Mutagenetix > Incidental Mutation

Incidental Mutation 'R2497:Dnah8'

251122

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

P1-Loop, Dnahc8, Hst6.7b

MMRRC Submission

040411-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.477) question?

Stock #

R2497 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

30845909-31094736 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 30960339 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 2239 (Q2239*)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000170651
AA Change: Q2239*

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: Q2239*

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.3%

Validation Efficiency

100% (60/60)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acox2	A	G	14: 8,251,612 (GRCm38)	V295A	probably benign	Het
Agrn	T	C	4: 156,258,268 (GRCm39)	E959G	probably benign	Het
Aqp5	T	C	15: 99,489,180 (GRCm39)	F10L	possibly damaging	Het
Arhgap39	C	A	15: 76,609,585 (GRCm39)	V1025L	probably damaging	Het
Atg4d	C	T	9: 21,184,682 (GRCm39)	R459*	probably null	Het
Atp11b	A	G	3: 35,909,294 (GRCm39)	S1163G	probably damaging	Het
Atp13a5	G	T	16: 29,157,889 (GRCm39)	S173*	probably null	Het
Atp6v1g2	T	A	17: 35,455,762 (GRCm39)	I8N	probably damaging	Het
Ccdc77	C	T	6: 120,302,433 (GRCm39)	G430R	possibly damaging	Het
Cdc34b	A	G	11: 94,633,207 (GRCm39)	T136A	probably benign	Het
Cdkal1	A	G	13: 29,658,524 (GRCm39)	S23P	unknown	Het
Cdkl2	T	A	5: 92,156,857 (GRCm39)	H566L	probably benign	Het
Cers6	T	C	2: 68,901,790 (GRCm39)		probably benign	Het
Cfap251	T	C	5: 123,421,432 (GRCm39)	V98A	probably damaging	Het
Clspn	A	G	4: 126,466,140 (GRCm39)	T557A	possibly damaging	Het
Cmya5	T	C	13: 93,234,513 (GRCm39)	T192A	possibly damaging	Het
Csmd3	CCTTTGCGCTT	CCTT	15: 47,604,632 (GRCm39)		probably null	Het
Dnah17	T	G	11: 117,977,850 (GRCm39)		probably null	Het
Dscaml1	T	C	9: 45,656,376 (GRCm39)	V1572A	probably benign	Het
Elfn2	C	G	15: 78,558,464 (GRCm39)	E28Q	probably damaging	Het
Enam	T	A	5: 88,650,553 (GRCm39)	N687K	probably benign	Het
Flywch1	G	A	17: 23,974,685 (GRCm39)	R652W	probably benign	Het
Gm5612	T	C	9: 18,338,975 (GRCm39)		probably benign	Het
Hgsnat	C	T	8: 26,435,280 (GRCm39)	W618*	probably null	Het
Mmp3	A	G	9: 7,450,131 (GRCm39)	T288A	probably benign	Het
Mtmr4	T	A	11: 87,491,649 (GRCm39)	F168L	probably damaging	Het
Mtres1	T	C	10: 43,401,263 (GRCm39)		probably benign	Het
Myo1d	T	A	11: 80,565,647 (GRCm39)	N393Y	probably damaging	Het
Nacc2	A	T	2: 25,979,580 (GRCm39)	Y285*	probably null	Het
Nf1	G	T	11: 79,334,710 (GRCm39)	G844V	probably damaging	Het
Nox4	T	A	7: 86,945,084 (GRCm39)	Y113*	probably null	Het
Pcdha3	T	C	18: 37,080,556 (GRCm39)	C433R	probably benign	Het
Pde6c	A	G	19: 38,142,142 (GRCm39)	I358V	probably damaging	Het
Pdgfrb	A	T	18: 61,211,700 (GRCm39)	D819V	possibly damaging	Het
Phf3	C	A	1: 30,869,095 (GRCm39)	R651L	probably damaging	Het
Prrx1	A	G	1: 163,075,834 (GRCm39)	V244A	possibly damaging	Het
Ptges	C	T	2: 30,782,722 (GRCm39)	G110D	possibly damaging	Het
Rab27a	T	C	9: 72,992,263 (GRCm39)	L97P	probably damaging	Het
Rnf20	G	A	4: 49,652,676 (GRCm39)		probably null	Het
Sdad1	T	C	5: 92,447,958 (GRCm39)	N259S	probably benign	Het
Serpinb9d	T	C	13: 33,380,500 (GRCm39)	S129P	probably damaging	Het
Slc1a4	T	C	11: 20,282,620 (GRCm39)		probably benign	Het
Smyd2	T	A	1: 189,617,534 (GRCm39)	N300I	possibly damaging	Het
Snd1	A	G	6: 28,888,078 (GRCm39)	I875V	probably benign	Het
Ssh1	T	C	5: 114,096,919 (GRCm39)	N174S	probably damaging	Het
Stimate	C	T	14: 30,594,537 (GRCm39)	L217F	probably damaging	Het
Tanc2	T	C	11: 105,564,319 (GRCm39)		probably null	Het
Tectb	C	G	19: 55,169,431 (GRCm39)		probably benign	Het
Tpcn1	C	T	5: 120,677,063 (GRCm39)		probably null	Het
Unc45b	A	T	11: 82,827,269 (GRCm39)	I699F	probably damaging	Het
Uspl1	C	T	5: 149,124,664 (GRCm39)	P27L	probably damaging	Het
Ylpm1	C	G	12: 85,043,535 (GRCm39)	P91R	probably damaging	Het
Zdhhc23	G	A	16: 43,794,278 (GRCm39)	T132M	probably damaging	Het
Zfp148	T	C	16: 33,316,755 (GRCm39)	Y434H	probably damaging	Het
Zhx2	T	C	15: 57,686,551 (GRCm39)	V640A	possibly damaging	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,896,150 (GRCm39)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	31,074,904 (GRCm39)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	31,034,677 (GRCm39)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,882,452 (GRCm39)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,875,615 (GRCm39)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,986,880 (GRCm39)	nonsense	probably null
IGL00840:Dnah8	APN	17	31,009,915 (GRCm39)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	31,038,250 (GRCm39)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,925,431 (GRCm39)	nonsense	probably null
IGL00976:Dnah8	APN	17	31,070,684 (GRCm39)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,854,979 (GRCm39)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,902,688 (GRCm39)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,867,459 (GRCm39)	missense	probably benign
IGL01723:Dnah8	APN	17	30,927,445 (GRCm39)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,970,565 (GRCm39)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,955,115 (GRCm39)	missense	probably benign
