Incidental Mutation 'R2399:Myh15'
ID 248641
Institutional Source Beutler Lab
Gene Symbol Myh15
Ensembl Gene ENSMUSG00000092009
Gene Name myosin, heavy chain 15
Synonyms EG667772
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R2399 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 48877849-49019467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48957952 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 923 (I923T)
Ref Sequence ENSEMBL: ENSMUSP00000127539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168680]
AlphaFold E9Q264
Predicted Effect probably damaging
Transcript: ENSMUST00000168680
AA Change: I923T

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: I923T

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A G 5: 88,120,338 (GRCm39) E365G probably damaging Het
Abtb1 G A 6: 88,815,720 (GRCm39) T221M possibly damaging Het
Atp2b1 T A 10: 98,835,785 (GRCm39) I510N probably benign Het
Atr T A 9: 95,753,652 (GRCm39) H751Q probably benign Het
Cacna1d T C 14: 29,774,444 (GRCm39) D1650G probably benign Het
Cd93 A G 2: 148,284,071 (GRCm39) I425T probably benign Het
Dpep2 A G 8: 106,716,224 (GRCm39) S135P probably damaging Het
Gm10717 A G 9: 3,025,532 (GRCm39) Y39C probably benign Het
Heatr4 T C 12: 84,027,107 (GRCm39) H50R probably benign Het
Itga6 T C 2: 71,650,358 (GRCm39) Y135H probably damaging Het
Kat6b AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 14: 21,712,417 (GRCm39) probably benign Het
Or5b108 T A 19: 13,168,709 (GRCm39) I226K probably benign Het
Or7e170 C T 9: 19,795,220 (GRCm39) C127Y probably damaging Het
Or7g16 T A 9: 18,727,323 (GRCm39) D89V probably benign Het
Styxl1 C T 5: 135,776,635 (GRCm39) E318K possibly damaging Het
Tmcc1 C CAT 6: 116,019,831 (GRCm39) probably null Het
Zc3h7a G A 16: 10,965,265 (GRCm39) R623C probably damaging Het
Zfp608 T C 18: 55,030,974 (GRCm39) K989E probably damaging Het
Other mutations in Myh15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Myh15 APN 16 48,986,176 (GRCm39) missense probably damaging 0.98
IGL01095:Myh15 APN 16 48,952,378 (GRCm39) missense probably damaging 1.00
IGL01343:Myh15 APN 16 48,976,040 (GRCm39) missense probably benign 0.09
IGL01474:Myh15 APN 16 48,952,461 (GRCm39) missense probably damaging 1.00
IGL01572:Myh15 APN 16 48,920,585 (GRCm39) missense possibly damaging 0.55
IGL01595:Myh15 APN 16 48,993,312 (GRCm39) missense probably damaging 1.00
IGL01632:Myh15 APN 16 48,881,874 (GRCm39) missense probably benign 0.00
IGL01638:Myh15 APN 16 48,889,843 (GRCm39) missense probably damaging 1.00
IGL01667:Myh15 APN 16 49,015,942 (GRCm39) missense probably benign 0.20
IGL01715:Myh15 APN 16 48,877,847 (GRCm39) unclassified probably benign
IGL01833:Myh15 APN 16 48,934,421 (GRCm39) missense probably damaging 1.00
IGL02004:Myh15 APN 16 48,930,892 (GRCm39) splice site probably benign
IGL02033:Myh15 APN 16 48,965,707 (GRCm39) missense probably benign 0.05
IGL02148:Myh15 APN 16 48,936,678 (GRCm39) missense probably damaging 1.00
IGL02225:Myh15 APN 16 48,911,526 (GRCm39) missense probably benign 0.14
IGL02249:Myh15 APN 16 48,930,847 (GRCm39) missense probably damaging 0.99
IGL02505:Myh15 APN 16 48,937,626 (GRCm39) missense possibly damaging 0.90
IGL02622:Myh15 APN 16 48,997,317 (GRCm39) missense probably benign 0.02
IGL02814:Myh15 APN 16 48,965,801 (GRCm39) splice site probably benign
IGL02869:Myh15 APN 16 48,965,767 (GRCm39) missense probably benign
IGL02879:Myh15 APN 16 48,993,422 (GRCm39) missense possibly damaging 0.68
