Incidental Mutation 'R2697:Or11g27'
ID 251224
Institutional Source Beutler Lab
Gene Symbol Or11g27
Ensembl Gene ENSMUSG00000094285
Gene Name olfactory receptor family 11 subfamily G member 27
Synonyms GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264, Olfr743, Olfr743-ps1, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14
MMRRC Submission 040435-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R2697 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50770871-50771806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 50771238 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 123 (A123V)
Ref Sequence ENSEMBL: ENSMUSP00000150946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071294] [ENSMUST00000215793]
AlphaFold L7N1Y2
Predicted Effect probably damaging
Transcript: ENSMUST00000071294
AA Change: A123V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071263
Gene: ENSMUSG00000094285
AA Change: A123V

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.6e-56 PFAM
Pfam:7tm_1 45 294 1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215793
AA Change: A123V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630073D07Rik T C 6: 132,603,619 (GRCm39) S46G unknown Het
Acaca T A 11: 84,255,239 (GRCm39) D1932E probably damaging Het
Adam7 A T 14: 68,752,232 (GRCm39) C417* probably null Het
Adgrl4 A C 3: 151,216,260 (GRCm39) Q481P probably damaging Het
Adra2c C A 5: 35,438,042 (GRCm39) N271K probably benign Het
Ahctf1 T C 1: 179,580,097 (GRCm39) K2035R probably damaging Het
Ano3 T C 2: 110,625,305 (GRCm39) T182A possibly damaging Het
Armc3 T C 2: 19,308,746 (GRCm39) Y805H probably damaging Het
BC024139 TCCACCACCACCACCACCAC TCCACCACCACCACCAC 15: 76,004,393 (GRCm39) probably benign Het
Cabp7 C T 11: 4,688,837 (GRCm39) R211H probably damaging Het
Ccdc117 T C 11: 5,484,888 (GRCm39) N112S possibly damaging Het
Cep120 C T 18: 53,873,197 (GRCm39) D45N probably benign Het
Cpsf1 T C 15: 76,483,529 (GRCm39) Y872C probably damaging Het
Cradd A G 10: 95,011,807 (GRCm39) L111P probably damaging Het
Crhr2 A G 6: 55,079,815 (GRCm39) L155P probably damaging Het
Fgd2 A T 17: 29,595,895 (GRCm39) T518S probably damaging Het
Gpam C T 19: 55,071,641 (GRCm39) E367K probably damaging Het
Gtf3c1 T A 7: 125,243,126 (GRCm39) N1826I probably damaging Het
Kcnq5 T C 1: 21,549,656 (GRCm39) E357G probably damaging Het
Krt1 T A 15: 101,755,364 (GRCm39) D465V probably damaging Het
Lcor T A 19: 41,572,466 (GRCm39) V407E probably benign Het
Macrod1 T C 19: 7,174,157 (GRCm39) V221A probably damaging Het
Mbd1 T C 18: 74,406,688 (GRCm39) S144P possibly damaging Het
Mtfmt T C 9: 65,359,303 (GRCm39) V326A probably benign Het
Myo1b T C 1: 51,902,517 (GRCm39) D71G probably benign Het
Myo1h A G 5: 114,493,274 (GRCm39) Y705C probably damaging Het
Nudt9 T C 5: 104,212,859 (GRCm39) W311R probably damaging Het
Or2a57 A T 6: 43,213,060 (GRCm39) I173F probably damaging Het
Or2h15 A G 17: 38,441,900 (GRCm39) F61S probably damaging Het
Or6c65 G A 10: 129,603,793 (GRCm39) V143I probably benign Het
Osbp2 A T 11: 3,813,407 (GRCm39) L154Q probably benign Het
P3h1 A G 4: 119,104,377 (GRCm39) T633A probably damaging Het
Polq T G 16: 36,862,515 (GRCm39) L616R probably damaging Het
Pon3 A G 6: 5,232,429 (GRCm39) L197S possibly damaging Het
Rap1gds1 C T 3: 138,689,482 (GRCm39) probably null Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rfng C A 11: 120,674,865 (GRCm39) probably benign Het
Rps6ka2 T G 17: 7,567,721 (GRCm39) L728R probably benign Het
Slc41a3 C A 6: 90,619,302 (GRCm39) N360K possibly damaging Het
Sult1e1 T C 5: 87,726,397 (GRCm39) N239S probably damaging Het
Tacr1 T A 6: 82,469,578 (GRCm39) I154N probably damaging Het
Tacstd2 T A 6: 67,512,203 (GRCm39) H163L probably benign Het
Tent5a T C 9: 85,206,793 (GRCm39) D335G possibly damaging Het
Tiam1 T C 16: 89,590,052 (GRCm39) S1382G probably benign Het
Tmem43 A G 6: 91,456,911 (GRCm39) E164G possibly damaging Het
