Incidental Mutation 'R2402:Zbtb41'
ID 248720
Institutional Source Beutler Lab
Gene Symbol Zbtb41
Ensembl Gene ENSMUSG00000033964
Gene Name zinc finger and BTB domain containing 41
Synonyms 8430415N23Rik, 9830132G07Rik
MMRRC Submission 040368-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.200) question?
Stock # R2402 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 139350026-139380743 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 139350925 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 13 (E13*)
Ref Sequence ENSEMBL: ENSMUSP00000142797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039867] [ENSMUST00000200243]
AlphaFold Q811F1
Predicted Effect probably null
Transcript: ENSMUST00000039867
AA Change: E13*
SMART Domains Protein: ENSMUSP00000045570
Gene: ENSMUSG00000033964
AA Change: E13*

DomainStartEndE-ValueType
low complexity region 70 81 N/A INTRINSIC
BTB 89 183 7.06e-16 SMART
ZnF_C2H2 208 231 3.78e-1 SMART
low complexity region 234 245 N/A INTRINSIC
low complexity region 265 279 N/A INTRINSIC
low complexity region 301 327 N/A INTRINSIC
ZnF_C2H2 360 382 4.17e-3 SMART
ZnF_C2H2 388 410 8.34e-3 SMART
ZnF_C2H2 421 444 2.67e-1 SMART
ZnF_C2H2 462 484 1.72e-4 SMART
ZnF_C2H2 490 513 1.41e0 SMART
ZnF_C2H2 517 540 1.12e-3 SMART
ZnF_C2H2 546 568 1.36e-2 SMART
ZnF_C2H2 574 596 2.91e-2 SMART
ZnF_C2H2 602 624 7.37e-4 SMART
ZnF_C2H2 630 653 3.39e-3 SMART
ZnF_C2H2 667 689 2.75e-3 SMART
ZnF_C2H2 695 717 3.16e-3 SMART
ZnF_C2H2 723 746 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000199011
Predicted Effect probably null
Transcript: ENSMUST00000200243
AA Change: E13*
SMART Domains Protein: ENSMUSP00000142797
Gene: ENSMUSG00000033964
AA Change: E13*

DomainStartEndE-ValueType
low complexity region 70 81 N/A INTRINSIC
BTB 89 183 4.7e-18 SMART
ZnF_C2H2 208 231 1.6e-3 SMART
low complexity region 234 245 N/A INTRINSIC
low complexity region 265 279 N/A INTRINSIC
low complexity region 301 327 N/A INTRINSIC
ZnF_C2H2 360 382 1.7e-5 SMART
ZnF_C2H2 388 410 3.5e-5 SMART
ZnF_C2H2 421 444 1.1e-3 SMART
ZnF_C2H2 462 484 7.2e-7 SMART
ZnF_C2H2 490 513 5.9e-3 SMART
ZnF_C2H2 517 540 4.7e-6 SMART
ZnF_C2H2 546 568 5.7e-5 SMART
ZnF_C2H2 574 596 1.3e-4 SMART
ZnF_C2H2 602 624 3e-6 SMART
ZnF_C2H2 630 653 1.5e-5 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.6%
  • 20x: 92.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T A 8: 87,235,770 (GRCm39) D1199V probably damaging Het
Abcc6 A T 7: 45,664,999 (GRCm39) S277R probably benign Het
Acvrl1 A G 15: 101,035,280 (GRCm39) S269G probably damaging Het
Akap10 T C 11: 61,806,048 (GRCm39) S227G probably benign Het
Angptl8 T C 9: 21,747,112 (GRCm39) probably null Het
Arsi T C 18: 61,049,539 (GRCm39) S141P possibly damaging Het
Atic T A 1: 71,608,216 (GRCm39) Y303* probably null Het
Bbs9 C T 9: 22,557,359 (GRCm39) P510L probably benign Het
Bcl2a1b A G 9: 89,081,795 (GRCm39) N128S probably benign Het
Bcl2a1d A T 9: 88,613,549 (GRCm39) M75K probably damaging Het
Carm1 T A 9: 21,494,836 (GRCm39) L324Q probably damaging Het
Caskin1 T A 17: 24,722,782 (GRCm39) L550Q probably damaging Het
Cd302 A G 2: 60,087,412 (GRCm39) I142T probably benign Het
Cep350 A T 1: 155,738,882 (GRCm39) D2320E probably benign Het
Cgnl1 A G 9: 71,632,461 (GRCm39) S297P probably damaging Het
Cr1l T A 1: 194,789,210 (GRCm39) Y398F probably benign Het
Ctsa A T 2: 164,676,813 (GRCm39) D145V probably benign Het