IGL02881:Myh15 APN 16 48,937,628 (GRCm39) missense possibly damaging 0.51
IGL03077:Myh15 APN 16 48,916,901 (GRCm39) missense probably benign 0.10
IGL03354:Myh15 APN 16 48,992,373 (GRCm39) missense probably benign 0.01
IGL03411:Myh15 APN 16 48,980,330 (GRCm39) missense possibly damaging 0.58
ANU74:Myh15 UTSW 16 48,993,295 (GRCm39) missense possibly damaging 0.58
P0027:Myh15 UTSW 16 48,901,571 (GRCm39) missense possibly damaging 0.77
PIT1430001:Myh15 UTSW 16 49,017,254 (GRCm39) critical splice donor site probably null
R0017:Myh15 UTSW 16 48,983,423 (GRCm39) missense probably damaging 0.97
R0038:Myh15 UTSW 16 48,891,504 (GRCm39) splice site probably benign
R0149:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0361:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0373:Myh15 UTSW 16 49,003,322 (GRCm39) missense possibly damaging 0.86
R0433:Myh15 UTSW 16 48,965,599 (GRCm39) missense probably damaging 1.00
R0525:Myh15 UTSW 16 48,952,414 (GRCm39) missense probably benign 0.03
R0586:Myh15 UTSW 16 48,992,250 (GRCm39) splice site probably benign
R0601:Myh15 UTSW 16 48,881,944 (GRCm39) missense probably damaging 1.00
R0717:Myh15 UTSW 16 48,963,356 (GRCm39) missense probably benign 0.03
R0963:Myh15 UTSW 16 48,952,512 (GRCm39) missense probably damaging 0.97
R1075:Myh15 UTSW 16 48,940,417 (GRCm39) missense possibly damaging 0.63
R1143:Myh15 UTSW 16 48,885,449 (GRCm39) missense probably benign 0.02
R1200:Myh15 UTSW 16 48,916,882 (GRCm39) missense probably damaging 1.00
R1644:Myh15 UTSW 16 48,952,566 (GRCm39) missense probably benign 0.12
R1646:Myh15 UTSW 16 49,015,931 (GRCm39) missense probably damaging 1.00
R1720:Myh15 UTSW 16 48,913,145 (GRCm39) missense probably damaging 1.00
R1768:Myh15 UTSW 16 48,983,498 (GRCm39) missense probably benign 0.27
R1881:Myh15 UTSW 16 48,891,446 (GRCm39) missense probably damaging 0.98
R2048:Myh15 UTSW 16 48,975,928 (GRCm39) missense probably damaging 0.99
R2064:Myh15 UTSW 16 48,975,984 (GRCm39) missense possibly damaging 0.50
R2184:Myh15 UTSW 16 48,957,874 (GRCm39) missense probably damaging 0.99
R2212:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R2216:Myh15 UTSW 16 48,986,201 (GRCm39) nonsense probably null
R2321:Myh15 UTSW 16 48,933,436 (GRCm39) missense possibly damaging 0.93
R2327:Myh15 UTSW 16 48,963,313 (GRCm39) missense probably benign 0.01
R2395:Myh15 UTSW 16 48,889,877 (GRCm39) missense probably benign 0.04
R3413:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R4234:Myh15 UTSW 16 48,983,405 (GRCm39) missense probably benign 0.04
R4382:Myh15 UTSW 16 48,963,306 (GRCm39) missense probably benign 0.03
R4421:Myh15 UTSW 16 48,929,707 (GRCm39) missense probably damaging 0.99
R4580:Myh15 UTSW 16 48,885,388 (GRCm39) missense possibly damaging 0.93
R4657:Myh15 UTSW 16 48,992,421 (GRCm39) nonsense probably null
R4780:Myh15 UTSW 16 48,940,420 (GRCm39) missense probably benign 0.13
R5004:Myh15 UTSW 16 48,952,411 (GRCm39) missense probably damaging 0.99
R5175:Myh15 UTSW 16 48,889,789 (GRCm39) missense possibly damaging 0.85
R5189:Myh15 UTSW 16 48,921,870 (GRCm39) missense probably benign 0.20
R5311:Myh15 UTSW 16 48,986,204 (GRCm39) missense possibly damaging 0.94
R5318:Myh15 UTSW 16 48,930,834 (GRCm39) missense probably damaging 0.99
R5404:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R5415:Myh15 UTSW 16 48,937,658 (GRCm39) missense probably null 1.00
R5558:Myh15 UTSW 16 48,889,900 (GRCm39) missense probably benign 0.32
R5977:Myh15 UTSW 16 48,973,866 (GRCm39) missense probably damaging 1.00
