Incidental Mutation 'R2429:Zfp574'
ID 250343
Institutional Source Beutler Lab
Gene Symbol Zfp574
Ensembl Gene ENSMUSG00000045252
Gene Name zinc finger protein 574
Synonyms A630056B21Rik
MMRRC Submission 040391-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2429 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 24775099-24782917 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 24779482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 168 (L168*)
Ref Sequence ENSEMBL: ENSMUSP00000136547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053410] [ENSMUST00000179556]
AlphaFold Q8BY46
Predicted Effect probably null
Transcript: ENSMUST00000053410
AA Change: L168*
SMART Domains Protein: ENSMUSP00000057817
Gene: ENSMUSG00000045252
AA Change: L168*

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000179556
AA Change: L168*
SMART Domains Protein: ENSMUSP00000136547
Gene: ENSMUSG00000045252
AA Change: L168*

DomainStartEndE-ValueType
ZnF_C2H2 16 38 4.98e-1 SMART
ZnF_C2H2 76 98 4.05e-1 SMART
low complexity region 107 118 N/A INTRINSIC
ZnF_C2H2 126 148 1.99e0 SMART
low complexity region 156 173 N/A INTRINSIC
ZnF_C2H2 213 235 4.4e-2 SMART
low complexity region 237 254 N/A INTRINSIC
low complexity region 289 298 N/A INTRINSIC
ZnF_C2H2 312 334 7.15e-2 SMART
ZnF_C2H2 339 361 1.04e-3 SMART
ZnF_C2H2 367 389 4.12e0 SMART
ZnF_C2H2 395 416 2.12e1 SMART
low complexity region 418 434 N/A INTRINSIC
ZnF_C2H2 469 492 1.03e-2 SMART
ZnF_C2H2 498 520 2.75e-3 SMART
ZnF_C2H2 526 548 3.39e-3 SMART
ZnF_C2H2 554 576 2.75e-3 SMART
ZnF_C2H2 582 604 2.86e-1 SMART
ZnF_C2H2 610 633 1.25e-1 SMART
ZnF_C2H2 639 659 4.5e1 SMART
low complexity region 660 666 N/A INTRINSIC
ZnF_C2H2 670 692 2.29e0 SMART
ZnF_C2H2 742 764 2.91e-2 SMART
ZnF_C2H2 770 792 5.59e-4 SMART
ZnF_C2H2 798 820 3.34e-2 SMART
ZnF_C2H2 826 848 4.24e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206530
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206733
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930470P17Rik A T 2: 170,421,745 (GRCm39) M45K unknown Het
Abcd3 A G 3: 121,586,512 (GRCm39) F63L probably damaging Het
Acsm3 A T 7: 119,367,223 (GRCm39) M19L probably benign Het
Actn4 T C 7: 28,597,496 (GRCm39) K41E probably benign Het
Atp8b3 T A 10: 80,362,728 (GRCm39) I677L probably benign Het
Auh C T 13: 53,073,052 (GRCm39) G110R probably damaging Het
Batf2 A G 19: 6,221,538 (GRCm39) Y116C probably damaging Het
Cntn6 T C 6: 104,627,526 (GRCm39) Y120H possibly damaging Het
Gnpat T C 8: 125,603,758 (GRCm39) F212S probably damaging Het
Gpd1 A G 15: 99,618,488 (GRCm39) M181V probably benign Het
Itgb3 A T 11: 104,527,914 (GRCm39) K216N probably damaging Het
Kif21a G A 15: 90,882,208 (GRCm39) T32M probably damaging Het
Macf1 A G 4: 123,326,377 (GRCm39) V3477A probably damaging Het
Mettl13 A T 1: 162,373,894 (GRCm39) L119* probably null Het
Myg1 G C 15: 102,246,171 (GRCm39) G349R probably damaging Het
Myh8 A G 11: 67,194,723 (GRCm39) N1645D probably benign Het
Myo6 T C 9: 80,210,583 (GRCm39) probably null Het
Npffr2 A T 5: 89,731,006 (GRCm39) Y312F probably damaging Het
Pla2r1 C A 2: 60,345,312 (GRCm39) C348F probably damaging Het