IGL01958:Dnah8	APN	17	31,074,869 (GRCm39)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,875,572 (GRCm39)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,936,854 (GRCm39)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,867,391 (GRCm39)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,925,487 (GRCm39)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,868,747 (GRCm39)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,978,588 (GRCm39)	missense	probably benign
IGL02263:Dnah8	APN	17	30,948,139 (GRCm39)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,932,021 (GRCm39)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,966,231 (GRCm39)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	31,013,770 (GRCm39)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	31,049,819 (GRCm39)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	31,037,025 (GRCm39)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,919,387 (GRCm39)	missense	probably benign
IGL02455:Dnah8	APN	17	30,891,308 (GRCm39)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,887,269 (GRCm39)	missense	probably benign
IGL02831:Dnah8	APN	17	30,931,250 (GRCm39)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,988,671 (GRCm39)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,940,084 (GRCm39)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,923,809 (GRCm39)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,965,735 (GRCm39)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,937,980 (GRCm39)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,905,347 (GRCm39)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,961,754 (GRCm39)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	31,003,118 (GRCm39)	missense	probably benign
IGL03176:Dnah8	APN	17	30,913,011 (GRCm39)	missense	probably benign
IGL03191:Dnah8	APN	17	30,945,804 (GRCm39)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	31,034,639 (GRCm39)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,892,894 (GRCm39)	splice site	probably null
IGL03255:Dnah8	APN	17	30,960,355 (GRCm39)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,891,323 (GRCm39)	missense	probably benign
IGL03348:Dnah8	APN	17	30,965,960 (GRCm39)	missense	probably damaging	0.99
Alternator	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
armature	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
Brush	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
Dynos	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
joule	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
solenoid	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,854,437 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,451 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,439 (GRCm39)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,882,428 (GRCm39)	missense	probably benign
P0029:Dnah8	UTSW	17	30,984,694 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,927,419 (GRCm39)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,882,290 (GRCm39)	missense	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,974,093 (GRCm39)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	31,003,064 (GRCm39)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0184:Dnah8	UTSW	17	30,902,657 (GRCm39)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,909,245 (GRCm39)	missense	probably benign
R0268:Dnah8	UTSW	17	30,988,681 (GRCm39)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,955,130 (GRCm39)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	31,090,325 (GRCm39)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,920,955 (GRCm39)	missense	probably benign
R0470:Dnah8	UTSW	17	30,927,514 (GRCm39)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,974,054 (GRCm39)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R0499:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,937,935 (GRCm39)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,927,332 (GRCm39)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,903,147 (GRCm39)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,955,129 (GRCm39)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,923,636 (GRCm39)	missense	probably benign
R0843:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	31,022,217 (GRCm39)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,892,894 (GRCm39)	splice site	probably null
R1102:Dnah8	UTSW	17	31,073,738 (GRCm39)	splice site	probably null
R1137:Dnah8	UTSW	17	31,074,910 (GRCm39)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,939,974 (GRCm39)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,956,269 (GRCm39)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	31,059,596 (GRCm39)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,971,049 (GRCm39)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,892,862 (GRCm39)	missense	probably benign
R1541:Dnah8	UTSW	17	30,966,221 (GRCm39)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,854,638 (GRCm39)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,944,098 (GRCm39)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	31,073,914 (GRCm39)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,988,625 (GRCm39)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,941,911 (GRCm39)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,927,381 (GRCm39)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,903,160 (GRCm39)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,950,154 (GRCm39)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,854,479 (GRCm39)	missense	unknown
