Incidental Mutation 'R2510:Spg11'
| ID |
251910 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Spg11
|
| Ensembl Gene |
ENSMUSG00000033396 |
| Gene Name |
SPG11, spatacsin vesicle trafficking associated |
| Synonyms |
6030465E24Rik, C530005A01Rik, spastic paraplegia 11 |
| MMRRC Submission |
040416-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.130)
|
| Stock # |
R2510 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
121884001-121948867 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 121905791 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 1285
(I1285L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037543
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036450]
|
| AlphaFold |
Q3UHA3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000036450
AA Change: I1285L
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000037543
Gene: ENSMUSG00000033396
AA Change: I1285L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
254 |
276 |
N/A |
INTRINSIC |
|
low complexity region
|
945 |
958 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1305 |
1313 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
low complexity region
|
1772 |
1784 |
N/A |
INTRINSIC |
|
Pfam:Spatacsin_C
|
2082 |
2374 |
1.1e-105 |
PFAM |
|
| Meta Mutation Damage Score |
0.0606 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 94.9%
|
| Validation Efficiency |
99% (77/78) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
PHENOTYPE: Mice homozygous for a knock-out allele develop a progressive spastic and ataxic gait disorder and show loss of cortical motoneurons and Purkinje cells, a reduced number of lysosomes available for fusion with autophagosomes in degenerating neurons, and accumulation of autolysosome-derived material. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(10) : Gene trapped(10)
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930571K23Rik |
C |
A |
7: 124,968,311 (GRCm39) |
|
noncoding transcript |
Het |
| Adra1d |
C |
A |
2: 131,404,055 (GRCm39) |
E12* |
probably null |
Het |
| Ago4 |
A |
T |
4: 126,410,864 (GRCm39) |
D208E |
probably damaging |
Het |
| Agrn |
A |
T |
4: 156,250,881 (GRCm39) |
|
probably null |
Het |
| Atxn2 |
C |
T |
5: 121,919,456 (GRCm39) |
S388L |
probably damaging |
Het |
| Bbox1 |
A |
T |
2: 110,135,976 (GRCm39) |
M1K |
probably null |
Het |
| Btaf1 |
G |
A |
19: 36,979,845 (GRCm39) |
R1538H |
probably benign |
Het |
| Car11 |
G |
A |
7: 45,350,783 (GRCm39) |
G93E |
probably damaging |
Het |
| Col18a1 |
A |
G |
10: 76,932,102 (GRCm39) |
L329P |
unknown |
Het |
| Copb2 |
T |
A |
9: 98,453,701 (GRCm39) |
|
probably benign |
Het |
| Cracdl |
T |
C |
1: 37,664,381 (GRCm39) |
M506V |
probably benign |
Het |
| Dnah2 |
G |
T |
11: 69,415,032 (GRCm39) |
S234* |
probably null |
Het |
| Dnah9 |
T |
C |
11: 65,895,995 (GRCm39) |
Y2460C |
probably damaging |
Het |
| Dnai2 |
G |
C |
11: 114,647,993 (GRCm39) |
|
probably benign |
Het |
| Dst |
C |
A |
1: 34,251,367 (GRCm39) |
T1814K |
probably benign |
Het |
| F11 |
A |
G |
8: 45,701,675 (GRCm39) |
S353P |
probably damaging |
Het |
| Fancm |
A |
T |
12: 65,160,544 (GRCm39) |
|
probably benign |
Het |
| Fsip2 |
T |
C |
2: 82,816,782 (GRCm39) |
S4172P |
probably benign |
Het |
| G530012D18Rik |
T |
G |
1: 85,504,925 (GRCm39) |
|
probably benign |
Het |
| Gca |
T |
G |
2: 62,520,318 (GRCm39) |
S159R |
probably damaging |
Het |
| Gja8 |
T |
G |
3: 96,827,033 (GRCm39) |
T210P |
probably damaging |
Het |
| Gm5117 |
T |
A |
8: 32,228,383 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5900 |
T |
A |
7: 104,599,571 (GRCm39) |
|
noncoding transcript |
Het |
| Gpi1 |
A |
G |
7: 33,905,348 (GRCm39) |
S359P |
probably damaging |
Het |
| Grm5 |
A |
G |
7: 87,685,299 (GRCm39) |
E472G |
probably benign |
Het |
| Gsta5 |
T |
A |
9: 78,202,089 (GRCm39) |
M1K |
probably null |
Het |
| Hoxd12 |
G |
A |
2: 74,505,815 (GRCm39) |
A129T |
possibly damaging |
Het |
| Ifnlr1 |
G |
T |
4: 135,432,559 (GRCm39) |
D332Y |
probably damaging |
Het |
| Ift140 |
T |
C |
17: 25,255,282 (GRCm39) |
I466T |
probably benign |
Het |
| Kansl2 |
A |
G |
15: 98,426,742 (GRCm39) |
|
probably null |
Het |
| Kat2a |
