Incidental Mutation 'R2443:Or5l14'
ID 249854
Institutional Source Beutler Lab
Gene Symbol Or5l14
Ensembl Gene ENSMUSG00000075143
Gene Name olfactory receptor family 5 subfamily L member 14
Synonyms MOR174-1, GA_x6K02T2Q125-49446395-49445457, Olfr1157
MMRRC Submission 040401-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R2443 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87792296-87798601 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87793209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 9 (V9E)
Ref Sequence ENSEMBL: ENSMUSP00000097429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099841]
AlphaFold A2AVC4
Predicted Effect possibly damaging
Transcript: ENSMUST00000099841
AA Change: V9E

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097429
Gene: ENSMUSG00000075143
AA Change: V9E

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.7e-48 PFAM
Pfam:7tm_1 41 290 2.6e-20 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc13 C T 9: 102,511,222 (GRCm39) P37S probably damaging Het
Asxl3 T A 18: 22,544,596 (GRCm39) D39E probably benign Het
Cfap91 A G 16: 38,123,094 (GRCm39) Y645H probably damaging Het
Clec4d G A 6: 123,245,076 (GRCm39) V119M probably benign Het
Dennd11 T C 6: 40,383,710 (GRCm39) D444G probably damaging Het
Dlx2 A G 2: 71,376,349 (GRCm39) S130P probably benign Het
Dync2li1 C A 17: 84,955,093 (GRCm39) Q251K probably benign Het
Edem1 A T 6: 108,828,230 (GRCm39) K518N probably benign Het
Elapor1 A T 3: 108,388,665 (GRCm39) N239K probably damaging Het
Fbln2 T C 6: 91,236,693 (GRCm39) V736A probably damaging Het
Fga A G 3: 82,935,848 (GRCm39) K25R probably benign Het
Hmcn1 C A 1: 150,474,783 (GRCm39) R4701S probably benign Het
Ighv8-5 G A 12: 115,031,440 (GRCm39) P33L probably damaging Het
Kcnip3 T A 2: 127,301,983 (GRCm39) I194F probably damaging Het
Kif26b A C 1: 178,742,579 (GRCm39) I892L probably damaging Het
Krt78 C T 15: 101,855,033 (GRCm39) G926E probably damaging Het
Map1b T C 13: 99,566,919 (GRCm39) Y1934C unknown Het
Masp1 A T 16: 23,295,062 (GRCm39) Y400N probably damaging Het
Methig1 T C 15: 100,251,092 (GRCm39) M1T probably null Het
Mmp19 A G 10: 128,634,725 (GRCm39) E447G possibly damaging Het
Ms4a6d G A 19: 11,567,557 (GRCm39) H115Y possibly damaging Het
Myo1e C T 9: 70,234,454 (GRCm39) S269L probably benign Het
Myo7a G A 7: 97,744,976 (GRCm39) T288I probably benign Het
Npy5r T A 8: 67,133,942 (GRCm39) K284* probably null Het
Oas3 C A 5: 120,915,553 (GRCm39) R46L probably benign Het
Pkd1l3 T A 8: 110,350,447 (GRCm39) S431T probably benign Het
Pnpla2 T C 7: 141,037,982 (GRCm39) V184A possibly damaging Het
Pomt2 C A 12: 87,180,154 (GRCm39) K282N probably damaging Het
Psmd12 T A 11: 107,386,563 (GRCm39) M378K probably damaging Het
Sla2 G A 2: 156,717,862 (GRCm39) R137C probably damaging Het
Strn3 A T 12: 51,674,618 (GRCm39) Y389N probably damaging Het
Tdrd1 C T 19: 56,829,786 (GRCm39) A220V probably null Het
Tecpr2 T G 12: 110,862,759 (GRCm39) L57R probably damaging Het
Tkfc A G 19: 10,571,902 (GRCm39) L378P probably damaging Het
Tmprss2 T G 16: 97,369,703 (GRCm39) D357A possibly damaging Het
Tollip C T 7: 141,444,560 (GRCm39) W64* probably null Het
Vcan A G 13: 89,852,794 (GRCm39) F722S probably damaging Het
Vcp A T 4: 42,983,385 (GRCm39) N558K probably damaging Het
Vmn1r232 A G 17: 21,133,646 (GRCm39) I318T probably damaging Het
Vmn1r33 A T 6: 66,588,957 (GRCm39) I199K possibly damaging Het
Zfp61 A G 7: 23,991,194 (GRCm39) V319A probably benign Het
Zfyve28 A G 5: 34,374,238 (GRCm39) V592A possibly damaging Het
Other mutations in Or5l14
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Or5l14 UTSW 2 87,792,802 (GRCm39) missense possibly damaging 0.90
R1502:Or5l14 UTSW 2 87,792,379 (GRCm39) missense probably damaging 1.00
R2127:Or5l14 UTSW 2 87,793,176 (GRCm39) missense probably benign 0.01
R2284:Or5l14 UTSW 2 87,793,137 (GRCm39) missense probably damaging 0.99
R4021:Or5l14 UTSW 2 87,793,066 (GRCm39) missense possibly damaging 0.77
R4693:Or5l14 UTSW 2 87,793,053 (GRCm39) missense probably benign 0.39
R4752:Or5l14 UTSW 2 87,792,693 (GRCm39) missense probably damaging 1.00
R4879:Or5l14 UTSW 2 87,793,040 (GRCm39) missense possibly damaging 0.91
R4983:Or5l14 UTSW 2 87,793,042 (GRCm39) missense probably benign 0.26
R5592:Or5l14 UTSW 2 87,792,684 (GRCm39) missense probably damaging 1.00
R5945:Or5l14 UTSW 2 87,792,946 (GRCm39) missense probably damaging 1.00
R6412:Or5l14 UTSW 2 87,792,693 (GRCm39) missense probably damaging 1.00
R7470:Or5l14 UTSW 2 87,792,793 (GRCm39) missense possibly damaging 0.74
R9585:Or5l14 UTSW 2 87,792,919 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TCCACAAAGGACAGATGGCTG -3'
(R):5'- CTTCTGAGTTCAATCGTGGGTTTAAC -3'

Sequencing Primer
(F):5'- GGCGGTGACTCCATAAAT -3'
(R):5'- GTTCAATCGTGGGTTTAACTACTTC -3'
Posted On 2014-11-12