R1935:Dnah8	UTSW	17	30,945,870 (GRCm39)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,950,181 (GRCm39)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,931,359 (GRCm39)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,950,133 (GRCm39)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,977,255 (GRCm39)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,854,632 (GRCm39)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,956,232 (GRCm39)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,872,367 (GRCm39)	missense	probably benign
R2180:Dnah8	UTSW	17	31,059,621 (GRCm39)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	31,013,718 (GRCm39)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,990,846 (GRCm39)	missense	probably benign
R2357:Dnah8	UTSW	17	31,093,909 (GRCm39)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,896,178 (GRCm39)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	31,070,705 (GRCm39)	missense	probably damaging	1.00
R2509:Dnah8	UTSW	17	30,994,019 (GRCm39)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	31,052,542 (GRCm39)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,958,631 (GRCm39)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,958,622 (GRCm39)	nonsense	probably null
R3747:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3748:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3749:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,974,015 (GRCm39)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,889,621 (GRCm39)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,882,396 (GRCm39)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	31,073,911 (GRCm39)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,913,039 (GRCm39)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,988,813 (GRCm39)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,967,533 (GRCm39)	missense	probably benign
R4326:Dnah8	UTSW	17	30,971,066 (GRCm39)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,944,072 (GRCm39)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,971,120 (GRCm39)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	31,032,125 (GRCm39)	missense	probably benign
R4475:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,919,380 (GRCm39)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,881,026 (GRCm39)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,970,541 (GRCm39)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,903,211 (GRCm39)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,902,608 (GRCm39)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,944,140 (GRCm39)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	31,070,721 (GRCm39)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,986,898 (GRCm39)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,965,949 (GRCm39)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	31,059,688 (GRCm39)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	31,038,113 (GRCm39)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,948,116 (GRCm39)	missense	probably benign
R4969:Dnah8	UTSW	17	30,941,988 (GRCm39)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,882,275 (GRCm39)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	31,006,159 (GRCm39)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,955,070 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	31,019,505 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,958,731 (GRCm39)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,950,012 (GRCm39)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	31,029,327 (GRCm39)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,984,571 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,931,269 (GRCm39)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,965,739 (GRCm39)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	31,009,891 (GRCm39)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R5358:Dnah8	UTSW	17	30,965,928 (GRCm39)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	31,019,521 (GRCm39)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	31,009,930 (GRCm39)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,971,890 (GRCm39)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,925,360 (GRCm39)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	31,022,082 (GRCm39)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	31,019,561 (GRCm39)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,956,307 (GRCm39)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	31,022,235 (GRCm39)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	31,029,298 (GRCm39)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,937,981 (GRCm39)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,909,235 (GRCm39)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	31,093,978 (GRCm39)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,947,165 (GRCm39)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,875,659 (GRCm39)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	31,034,638 (GRCm39)	nonsense	probably null
R5986:Dnah8	UTSW	17	31,070,604 (GRCm39)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,882,279 (GRCm39)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,966,239 (GRCm39)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,966,828 (GRCm39)	nonsense	probably null
R6239:Dnah8	UTSW	17	31,029,333 (GRCm39)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
R6443:Dnah8	UTSW	17	30,990,859 (GRCm39)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,882,266 (GRCm39)	splice site	probably null
