Incidental Mutation 'R0311:Vmn2r73'
ID 25197
Institutional Source Beutler Lab
Gene Symbol Vmn2r73
Ensembl Gene ENSMUSG00000070458
Gene Name vomeronasal 2, receptor 73
Synonyms EG620928
MMRRC Submission 038521-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R0311 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 85506755-85525146 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85520997 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 324 (S324P)
Ref Sequence ENSEMBL: ENSMUSP00000076687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077478]
AlphaFold D3Z7M3
Predicted Effect probably benign
Transcript: ENSMUST00000077478
AA Change: S324P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: S324P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 465 1.4e-30 PFAM
Pfam:NCD3G 508 560 5.9e-21 PFAM
Pfam:7tm_3 590 827 4.4e-51 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.6%
  • 20x: 91.6%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 A C 7: 120,002,127 (GRCm39) M1547L probably damaging Het
Abcb4 A G 5: 8,984,243 (GRCm39) K658E probably benign Het
Abr A G 11: 76,399,953 (GRCm39) S15P possibly damaging Het
Adgrb2 G C 4: 129,910,922 (GRCm39) A1168P probably damaging Het
Adgre4 A T 17: 56,109,010 (GRCm39) E339V probably benign Het
Asprv1 T C 6: 86,605,822 (GRCm39) W223R probably damaging Het
Ccdc89 A G 7: 90,075,901 (GRCm39) E37G probably damaging Het
Cd48 C A 1: 171,527,148 (GRCm39) Y191* probably null Het
Chd4 T C 6: 125,078,628 (GRCm39) I257T probably benign Het
Clca4b T C 3: 144,638,257 (GRCm39) M2V probably benign Het
Dnah11 A T 12: 118,090,868 (GRCm39) D1025E probably benign Het
Erich5 A G 15: 34,473,085 (GRCm39) *363W probably null Het
Etl4 A G 2: 20,811,940 (GRCm39) D1341G probably damaging Het
Fbxw11 A G 11: 32,672,083 (GRCm39) T184A probably benign Het
Fktn A G 4: 53,744,620 (GRCm39) Q300R probably benign Het
G3bp1 T C 11: 55,389,452 (GRCm39) F383L probably damaging Het
Gdpd3 G A 7: 126,366,361 (GRCm39) R66Q possibly damaging Het
Hexb A G 13: 97,320,327 (GRCm39) probably benign Het
Kdm4b A G 17: 56,693,200 (GRCm39) R346G probably benign Het
Mbtd1 T A 11: 93,812,183 (GRCm39) probably null Het
Med23 T A 10: 24,773,256 (GRCm39) C653S possibly damaging Het
Nwd2 A T 5: 63,962,341 (GRCm39) I642L probably damaging Het
Or5b12 T A 19: 12,897,460 (GRCm39) Y71F possibly damaging Het
Or5b21 A G 19: 12,839,233 (GRCm39) I31M probably benign Het
Or8b48 T C 9: 38,450,593 (GRCm39) V134A probably benign Het
Pbld2 T C 10: 62,890,286 (GRCm39) probably null Het
Pkd1l3 C G 8: 110,350,281 (GRCm39) D375E possibly damaging Het
Pkd1l3 G A 8: 110,350,295 (GRCm39) S380N probably benign Het
Plpp2 C T 10: 79,363,414 (GRCm39) R77K probably damaging Het
Pym1 G T 10: 128,601,853 (GRCm39) R168L possibly damaging Het
Rbm4 T C 19: 4,837,584 (GRCm39) Y300C probably damaging Het
Rnf207 A G 4: 152,400,236 (GRCm39) C175R probably damaging Het
Sema6a G A 18: 47,423,112 (GRCm39) probably null Het
Speg T C 1: 75,407,581 (GRCm39) V3196A probably damaging Het
Syne1 T A 10: 5,298,943 (GRCm39) I1048L possibly damaging Het
Th T C 7: 142,449,778 (GRCm39) E41G probably damaging Het
Tmx4 T A 2: 134,440,446 (GRCm39) *336L probably null Het
Tnfrsf18 T C 4: 156,110,872 (GRCm39) V10A possibly damaging Het
