Incidental Mutation 'R2504:Ubr3'
| ID |
252070 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr3
|
| Ensembl Gene |
ENSMUSG00000044308 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 3 |
| Synonyms |
1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650 |
| MMRRC Submission |
040412-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2504 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
69727590-69854357 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 69768542 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 450
(F450I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055758]
[ENSMUST00000112251]
|
| AlphaFold |
Q5U430 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055758
AA Change: F451I
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000060159
Gene: ENSMUSG00000044308
AA Change: F451I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
118 |
188 |
1.6e-19 |
PFAM |
|
low complexity region
|
339 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
570 |
580 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1082 |
1101 |
N/A |
INTRINSIC |
|
coiled coil region
|
1167 |
1199 |
N/A |
INTRINSIC |
|
Blast:RING
|
1289 |
1363 |
8e-39 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112251
AA Change: F450I
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000107870
Gene: ENSMUSG00000044308
AA Change: F450I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
119 |
187 |
1.7e-21 |
PFAM |
|
low complexity region
|
338 |
353 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
579 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1026 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1100 |
N/A |
INTRINSIC |
|
coiled coil region
|
1166 |
1198 |
N/A |
INTRINSIC |
|
Blast:RING
|
1288 |
1362 |
8e-39 |
BLAST |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000131553
AA Change: F447I
|
| SMART Domains |
Protein: ENSMUSP00000121401
Gene: ENSMUSG00000044308
AA Change: F447I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
11 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
65 |
86 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
117 |
185 |
1.2e-21 |
PFAM |
|
low complexity region
|
336 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142563
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
C |
11: 119,909,681 (GRCm39) |
D28G |
probably benign |
Het |
| Abcg1 |
T |
A |
17: 31,311,369 (GRCm39) |
S125T |
probably damaging |
Het |
| Actbl2 |
T |
C |
13: 111,392,717 (GRCm39) |
S351P |
possibly damaging |
Het |
| Ankrd34b |
A |
G |
13: 92,575,569 (GRCm39) |
|
probably null |
Het |
| BC051665 |
C |
T |
13: 60,930,468 (GRCm39) |
V295I |
probably benign |
Het |
| C1qtnf2 |
A |
G |
11: 43,381,983 (GRCm39) |
N265S |
probably damaging |
Het |
| Ccdc14 |
C |
T |
16: 34,542,220 (GRCm39) |
R573* |
probably null |
Het |
| Cd55b |
A |
T |
1: 130,337,612 (GRCm39) |
Y247N |
probably damaging |
Het |
| Celsr2 |
A |
T |
3: 108,320,907 (GRCm39) |
V635E |
probably benign |
Het |
| Clec16a |
T |
C |
16: 10,377,551 (GRCm39) |
|
probably benign |
Het |
| Clec4b1 |
A |
G |
6: 123,042,904 (GRCm39) |
Y41C |
probably damaging |
Het |
| Cntn5 |
A |
T |
9: 10,172,126 (GRCm39) |
D19E |
probably benign |
Het |
| Cop1 |
A |
G |
1: 159,060,375 (GRCm39) |
N53S |
probably damaging |
Het |
| Cplane1 |
G |
A |
15: 8,248,700 (GRCm39) |
E1750K |
probably damaging |
Het |
| Csad |
A |
T |
15: 102,097,102 (GRCm39) |
M1K |
probably null |
Het |
| Cyb5rl |
A |
G |
4: 106,938,142 (GRCm39) |
I200V |
probably benign |
Het |
| Cyp26a1 |
A |
G |
19: 37,686,790 (GRCm39) |
T81A |
probably damaging |
Het |
| Cyp2d12 |
A |
T |
15: 82,443,237 (GRCm39) |
H433L |