T |
C |
11: 100,602,968 (GRCm39) |
Q88R |
probably benign |
Het |
| Kcnh7 |
T |
C |
2: 62,552,261 (GRCm39) |
D910G |
probably benign |
Het |
| Klk1b1 |
T |
C |
7: 43,618,803 (GRCm39) |
V60A |
probably damaging |
Het |
| Krt7 |
A |
C |
15: 101,310,538 (GRCm39) |
I62L |
probably benign |
Het |
| Llgl1 |
A |
G |
11: 60,600,862 (GRCm39) |
K653E |
probably damaging |
Het |
| Lmo2 |
T |
C |
2: 103,811,407 (GRCm39) |
Y147H |
probably damaging |
Het |
| Maco1 |
A |
G |
4: 134,531,699 (GRCm39) |
S657P |
probably damaging |
Het |
| Mafb |
T |
G |
2: 160,208,496 (GRCm39) |
E34A |
probably damaging |
Het |
| Meiob |
T |
C |
17: 25,035,571 (GRCm39) |
|
probably benign |
Het |
| Mllt10 |
C |
A |
2: 18,069,935 (GRCm39) |
D30E |
possibly damaging |
Het |
| Mprip |
T |
A |
11: 59,640,334 (GRCm39) |
|
probably benign |
Het |
| Muc5b |
A |
T |
7: 141,412,798 (GRCm39) |
N1915Y |
unknown |
Het |
| Mycbp2 |
C |
T |
14: 103,392,691 (GRCm39) |
R3290Q |
probably damaging |
Het |
| Ntaq1 |
C |
A |
15: 58,017,020 (GRCm39) |
A145D |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,933,140 (GRCm39) |
|
probably benign |
Het |
| Olfm3 |
T |
A |
3: 114,915,959 (GRCm39) |
V277D |
probably damaging |
Het |
| Omp |
A |
T |
7: 97,794,552 (GRCm39) |
M25K |
possibly damaging |
Het |
| Or10d4b |
T |
A |
9: 39,534,727 (GRCm39) |
F101I |
probably damaging |
Het |
| Or4b12 |
C |
T |
2: 90,095,950 (GRCm39) |
V275I |
probably damaging |
Het |
| Or4k40 |
G |
A |
2: 111,250,796 (GRCm39) |
P167S |
possibly damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,894 (GRCm39) |
H26Y |
probably benign |
Het |
| Otoa |
C |
T |
7: 120,759,695 (GRCm39) |
T1099I |
probably benign |
Het |
| Pcdh15 |
T |
G |
10: 74,467,331 (GRCm39) |
S1715A |
probably benign |
Het |
| Pcnx4 |
T |
C |
12: 72,613,746 (GRCm39) |
W564R |
probably damaging |
Het |
| Pde12 |
T |
C |
14: 26,386,681 (GRCm39) |
*609W |
probably null |
Het |
| Pitpnm2 |
T |
C |
5: 124,274,389 (GRCm39) |
E240G |
probably damaging |
Het |
| Plppr4 |
G |
T |
3: 117,125,355 (GRCm39) |
N161K |
probably damaging |
Het |
| Ppp1r37 |
T |
C |
7: 19,266,357 (GRCm39) |
K470E |
possibly damaging |
Het |
| Pramel27 |
G |
A |
4: 143,578,561 (GRCm39) |
V274I |
probably benign |
Het |
| Ptprd |
C |
A |
4: 76,004,248 (GRCm39) |
|
probably null |
Het |
| Rgs9 |
T |
C |
11: 109,159,798 (GRCm39) |
Y178C |
probably benign |
Het |
| Rims2 |
T |
G |
15: 39,449,048 (GRCm39) |
S1217R |
probably damaging |
Het |
| Rorc |
C |
T |
3: 94,296,427 (GRCm39) |
T208I |
probably benign |
Het |
| Ryr3 |
C |
T |
2: 112,506,249 (GRCm39) |
E3458K |
probably benign |
Het |
| Scn5a |
A |
T |
9: 119,362,751 (GRCm39) |
V623E |
probably benign |
Het |
| Slc28a2 |
C |
T |
2: 122,281,497 (GRCm39) |
Q229* |
probably null |
Het |
| Slc35f3 |
C |
T |
8: 127,025,445 (GRCm39) |
|
probably benign |
Het |
| Sstr2 |
A |
T |
11: 113,515,749 (GRCm39) |
I223F |
probably damaging |
Het |
| Susd1 |
A |
T |
4: 59,349,855 (GRCm39) |
V527E |
possibly damaging |
Het |
| Tas1r2 |
A |
G |
4: 139,387,162 (GRCm39) |
N207S |
probably damaging |
Het |
| Trappc10 |
A |
G |
10: 78,047,357 (GRCm39) |
S380P |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,571,336 (GRCm39) |
D26519G |
probably damaging |
Het |
| Vmn1r215 |
A |
G |
13: 23,260,343 (GRCm39) |
I128V |
probably benign |
Het |
| Vmn1r37 |
T |
C |
6: 66,708,935 (GRCm39) |
L150P |
probably damaging |
Het |
| Vmn2r129 |
G |
T |
4: 156,686,692 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r52 |
G |
T |
7: 9,904,795 (GRCm39) |
A348E |
probably benign |
Het |
| Ypel5 |
T |
C |
17: 73,153,386 (GRCm39) |
L30P |
probably damaging |
Het |
| Zfp985 |
A |
G |
4: 147,667,443 (GRCm39) |
T104A |
possibly damaging |
Het |
|
| Other mutations in Spg11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Spg11
|
APN |
2 |
121,896,041 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00495:Spg11
|
APN |
2 |
121,924,937 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00757:Spg11
|
APN |
2 |
121,901,440 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01304:Spg11
|
APN |
2 |
121,902,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01355:Spg11
|
APN |
2 |
121,943,637 (GRCm39) |
