Incidental Mutation 'R2496:Zfp804a'
ID 251151
Institutional Source Beutler Lab
Gene Symbol Zfp804a
Ensembl Gene ENSMUSG00000070866
Gene Name zinc finger protein 804A
Synonyms C630007C17Rik
MMRRC Submission 040410-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R2496 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 81883566-82090223 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 82066188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 53 (L53Q)
Ref Sequence ENSEMBL: ENSMUSP00000041941 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047527]
AlphaFold A2AKY4
Predicted Effect probably damaging
Transcript: ENSMUST00000047527
AA Change: L53Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041941
Gene: ENSMUSG00000070866
AA Change: L53Q

DomainStartEndE-ValueType
ZnF_C2H2 57 81 7.29e0 SMART
low complexity region 588 595 N/A INTRINSIC
low complexity region 801 808 N/A INTRINSIC
low complexity region 1012 1029 N/A INTRINSIC
low complexity region 1061 1077 N/A INTRINSIC
low complexity region 1168 1191 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127187
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan T C 7: 78,761,065 (GRCm39) W1926R probably damaging Het
Arhgef25 T C 10: 127,023,063 (GRCm39) T106A probably benign Het
Baz1b G A 5: 135,239,629 (GRCm39) R243Q probably damaging Het
Cdhr3 A G 12: 33,099,068 (GRCm39) Y508H probably benign Het
Cyp2d9 T A 15: 82,336,680 (GRCm39) W10R probably damaging Het
Dmxl1 A G 18: 50,013,858 (GRCm39) T1549A possibly damaging Het
Dnah8 A T 17: 31,070,705 (GRCm39) R4464W probably damaging Het
Dpp4 G A 2: 62,217,477 (GRCm39) T40M possibly damaging Het
Dync1h1 A G 12: 110,607,654 (GRCm39) H2723R possibly damaging Het
E2f3 C T 13: 30,095,289 (GRCm39) S333N probably damaging Het
Fam120a G T 13: 49,121,069 (GRCm39) A79E probably damaging Het
Fat3 A G 9: 15,877,399 (GRCm39) S3405P probably benign Het
Gaa T C 11: 119,174,531 (GRCm39) S793P possibly damaging Het
Galc A C 12: 98,193,540 (GRCm39) F350V probably damaging Het
Garre1 A G 7: 33,955,916 (GRCm39) V391A possibly damaging Het
Gm136 A G 4: 34,746,541 (GRCm39) C157R probably damaging Het
Gm3327 A C 14: 44,363,720 (GRCm39) N108T unknown Het
H2-M10.2 A G 17: 36,596,771 (GRCm39) Y102H possibly damaging Het
Hmcn1 A T 1: 150,490,972 (GRCm39) D4192E probably benign Het
Hpse2 A C 19: 43,001,482 (GRCm39) probably null Het
Idh3a T C 9: 54,510,633 (GRCm39) V362A probably benign Het
Kdm7a A T 6: 39,147,697 (GRCm39) probably null Het
Krt6b A G 15: 101,588,216 (GRCm39) V148A probably damaging Het
Lrba G A 3: 86,439,394 (GRCm39) R1977H probably damaging Het
Magi2 A T 5: 19,883,750 (GRCm39) Y134F probably benign Het
Mamdc4 T C 2: 25,455,914 (GRCm39) Y801C probably damaging Het
Maml1 T C 11: 50,149,371 (GRCm39) T790A probably benign Het
Map3k19 A G 1: 127,750,823 (GRCm39) Y843H probably damaging Het
Mdfic A T 6: 15,741,041 (GRCm39) H45L possibly damaging Het
Mlx C T 11: 100,979,080 (GRCm39) T87I probably benign Het
Mms22l T A 4: 24,521,269 (GRCm39) I382K probably benign Het
