRCm39) missense probably benign 0.02
IGL01958:Scart2 APN 7 139,854,040 (GRCm39) missense probably damaging 1.00
IGL02150:Scart2 APN 7 139,877,772 (GRCm39) missense possibly damaging 0.84
IGL02193:Scart2 APN 7 139,828,913 (GRCm39) missense probably benign 0.17
IGL02239:Scart2 APN 7 139,875,756 (GRCm39) missense probably damaging 1.00
IGL02335:Scart2 APN 7 139,876,453 (GRCm39) missense probably damaging 1.00
IGL02569:Scart2 APN 7 139,878,275 (GRCm39) missense probably benign 0.01
IGL02993:Scart2 APN 7 139,876,486 (GRCm39) missense probably benign 0.07
IGL03261:Scart2 APN 7 139,874,746 (GRCm39) missense probably benign 0.00
IGL03365:Scart2 APN 7 139,876,682 (GRCm39) missense probably damaging 1.00
IGL03399:Scart2 APN 7 139,827,869 (GRCm39) missense probably benign 0.00
IGL03052:Scart2 UTSW 7 139,828,827 (GRCm39) missense probably damaging 1.00
PIT4791001:Scart2 UTSW 7 139,853,975 (GRCm39) missense possibly damaging 0.53
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0347:Scart2 UTSW 7 139,877,767 (GRCm39) missense probably damaging 1.00
R0374:Scart2 UTSW 7 139,828,874 (GRCm39) missense probably damaging 1.00
R0639:Scart2 UTSW 7 139,827,872 (GRCm39) missense probably benign 0.01
R0667:Scart2 UTSW 7 139,841,450 (GRCm39) missense possibly damaging 0.73
R0789:Scart2 UTSW 7 139,828,133 (GRCm39) missense probably damaging 1.00
R0959:Scart2 UTSW 7 139,874,704 (GRCm39) missense probably damaging 1.00
R1316:Scart2 UTSW 7 139,879,583 (GRCm39) missense probably benign 0.09
R1764:Scart2 UTSW 7 139,877,178 (GRCm39) missense probably benign 0.00
R2247:Scart2 UTSW 7 139,829,042 (GRCm39) missense probably null 0.96
R4112:Scart2 UTSW 7 139,878,281 (GRCm39) nonsense probably null
R4114:Scart2 UTSW 7 139,877,823 (GRCm39) missense probably damaging 1.00
R4346:Scart2 UTSW 7 139,827,878 (GRCm39) missense probably damaging 0.97
R4836:Scart2 UTSW 7 139,879,021 (GRCm39) missense probably benign
R4956:Scart2 UTSW 7 139,878,275 (GRCm39) missense probably benign 0.00
R5208:Scart2 UTSW 7 139,877,949 (GRCm39) missense probably benign 0.00
R5571:Scart2 UTSW 7 139,829,036 (GRCm39) missense probably damaging 1.00
R5583:Scart2 UTSW 7 139,876,739 (GRCm39) missense probably damaging 1.00
R5645:Scart2 UTSW 7 139,828,853 (GRCm39) missense possibly damaging 0.95
R6183:Scart2 UTSW 7 139,875,947 (GRCm39) missense possibly damaging 0.82
R6995:Scart2 UTSW 7 139,841,514 (GRCm39) missense probably benign
R7436:Scart2 UTSW 7 139,841,520 (GRCm39) missense probably benign
R7621:Scart2 UTSW 7 139,876,742 (GRCm39) missense probably damaging 1.00
R7662:Scart2 UTSW 7 139,874,725 (GRCm39) missense possibly damaging 0.58
R7669:Scart2 UTSW 7 139,876,234 (GRCm39) missense possibly damaging 0.47
R7686:Scart2 UTSW 7 139,828,965 (GRCm39) missense probably benign 0.00
R7985:Scart2 UTSW 7 139,876,806 (GRCm39) missense probably damaging 1.00
R8330:Scart2 UTSW 7 139,876,231 (GRCm39) nonsense probably null
R8843:Scart2 UTSW 7 139,828,913 (GRCm39) missense possibly damaging 0.93
R8888:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R8895:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R9044:Scart2 UTSW 7 139,828,010 (GRCm39) missense probably damaging 1.00
R9142:Scart2 UTSW 7 139,877,806 (GRCm39) missense probably damaging 1.00
R9152:Scart2 UTSW 7 139,877,256 (GRCm39) missense possibly damaging 0.55
R9470:Scart2 UTSW 7 139,827,345 (GRCm39) missense probably benign 0.07
R9509:Scart2 UTSW 7 139,879,644 (GRCm39) nonsense probably null
R9522:Scart2 UTSW 7 139,853,987 (GRCm39) missense possibly damaging 0.73
R9755:Scart2 UTSW 7 139,841,544 (GRCm39) critical splice donor site probably null
R9794:Scart2 UTSW 7 139,874,716 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCTCTGCAGGTTCTGGAGC -3'
(R):5'- GAAGGCTCTGAAGACCATCC -3'

Sequencing Primer
(F):5'- CAGGTTCTGGAGCAGTGGC -3'
(R):5'- AGAGGTCCTGAGTTCAATTCCCAG -3'
Posted On 2014-11-11