Incidental Mutation 'R2427:Zfp648'
ID 250256
Institutional Source Beutler Lab
Gene Symbol Zfp648
Ensembl Gene ENSMUSG00000066797
Gene Name zinc finger protein 648
Synonyms Gm10178, LOC207678
MMRRC Submission 040389-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R2427 (G1)
Quality Score 134
Status Validated
Chromosome 1
Chromosomal Location 154076933-154081435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 154080819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 326 (C326Y)
Ref Sequence ENSEMBL: ENSMUSP00000083370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086195]
AlphaFold D3Z0W3
Predicted Effect probably damaging
Transcript: ENSMUST00000086195
AA Change: C326Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: C326Y

DomainStartEndE-ValueType
ZnF_C2H2 236 258 1.82e-3 SMART
ZnF_C2H2 264 286 1.28e-3 SMART
ZnF_C2H2 292 315 1.2e-3 SMART
ZnF_C2H2 321 343 1.95e-3 SMART
ZnF_C2H2 349 371 8.94e-3 SMART
ZnF_C2H2 377 399 8.34e-3 SMART
ZnF_C2H2 405 427 4.54e-4 SMART
ZnF_C2H2 433 455 4.47e-3 SMART
ZnF_C2H2 461 483 5.81e-2 SMART
ZnF_C2H2 489 511 1.2e-3 SMART
Meta Mutation Damage Score 0.7735 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankmy1 A G 1: 92,798,529 (GRCm39) probably null Het
Atp2a1 T A 7: 126,045,755 (GRCm39) *995L probably null Het
Axin2 T A 11: 108,814,800 (GRCm39) N229K possibly damaging Het
Capn13 A T 17: 73,633,312 (GRCm39) probably benign Het
Ccdc180 A G 4: 45,929,545 (GRCm39) I1202V probably benign Het
Cep295 A G 9: 15,245,534 (GRCm39) L974P probably damaging Het
Cers3 T C 7: 66,445,541 (GRCm39) Y321H probably benign Het
Chrnb4 T C 9: 54,942,101 (GRCm39) Y391C probably benign Het
Ciao1 T C 2: 127,088,611 (GRCm39) H104R probably damaging Het
Cldn4 A T 5: 134,975,331 (GRCm39) V90E probably damaging Het
Crbn T C 6: 106,760,433 (GRCm39) E253G probably damaging Het
Ctns A G 11: 73,087,512 (GRCm39) W5R probably damaging Het
Eme1 G A 11: 94,541,801 (GRCm39) probably benign Het
Fat2 T A 11: 55,201,638 (GRCm39) T479S probably benign Het
Fbxw25 T C 9: 109,481,928 (GRCm39) N253D probably benign Het
Fer A G 17: 64,264,298 (GRCm39) I39V probably benign Het
Fmnl2 A G 2: 53,006,991 (GRCm39) M768V probably damaging Het
Frg1 T C 8: 41,867,903 (GRCm39) K24E probably damaging Het
I830077J02Rik G T 3: 105,835,320 (GRCm39) A19D probably damaging Het
Ighv1-20 C T 12: 114,687,692 (GRCm39) silent Het
Igsf9 A G 1: 172,318,306 (GRCm39) S149G probably damaging Het
Klra10 T A 6: 130,256,298 (GRCm39) I119F probably benign Het
Lrrc4b T A 7: 44,111,976 (GRCm39) I616N probably damaging Het
Lrrc71 T C 3: 87,653,309 (GRCm39) T64A probably benign Het
Ly9 A T 1: 171,434,800 (GRCm39) I31N probably damaging Het
Mef2a A G 7: 66,915,808 (GRCm39) S165P probably damaging Het
Nol4 T G 18: 22,983,755 (GRCm39) probably benign Het
Nt5el T C 13: 105,246,269 (GRCm39) F277L probably benign Het