Mtf1 A G 4: 124,732,697 (GRCm39) N585S probably benign Het
Mylk2 C T 2: 152,755,588 (GRCm39) P251S probably damaging Het
Myorg A G 4: 41,499,165 (GRCm39) V155A probably benign Het
Nox4 A T 7: 86,955,958 (GRCm39) T157S probably benign Het
Oas2 A T 5: 120,886,682 (GRCm39) H161Q probably benign Het
Obscn A T 11: 58,994,268 (GRCm39) V1563E probably damaging Het
Or2n1b T C 17: 38,460,322 (GRCm39) V281A possibly damaging Het
Or55b3 T C 7: 102,126,354 (GRCm39) K241R probably damaging Het
Or6c203 A C 10: 129,009,966 (GRCm39) F308C probably benign Het
Pcdhb11 T A 18: 37,555,375 (GRCm39) I235N probably benign Het
Pcsk5 A T 19: 17,443,522 (GRCm39) C1212* probably null Het
Ptges C T 2: 30,782,722 (GRCm39) G110D possibly damaging Het
Rsph4a A T 10: 33,784,094 (GRCm39) I239L possibly damaging Het
Setx A G 2: 29,034,813 (GRCm39) I433V probably benign Het
Smyd4 T C 11: 75,281,927 (GRCm39) S467P probably benign Het
Snai2 A T 16: 14,523,866 (GRCm39) H10L possibly damaging Het
Snw1 T C 12: 87,497,589 (GRCm39) I467V probably benign Het
Stab1 A T 14: 30,883,420 (GRCm39) C301S probably damaging Het
Tax1bp1 T A 6: 52,735,342 (GRCm39) probably null Het
Tmem70 C A 1: 16,735,575 (GRCm39) P15Q probably benign Het
Tmem87a T C 2: 120,224,859 (GRCm39) E134G probably damaging Het
Ubr4 C T 4: 139,200,516 (GRCm39) probably benign Het
Ugt2b37 C T 5: 87,402,569 (GRCm39) V21M probably damaging Het
Ugt2b38 T A 5: 87,569,551 (GRCm39) I259F probably damaging Het
Other mutations in Zfp804a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00466:Zfp804a APN 2 81,884,219 (GRCm39) missense probably benign 0.30
IGL02011:Zfp804a APN 2 82,087,035 (GRCm39) missense probably damaging 1.00
IGL02218:Zfp804a APN 2 82,089,546 (GRCm39) missense probably damaging 1.00
IGL02645:Zfp804a APN 2 81,884,220 (GRCm39) missense possibly damaging 0.94
PIT4431001:Zfp804a UTSW 2 82,089,536 (GRCm39) missense probably benign 0.04
R0027:Zfp804a UTSW 2 82,087,544 (GRCm39) missense probably damaging 1.00
R0167:Zfp804a UTSW 2 82,086,860 (GRCm39) missense probably damaging 1.00
R0437:Zfp804a UTSW 2 81,884,135 (GRCm39) start codon destroyed probably null 0.08
R0521:Zfp804a UTSW 2 82,089,761 (GRCm39) nonsense probably null
R0546:Zfp804a UTSW 2 82,089,264 (GRCm39) missense possibly damaging 0.91
R0609:Zfp804a UTSW 2 82,087,932 (GRCm39) missense probably damaging 1.00
R0694:Zfp804a UTSW 2 81,884,148 (GRCm39) missense probably damaging 1.00
R0837:Zfp804a UTSW 2 82,089,506 (GRCm39) missense probably damaging 1.00
R0947:Zfp804a UTSW 2 82,089,062 (GRCm39) missense possibly damaging 0.58
R1103:Zfp804a UTSW 2 82,087,844 (GRCm39) missense probably damaging 0.99
R1168:Zfp804a UTSW 2 82,087,041 (GRCm39) missense probably benign 0.43
R1365:Zfp804a UTSW 2 82,087,590 (GRCm39) missense probably benign 0.00
R1377:Zfp804a UTSW 2 82,088,841 (GRCm39) missense probably benign 0.39
R1501:Zfp804a UTSW 2 82,066,143 (GRCm39) missense probably damaging 1.00
R1526:Zfp804a UTSW 2 82,088,532 (GRCm39) missense probably benign
R1585:Zfp804a UTSW 2 81,884,095 (GRCm39) start gained probably benign
