Incidental Mutation 'R2436:Or5k1'
ID 249605
Institutional Source Beutler Lab
Gene Symbol Or5k1
Ensembl Gene ENSMUSG00000049362
Gene Name olfactory receptor family 5 subfamily K member 1
Synonyms MOR184-3, GA_x54KRFPKG5P-54960233-54959268, Olfr173
MMRRC Submission 040397-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R2436 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58617142-58618305 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 58617607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 201 (V201I)
Ref Sequence ENSEMBL: ENSMUSP00000145946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049940] [ENSMUST00000206205]
AlphaFold E9QAT7
Predicted Effect probably benign
Transcript: ENSMUST00000049940
AA Change: V201I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000052798
Gene: ENSMUSG00000049362
AA Change: V201I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.7e-52 PFAM
Pfam:7tm_1 41 290 9.7e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206205
AA Change: V201I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg7 A G 16: 56,582,308 (GRCm39) S277P possibly damaging Het
Arl6ip4 T C 5: 124,254,662 (GRCm39) S52P probably benign Het
Barx2 T C 9: 31,824,383 (GRCm39) H2R probably damaging Het
Calhm3 T C 19: 47,140,404 (GRCm39) T230A probably damaging Het
Card11 C T 5: 140,868,117 (GRCm39) V844M possibly damaging Het
Dnah6 C T 6: 73,126,156 (GRCm39) R1327Q probably benign Het
Dnai4 T C 4: 102,923,549 (GRCm39) I427V probably benign Het
Ehbp1 C A 11: 22,039,524 (GRCm39) probably null Het
Fgg T A 3: 82,921,496 (GRCm39) I393N possibly damaging Het
Foxq1 A T 13: 31,742,516 (GRCm39) probably benign Het
Hmgxb3 T C 18: 61,280,566 (GRCm39) T646A probably benign Het
Homer3 G A 8: 70,745,706 (GRCm39) E324K possibly damaging Het
Krt80 A G 15: 101,257,384 (GRCm39) F183L probably damaging Het
Map3k21 A T 8: 126,668,354 (GRCm39) K647* probably null Het
Mcm3ap A G 10: 76,325,891 (GRCm39) Y1067C probably damaging Het
Myh1 G T 11: 67,104,097 (GRCm39) Q921H probably benign Het
Nme8 A G 13: 19,862,029 (GRCm39) F200S probably damaging Het
Nploc4 T C 11: 120,309,143 (GRCm39) N153S possibly damaging Het
Or14c45 T C 7: 86,176,591 (GRCm39) F209L probably damaging Het
Or2ak6 T C 11: 58,592,952 (GRCm39) C142R probably damaging Het
Or4a73 A G 2: 89,421,117 (GRCm39) V114A probably benign Het
Pipox T A 11: 77,782,943 (GRCm39) L86F probably damaging Het
Polr3h G T 15: 81,801,406 (GRCm39) L157I probably benign Het
Prex2 G A 1: 11,336,376 (GRCm39) V1525M possibly damaging Het
Rapgef2 A T 3: 78,996,079 (GRCm39) D561E possibly damaging Het
Sacs A T 14: 61,440,354 (GRCm39) D800V possibly damaging Het
Sbsn A T 7: 30,451,655 (GRCm39) L223F possibly damaging Het
Slc16a9 TCCCC TCCCCC 10: 70,091,911 (GRCm39) probably null Het
Srrm3 G T 5: 135,864,030 (GRCm39) E43* probably null Het
Tcaf3 G A 6: 42,570,663 (GRCm39) A363V probably damaging Het
Tmem138 A G 19: 10,552,268 (GRCm39) F78S probably damaging Het
Tnfrsf17 G A 16: 11,137,676 (GRCm39) D138N probably damaging Het
Tubgcp6 C T 15: 88,986,568 (GRCm39) V1344I probably benign Het
Usp24 T A 4: 106,266,842 (GRCm39) L1875* probably null Het
Vmn2r109 C A 17: 20,774,798 (GRCm39) G186C probably damaging Het
Zfp541 A G 7: 15,810,373 (GRCm39) N137D possibly damaging Het
Other mutations in Or5k1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02649:Or5k1 APN 16 58,617,713 (GRCm39) missense probably damaging 1.00
IGL02728:Or5k1 APN 16 58,617,843 (GRCm39) missense probably benign 0.07
IGL02893:Or5k1 APN 16 58,618,020 (GRCm39) missense probably damaging 1.00
R0035:Or5k1 UTSW 16 58,617,485 (GRCm39) nonsense probably null
R0480:Or5k1 UTSW 16 58,617,684 (GRCm39) missense probably benign 0.05
R1101:Or5k1 UTSW 16 58,617,615 (GRCm39) missense probably benign 0.27
R1434:Or5k1 UTSW 16 58,617,811 (GRCm39) missense probably benign 0.06
R1992:Or5k1 UTSW 16 58,617,309 (GRCm39) missense probably benign
R2220:Or5k1 UTSW 16 58,617,987 (GRCm39) missense possibly damaging 0.69
R4212:Or5k1 UTSW 16 58,617,732 (GRCm39) missense possibly damaging 0.67
R4910:Or5k1 UTSW 16 58,617,805 (GRCm39) missense probably benign 0.03
R5666:Or5k1 UTSW 16 58,617,424 (GRCm39) missense possibly damaging 0.75
R5670:Or5k1 UTSW 16 58,617,424 (GRCm39) missense possibly damaging 0.75
R5896:Or5k1 UTSW 16 58,618,095 (GRCm39) missense probably damaging 1.00
R6182:Or5k1 UTSW 16 58,617,655 (GRCm39) missense probably damaging 1.00
R6613:Or5k1 UTSW 16 58,617,894 (GRCm39) missense probably damaging 0.99
R6723:Or5k1 UTSW 16 58,617,795 (GRCm39) missense probably benign 0.06
R7051:Or5k1 UTSW 16 58,617,538 (GRCm39) missense probably benign 0.21
R7141:Or5k1 UTSW 16 58,617,771 (GRCm39) missense probably benign 0.05
R7179:Or5k1 UTSW 16 58,617,250 (GRCm39) missense probably benign 0.00
R7602:Or5k1 UTSW 16 58,617,343 (GRCm39) missense possibly damaging 0.62
R8425:Or5k1 UTSW 16 58,617,966 (GRCm39) missense probably benign 0.11
Z1176:Or5k1 UTSW 16 58,618,036 (GRCm39) missense probably damaging 0.99
Z1176:Or5k1 UTSW 16 58,617,786 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGGCATGTCCTTATCACC -3'
(R):5'- TCCAAGAAGCTCTGCCTTC -3'

Sequencing Primer
(F):5'- ATCACCTTCTTCTAGCAAATTTGG -3'
(R):5'- TCAGATGACGACGGGAGCTTTC -3'
Posted On 2014-11-12