Mutagenetix > Incidental Mutation

Incidental Mutation 'R2508:Dock2'

251582

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, Hch, MBC

MMRRC Submission

040414-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2508 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

34176815-34674719 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 34262485 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 957 (T957A)

Ref Sequence

ENSEMBL: ENSMUSP00000098916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093192] [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000165963]

AlphaFold

Q8C3J5

Predicted Effect

probably benign
Transcript: ENSMUST00000093192

SMART Domains

Protein: ENSMUSP00000090883
Gene: ENSMUSG00000069911

Domain	Start	End	E-Value	Type
Pfam:FAM196	1	535	3.6e-196	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000093193
AA Change: T957A

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: T957A

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000101365
AA Change: T957A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: T957A

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147359

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157036

Predicted Effect

probably benign
Transcript: ENSMUST00000165963

SMART Domains

Protein: ENSMUSP00000129183
Gene: ENSMUSG00000069911

Domain	Start	End	E-Value	Type
Pfam:FAM196	3	535	1.3e-168	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 110 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430548M08Rik	C	T	8: 120,872,132 (GRCm39)	T20I	probably benign	Het
Adamts2	C	T	11: 50,679,516 (GRCm39)	T832I	possibly damaging	Het
Agbl1	G	A	7: 76,239,298 (GRCm39)		probably null	Het
Ankrd61	T	C	5: 143,833,894 (GRCm39)		probably benign	Het
Anpep	T	G	7: 79,488,039 (GRCm39)	Y506S	possibly damaging	Het
Aox1	T	A	1: 58,382,832 (GRCm39)	H1037Q	probably benign	Het
Auh	G	A	13: 53,052,755 (GRCm39)	R47*	probably null	Het
B4galt5	T	A	2: 167,148,558 (GRCm39)	M187L	probably benign	Het
Bub1	A	T	2: 127,643,343 (GRCm39)	D1000E	probably benign	Het
Cacna1f	T	G	X: 7,492,687 (GRCm39)		probably null	Het
Cdh3	T	C	8: 107,279,039 (GRCm39)	L667P	probably damaging	Het
Cenpe	A	T	3: 134,946,834 (GRCm39)	R1116S	possibly damaging	Het
Ces1b	T	A	8: 93,799,969 (GRCm39)	M136L	possibly damaging	Het
Cfap54	T	C	10: 92,833,236 (GRCm39)	E1130G	possibly damaging	Het
Chd9	C	T	8: 91,760,615 (GRCm39)	P2120L	probably benign	Het
Clu	T	C	14: 66,212,452 (GRCm39)	V135A	probably damaging	Het
Cmip	T	A	8: 118,163,432 (GRCm39)	S388T	probably benign	Het
Cnga1	C	T	5: 72,776,404 (GRCm39)	V20I	possibly damaging	Het
Cox4i1	T	A	8: 121,400,029 (GRCm39)	V51E	possibly damaging	Het
Crym	T	C	7: 119,801,050 (GRCm39)	N33S	probably benign	Het
Ctcf	T	A	8: 106,398,016 (GRCm39)	V434E	probably damaging	Het
Daam1	G	A	12: 72,021,997 (GRCm39)	D732N	probably damaging	Het
Dcaf13	A	G	15: 39,008,547 (GRCm39)	Y383C	probably benign	Het
Duox1	A	G	2: 122,163,619 (GRCm39)	D817G	probably benign	Het
Eif1ad16	T	C	12: 87,985,258 (GRCm39)	Y95C	probably damaging	Het
Fads3	A	G	19: 10,033,818 (GRCm39)	Y401C	probably damaging	Het
Fam72a	T	C	1: 131,456,592 (GRCm39)		probably null	Het
Fbxw21	C	A	9: 108,974,553 (GRCm39)	K322N	probably benign	Het
Fdxr	G	A	11: 115,162,806 (GRCm39)	T100I	probably damaging	Het
Galnt11	C	G	5: 25,452,610 (GRCm39)	P41A	probably damaging	Het
Glb1l	T	C	1: 75,178,473 (GRCm39)	T322A	probably damaging	Het
Gm6871	T	A	7: 41,197,414 (GRCm39)	T149S	probably benign	Het
Gpr26	C	T	7: 131,568,823 (GRCm39)	T56I	probably damaging	Het
Grik4	C	A	9: 42,533,438 (GRCm39)	G361C	probably damaging	Het
Gsr	T	G	8: 34,170,316 (GRCm39)	D200E	probably benign	Het
Igsf5	T	A	16: 96,165,247 (GRCm39)	D7E	probably benign	Het
Inpp5e	T	A	2: 26,289,355 (GRCm39)	I522F	probably damaging	Het
Insm2	C	A	12: 55,647,096 (GRCm39)	T280K	probably benign	Het
Itih4	T	C	14: 30,617,435 (GRCm39)	V585A	probably damaging	Het
Katnip	T	A	7: 125,394,515 (GRCm39)	V197D	probably benign	Het
Knl1	A	T	2: 118,888,849 (GRCm39)	R17*	probably null	Het
Lag3	G	T	6: 124,888,272 (GRCm39)	L15I	possibly damaging	Het
Lepr	T	A	4: 101,648,093 (GRCm39)	S861T	probably damaging	Het
Mcur1	A	T	13: 43,697,941 (GRCm39)	Y320N	probably damaging	Het
Mgam	A	T	6: 40,736,717 (GRCm39)	D872V	probably damaging	Het
Mlycd	T	C	8: 120,134,446 (GRCm39)		probably null	Het
Mpl	C	A	4: 118,312,954 (GRCm39)	C193F	probably damaging	Het
Mycbp2	C	A	14: 103,368,681 (GRCm39)	A4142S	probably damaging	Het
Myh1	T	A	11: 67,104,424 (GRCm39)	D993E	possibly damaging	Het
N4bp2	T	A	5: 65,947,404 (GRCm39)	D11E	probably benign	Het
Neb	T	C	2: 52,085,533 (GRCm39)	I1521V	probably benign	Het
Notch1	A	G	2: 26,355,485 (GRCm39)	V1744A	possibly damaging	Het
Numa1	T	C	7: 101,644,731 (GRCm39)	S236P	possibly damaging	Het
Or4p20	T	C	2: 88,253,800 (GRCm39)	T190A	possibly damaging	Het
Or6c66	T	A	10: 129,461,784 (GRCm39)	I49L	probably benign	Het
Or8k23	A	G	2: 86,186,708 (GRCm39)	L6P	possibly damaging	Het
Otogl	A	G	10: 107,710,361 (GRCm39)	L576P	probably damaging	Het
P2ry1	C	T	3: 60,910,900 (GRCm39)	T13M	probably damaging	Het
Pak6	A	T	2: 118,525,050 (GRCm39)	R559*	probably null	Het
Parvb	A	T	15: 84,182,171 (GRCm39)	M234L	probably benign	Het
Pcdha11	T	C	18: 37,145,907 (GRCm39)	V666A	possibly damaging	Het
Pde3b	T	A	7: 114,126,092 (GRCm39)	Y775*	probably null	Het
Pgam5	A	G	5: 110,413,869 (GRCm39)	L98P	probably damaging	Het
Phip	T	C	9: 82,797,392 (GRCm39)	H537R	possibly damaging	Het
Pkib	T	G	10: 57,604,205 (GRCm39)	D4E	probably damaging	Het
Plcb1	A	T	2: 135,102,428 (GRCm39)	I202F	probably benign	Het
Pold3	A	G	7: 99,770,590 (GRCm39)	V14A	probably damaging	Het
Prdm1	T	A	10: 44,322,803 (GRCm39)	T249S	probably benign	Het
Prpf39	T	A	12: 65,104,589 (GRCm39)	F551L	probably benign	Het
Prune2	A	G	19: 17,099,986 (GRCm39)	E1830G	probably benign	Het
Ralgapa1	G	A	12: 55,764,986 (GRCm39)	P889S	probably damaging	Het
Rassf2	A	T	2: 131,840,163 (GRCm39)		probably null	Het
Rnf185	A	G	11: 3,368,067 (GRCm39)	Y204H	probably benign	Het
Rpap1	A	G	2: 119,610,535 (GRCm39)		probably null	Het
Rufy3	T	C	5: 88,797,757 (GRCm39)	S645P	probably damaging	Het
Scn11a	T	A	9: 119,594,595 (GRCm39)	Y1266F	probably damaging	Het
Senp7	T	A	16: 55,971,725 (GRCm39)	H287Q	probably benign	Het
Sgsm3	T	C	15: 80,888,073 (GRCm39)		probably null	Het
Slc25a11	A	T	11: 70,536,658 (GRCm39)	V104E	possibly damaging	Het
Slc25a13	G	A	6: 6,117,190 (GRCm39)	T175I	probably benign	Het
Slc26a3	T	A	12: 31,520,902 (GRCm39)	F702Y	probably damaging	Het
Smco2	T	A	6: 146,761,465 (GRCm39)	L184H	probably damaging	Het
Ssc4d	A	T	5: 135,994,461 (GRCm39)	C90S	probably damaging	Het
Sspo	T	C	6: 48,441,298 (GRCm39)	S1835P	probably damaging	Het
Stk35	A	G	2: 129,643,435 (GRCm39)	T140A	probably damaging	Het
Syngr1	C	T	15: 79,995,941 (GRCm39)	T160M	probably damaging	Het
Tent2	A	G	13: 93,320,726 (GRCm39)	L109S	probably damaging	Het
Tgfb1i1	A	G	7: 127,848,085 (GRCm39)		probably null	Het
Thoc1	T	A	18: 9,977,947 (GRCm39)	V296E	probably damaging	Het
Timp2	C	T	11: 118,201,412 (GRCm39)	C75Y	probably damaging	Het
Tlr1	T	C	5: 65,082,639 (GRCm39)	Y646C	probably damaging	Het
Tprn	G	A	2: 25,158,940 (GRCm39)	E655K	possibly damaging	Het
Trbv14	A	C	6: 41,112,424 (GRCm39)	I74L	probably benign	Het
Trbv5	T	A	6: 41,039,555 (GRCm39)	Y53*	probably null	Het
Trpm5	T	C	7: 142,642,656 (GRCm39)	Q97R	possibly damaging	Het
Tut1	A	G	19: 8,932,931 (GRCm39)	D88G	probably damaging	Het
Ucp2	A	T	7: 100,147,620 (GRCm39)	I200F	probably benign	Het
Unc45a	G	A	7: 79,988,623 (GRCm39)	S131L	probably benign	Het
Uty	A	T	Y: 1,158,182 (GRCm39)	H573Q	probably damaging	Het
Vmn1r17	T	A	6: 57,337,855 (GRCm39)	Y121F	possibly damaging	Het
Vmn1r53	T	C	6: 90,200,554 (GRCm39)	I257V	probably benign	Het
Vmn2r90	C	T	17: 17,954,229 (GRCm39)	L798F	probably damaging	Het
Vmn2r94	A	T	17: 18,477,736 (GRCm39)	M225K	probably benign	Het
Wdr24	A	T	17: 26,043,273 (GRCm39)	I32F	possibly damaging	Het
Zc3h11a	T	A	1: 133,552,521 (GRCm39)	T529S	probably benign	Het
Zc3h4	A	G	7: 16,168,264 (GRCm39)	H791R	unknown	Het
Zfp24	A	G	18: 24,150,927 (GRCm39)	L73P	probably damaging	Het
Zfp616	T	C	11: 73,974,121 (GRCm39)	I130T	probably benign	Het
Zim1	ACAGCAG	ACAGCAGCAG	7: 6,680,429 (GRCm39)		probably benign	Het
Zim1	CAG	CAGAAG	7: 6,680,430 (GRCm39)		probably benign	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,595,488 (GRCm39)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,179,603 (GRCm39)	splice site	probably benign
