Incidental Mutation 'R2697:Tacstd2'
ID 251178
Institutional Source Beutler Lab
Gene Symbol Tacstd2
Ensembl Gene ENSMUSG00000051397
Gene Name tumor-associated calcium signal transducer 2
Synonyms Ly97, TROP2, EGP-1, GA733-1
MMRRC Submission 040435-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.264) question?
Stock # R2697 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 67511046-67512780 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 67512203 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 163 (H163L)
Ref Sequence ENSEMBL: ENSMUSP00000060099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058178]
AlphaFold Q8BGV3
Predicted Effect probably benign
Transcript: ENSMUST00000058178
AA Change: H163L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000060099
Gene: ENSMUSG00000051397
AA Change: H163L

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
TY 99 143 1.04e-7 SMART
transmembrane domain 269 291 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199480
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal development, life expectancy and tumorigenesis. When combined with a Cdkn2a knock-out allele, mice exhibit increased incidence of induced spindle cell carcinoma and immortalized keratinocyte proliferation and migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630073D07Rik T C 6: 132,603,619 (GRCm39) S46G unknown Het
Acaca T A 11: 84,255,239 (GRCm39) D1932E probably damaging Het
Adam7 A T 14: 68,752,232 (GRCm39) C417* probably null Het
Adgrl4 A C 3: 151,216,260 (GRCm39) Q481P probably damaging Het
Adra2c C A 5: 35,438,042 (GRCm39) N271K probably benign Het
Ahctf1 T C 1: 179,580,097 (GRCm39) K2035R probably damaging Het
Ano3 T C 2: 110,625,305 (GRCm39) T182A possibly damaging Het
Armc3 T C 2: 19,308,746 (GRCm39) Y805H probably damaging Het
BC024139 TCCACCACCACCACCACCAC TCCACCACCACCACCAC 15: 76,004,393 (GRCm39) probably benign Het
Cabp7 C T 11: 4,688,837 (GRCm39) R211H probably damaging Het
Ccdc117 T C 11: 5,484,888 (GRCm39) N112S possibly damaging Het
Cep120 C T 18: 53,873,197 (GRCm39) D45N probably benign Het
Cpsf1 T C 15: 76,483,529 (GRCm39) Y872C probably damaging Het
Cradd A G 10: 95,011,807 (GRCm39) L111P probably damaging Het
Crhr2 A G 6: 55,079,815 (GRCm39) L155P probably damaging Het
Fgd2 A T 17: 29,595,895 (GRCm39) T518S probably damaging Het
Gpam C T 19: 55,071,641 (GRCm39) E367K probably damaging Het
Gtf3c1 T A 7: 125,243,126 (GRCm39) N1826I probably damaging Het
Kcnq5 T C 1: 21,549,656 (GRCm39) E357G probably damaging Het
Krt1 T A 15: 101,755,364 (GRCm39) D465V probably damaging Het
Lcor T A 19: 41,572,466 (GRCm39) V407E probably benign Het
Macrod1 T C 19: 7,174,157 (GRCm39) V221A probably damaging Het
Mbd1 T C 18: 74,406,688 (GRCm39) S144P possibly damaging Het
Mtfmt T C 9: 65,359,303 (GRCm39) V326A probably benign Het
Myo1b T C 1: 51,902,517 (GRCm39) D71G probably benign Het
Myo1h A G 5: 114,493,274 (GRCm39) Y705C probably damaging Het
Nudt9 T C 5: 104,212,859 (GRCm39) W311R probably damaging Het
Or11g27 C T 14: 50,771,238 (GRCm39) A123V probably damaging Het
Or2a57 A T 6: 43,213,060 (GRCm39) I173F probably damaging Het
Or2h15 A G 17: 38,441,900 (GRCm39) F61S probably damaging Het
Or6c65 G A 10: 129,603,793 (GRCm39) V143I probably benign Het
Osbp2 A T 11: 3,813,407 (GRCm39) L154Q probably benign Het
P3h1 A G 4: 119,104,377 (GRCm39) T633A probably damaging Het
Polq T G 16: 36,862,515 (GRCm39) L616R probably damaging Het
Pon3 A G 6: 5,232,429 (GRCm39) L197S possibly damaging Het
Rap1gds1 C T 3: 138,689,482 (GRCm39) probably null Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rfng C A 11: 120,674,865 (GRCm39) probably benign Het
Rps6ka2 T G 17: 7,567,721 (GRCm39) L728R probably benign Het
Slc41a3 C A 6: 90,619,302 (GRCm39) N360K possibly damaging Het
Sult1e1 T C 5: 87,726,397 (GRCm39) N239S probably damaging Het
Tacr1 T A 6: 82,469,578 (GRCm39) I154N probably damaging Het
Tent5a T C 9: 85,206,793 (GRCm39) D335G possibly damaging Het
Tiam1 T C 16: 89,590,052 (GRCm39) S1382G probably benign Het
Tmem43 A G 6: 91,456,911 (GRCm39) E164G possibly damaging Het
U2af2 G A 7: 5,070,545 (GRCm39) R78H probably benign Het
Yipf7 T A 5: 69,698,483 (GRCm39) D8V possibly damaging Het
Zfp58 G A 13: 67,639,124 (GRCm39) H456Y probably damaging Het
Zfp799 G A 17: 33,039,214 (GRCm39) R351* probably null Het
Zfyve9 T C 4: 108,553,016 (GRCm39) D715G probably damaging Het
Other mutations in Tacstd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Tacstd2 APN 6 67,511,783 (GRCm39) missense possibly damaging 0.68
IGL02714:Tacstd2 APN 6 67,512,053 (GRCm39) missense probably damaging 1.00
R0948:Tacstd2 UTSW 6 67,512,102 (GRCm39) missense probably damaging 0.99
R3735:Tacstd2 UTSW 6 67,511,843 (GRCm39) missense probably damaging 1.00
R4434:Tacstd2 UTSW 6 67,512,128 (GRCm39) missense possibly damaging 0.89
R4614:Tacstd2 UTSW 6 67,512,170 (GRCm39) missense probably damaging 0.99
R5615:Tacstd2 UTSW 6 67,512,033 (GRCm39) missense probably damaging 1.00
R7187:Tacstd2 UTSW 6 67,512,180 (GRCm39) missense probably damaging 1.00
R7216:Tacstd2 UTSW 6 67,511,979 (GRCm39) missense probably benign 0.00
R7815:Tacstd2 UTSW 6 67,512,140 (GRCm39) missense possibly damaging 0.94
R8051:Tacstd2 UTSW 6 67,512,383 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTCGAAGTAGTAGGCGGCATC -3'
(R):5'- ACGCGATACTGGACAACGATG -3'

Sequencing Primer
(F):5'- ATCAGCGATGTCCACGTC -3'
(R):5'- GACAACGATGGCCTCTACG -3'
Posted On 2014-12-04