R6765:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,854,640 (GRCm39)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,984,698 (GRCm39)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,867,439 (GRCm39)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,960,147 (GRCm39)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,929,525 (GRCm39)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,965,933 (GRCm39)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	31,013,633 (GRCm39)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,986,899 (GRCm39)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,958,712 (GRCm39)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,881,065 (GRCm39)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,862,249 (GRCm39)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,923,698 (GRCm39)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	31,090,366 (GRCm39)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,988,618 (GRCm39)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,863,591 (GRCm39)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	31,093,988 (GRCm39)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	31,003,099 (GRCm39)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,986,939 (GRCm39)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,923,743 (GRCm39)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,925,363 (GRCm39)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	31,006,165 (GRCm39)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,994,077 (GRCm39)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	31,004,081 (GRCm39)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,868,651 (GRCm39)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,876,947 (GRCm39)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	31,074,918 (GRCm39)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R7866:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,882,348 (GRCm39)	missense	probably benign
R7891:Dnah8	UTSW	17	30,931,263 (GRCm39)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,960,311 (GRCm39)	nonsense	probably null
R8076:Dnah8	UTSW	17	31,003,127 (GRCm39)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,892,797 (GRCm39)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	31,090,393 (GRCm39)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8270:Dnah8	UTSW	17	31,059,687 (GRCm39)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,984,701 (GRCm39)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,988,805 (GRCm39)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8348:Dnah8	UTSW	17	30,955,121 (GRCm39)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,862,234 (GRCm39)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,914,152 (GRCm39)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8459:Dnah8	UTSW	17	30,944,221 (GRCm39)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,875,603 (GRCm39)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,940,108 (GRCm39)	missense	probably benign
R8524:Dnah8	UTSW	17	30,934,472 (GRCm39)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,940,084 (GRCm39)	nonsense	probably null
R8698:Dnah8	UTSW	17	31,094,009 (GRCm39)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,960,289 (GRCm39)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,944,078 (GRCm39)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	31,013,712 (GRCm39)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,981,616 (GRCm39)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,927,286 (GRCm39)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	31,070,628 (GRCm39)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	31,009,807 (GRCm39)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,956,401 (GRCm39)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,975,729 (GRCm39)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,854,647 (GRCm39)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	31,004,071 (GRCm39)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,944,099 (GRCm39)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,990,857 (GRCm39)	missense	probably benign
R9347:Dnah8	UTSW	17	30,927,333 (GRCm39)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,872,361 (GRCm39)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	31,029,297 (GRCm39)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	31,049,777 (GRCm39)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,932,021 (GRCm39)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,932,029 (GRCm39)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,998,112 (GRCm39)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	31,037,115 (GRCm39)	missense	probably benign
R9789:Dnah8	UTSW	17	30,980,104 (GRCm39)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,854,450 (GRCm39)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,967,654 (GRCm39)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	31,038,160 (GRCm39)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,867,514 (GRCm39)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,932,069 (GRCm39)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,913,007 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- ATGATGGTTCCTGATCGGC -3'
(R):5'- TCTCACTGATTAGCATCTATCAAGG -3'

Sequencing Primer
(F):5'- CAGGTACGTCCCAGGACTTGTG -3'
(R):5'- GTCTGAAGACAGCTACAGTGTACTC -3'

Posted On

2014-12-04