Incidental Mutation 'R2412:Cyp3a44'
ID 250031
Institutional Source Beutler Lab
Gene Symbol Cyp3a44
Ensembl Gene ENSMUSG00000054417
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 44
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R2412 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 145710793-145742684 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 145716389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 400 (Y400*)
Ref Sequence ENSEMBL: ENSMUSP00000069932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067479]
AlphaFold Q9EQW4
Predicted Effect probably null
Transcript: ENSMUST00000067479
AA Change: Y400*
SMART Domains Protein: ENSMUSP00000069932
Gene: ENSMUSG00000054417
AA Change: Y400*

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
Pfam:p450 38 494 2.4e-133 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 A T 3: 36,127,740 (GRCm39) Q114L probably benign Het
Adamts3 A G 5: 89,849,630 (GRCm39) Y597H probably damaging Het
Bmi1 A G 2: 18,688,525 (GRCm39) H172R probably damaging Het
Dennd5b T C 6: 148,906,736 (GRCm39) T1062A possibly damaging Het
Dync2h1 T C 9: 7,144,246 (GRCm39) D1065G probably benign Het
Ephb1 G A 9: 101,879,015 (GRCm39) R492C possibly damaging Het
Fat4 A T 3: 39,011,221 (GRCm39) H2107L probably benign Het
Itga8 A G 2: 12,306,526 (GRCm39) V23A probably benign Het
Lrba A G 3: 86,235,007 (GRCm39) N851D probably damaging Het
Ltbp3 A G 19: 5,796,673 (GRCm39) T322A probably benign Het
Ntpcr T C 8: 126,472,144 (GRCm39) V151A probably damaging Het
Or8h7 T C 2: 86,721,178 (GRCm39) I114V probably benign Het
Or9g3 C A 2: 85,590,024 (GRCm39) G232V probably damaging Het
Pramel51 A G 12: 88,143,880 (GRCm39) V311A probably damaging Het
Rps6ka4 A T 19: 6,807,309 (GRCm39) *774K probably null Het
Slc12a5 T C 2: 164,818,382 (GRCm39) probably null Het
Tmem219 T C 7: 126,495,939 (GRCm39) S37G probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Tubb1 A G 2: 174,298,903 (GRCm39) N195S possibly damaging Het
Zan A G 5: 137,412,425 (GRCm39) probably null Het
Zfp85 T C 13: 67,897,765 (GRCm39) I102M probably damaging Het
Other mutations in Cyp3a44
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00813:Cyp3a44 APN 5 145,711,157 (GRCm39) makesense probably null
IGL00972:Cyp3a44 APN 5 145,716,534 (GRCm39) missense possibly damaging 0.84
IGL01062:Cyp3a44 APN 5 145,731,149 (GRCm39) missense possibly damaging 0.88
IGL01072:Cyp3a44 APN 5 145,728,438 (GRCm39) missense probably benign 0.01
IGL01515:Cyp3a44 APN 5 145,736,228 (GRCm39) nonsense probably null
IGL01738:Cyp3a44 APN 5 145,731,745 (GRCm39) missense probably damaging 1.00
IGL01869:Cyp3a44 APN 5 145,727,496 (GRCm39) missense probably damaging 0.99
IGL02269:Cyp3a44 APN 5 145,742,547 (GRCm39) missense probably benign 0.23
IGL02284:Cyp3a44 APN 5 145,725,179 (GRCm39) missense possibly damaging 0.91
IGL02479:Cyp3a44 APN 5 145,727,477 (GRCm39) missense probably benign 0.01
IGL02480:Cyp3a44 APN 5 145,731,715 (GRCm39) missense possibly damaging 0.93
IGL02506:Cyp3a44 APN 5 145,736,198 (GRCm39) missense probably damaging 1.00
IGL02957:Cyp3a44 APN 5 145,716,472 (GRCm39) nonsense probably null