missense |
probably benign |
|
|
IGL01626:Spg11
|
APN |
2 |
121,891,452 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01739:Spg11
|
APN |
2 |
121,945,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Spg11
|
APN |
2 |
121,918,705 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02129:Spg11
|
APN |
2 |
121,926,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02178:Spg11
|
APN |
2 |
121,927,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02199:Spg11
|
APN |
2 |
121,890,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Spg11
|
APN |
2 |
121,938,638 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02605:Spg11
|
APN |
2 |
121,922,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02635:Spg11
|
APN |
2 |
121,943,549 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02743:Spg11
|
APN |
2 |
121,889,988 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02822:Spg11
|
APN |
2 |
121,905,015 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02992:Spg11
|
APN |
2 |
121,888,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03010:Spg11
|
APN |
2 |
121,918,801 (GRCm39) |
missense |
probably damaging |
0.96 |
|
3-1:Spg11
|
UTSW |
2 |
121,917,371 (GRCm39) |
missense |
probably damaging |
0.98 |
|
PIT4354001:Spg11
|
UTSW |
2 |
121,918,666 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Spg11
|
UTSW |
2 |
121,901,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0206:Spg11
|
UTSW |
2 |
121,886,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0208:Spg11
|
UTSW |
2 |
121,886,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0302:Spg11
|
UTSW |
2 |
121,922,668 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0347:Spg11
|
UTSW |
2 |
121,927,850 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0357:Spg11
|
UTSW |
2 |
121,896,713 (GRCm39) |
splice site |
probably benign |
|
|
R0372:Spg11
|
UTSW |
2 |
121,889,928 (GRCm39) |
frame shift |
probably null |
|
|
R0715:Spg11
|
UTSW |
2 |
121,915,464 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0927:Spg11
|
UTSW |
2 |
121,924,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1163:Spg11
|
UTSW |
2 |
121,901,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1534:Spg11
|
UTSW |
2 |
121,922,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1555:Spg11
|
UTSW |
2 |
121,927,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1569:Spg11
|
UTSW |
2 |
121,932,187 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1840:Spg11
|
UTSW |
2 |
121,932,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1929:Spg11
|
UTSW |
2 |
121,890,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2265:Spg11
|
UTSW |
2 |
121,938,788 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2303:Spg11
|
UTSW |
2 |
121,899,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2760:Spg11
|
UTSW |
2 |
121,927,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2918:Spg11
|
UTSW |
2 |
121,905,782 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3195:Spg11
|
UTSW |
2 |
121,913,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3423:Spg11
|
UTSW |
2 |
121,901,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4353:Spg11
|
UTSW |
2 |
121,943,675 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4407:Spg11
|
UTSW |
2 |
121,905,813 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4644:Spg11
|
UTSW |
2 |
121,891,510 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4663:Spg11
|
UTSW |
2 |
121,928,580 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4684:Spg11
|
UTSW |
2 |
121,895,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Spg11
|
UTSW |
2 |
121,895,963 (GRCm39) |
nonsense |
probably null |
|
|
R4810:Spg11
|
UTSW |
2 |
121,890,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Spg11
|
UTSW |
2 |
121,938,936 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5089:Spg11
|
UTSW |
2 |
121,945,198 (GRCm39) |
nonsense |
probably null |
|
|
R5362:Spg11
|
UTSW |
2 |
121,891,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5684:Spg11
|
UTSW |
2 |
121,923,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5899:Spg11
|
UTSW |
2 |
121,928,680 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5923:Spg11