IGL01061:Dock2	APN	11	34,596,653 (GRCm39)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,589,617 (GRCm39)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,260,390 (GRCm39)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,596,608 (GRCm39)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,189,528 (GRCm39)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,647,100 (GRCm39)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,212,433 (GRCm39)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,212,391 (GRCm39)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,596,668 (GRCm39)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,582,744 (GRCm39)	nonsense	probably null
IGL01835:Dock2	APN	11	34,260,435 (GRCm39)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,599,692 (GRCm39)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,623,183 (GRCm39)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,218,053 (GRCm39)	missense	probably benign
IGL02081:Dock2	APN	11	34,204,355 (GRCm39)	missense	probably benign
IGL02105:Dock2	APN	11	34,605,352 (GRCm39)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,180,670 (GRCm39)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,217,949 (GRCm39)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,622,337 (GRCm39)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,589,567 (GRCm39)	splice site	probably benign
IGL02409:Dock2	APN	11	34,451,204 (GRCm39)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,199,801 (GRCm39)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,451,168 (GRCm39)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,218,048 (GRCm39)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,260,448 (GRCm39)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,583,086 (GRCm39)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,578,360 (GRCm39)	missense	probably damaging	0.99
Arches	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
denali	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
dew	UTSW	11	34,198,636 (GRCm39)	nonsense	probably null
Dinghy	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
Dry	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
frazz	UTSW	11	34,198,572 (GRCm39)	critical splice donor site	probably benign
frizz	UTSW	11	34,208,184 (GRCm39)	splice site	probably benign
gildenstern	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
godsgrace	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
Harborside	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
Landing	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
latest	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
Launch	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
liaoning	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
lucre	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
midas	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
muelle	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
narrowest	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
pier	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
Plank	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
riches	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
skiff	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
Slip	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
toothskin	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
Touch	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
wassup	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
Wharf	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,182,853 (GRCm39)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,611,835 (GRCm39)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,262,453 (GRCm39)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,674,622 (GRCm39)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34,647,111 (GRCm39)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,579,392 (GRCm39)	intron	probably benign
R0149:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,388,327 (GRCm39)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,218,052 (GRCm39)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,579,380 (GRCm39)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,595,545 (GRCm39)	splice site	probably benign
R0543:Dock2	UTSW	11	34,244,325 (GRCm39)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,198,621 (GRCm39)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,586,063 (GRCm39)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,414,970 (GRCm39)	splice site	probably benign
R0801:Dock2	UTSW	11	34,599,620 (GRCm39)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,206,535 (GRCm39)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,586,068 (GRCm39)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,223,309 (GRCm39)	splice site	probably benign
R1445:Dock2	UTSW	11	34,189,705 (GRCm39)	missense	probably benign
R1494:Dock2	UTSW	11	34,232,761 (GRCm39)	nonsense	probably null
R1589:Dock2	UTSW	11	34,597,288 (GRCm39)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,595,474 (GRCm39)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,212,480 (GRCm39)	splice site	probably null
R1749:Dock2	UTSW	11	34,182,767 (GRCm39)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,598,169 (GRCm39)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,244,286 (GRCm39)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,414,934 (GRCm39)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,618,297 (GRCm39)	splice site	probably benign
R2045:Dock2	UTSW	11	34,244,106 (GRCm39)	splice site	probably null
R2098:Dock2	UTSW	11	34,609,832 (GRCm39)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,216,279 (GRCm39)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,618,242 (GRCm39)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,179,472 (GRCm39)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,244,323 (GRCm39)	missense	probably damaging	0.99
R2875:Dock2	UTSW	11	34,609,712 (GRCm39)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,580,593 (GRCm39)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,182,910 (GRCm39)	splice site	probably benign
R3081:Dock2	UTSW	11	34,181,610 (GRCm39)	missense	probably benign
R3418:Dock2	UTSW	11	34,580,587 (GRCm39)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,611,787 (GRCm39)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,599,722 (GRCm39)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,623,198 (GRCm39)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,605,328 (GRCm39)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,189,536 (GRCm39)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,244,118 (GRCm39)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,586,298 (GRCm39)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,244,170 (GRCm39)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,223,767 (GRCm39)	splice site	probably null
R4884:Dock2	UTSW	11	34,216,248 (GRCm39)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,586,078 (GRCm39)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,178,643 (GRCm39)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,618,233 (GRCm39)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,204,391 (GRCm39)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,199,836 (GRCm39)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,212,445 (GRCm39)	missense	probably benign
R5860:Dock2	UTSW	11	34,206,562 (GRCm39)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,599,614 (GRCm39)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,244,123 (GRCm39)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,197,789 (GRCm39)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,212,388 (GRCm39)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,179,476 (GRCm39)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,453,396 (GRCm39)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,181,652 (GRCm39)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,598,152 (GRCm39)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,182,874 (GRCm39)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,453,413 (GRCm39)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,312,822 (GRCm39)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,578,365 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,670 (GRCm39)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,596,669 (GRCm39)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,579,279 (GRCm39)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,647,049 (GRCm39)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,414,922 (GRCm39)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,586,044 (GRCm39)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,177,684 (GRCm39)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,260,363 (GRCm39)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,189,675 (GRCm39)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,181,677 (GRCm39)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,605,340 (GRCm39)	nonsense	probably null
R7250:Dock2	UTSW	11	34,586,120 (GRCm39)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,586,032 (GRCm39)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,223,750 (GRCm39)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,180,672 (GRCm39)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,609,816 (GRCm39)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,586,105 (GRCm39)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,262,542 (GRCm39)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,611,778 (GRCm39)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,611,854 (GRCm39)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,605,282 (GRCm39)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,232,652 (GRCm39)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,223,698 (GRCm39)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,598,154 (GRCm39)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,217,998 (GRCm39)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,596,677 (GRCm39)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,623,166 (GRCm39)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,586,280 (GRCm39)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,260,362 (GRCm39)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,609,795 (GRCm39)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,180,825 (GRCm39)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,181,622 (GRCm39)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,212,457 (GRCm39)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,618,287 (GRCm39)	nonsense	probably null
R8743:Dock2	UTSW	11	34,223,252 (GRCm39)	nonsense	probably null
R8757:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,586,067 (GRCm39)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,451,215 (GRCm39)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,595,436 (GRCm39)	frame shift	probably null
R8885:Dock2	UTSW	11	34,260,396 (GRCm39)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,599,646 (GRCm39)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,589,670 (GRCm39)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,260,398 (GRCm39)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,622,366 (GRCm39)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,244,139 (GRCm39)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,212,460 (GRCm39)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,589,582 (GRCm39)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,599,638 (GRCm39)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,178,607 (GRCm39)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,218,054 (GRCm39)	missense	probably benign
R9697:Dock2	UTSW	11	34,204,417 (GRCm39)	missense	probably benign
R9753:Dock2	UTSW	11	34,223,673 (GRCm39)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,208,128 (GRCm39)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,216,271 (GRCm39)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,182,833 (GRCm39)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,206,564 (GRCm39)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,260,357 (GRCm39)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,583,209 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,388,300 (GRCm39)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,586,039 (GRCm39)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,609,751 (GRCm39)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,262,553 (GRCm39)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- ATGGGCTGGAGATACGTTCTAG -3'
(R):5'- CAAGAGGAGATGCTTTGCTGC -3'

Sequencing Primer
(F):5'- CGTTCTAGAAATGGAATCAGATTCG -3'
(R):5'- CTGCTGGGTGGTCCTTTATGAG -3'

Posted On

2014-12-04