IGL02978:Cyp3a44 APN 5 145,725,208 (GRCm39) missense probably damaging 0.98
R0427:Cyp3a44 UTSW 5 145,716,412 (GRCm39) missense possibly damaging 0.85
R1240:Cyp3a44 UTSW 5 145,711,250 (GRCm39) missense probably benign 0.02
R1247:Cyp3a44 UTSW 5 145,728,477 (GRCm39) missense probably damaging 1.00
R1657:Cyp3a44 UTSW 5 145,716,553 (GRCm39) missense probably damaging 0.99
R2096:Cyp3a44 UTSW 5 145,725,215 (GRCm39) missense probably damaging 1.00
R2156:Cyp3a44 UTSW 5 145,740,480 (GRCm39) nonsense probably null
R4817:Cyp3a44 UTSW 5 145,740,565 (GRCm39) missense possibly damaging 0.64
R4884:Cyp3a44 UTSW 5 145,714,792 (GRCm39) missense probably damaging 1.00
R5266:Cyp3a44 UTSW 5 145,731,207 (GRCm39) missense possibly damaging 0.66
R5301:Cyp3a44 UTSW 5 145,725,326 (GRCm39) missense probably damaging 0.99
R5463:Cyp3a44 UTSW 5 145,740,554 (GRCm39) missense probably benign 0.00
R5625:Cyp3a44 UTSW 5 145,716,376 (GRCm39) missense possibly damaging 0.74
R5635:Cyp3a44 UTSW 5 145,738,124 (GRCm39) missense possibly damaging 0.90
R5924:Cyp3a44 UTSW 5 145,731,137 (GRCm39) missense possibly damaging 0.54
R5964:Cyp3a44 UTSW 5 145,725,277 (GRCm39) missense possibly damaging 0.95
R5988:Cyp3a44 UTSW 5 145,731,728 (GRCm39) missense probably damaging 1.00
R6011:Cyp3a44 UTSW 5 145,738,084 (GRCm39) critical splice donor site probably null
R6032:Cyp3a44 UTSW 5 145,714,756 (GRCm39) missense probably damaging 1.00
R6032:Cyp3a44 UTSW 5 145,714,756 (GRCm39) missense probably damaging 1.00
R6413:Cyp3a44 UTSW 5 145,731,254 (GRCm39) missense probably damaging 1.00
R6579:Cyp3a44 UTSW 5 145,727,516 (GRCm39) missense probably damaging 0.99
R6587:Cyp3a44 UTSW 5 145,742,569 (GRCm39) missense probably benign 0.23
R6709:Cyp3a44 UTSW 5 145,714,902 (GRCm39) splice site probably null
R6727:Cyp3a44 UTSW 5 145,731,781 (GRCm39) nonsense probably null
R6825:Cyp3a44 UTSW 5 145,716,396 (GRCm39) missense probably damaging 1.00
R7142:Cyp3a44 UTSW 5 145,714,771 (GRCm39) missense probably benign 0.24
R7352:Cyp3a44 UTSW 5 145,740,498 (GRCm39) missense probably benign 0.01
R7921:Cyp3a44 UTSW 5 145,728,498 (GRCm39) missense probably damaging 1.00
R7962:Cyp3a44 UTSW 5 145,738,135 (GRCm39) missense probably benign
R8099:Cyp3a44 UTSW 5 145,725,212 (GRCm39) missense probably benign 0.12
R8240:Cyp3a44 UTSW 5 145,725,257 (GRCm39) missense probably damaging 0.99
R8836:Cyp3a44 UTSW 5 145,731,728 (GRCm39) missense probably damaging 1.00
R8923:Cyp3a44 UTSW 5 145,736,171 (GRCm39) missense probably damaging 1.00
R8934:Cyp3a44 UTSW 5 145,731,786 (GRCm39) missense possibly damaging 0.70
R9019:Cyp3a44 UTSW 5 145,727,519 (GRCm39) missense probably damaging 1.00
R9287:Cyp3a44 UTSW 5 145,725,202 (GRCm39) missense possibly damaging 0.93
R9293:Cyp3a44 UTSW 5 145,711,187 (GRCm39) missense probably benign 0.00
R9425:Cyp3a44 UTSW 5 145,740,548 (GRCm39) nonsense probably null
Z1176:Cyp3a44 UTSW 5 145,728,474 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTAGACTTTCTGCCAGTCGC -3'
(R):5'- ACTCCCACCTGTGATACTGTG -3'

Sequencing Primer
(F):5'- GCCATTCTCCTCACACAATGC -3'
(R):5'- CCCACCTGTGATACTGTGATGGAG -3'
Posted On 2014-11-12