R6004:Myh15 UTSW 16 48,980,062 (GRCm39) missense probably benign 0.00
R6275:Myh15 UTSW 16 48,965,610 (GRCm39) missense probably benign 0.00
R6381:Myh15 UTSW 16 48,921,844 (GRCm39) missense probably damaging 1.00
R6448:Myh15 UTSW 16 48,992,295 (GRCm39) missense probably damaging 0.99
R6516:Myh15 UTSW 16 48,957,996 (GRCm39) missense probably benign 0.19
R6752:Myh15 UTSW 16 49,003,290 (GRCm39) missense probably damaging 1.00
R6847:Myh15 UTSW 16 48,965,451 (GRCm39) missense possibly damaging 0.70
R6868:Myh15 UTSW 16 48,889,766 (GRCm39) missense probably damaging 1.00
R6889:Myh15 UTSW 16 48,973,474 (GRCm39) missense possibly damaging 0.75
R6896:Myh15 UTSW 16 48,933,434 (GRCm39) missense probably benign 0.44
R6955:Myh15 UTSW 16 48,901,598 (GRCm39) critical splice donor site probably null
R6984:Myh15 UTSW 16 48,930,775 (GRCm39) missense probably damaging 1.00
R7046:Myh15 UTSW 16 48,929,662 (GRCm39) nonsense probably null
R7095:Myh15 UTSW 16 48,992,272 (GRCm39) missense possibly damaging 0.90
R7098:Myh15 UTSW 16 48,997,420 (GRCm39) missense possibly damaging 0.53
R7134:Myh15 UTSW 16 48,901,705 (GRCm39) missense possibly damaging 0.86
R7159:Myh15 UTSW 16 48,881,937 (GRCm39) missense probably damaging 0.97
R7244:Myh15 UTSW 16 49,017,149 (GRCm39) missense probably damaging 1.00
R7278:Myh15 UTSW 16 48,911,468 (GRCm39) missense probably damaging 0.98
R7309:Myh15 UTSW 16 48,916,828 (GRCm39) missense probably benign 0.34
R7327:Myh15 UTSW 16 48,993,369 (GRCm39) missense possibly damaging 0.88
R7418:Myh15 UTSW 16 48,975,900 (GRCm39) missense possibly damaging 0.69
R7937:Myh15 UTSW 16 48,976,009 (GRCm39) missense probably benign 0.00
R8053:Myh15 UTSW 16 48,963,302 (GRCm39) missense possibly damaging 0.89
R8313:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8315:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8316:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8317:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8342:Myh15 UTSW 16 48,913,120 (GRCm39) missense probably benign
R8379:Myh15 UTSW 16 48,901,551 (GRCm39) missense probably benign
R8445:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8707:Myh15 UTSW 16 48,973,450 (GRCm39) missense probably damaging 1.00
R8729:Myh15 UTSW 16 48,881,851 (GRCm39) missense probably damaging 0.97
R8773:Myh15 UTSW 16 49,015,900 (GRCm39) missense possibly damaging 0.89
R8869:Myh15 UTSW 16 48,997,366 (GRCm39) missense probably benign
R8890:Myh15 UTSW 16 48,959,130 (GRCm39) missense probably damaging 1.00
R9026:Myh15 UTSW 16 49,007,433 (GRCm39) missense probably damaging 1.00
R9063:Myh15 UTSW 16 48,913,118 (GRCm39) missense probably benign 0.00
R9290:Myh15 UTSW 16 48,997,375 (GRCm39) missense probably damaging 1.00
R9630:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R9710:Myh15 UTSW 16 48,959,044 (GRCm39) missense probably damaging 1.00
X0012:Myh15 UTSW 16 48,963,341 (GRCm39) missense probably damaging 1.00
X0020:Myh15 UTSW 16 48,986,237 (GRCm39) missense probably damaging 1.00
Z1176:Myh15 UTSW 16 48,916,894 (GRCm39) missense probably damaging 0.98
Z1177:Myh15 UTSW 16 48,980,189 (GRCm39) missense probably benign 0.09
Z1177:Myh15 UTSW 16 48,975,981 (GRCm39) missense probably damaging 0.97
Z1177:Myh15 UTSW 16 48,901,591 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CTCCTTACTGTGGCAAGCAG -3'
(R):5'- GCCGCTGTGCTAATAAATAAAACAC -3'

Sequencing Primer
(F):5'- AGCACTGTCACCAGCTGATG -3'
(R):5'- CTTCTGGTACCAAAGAACCAAGTC -3'
Posted On 2014-11-11