Plcb1 A G 2: 135,179,362 (GRCm39) N590S probably damaging Het
Prpsap1 G A 11: 116,363,061 (GRCm39) T314M probably damaging Het
Prss35 T C 9: 86,637,398 (GRCm39) V56A probably benign Het
Setx T C 2: 29,069,910 (GRCm39) S2572P probably benign Het
Sf3b1 T C 1: 55,055,960 (GRCm39) D93G possibly damaging Het
Slc26a7 C A 4: 14,506,399 (GRCm39) probably benign Het
Slc39a12 T G 2: 14,409,897 (GRCm39) S298A probably benign Het
Sorl1 G T 9: 41,948,366 (GRCm39) D806E probably damaging Het
Syt1 T C 10: 108,526,781 (GRCm39) K43E possibly damaging Het
Trmt1l T A 1: 151,309,581 (GRCm39) L88Q probably damaging Het
Zfp334 G A 2: 165,222,432 (GRCm39) T537I probably damaging Het
Other mutations in Zfp574
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Zfp574 APN 7 24,781,015 (GRCm39) missense probably benign 0.00
IGL02370:Zfp574 APN 7 24,779,014 (GRCm39) missense possibly damaging 0.95
IGL02706:Zfp574 APN 7 24,780,790 (GRCm39) missense probably damaging 0.98
IGL03119:Zfp574 APN 7 24,779,898 (GRCm39) missense probably benign
glue UTSW 7 24,780,515 (GRCm39) missense
BB004:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
BB014:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R0866:Zfp574 UTSW 7 24,779,323 (GRCm39) missense probably damaging 1.00
R3123:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3124:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R3125:Zfp574 UTSW 7 24,781,026 (GRCm39) missense possibly damaging 0.88
R4581:Zfp574 UTSW 7 24,780,738 (GRCm39) missense probably damaging 0.98
R4591:Zfp574 UTSW 7 24,778,969 (GRCm39) start gained probably benign
R4915:Zfp574 UTSW 7 24,780,151 (GRCm39) missense probably damaging 0.98
R4953:Zfp574 UTSW 7 24,780,388 (GRCm39) missense probably damaging 0.97
R5305:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
R5541:Zfp574 UTSW 7 24,781,375 (GRCm39) missense probably damaging 0.99
R5934:Zfp574 UTSW 7 24,779,757 (GRCm39) missense probably benign
R6088:Zfp574 UTSW 7 24,779,764 (GRCm39) missense probably benign 0.01
R7061:Zfp574 UTSW 7 24,779,622 (GRCm39) missense possibly damaging 0.95
R7563:Zfp574 UTSW 7 24,780,777 (GRCm39) missense possibly damaging 0.94
R7615:Zfp574 UTSW 7 24,780,001 (GRCm39) missense possibly damaging 0.95
R7927:Zfp574 UTSW 7 24,779,572 (GRCm39) missense probably benign
R8017:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8019:Zfp574 UTSW 7 24,780,095 (GRCm39) nonsense probably null
R8788:Zfp574 UTSW 7 24,779,816 (GRCm39) missense unknown
R8871:Zfp574 UTSW 7 24,780,562 (GRCm39) missense probably damaging 0.99
R8915:Zfp574 UTSW 7 24,780,769 (GRCm39) missense probably damaging 1.00
R9484:Zfp574 UTSW 7 24,781,404 (GRCm39) missense possibly damaging 0.77
R9533:Zfp574 UTSW 7 24,780,379 (GRCm39) missense probably damaging 1.00
R9606:Zfp574 UTSW 7 24,780,640 (GRCm39) missense probably damaging 1.00
R9623:Zfp574 UTSW 7 24,780,515 (GRCm39) missense
X0026:Zfp574 UTSW 7 24,780,477 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGAAGATGATGGCACCGCAG -3'
(R):5'- AACTGTGATCAGAGGCTGGC -3'

Sequencing Primer
(F):5'- AGTGCCAGCCAAGCCAC -3'
(R):5'- TGAGACACTGCTGCCTCAG -3'
Posted On 2014-11-12