Incidental Mutation 'R2446:Prss3b'
ID 250567
Institutional Source Beutler Lab
Gene Symbol Prss3b
Ensembl Gene ENSMUSG00000029882
Gene Name serine protease 3B
Synonyms 2210010C04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R2446 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 41007202-41012443 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41008582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 244 (I244T)
Ref Sequence ENSEMBL: ENSMUSP00000031931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031931]
AlphaFold Q9CPN9
Predicted Effect probably benign
Transcript: ENSMUST00000031931
AA Change: I244T

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000031931
Gene: ENSMUSG00000029882
AA Change: I244T

DomainStartEndE-ValueType
Tryp_SPc 24 240 3.52e-102 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,225,101 (GRCm39) R527G probably benign Het
Cap1 T A 4: 122,758,401 (GRCm39) I260F probably benign Het
Chst9 T C 18: 15,585,895 (GRCm39) K223E possibly damaging Het
Dpy19l4 A T 4: 11,304,143 (GRCm39) probably null Het
Ercc2 T C 7: 19,120,869 (GRCm39) I223T probably damaging Het
Hydin T C 8: 111,314,347 (GRCm39) L4277P possibly damaging Het
Ibtk T C 9: 85,585,126 (GRCm39) N1173D probably benign Het
Klra17 T A 6: 129,808,477 (GRCm39) H252L probably benign Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Npc1 A G 18: 12,347,396 (GRCm39) V208A probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or5b107 T G 19: 13,142,811 (GRCm39) C144W probably benign Het
P2rx7 A T 5: 122,818,879 (GRCm39) M434L probably benign Het
Pcdhb9 G A 18: 37,536,340 (GRCm39) G778E probably damaging Het
Scn7a A G 2: 66,523,002 (GRCm39) Y901H probably damaging Het
Tlcd1 G A 11: 78,069,623 (GRCm39) probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Vmn2r3 A G 3: 64,182,733 (GRCm39) I322T probably damaging Het
Zbtb38 C T 9: 96,569,699 (GRCm39) V462M probably damaging Het
Other mutations in Prss3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01120:Prss3b APN 6 41,008,607 (GRCm39) missense probably damaging 1.00
IGL01625:Prss3b APN 6 41,009,882 (GRCm39) missense probably benign 0.01
IGL02159:Prss3b APN 6 41,009,891 (GRCm39) missense probably benign 0.34
IGL03161:Prss3b APN 6 41,011,240 (GRCm39) missense probably damaging 0.96
R0419:Prss3b UTSW 6 41,011,281 (GRCm39) missense probably benign 0.05
R1715:Prss3b UTSW 6 41,009,870 (GRCm39) splice site probably null
R2057:Prss3b UTSW 6 41,009,315 (GRCm39) missense probably benign 0.06
R2059:Prss3b UTSW 6 41,009,315 (GRCm39) missense probably benign 0.06
R2136:Prss3b UTSW 6 41,012,396 (GRCm39) missense probably benign 0.28
R4862:Prss3b UTSW 6 41,009,345 (GRCm39) missense possibly damaging 0.74
R5068:Prss3b UTSW 6 41,009,370 (GRCm39) missense probably benign 0.35
R5369:Prss3b UTSW 6 41,009,940 (GRCm39) missense probably benign 0.00
R6392:Prss3b UTSW 6 41,009,306 (GRCm39) missense probably damaging 1.00
R7010:Prss3b UTSW 6 41,009,247 (GRCm39) missense probably benign 0.42
R7567:Prss3b UTSW 6 41,010,127 (GRCm39) missense probably benign 0.04
R7727:Prss3b UTSW 6 41,010,127 (GRCm39) missense probably benign 0.04
R7962:Prss3b UTSW 6 41,012,387 (GRCm39) missense probably benign 0.01
R8373:Prss3b UTSW 6 41,008,622 (GRCm39) missense possibly damaging 0.53
R8529:Prss3b UTSW 6 41,009,369 (GRCm39) missense probably benign 0.00
R8883:Prss3b UTSW 6 41,009,305 (GRCm39) nonsense probably null
R8916:Prss3b UTSW 6 41,010,103 (GRCm39) missense probably damaging 1.00
R9066:Prss3b UTSW 6 41,008,640 (GRCm39) missense probably benign 0.41
R9095:Prss3b UTSW 6 41,010,038 (GRCm39) missense possibly damaging 0.76
R9180:Prss3b UTSW 6 41,008,681 (GRCm39) missense probably damaging 1.00
R9389:Prss3b UTSW 6 41,010,079 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCAACTAAGGTGTGCCAGC -3'
(R):5'- AGTGGCCCGAGATAATCAAG -3'

Sequencing Primer
(F):5'- AGGTGTGCCAGCTATATTAATAAAC -3'
(R):5'- GCCCGAGATAATCAAGTAACAACTTG -3'
Posted On 2014-11-12