Incidental Mutation 'R2410:Zfp954'
| ID |
249949 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp954
|
| Ensembl Gene |
ENSMUSG00000062116 |
| Gene Name |
zinc finger protein 954 |
| Synonyms |
5730403M16Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R2410 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
7117682-7124475 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 7120808 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 74
(I74N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072585
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056246]
|
| AlphaFold |
Q7TNU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000056246
AA Change: I74N
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000072585
Gene: ENSMUSG00000062116
AA Change: I74N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
42 |
102 |
4.6e-14 |
SMART |
|
ZnF_C2H2
|
198 |
220 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
226 |
248 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
2.01e-5 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
1.26e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207756
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210142
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
G |
T |
11: 109,684,980 (GRCm39) |
C172* |
probably null |
Het |
| Adgrf5 |
C |
A |
17: 43,766,157 (GRCm39) |
N1326K |
probably benign |
Het |
| Ciita |
A |
G |
16: 10,328,568 (GRCm39) |
E284G |
probably damaging |
Het |
| Ctbp2 |
T |
C |
7: 132,616,083 (GRCm39) |
Y284C |
probably benign |
Het |
| Dnah11 |
T |
C |
12: 117,991,262 (GRCm39) |
D2368G |
probably damaging |
Het |
| Enpp3 |
C |
T |
10: 24,650,716 (GRCm39) |
V807I |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,439,240 (GRCm39) |
D491G |
probably damaging |
Het |
| Ero1a |
C |
T |
14: 45,542,723 (GRCm39) |
V101I |
possibly damaging |
Het |
| Fbxl7 |
A |
G |
15: 26,895,111 (GRCm39) |
Y9H |
possibly damaging |
Het |
| Fzd2 |
A |
G |
11: 102,496,453 (GRCm39) |
Y299C |
possibly damaging |
Het |
| Lamc1 |
G |
A |
1: 153,123,141 (GRCm39) |
T683M |
possibly damaging |
Het |
| Lrrc39 |
C |
T |
3: 116,374,899 (GRCm39) |
P327S |
probably benign |
Het |
| Marf1 |
A |
T |
16: 13,933,691 (GRCm39) |
F1566I |
probably benign |
Het |
| Me2 |
A |
T |
18: 73,924,183 (GRCm39) |
M343K |
probably damaging |
Het |
| Mlxip |
T |
A |
5: 123,581,132 (GRCm39) |
W260R |
probably damaging |
Het |
| Mrps17 |
T |
C |
5: 129,795,047 (GRCm39) |
V64A |
probably damaging |
Het |
| Or4c118 |
A |
T |
2: 88,974,899 (GRCm39) |
I156N |
possibly damaging |
Het |
| Phldb3 |
C |
T |
7: 24,323,719 (GRCm39) |
S450L |
probably benign |
Het |
| Pi4k2a |
A |
G |
19: 42,093,316 (GRCm39) |
E219G |
possibly damaging |
Het |
| Polr1a |
T |
C |
6: 71,951,866 (GRCm39) |
S1478P |
probably benign |
Het |
| Rab14 |
T |
C |
2: 35,076,762 (GRCm39) |
|
probably null |
Het |
| Rnf43 |
T |
C |
11: 87,623,085 (GRCm39) |
Y729H |
possibly damaging |
Het |
| Sgms1 |
G |
A |
19: 32,137,072 (GRCm39) |
R165* |
probably null |
Het |
| Sorbs1 |
T |
A |
19: 40,361,959 (GRCm39) |
I142F |
probably damaging |
Het |
| Tmem255b |
A |
G |
8: 13,491,278 (GRCm39) |
I66V |
probably benign |
Het |
| Vmn2r9 |
T |
C |
5: 108,996,123 (GRCm39) |
D175G |
probably damaging |
Het |
|
| Other mutations in Zfp954 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00588:Zfp954
|
APN |
7 |
7,118,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01696:Zfp954
|
APN |
7 |
7,118,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0196:Zfp954
|
UTSW |
7 |
7,118,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1723:Zfp954
|
UTSW |
7 |
7,118,837 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2112:Zfp954
|
UTSW |
7 |
7,118,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2255:Zfp954
|
UTSW |
7 |
7,118,321 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5118:Zfp954
|
UTSW |
7 |
7,118,714 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5191:Zfp954
|
UTSW |
7 |
7,119,022 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5832:Zfp954
|
UTSW |
7 |
7,118,389 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5851:Zfp954
|
UTSW |
7 |
7,118,624 (GRCm39) |
nonsense |
probably null |
|
|
R7633:Zfp954
|
UTSW |
7 |
7,118,823 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7646:Zfp954
|
UTSW |
7 |
7,118,720 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7710:Zfp954
|
UTSW |
7 |
7,120,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Zfp954
|
UTSW |
7 |
7,118,470 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9054:Zfp954
|
UTSW |
7 |
7,119,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9192:Zfp954
|
UTSW |
7 |
7,118,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAAAGGTAGTTGTGTAACAAGCC -3'
(R):5'- ATAGGTTCACAGCCTGGTACC -3'
Sequencing Primer
(F):5'- AGGTAGTTGTGTAACAAGCCTATGTC -3'
(R):5'- TACCCTCTGAGATAGGAGCCTAAG -3'
|
| Posted On |
2014-11-12 |
Incidental Mutation