Tnxb A T 17: 34,935,958 (GRCm39) I2670F probably damaging Het
Tpx2 T C 2: 152,732,412 (GRCm39) V562A probably damaging Het
Vps18 T C 2: 119,127,846 (GRCm39) Y890H probably benign Het
Ythdc1 G A 5: 86,983,564 (GRCm39) D670N probably damaging Het
Other mutations in Vmn2r73
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Vmn2r73 APN 7 85,506,795 (GRCm39) missense
IGL01151:Vmn2r73 APN 7 85,507,086 (GRCm39) missense probably damaging 0.99
IGL01408:Vmn2r73 APN 7 85,521,455 (GRCm39) missense probably benign 0.45
IGL01505:Vmn2r73 APN 7 85,507,267 (GRCm39) nonsense probably null
IGL01731:Vmn2r73 APN 7 85,506,757 (GRCm39) makesense probably null
IGL01818:Vmn2r73 APN 7 85,519,109 (GRCm39) splice site probably benign
IGL02236:Vmn2r73 APN 7 85,521,902 (GRCm39) missense probably benign 0.00
IGL02265:Vmn2r73 APN 7 85,520,847 (GRCm39) missense probably benign 0.02
IGL02266:Vmn2r73 APN 7 85,525,007 (GRCm39) missense possibly damaging 0.52
IGL02276:Vmn2r73 APN 7 85,518,980 (GRCm39) critical splice donor site probably null
IGL02284:Vmn2r73 APN 7 85,507,123 (GRCm39) missense possibly damaging 0.92
IGL02380:Vmn2r73 APN 7 85,507,383 (GRCm39) missense probably benign 0.00
IGL02466:Vmn2r73 APN 7 85,522,084 (GRCm39) missense probably damaging 1.00
IGL03172:Vmn2r73 APN 7 85,507,495 (GRCm39) missense probably benign 0.01
IGL03179:Vmn2r73 APN 7 85,519,468 (GRCm39) missense probably benign 0.04
G1Funyon:Vmn2r73 UTSW 7 85,507,510 (GRCm39) missense probably benign 0.00
R0077:Vmn2r73 UTSW 7 85,525,075 (GRCm39) missense probably benign 0.00
R0413:Vmn2r73 UTSW 7 85,521,087 (GRCm39) missense possibly damaging 0.68
R0494:Vmn2r73 UTSW 7 85,522,140 (GRCm39) missense probably benign
R1523:Vmn2r73 UTSW 7 85,519,486 (GRCm39) missense probably benign 0.02
R1618:Vmn2r73 UTSW 7 85,525,120 (GRCm39) nonsense probably null
R1667:Vmn2r73 UTSW 7 85,506,889 (GRCm39) missense probably benign 0.00
R1728:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R1729:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R1747:Vmn2r73 UTSW 7 85,507,375 (GRCm39) missense probably damaging 1.00
R1784:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R2152:Vmn2r73 UTSW 7 85,506,936 (GRCm39) missense probably benign 0.03
R2395:Vmn2r73 UTSW 7 85,506,975 (GRCm39) missense probably damaging 1.00
R2415:Vmn2r73 UTSW 7 85,521,431 (GRCm39) missense probably damaging 1.00
R2926:Vmn2r73 UTSW 7 85,520,871 (GRCm39) missense probably benign 0.17
R3719:Vmn2r73 UTSW 7 85,519,582 (GRCm39) missense probably damaging 1.00
R3766:Vmn2r73 UTSW 7 85,521,198 (GRCm39) missense probably benign
R3838:Vmn2r73 UTSW 7 85,507,258 (GRCm39) missense probably benign 0.00
R3890:Vmn2r73 UTSW 7 85,507,144 (GRCm39) missense probably benign
R4030:Vmn2r73 UTSW 7 85,521,044 (GRCm39) missense possibly damaging 0.92
R4247:Vmn2r73 UTSW 7 85,521,883 (GRCm39) missense probably damaging 0.99
R4409:Vmn2r73 UTSW 7 85,520,768 (GRCm39) missense probably damaging 0.97
R4427:Vmn2r73 UTSW 7 85,506,981 (GRCm39) missense probably damaging 1.00
R4430:Vmn2r73 UTSW 7 85,519,449 (GRCm39) missense probably benign
R4552:Vmn2r73 UTSW 7 85,525,055 (GRCm39) missense probably benign 0.12
R4779:Vmn2r73 UTSW 7 85,520,923 (GRCm39) nonsense probably null
R4906:Vmn2r73 UTSW 7 85,506,829 (GRCm39) missense probably damaging 0.99
R4942:Vmn2r73 UTSW 7 85,519,582 (GRCm39) missense probably damaging 1.00
R5280:Vmn2r73 UTSW 7 85,507,155 (GRCm39) missense probably damaging 0.98
R5344:Vmn2r73 UTSW 7 85,525,046 (GRCm39) missense probably benign 0.00
R5478:Vmn2r73 UTSW 7 85,518,996 (GRCm39) missense probably damaging 1.00
R5527:Vmn2r73 UTSW 7 85,507,575 (GRCm39) missense possibly damaging 0.65
R5691:Vmn2r73 UTSW 7 85,507,299 (GRCm39) missense probably damaging 1.00
R5826:Vmn2r73 UTSW 7 85,524,956 (GRCm39) missense possibly damaging 0.77
R6018:Vmn2r73 UTSW 7 85,521,875 (GRCm39) missense possibly damaging 0.48
R6082:Vmn2r73 UTSW 7 85,507,429 (GRCm39) missense probably benign 0.00
R6111:Vmn2r73 UTSW 7 85,520,997 (GRCm39) missense probably benign
R6233:Vmn2r73 UTSW 7 85,519,099 (GRCm39) missense probably benign 0.00
R6278:Vmn2r73 UTSW 7 85,522,140 (GRCm39) missense probably benign
R6283:Vmn2r73 UTSW 7 85,521,049 (GRCm39) missense probably benign 0.00
R6307:Vmn2r73 UTSW 7 85,506,828 (GRCm39) missense probably damaging 1.00
R6413:Vmn2r73 UTSW 7 85,519,544 (GRCm39) nonsense probably null
R6782:Vmn2r73 UTSW 7 85,519,563 (GRCm39) missense probably benign 0.00
R6884:Vmn2r73 UTSW 7 85,507,213 (GRCm39) missense probably benign 0.05
R6921:Vmn2r73 UTSW 7 85,507,446 (GRCm39) missense probably benign 0.27
R7169:Vmn2r73 UTSW 7 85,507,663 (GRCm39) nonsense probably null
R7206:Vmn2r73 UTSW 7 85,522,075 (GRCm39) missense probably benign 0.03
R7311:Vmn2r73 UTSW 7 85,521,192 (GRCm39) missense possibly damaging 0.80
R7650:Vmn2r73 UTSW 7 85,521,147 (GRCm39) missense probably benign
R7811:Vmn2r73 UTSW 7 85,524,956 (GRCm39) missense possibly damaging 0.77
R8263:Vmn2r73 UTSW 7 85,507,619 (GRCm39) missense probably benign
R8301:Vmn2r73 UTSW 7 85,507,510 (GRCm39) missense probably benign 0.00
R8341:Vmn2r73 UTSW 7 85,507,128 (GRCm39) missense probably benign 0.01
R8500:Vmn2r73 UTSW 7 85,519,638 (GRCm39) missense probably benign 0.01
R8673:Vmn2r73 UTSW 7 85,521,902 (GRCm39) missense probably benign 0.01
R8719:Vmn2r73 UTSW 7 85,521,095 (GRCm39) missense probably damaging 0.96
R8783:Vmn2r73 UTSW 7 85,507,668 (GRCm39) missense probably damaging 0.96
R8828:Vmn2r73 UTSW 7 85,521,179 (GRCm39) missense probably damaging 0.98
R8860:Vmn2r73 UTSW 7 85,522,149 (GRCm39) splice site probably benign
R9002:Vmn2r73 UTSW 7 85,507,284 (GRCm39) missense probably benign 0.32
R9008:Vmn2r73 UTSW 7 85,521,904 (GRCm39) missense probably damaging 0.96
R9159:Vmn2r73 UTSW 7 85,521,931 (GRCm39) missense possibly damaging 0.90
R9180:Vmn2r73 UTSW 7 85,507,123 (GRCm39) missense probably benign 0.07
R9198:Vmn2r73 UTSW 7 85,518,987 (GRCm39) missense probably benign 0.01
R9329:Vmn2r73 UTSW 7 85,519,073 (GRCm39) missense probably benign
R9448:Vmn2r73 UTSW 7 85,522,027 (GRCm39) missense probably benign 0.00
R9463:Vmn2r73 UTSW 7 85,506,795 (GRCm39) missense
R9589:Vmn2r73 UTSW 7 85,519,659 (GRCm39) missense probably benign 0.03
X0023:Vmn2r73 UTSW 7 85,507,664 (GRCm39) missense probably benign 0.31
Z1176:Vmn2r73 UTSW 7 85,521,176 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r73 UTSW 7 85,521,480 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCAGCAGCATCTCATGGAGTG -3'
(R):5'- GTTTATGGAGACCACAACTCGCCC -3'

Sequencing Primer
(F):5'- GTGGGCTACAGCATATATAGCATTG -3'
(R):5'- AACTCGCCCATAAAGTTTGTC -3'
Posted On 2013-04-16