Ctsj C T 13: 61,148,388 (GRCm39) G303D probably damaging Het
Dnah17 T C 11: 118,016,800 (GRCm39) I250M probably benign Het
Doc2a C A 7: 126,447,919 (GRCm39) C54* probably null Het
Dpy19l2 T C 9: 24,492,544 (GRCm39) T685A probably damaging Het
Dtna T A 18: 23,728,535 (GRCm39) C243* probably null Het
Exoc3l4 A G 12: 111,388,690 (GRCm39) T60A possibly damaging Het
Exph5 C A 9: 53,286,225 (GRCm39) S1102* probably null Het
Fhl3 T C 4: 124,599,481 (GRCm39) Y19H probably damaging Het
Flt4 A G 11: 49,528,646 (GRCm39) E1012G possibly damaging Het
Flvcr2 A G 12: 85,829,777 (GRCm39) N262S probably benign Het
Gon4l G T 3: 88,766,350 (GRCm39) C463F probably damaging Het
H2-T10 A T 17: 36,428,631 (GRCm39) probably null Het
Heatr3 T C 8: 88,871,200 (GRCm39) C185R probably benign Het
Hectd1 A G 12: 51,792,317 (GRCm39) V2474A probably benign Het
Htr3a C T 9: 48,812,795 (GRCm39) E215K probably damaging Het
Ica1l T C 1: 60,045,451 (GRCm39) T271A probably benign Het
Klra2 A G 6: 131,220,864 (GRCm39) I66T probably benign Het
Neto2 T C 8: 86,417,541 (GRCm39) K21R probably benign Het
Niban1 A G 1: 151,565,365 (GRCm39) T232A probably benign Het
Nisch T A 14: 30,906,971 (GRCm39) probably benign Het
Nr4a1 G T 15: 101,169,618 (GRCm39) R296L probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or7g19 T A 9: 18,856,496 (GRCm39) I184N probably damaging Het
Or8b50 T C 9: 38,518,397 (GRCm39) V212A probably benign Het
Pcsk5 A T 19: 17,452,198 (GRCm39) C1102* probably null Het
Phip C T 9: 82,757,358 (GRCm39) A1605T probably benign Het
Pstpip2 T A 18: 77,942,564 (GRCm39) M105K possibly damaging Het
Qprt C T 7: 126,707,532 (GRCm39) V219I probably benign Het
Ralgapa2 A T 2: 146,195,112 (GRCm39) N1271K probably damaging Het
Reg3g A T 6: 78,444,475 (GRCm39) L106H probably damaging Het
Rhobtb1 G A 10: 69,106,254 (GRCm39) G273D probably benign Het
Rimbp2 T C 5: 128,861,952 (GRCm39) D771G probably damaging Het
Sos2 T C 12: 69,643,573 (GRCm39) I935V possibly damaging Het
Tcf12 A T 9: 71,763,792 (GRCm39) N397K probably damaging Het
Tgtp2 T C 11: 48,949,957 (GRCm39) Q205R probably benign Het
Tle5 T A 10: 81,400,712 (GRCm39) C89S possibly damaging Het
Tubb2b T C 13: 34,312,209 (GRCm39) N195D probably benign Het
Unc13b A G 4: 43,095,843 (GRCm39) T84A probably benign Het
Usb1 T A 8: 96,069,759 (GRCm39) F102L probably benign Het
Vmn2r61 A G 7: 41,949,529 (GRCm39) T650A possibly damaging Het
Zfp821 C T 8: 110,447,872 (GRCm39) S71F probably damaging Het
Other mutations in Zbtb41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Zbtb41 APN 1 139,358,062 (GRCm39) missense probably benign 0.01
IGL01796:Zbtb41 APN 1 139,370,621 (GRCm39) missense probably damaging 0.99
IGL01844:Zbtb41 APN 1 139,375,065 (GRCm39) missense probably benign 0.01
IGL02150:Zbtb41 APN 1 139,368,186 (GRCm39) missense possibly damaging 0.73
IGL02346:Zbtb41 APN 1 139,374,838 (GRCm39) missense probably damaging 1.00
IGL03139:Zbtb41 APN 1 139,351,576 (GRCm39) missense probably benign 0.00
IGL03215:Zbtb41 APN 1 139,374,688 (GRCm39) missense probably damaging 1.00
IGL03309:Zbtb41 APN 1 139,359,816 (GRCm39) critical splice donor site probably null
memorialized UTSW 1 139,368,132 (GRCm39) missense probably benign 0.00
Noted UTSW 1 139,366,769 (GRCm39) missense probably damaging 0.99
R7584_zbtb41_939 UTSW 1 139,351,795 (GRCm39) missense probably benign 0.14
