Incidental Mutation 'R2425:Or8k21'
ID 250130
Institutional Source Beutler Lab
Gene Symbol Or8k21
Ensembl Gene ENSMUSG00000075192
Gene Name olfactory receptor family 8 subfamily K member 21
Synonyms GA_x6K02T2Q125-47793414-47792471, MOR187-4, Olfr1053-ps1, Olfr1053
MMRRC Submission 040387-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R2425 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86144687-86145628 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86144739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 297 (V297A)
Ref Sequence ENSEMBL: ENSMUSP00000097481 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099897]
AlphaFold L7MU59
Predicted Effect probably damaging
Transcript: ENSMUST00000099897
AA Change: V297A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097481
Gene: ENSMUSG00000075192
AA Change: V297A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1e-45 PFAM
Pfam:7tm_1 41 290 1.2e-17 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T C 7: 119,959,033 (GRCm39) F621S probably damaging Het
Abcc10 A G 17: 46,621,083 (GRCm39) Y976H probably damaging Het
Abhd6 T A 14: 8,049,857 (GRCm38) N215K probably benign Het
Adcy4 T C 14: 56,015,474 (GRCm39) T479A probably damaging Het
Amacr A G 15: 10,983,454 (GRCm39) Q88R possibly damaging Het
Ankrd11 T A 8: 123,619,902 (GRCm39) I1317F possibly damaging Het
Ano3 C A 2: 110,693,188 (GRCm39) A137S probably benign Het
Astn1 T G 1: 158,407,236 (GRCm39) S562A probably damaging Het
Cd44 T A 2: 102,691,931 (GRCm39) Y119F probably damaging Het
CN725425 A C 15: 91,130,058 (GRCm39) D307A probably damaging Het
Col12a1 T C 9: 79,585,648 (GRCm39) Y1243C probably damaging Het
Cyp2c50 T C 19: 40,078,292 (GRCm39) I50T probably benign Het
Dhrs9 A G 2: 69,223,308 (GRCm39) K19E probably benign Het
Dnajb14 T G 3: 137,598,666 (GRCm39) F135V probably null Het
Draxin T A 4: 148,197,213 (GRCm39) T195S possibly damaging Het
Elane C T 10: 79,723,610 (GRCm39) R192C probably benign Het
Fam171a2 A C 11: 102,329,187 (GRCm39) I524S possibly damaging Het
Fbxo10 C T 4: 45,051,642 (GRCm39) E490K possibly damaging Het
Fkbp15 T C 4: 62,230,602 (GRCm39) T704A probably benign Het
Fndc1 T A 17: 8,023,850 (GRCm39) D35V probably damaging Het
Galntl5 A G 5: 25,425,079 (GRCm39) K366E probably damaging Het
Gas7 G A 11: 67,534,121 (GRCm39) A74T probably benign Het
Gjd4 G T 18: 9,280,811 (GRCm39) S89* probably null Het
Gldc T A 19: 30,109,190 (GRCm39) N583Y probably damaging Het
Gpr161 T A 1: 165,138,192 (GRCm39) S259R possibly damaging Het
Igfn1 T A 1: 135,890,840 (GRCm39) T2387S probably damaging Het
Il3 A T 11: 54,156,375 (GRCm39) V119D possibly damaging Het
Ints3 T C 3: 90,301,417 (GRCm39) T822A possibly damaging Het
Jakmip1 C T 5: 37,299,149 (GRCm39) Q790* probably null Het
Kcne1 A G 16: 92,145,646 (GRCm39) I66T probably damaging Het
Nipbl A G 15: 8,380,966 (GRCm39) S609P probably benign Het
Or10d5 T C 9: 39,861,137 (GRCm39) E310G probably null Het
Or2t48 A G 11: 58,420,137 (GRCm39) I225T probably damaging Het
Pdxdc1 A T 16: 13,697,372 (GRCm39) S103T possibly damaging Het
Pla2g2a C A 4: 138,560,229 (GRCm39) A24E possibly damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Pramel1 T G 4: 143,125,036 (GRCm39) L320R probably damaging Het
Rad23b T A 4: 55,385,438 (GRCm39) I325N probably damaging Het
Rasgrp1 C G 2: 117,119,931 (GRCm39) probably null Het
Rbm12b1 T A 4: 12,146,443 (GRCm39) I805N probably damaging Het
Shld2 A G 14: 33,990,646 (GRCm39) S87P probably damaging Het
Slc12a9 G T 5: 137,313,859 (GRCm39) A700E probably damaging Het
Tbc1d24 A T 17: 24,404,982 (GRCm39) V54E probably damaging Het
Tmc8 A G 11: 117,683,395 (GRCm39) D650G probably damaging Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Ush2a T A 1: 188,270,001 (GRCm39) N1749K possibly damaging Het
Usp42 T C 5: 143,701,594 (GRCm39) T810A probably benign Het
Wdr70 C A 15: 7,916,840 (GRCm39) E526* probably null Het
Zfp935 G T 13: 62,602,922 (GRCm39) Q93K probably benign Het
Other mutations in Or8k21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Or8k21 APN 2 86,145,288 (GRCm39) missense probably damaging 1.00
IGL02063:Or8k21 APN 2 86,145,137 (GRCm39) missense possibly damaging 0.50
IGL02503:Or8k21 APN 2 86,144,983 (GRCm39) missense possibly damaging 0.71
IGL03342:Or8k21 APN 2 86,145,579 (GRCm39) missense possibly damaging 0.85
PIT4520001:Or8k21 UTSW 2 86,145,142 (GRCm39) missense possibly damaging 0.78
R0562:Or8k21 UTSW 2 86,144,869 (GRCm39) missense probably benign 0.00
R1026:Or8k21 UTSW 2 86,145,558 (GRCm39) missense possibly damaging 0.80
R1134:Or8k21 UTSW 2 86,145,525 (GRCm39) missense probably damaging 1.00
R1200:Or8k21 UTSW 2 86,145,477 (GRCm39) missense probably damaging 0.99
R1566:Or8k21 UTSW 2 86,145,129 (GRCm39) missense probably benign 0.01
R1588:Or8k21 UTSW 2 86,144,874 (GRCm39) missense probably damaging 1.00
R1747:Or8k21 UTSW 2 86,145,211 (GRCm39) missense probably benign 0.00
R1951:Or8k21 UTSW 2 86,145,504 (GRCm39) missense probably damaging 1.00
R1975:Or8k21 UTSW 2 86,145,498 (GRCm39) missense probably damaging 0.99
R2291:Or8k21 UTSW 2 86,145,524 (GRCm39) nonsense probably null
R5092:Or8k21 UTSW 2 86,144,706 (GRCm39) missense probably benign 0.00
R5651:Or8k21 UTSW 2 86,144,784 (GRCm39) missense probably benign 0.23
R5733:Or8k21 UTSW 2 86,145,558 (GRCm39) missense probably damaging 0.98
R5767:Or8k21 UTSW 2 86,144,742 (GRCm39) missense probably damaging 1.00
R6307:Or8k21 UTSW 2 86,145,468 (GRCm39) missense probably benign
R6720:Or8k21 UTSW 2 86,145,409 (GRCm39) missense probably damaging 0.99
R7067:Or8k21 UTSW 2 86,144,911 (GRCm39) missense probably damaging 1.00
R7289:Or8k21 UTSW 2 86,145,369 (GRCm39) missense probably benign 0.00
R7604:Or8k21 UTSW 2 86,145,244 (GRCm39) missense probably damaging 1.00
R7773:Or8k21 UTSW 2 86,145,034 (GRCm39) missense probably benign 0.01
R8345:Or8k21 UTSW 2 86,145,451 (GRCm39) missense probably damaging 1.00
R9246:Or8k21 UTSW 2 86,145,222 (GRCm39) missense probably damaging 0.99
R9454:Or8k21 UTSW 2 86,145,178 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCAGGTACAGTGCTAGATATAAC -3'
(R):5'- ACATGTGGGTCTCATTTGACAGTG -3'

Sequencing Primer
(F):5'- AGTGCTAGATATAACGAAAATTCTGG -3'
(R):5'- CTCATTTGACAGTGGTTGTGG -3'
Posted On 2014-11-12