U2af2 G A 7: 5,070,545 (GRCm39) R78H probably benign Het
Yipf7 T A 5: 69,698,483 (GRCm39) D8V possibly damaging Het
Zfp58 G A 13: 67,639,124 (GRCm39) H456Y probably damaging Het
Zfp799 G A 17: 33,039,214 (GRCm39) R351* probably null Het
Zfyve9 T C 4: 108,553,016 (GRCm39) D715G probably damaging Het
Other mutations in Or11g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01128:Or11g27 APN 14 50,771,406 (GRCm39) missense probably damaging 1.00
IGL01551:Or11g27 APN 14 50,771,618 (GRCm39) missense probably benign
IGL02024:Or11g27 APN 14 50,771,307 (GRCm39) missense probably benign 0.00
IGL02867:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL02889:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL03195:Or11g27 APN 14 50,770,877 (GRCm39) missense probably benign
IGL03296:Or11g27 APN 14 50,771,402 (GRCm39) missense possibly damaging 0.90
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0102:Or11g27 UTSW 14 50,771,088 (GRCm39) missense probably damaging 1.00
R0556:Or11g27 UTSW 14 50,771,381 (GRCm39) missense probably benign 0.01
R0626:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0661:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
R0759:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0761:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0894:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1109:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1110:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1312:Or11g27 UTSW 14 50,771,652 (GRCm39) missense probably benign
R1446:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1502:Or11g27 UTSW 14 50,771,234 (GRCm39) missense possibly damaging 0.47
R1518:Or11g27 UTSW 14 50,771,622 (GRCm39) missense probably damaging 1.00
R1529:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1624:Or11g27 UTSW 14 50,771,100 (GRCm39) missense probably damaging 1.00
R1646:Or11g27 UTSW 14 50,771,040 (GRCm39) missense probably benign 0.01
R1687:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1795:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R2011:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 1.00
R2120:Or11g27 UTSW 14 50,771,403 (GRCm39) missense probably damaging 1.00
R2857:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R2858:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R3906:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R4327:Or11g27 UTSW 14 50,770,971 (GRCm39) missense probably benign 0.05
R4355:Or11g27 UTSW 14 50,771,216 (GRCm39) missense possibly damaging 0.94
R4663:Or11g27 UTSW 14 50,771,061 (GRCm39) missense probably damaging 1.00
R5214:Or11g27 UTSW 14 50,771,804 (GRCm39) makesense probably null
R5964:Or11g27 UTSW 14 50,771,655 (GRCm39) missense probably damaging 0.99
R6148:Or11g27 UTSW 14 50,771,778 (GRCm39) missense probably benign 0.00
R6167:Or11g27 UTSW 14 50,771,612 (GRCm39) missense probably damaging 1.00
R6301:Or11g27 UTSW 14 50,771,711 (GRCm39) missense probably benign 0.02
R6616:Or11g27 UTSW 14 50,771,364 (GRCm39) missense probably benign 0.43
R6910:Or11g27 UTSW 14 50,771,330 (GRCm39) missense probably benign 0.31
R7076:Or11g27 UTSW 14 50,771,278 (GRCm39) nonsense probably null
R7483:Or11g27 UTSW 14 50,771,472 (GRCm39) missense probably benign 0.06
R7574:Or11g27 UTSW 14 50,771,770 (GRCm39) missense probably benign 0.01
R7731:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 0.99
R8691:Or11g27 UTSW 14 50,770,910 (GRCm39) missense probably benign 0.01
R9072:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9073:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9321:Or11g27 UTSW 14 50,771,471 (GRCm39) missense probably benign 0.01
R9478:Or11g27 UTSW 14 50,771,051 (GRCm39) missense probably benign 0.01
R9557:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AACGCTTCCATCATCTGTGC -3'
(R):5'- GGTCTATAATTCTGGACCCACAG -3'

Sequencing Primer
(F):5'- GTGTACTGTGATCAGAGACTCCAC -3'
(R):5'- TCTGGACCCACAGAAGGAC -3'
Posted On 2014-12-04