unforgotten UTSW 1 139,359,816 (GRCm39) critical splice donor site probably null
R0004:Zbtb41 UTSW 1 139,370,626 (GRCm39) missense possibly damaging 0.90
R0010:Zbtb41 UTSW 1 139,351,268 (GRCm39) missense probably damaging 1.00
R0010:Zbtb41 UTSW 1 139,351,268 (GRCm39) missense probably damaging 1.00
R0048:Zbtb41 UTSW 1 139,369,572 (GRCm39) missense probably damaging 1.00
R0230:Zbtb41 UTSW 1 139,374,673 (GRCm39) missense probably damaging 1.00
R0309:Zbtb41 UTSW 1 139,366,722 (GRCm39) missense probably damaging 0.99
R0458:Zbtb41 UTSW 1 139,351,214 (GRCm39) missense probably damaging 1.00
R0606:Zbtb41 UTSW 1 139,351,348 (GRCm39) missense probably benign 0.28
R0964:Zbtb41 UTSW 1 139,366,769 (GRCm39) missense probably damaging 0.99
R1531:Zbtb41 UTSW 1 139,350,931 (GRCm39) missense probably benign 0.00
R1723:Zbtb41 UTSW 1 139,351,301 (GRCm39) missense probably benign 0.39
R1765:Zbtb41 UTSW 1 139,368,132 (GRCm39) missense probably benign 0.00
R1829:Zbtb41 UTSW 1 139,374,660 (GRCm39) nonsense probably null
R2077:Zbtb41 UTSW 1 139,351,831 (GRCm39) missense probably damaging 1.00
R2292:Zbtb41 UTSW 1 139,368,097 (GRCm39) missense probably damaging 0.99
R2380:Zbtb41 UTSW 1 139,351,552 (GRCm39) missense probably damaging 0.99
R2402:Zbtb41 UTSW 1 139,350,923 (GRCm39) missense probably benign 0.10
R3847:Zbtb41 UTSW 1 139,351,734 (GRCm39) missense probably benign
R3848:Zbtb41 UTSW 1 139,351,734 (GRCm39) missense probably benign
R3849:Zbtb41 UTSW 1 139,351,734 (GRCm39) missense probably benign
R4077:Zbtb41 UTSW 1 139,357,064 (GRCm39) missense probably benign 0.11
R4641:Zbtb41 UTSW 1 139,370,557 (GRCm39) missense probably damaging 0.98
R4772:Zbtb41 UTSW 1 139,375,152 (GRCm39) missense probably damaging 1.00
R5646:Zbtb41 UTSW 1 139,351,501 (GRCm39) missense probably benign 0.05
R5754:Zbtb41 UTSW 1 139,359,816 (GRCm39) critical splice donor site probably null
R6002:Zbtb41 UTSW 1 139,351,397 (GRCm39) missense probably damaging 1.00
R6045:Zbtb41 UTSW 1 139,351,770 (GRCm39) missense probably benign 0.34
R6302:Zbtb41 UTSW 1 139,357,027 (GRCm39) missense possibly damaging 0.67
R6318:Zbtb41 UTSW 1 139,358,044 (GRCm39) missense possibly damaging 0.91
R6430:Zbtb41 UTSW 1 139,374,945 (GRCm39) missense probably benign 0.02
R6906:Zbtb41 UTSW 1 139,351,128 (GRCm39) missense possibly damaging 0.59
R7584:Zbtb41 UTSW 1 139,351,795 (GRCm39) missense probably benign 0.14
R7753:Zbtb41 UTSW 1 139,374,895 (GRCm39) missense probably benign
R8132:Zbtb41 UTSW 1 139,350,955 (GRCm39) missense probably benign 0.00
R8138:Zbtb41 UTSW 1 139,369,545 (GRCm39) missense probably damaging 1.00
R8205:Zbtb41 UTSW 1 139,356,919 (GRCm39) missense possibly damaging 0.96
R8823:Zbtb41 UTSW 1 139,350,892 (GRCm39) missense probably damaging 1.00
R8967:Zbtb41 UTSW 1 139,370,587 (GRCm39) missense probably benign
R9431:Zbtb41 UTSW 1 139,350,781 (GRCm39) start gained probably benign
R9500:Zbtb41 UTSW 1 139,359,806 (GRCm39) missense probably damaging 1.00
R9559:Zbtb41 UTSW 1 139,358,053 (GRCm39) missense probably benign 0.14
R9603:Zbtb41 UTSW 1 139,375,255 (GRCm39) missense probably damaging 1.00
R9789:Zbtb41 UTSW 1 139,368,084 (GRCm39) missense probably damaging 1.00
Z1177:Zbtb41 UTSW 1 139,351,154 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTGGAGCTCTTACCTGATTCTC -3'
(R):5'- GACGGTTGCTTCTGCCTATC -3'

Sequencing Primer
(F):5'- CACTCTTTTTGCAGACCATGAAACG -3'
(R):5'- GCCTATCATCGTTCAAATACTTCAG -3'
Posted On 2014-11-11