|
UTSW |
2 |
121,923,959 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6052:Spg11
|
UTSW |
2 |
121,927,837 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6111:Spg11
|
UTSW |
2 |
121,923,963 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Spg11
|
UTSW |
2 |
121,917,286 (GRCm39) |
splice site |
probably null |
|
|
R6226:Spg11
|
UTSW |
2 |
121,918,743 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6336:Spg11
|
UTSW |
2 |
121,943,440 (GRCm39) |
splice site |
probably null |
|
|
R6480:Spg11
|
UTSW |
2 |
121,922,786 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6494:Spg11
|
UTSW |
2 |
121,943,706 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6582:Spg11
|
UTSW |
2 |
121,922,773 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6714:Spg11
|
UTSW |
2 |
121,926,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6791:Spg11
|
UTSW |
2 |
121,923,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6836:Spg11
|
UTSW |
2 |
121,890,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6928:Spg11
|
UTSW |
2 |
121,900,385 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7179:Spg11
|
UTSW |
2 |
121,932,270 (GRCm39) |
splice site |
probably null |
|
|
R7229:Spg11
|
UTSW |
2 |
121,938,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7337:Spg11
|
UTSW |
2 |
121,915,474 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7338:Spg11
|
UTSW |
2 |
121,885,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7351:Spg11
|
UTSW |
2 |
121,900,412 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7378:Spg11
|
UTSW |
2 |
121,888,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Spg11
|
UTSW |
2 |
121,924,026 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7505:Spg11
|
UTSW |
2 |
121,905,832 (GRCm39) |
nonsense |
probably null |
|
|
R7665:Spg11
|
UTSW |
2 |
121,896,748 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7685:Spg11
|
UTSW |
2 |
121,899,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7779:Spg11
|
UTSW |
2 |
121,901,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Spg11
|
UTSW |
2 |
121,922,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Spg11
|
UTSW |
2 |
121,923,426 (GRCm39) |
splice site |
probably null |
|
|
R8024:Spg11
|
UTSW |
2 |
121,927,802 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8033:Spg11
|
UTSW |
2 |
121,917,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Spg11
|
UTSW |
2 |
121,943,637 (GRCm39) |
missense |
probably benign |
|
|
R8121:Spg11
|
UTSW |
2 |
121,900,348 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8252:Spg11
|
UTSW |
2 |
121,918,820 (GRCm39) |
splice site |
probably benign |
|
|
R8358:Spg11
|
UTSW |
2 |
121,910,739 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8362:Spg11
|
UTSW |
2 |
121,948,842 (GRCm39) |
missense |
unknown |
|
|
R8385:Spg11
|
UTSW |
2 |
121,927,802 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8406:Spg11
|
UTSW |
2 |
121,923,923 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8480:Spg11
|
UTSW |
2 |
121,943,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8810:Spg11
|
UTSW |
2 |
121,901,425 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8883:Spg11
|
UTSW |
2 |
121,943,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8968:Spg11
|
UTSW |
2 |
121,922,687 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9008:Spg11
|
UTSW |
2 |
121,900,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9059:Spg11
|
UTSW |
2 |
121,918,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9296:Spg11
|
UTSW |
2 |
121,945,175 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9333:Spg11
|
UTSW |
2 |
121,932,244 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9657:Spg11
|
UTSW |
2 |
121,910,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Spg11
|
UTSW |
2 |
121,938,965 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Spg11
|
UTSW |
2 |
121,903,466 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAATTAATGAGGCTCAGGGTCATTC -3'
(R):5'- TTATTTTCTAGGATCCAGCAAGTAGGC -3'
Sequencing Primer
(F):5'- TGAGGCTCAGGGTCATTCAAACC -3'
(R):5'- GCAAGGAGGCCTATACCTTAG -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation