Incidental Mutation 'R2415:Tspan15'
ID 248973
Institutional Source Beutler Lab
Gene Symbol Tspan15
Ensembl Gene ENSMUSG00000037031
Gene Name tetraspanin 15
Synonyms Tm4sf15, 2700063A19Rik
MMRRC Submission 040379-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R2415 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 62021175-62067030 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 62037570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 115 (I115T)
Ref Sequence ENSEMBL: ENSMUSP00000047029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047883]
AlphaFold F7BWT7
Predicted Effect probably benign
Transcript: ENSMUST00000047883
AA Change: I115T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000047029
Gene: ENSMUSG00000037031
AA Change: I115T

DomainStartEndE-ValueType
Pfam:Tetraspannin 18 259 1.1e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220143
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano6 A T 15: 95,860,161 (GRCm39) N761I probably damaging Het
Atad5 T C 11: 79,985,077 (GRCm39) S55P probably damaging Het
Cul9 T A 17: 46,854,364 (GRCm39) T113S probably benign Het
Ddx56 G A 11: 6,211,727 (GRCm39) probably benign Het
Dnttip2 T C 3: 122,070,186 (GRCm39) V467A probably damaging Het
Efhb A T 17: 53,770,124 (GRCm39) F62I probably benign Het
Efl1 T A 7: 82,347,175 (GRCm39) M567K probably damaging Het
Fbxw21 G T 9: 108,985,469 (GRCm39) A103E possibly damaging Het
Flnb T A 14: 7,929,932 (GRCm38) S2021T probably benign Het
Gabpa T C 16: 84,641,256 (GRCm39) probably null Het
Grid1 A T 14: 35,172,326 (GRCm39) I611F possibly damaging Het
Hdac1 A C 4: 129,416,754 (GRCm39) probably null Het
Kcnk5 T C 14: 20,191,880 (GRCm39) E427G possibly damaging Het
Kcnu1 A T 8: 26,400,906 (GRCm39) T685S probably benign Het
Khdc1b A G 1: 21,454,534 (GRCm39) D79G probably benign Het
Ky G T 9: 102,419,090 (GRCm39) G366W probably damaging Het
Limch1 T C 5: 67,131,977 (GRCm39) S147P probably damaging Het
Mroh1 A G 15: 76,305,411 (GRCm39) K405E probably damaging Het
Myo15b T G 11: 115,770,390 (GRCm39) F67V probably benign Het
Nlrp4c A G 7: 6,069,047 (GRCm39) D316G probably damaging Het
Nudt12 A G 17: 59,313,603 (GRCm39) V325A probably damaging Het
Pdia4 G T 6: 47,783,490 (GRCm39) D184E probably benign Het
Per3 A C 4: 151,097,147 (GRCm39) F793V possibly damaging Het
Pla1a T A 16: 38,228,112 (GRCm39) Y255F possibly damaging Het
Rxfp1 A G 3: 79,570,626 (GRCm39) S269P probably benign Het
S100pbp A T 4: 129,075,614 (GRCm39) V118D possibly damaging Het
Sec24b A T 3: 129,789,729 (GRCm39) I764N probably benign Het
Sh3bp1 C T 15: 78,785,361 (GRCm39) probably benign Het
Surf6 C T 2: 26,782,274 (GRCm39) R351H probably damaging Het
Vmn2r73 T C 7: 85,521,431 (GRCm39) Y179C probably damaging Het
Zfp750 T C 11: 121,403,305 (GRCm39) D481G probably benign Het
Other mutations in Tspan15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02145:Tspan15 APN 10 62,029,751 (GRCm39) splice site probably benign
PIT1430001:Tspan15 UTSW 10 62,023,899 (GRCm39) missense probably damaging 0.98
R0071:Tspan15 UTSW 10 62,038,849 (GRCm39) splice site probably benign
R0071:Tspan15 UTSW 10 62,038,849 (GRCm39) splice site probably benign
R0310:Tspan15 UTSW 10 62,023,872 (GRCm39) missense probably benign 0.01
R4152:Tspan15 UTSW 10 62,025,621 (GRCm39) missense possibly damaging 0.87
R4766:Tspan15 UTSW 10 62,027,323 (GRCm39) missense probably benign 0.00
R7446:Tspan15 UTSW 10 62,029,734 (GRCm39) missense probably benign
R8814:Tspan15 UTSW 10 62,023,835 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCCTAGCCACTTAGCATGATG -3'
(R):5'- AGTCTCTAGCTTCAAGGCTTC -3'

Sequencing Primer
(F):5'- GCTATCCTAGTTTACCCAACC -3'
(R):5'- TTCTCTAGCACAGCCCTAGGAG -3'
Posted On 2014-11-12