R1674:Zfp804a UTSW 2 82,089,168 (GRCm39) missense probably benign 0.35
R2058:Zfp804a UTSW 2 82,087,710 (GRCm39) missense probably benign 0.00
R2146:Zfp804a UTSW 2 82,089,008 (GRCm39) missense probably benign 0.02
R2149:Zfp804a UTSW 2 82,089,008 (GRCm39) missense probably benign 0.02
R2171:Zfp804a UTSW 2 82,087,527 (GRCm39) missense possibly damaging 0.77
R2307:Zfp804a UTSW 2 82,087,201 (GRCm39) missense probably benign 0.04
R2398:Zfp804a UTSW 2 82,089,013 (GRCm39) missense possibly damaging 0.95
R2504:Zfp804a UTSW 2 82,087,863 (GRCm39) missense probably benign 0.00
R2919:Zfp804a UTSW 2 82,066,160 (GRCm39) missense probably damaging 1.00
R2943:Zfp804a UTSW 2 82,066,223 (GRCm39) missense probably damaging 1.00
R3116:Zfp804a UTSW 2 82,089,761 (GRCm39) missense probably damaging 1.00
R4170:Zfp804a UTSW 2 82,083,832 (GRCm39) missense probably damaging 1.00
R4393:Zfp804a UTSW 2 82,087,265 (GRCm39) missense probably benign 0.43
R4701:Zfp804a UTSW 2 82,086,926 (GRCm39) missense probably damaging 1.00
R4771:Zfp804a UTSW 2 82,088,286 (GRCm39) missense probably benign 0.01
R4793:Zfp804a UTSW 2 82,066,186 (GRCm39) missense probably damaging 1.00
R5523:Zfp804a UTSW 2 82,089,339 (GRCm39) missense probably damaging 1.00
R5526:Zfp804a UTSW 2 82,088,934 (GRCm39) missense probably benign 0.00
R5961:Zfp804a UTSW 2 82,088,346 (GRCm39) missense probably benign
R6181:Zfp804a UTSW 2 82,087,486 (GRCm39) missense probably damaging 1.00
R6209:Zfp804a UTSW 2 82,088,462 (GRCm39) missense probably damaging 1.00
R6325:Zfp804a UTSW 2 82,087,382 (GRCm39) missense possibly damaging 0.80
R7147:Zfp804a UTSW 2 82,088,531 (GRCm39) missense probably benign 0.00
R7229:Zfp804a UTSW 2 82,088,969 (GRCm39) missense probably benign 0.04
R7666:Zfp804a UTSW 2 82,089,404 (GRCm39) nonsense probably null
R7910:Zfp804a UTSW 2 82,086,917 (GRCm39) missense probably damaging 1.00
R8256:Zfp804a UTSW 2 81,884,193 (GRCm39) missense probably damaging 0.99
R8669:Zfp804a UTSW 2 82,088,106 (GRCm39) missense probably damaging 1.00
R8738:Zfp804a UTSW 2 82,089,450 (GRCm39) missense probably damaging 1.00
R8749:Zfp804a UTSW 2 82,087,919 (GRCm39) missense probably benign 0.18
R8751:Zfp804a UTSW 2 82,066,190 (GRCm39) missense probably damaging 0.96
R8828:Zfp804a UTSW 2 82,089,459 (GRCm39) missense possibly damaging 0.74
R8834:Zfp804a UTSW 2 82,089,441 (GRCm39) missense possibly damaging 0.76
R8924:Zfp804a UTSW 2 82,088,747 (GRCm39) missense probably benign 0.03
R8982:Zfp804a UTSW 2 82,066,172 (GRCm39) missense probably damaging 1.00
R9459:Zfp804a UTSW 2 82,089,753 (GRCm39) missense probably damaging 1.00
R9570:Zfp804a UTSW 2 82,088,844 (GRCm39) missense probably benign 0.22
X0064:Zfp804a UTSW 2 82,066,167 (GRCm39) missense probably damaging 1.00
Z1177:Zfp804a UTSW 2 82,088,907 (GRCm39) missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- TGACTCATGTTTTCAAACTTGTTTTGC -3'
(R):5'- CTTGATTCATCATCACAGAATTACAAC -3'

Sequencing Primer
(F):5'- CAAGGGAGTGCTCATTGT -3'
(R):5'- GTGGTCTTAACAATTCAGTCC -3'
Posted On 2014-12-04