Plxnd1 C T 6: 115,944,709 (GRCm39) probably null Het
Rab27b T C 18: 70,129,205 (GRCm39) T30A probably damaging Het
Rasa4 A G 5: 136,130,881 (GRCm39) D384G probably benign Het
Slx4 G A 16: 3,806,851 (GRCm39) L531F probably damaging Het
Tafa4 C T 6: 96,991,328 (GRCm39) probably benign Het
Tgm1 C T 14: 55,949,557 (GRCm39) probably null Het
Tpm2 T C 4: 43,523,306 (GRCm39) N17D probably damaging Het
Tyrp1 A G 4: 80,769,108 (GRCm39) T134A probably benign Het
Zfand6 T A 7: 84,283,498 (GRCm39) K35* probably null Het
Other mutations in Zfp648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp648 APN 1 154,079,935 (GRCm39) missense possibly damaging 0.88
IGL01150:Zfp648 APN 1 154,081,110 (GRCm39) missense probably damaging 1.00
IGL01557:Zfp648 APN 1 154,080,426 (GRCm39) missense probably benign
IGL01757:Zfp648 APN 1 154,080,671 (GRCm39) missense probably damaging 0.98
IGL02247:Zfp648 APN 1 154,079,923 (GRCm39) missense probably benign 0.01
PIT4519001:Zfp648 UTSW 1 154,080,687 (GRCm39) missense probably damaging 0.98
R0001:Zfp648 UTSW 1 154,081,032 (GRCm39) missense probably damaging 1.00
R0256:Zfp648 UTSW 1 154,081,414 (GRCm39) missense probably benign 0.08
R0266:Zfp648 UTSW 1 154,080,632 (GRCm39) missense probably damaging 1.00
R0371:Zfp648 UTSW 1 154,080,413 (GRCm39) missense possibly damaging 0.66
R1498:Zfp648 UTSW 1 154,081,119 (GRCm39) missense probably damaging 1.00
R1562:Zfp648 UTSW 1 154,080,138 (GRCm39) missense probably benign
R1687:Zfp648 UTSW 1 154,079,988 (GRCm39) missense probably benign 0.15
R2128:Zfp648 UTSW 1 154,080,353 (GRCm39) missense probably benign
R2567:Zfp648 UTSW 1 154,080,695 (GRCm39) missense probably damaging 0.98
R2844:Zfp648 UTSW 1 154,080,881 (GRCm39) nonsense probably null
R3711:Zfp648 UTSW 1 154,080,304 (GRCm39) missense probably benign 0.30
R4491:Zfp648 UTSW 1 154,080,873 (GRCm39) missense probably damaging 1.00
R4693:Zfp648 UTSW 1 154,080,152 (GRCm39) missense probably benign 0.01
R5666:Zfp648 UTSW 1 154,079,963 (GRCm39) missense probably benign 0.00
R5670:Zfp648 UTSW 1 154,079,963 (GRCm39) missense probably benign 0.00
R7432:Zfp648 UTSW 1 154,080,783 (GRCm39) missense possibly damaging 0.84
R8069:Zfp648 UTSW 1 154,079,862 (GRCm39) missense probably benign 0.34
R8137:Zfp648 UTSW 1 154,081,110 (GRCm39) missense probably damaging 1.00
R8282:Zfp648 UTSW 1 154,080,535 (GRCm39) missense probably benign 0.25
R9023:Zfp648 UTSW 1 154,080,914 (GRCm39) missense probably damaging 0.98
R9489:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
R9520:Zfp648 UTSW 1 154,081,221 (GRCm39) missense probably benign
R9605:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
Z1088:Zfp648 UTSW 1 154,080,266 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTCTGCGACAAGGCGTACAC -3'
(R):5'- CAGTCGGTGCATTTGAAGGG -3'

Sequencing Primer
(F):5'- AAGGCGTACACCTGGTCCTC -3'
(R):5'- ATTTGGTGAAGCACTTGCCGC -3'
Posted On 2014-11-12