probably benign |
Het |
| D7Ertd443e |
T |
A |
7: 133,951,208 (GRCm39) |
|
probably null |
Het |
| Dennd1b |
A |
G |
1: 139,097,908 (GRCm39) |
|
probably benign |
Het |
| Dmap1 |
G |
T |
4: 117,532,495 (GRCm39) |
T357K |
probably damaging |
Het |
| Dzip1 |
G |
T |
14: 119,118,456 (GRCm39) |
T759K |
probably benign |
Het |
| Elmo2 |
A |
G |
2: 165,140,607 (GRCm39) |
V300A |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,810,364 (GRCm39) |
D864G |
possibly damaging |
Het |
| Ep400 |
A |
G |
5: 110,816,511 (GRCm39) |
V2670A |
probably damaging |
Het |
| Epha3 |
T |
A |
16: 63,423,988 (GRCm39) |
I534F |
probably damaging |
Het |
| Epha4 |
A |
C |
1: 77,359,628 (GRCm39) |
Y742D |
probably damaging |
Het |
| Ergic2 |
A |
G |
6: 148,106,272 (GRCm39) |
|
probably null |
Het |
| Ero1a |
A |
T |
14: 45,536,545 (GRCm39) |
|
probably null |
Het |
| Fam229a |
A |
G |
4: 129,385,279 (GRCm39) |
D70G |
probably damaging |
Het |
| Fbn2 |
C |
T |
18: 58,226,431 (GRCm39) |
R781Q |
probably damaging |
Het |
| Fbxo16 |
A |
T |
14: 65,508,163 (GRCm39) |
|
probably benign |
Het |
| Fbxo39 |
T |
A |
11: 72,208,111 (GRCm39) |
S154R |
probably benign |
Het |
| Fer |
T |
A |
17: 64,298,575 (GRCm39) |
|
probably null |
Het |
| Filip1l |
A |
T |
16: 57,391,410 (GRCm39) |
D428V |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,025 (GRCm39) |
I538V |
possibly damaging |
Het |
| Fsip2 |
T |
C |
2: 82,809,954 (GRCm39) |
I2091T |
possibly damaging |
Het |
| Glyat |
A |
C |
19: 12,628,762 (GRCm39) |
T186P |
possibly damaging |
Het |
| Gm10604 |
A |
G |
4: 11,980,083 (GRCm39) |
S74P |
unknown |
Het |
| Gm4787 |
T |
G |
12: 81,425,911 (GRCm39) |
K82N |
possibly damaging |
Het |
| Hectd4 |
T |
C |
5: 121,358,683 (GRCm39) |
I50T |
unknown |
Het |
| Hectd4 |
T |
C |
5: 121,402,030 (GRCm39) |
S373P |
possibly damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,562,618 (GRCm39) |
C2313* |
probably null |
Het |
| Hrob |
T |
C |
11: 102,146,122 (GRCm39) |
Y133H |
possibly damaging |
Het |
| Igfn1 |
A |
T |
1: 135,897,054 (GRCm39) |
S1171T |
probably benign |
Het |
| Ints8 |
T |
C |
4: 11,241,642 (GRCm39) |
D267G |
probably benign |
Het |
| Itln1 |
A |
G |
1: 171,356,727 (GRCm39) |
C251R |
probably damaging |
Het |
| Jcad |
C |
T |
18: 4,674,026 (GRCm39) |
T596M |
probably damaging |
Het |
| Kcnj16 |
C |
T |
11: 110,916,409 (GRCm39) |
T357M |
probably benign |
Het |
| Kif13a |
G |
A |
13: 46,967,676 (GRCm39) |
T346M |
probably damaging |
Het |
| Klhl24 |
G |
A |
16: 19,938,917 (GRCm39) |
A491T |
probably benign |
Het |
| Kntc1 |
C |
T |
5: 123,916,410 (GRCm39) |
Q748* |
probably null |
Het |
| Krt25 |
T |
A |
11: 99,208,122 (GRCm39) |
K369* |
probably null |
Het |
| Krt75 |
C |
T |
15: 101,476,466 (GRCm39) |
R433Q |
probably benign |
Het |
| Krt76 |
A |
G |
15: 101,793,293 (GRCm39) |
F582L |
unknown |
Het |
| Lysmd1 |
G |
A |
3: 95,045,708 (GRCm39) |
V182I |
probably benign |
Het |
| Mab21l2 |
T |
A |
3: 86,454,862 (GRCm39) |
E46V |
probably damaging |
Het |
| Magi2 |
A |
T |
5: 20,563,934 (GRCm39) |
K355N |
probably damaging |
Het |
| Marchf10 |
T |
C |
11: 105,276,398 (GRCm39) |
D630G |
probably damaging |
Het |
| Mast4 |
A |
T |
13: 102,875,147 (GRCm39) |
I1215N |
probably damaging |
Het |
| Nckap1 |
G |
A |
2: 80,360,562 (GRCm39) |
T523I |
probably benign |
Het |
| Nexmif |
T |
A |
X: 103,127,999 (GRCm39) |
D1306V |
probably damaging |
Het |
| Nfkb1 |
A |
C |
3: 135,295,090 (GRCm39) |
I918R |
possibly damaging |
Het |
| Nt5el |
A |
G |
13: 105,246,250 (GRCm39) |
I270M |
probably benign |
Het |
| Nup50 |
A |
T |
15: 84,817,859 (GRCm39) |
T93S |
probably benign |
Het |
| Nwd2 |
T |
C |
5: 63,961,717 (GRCm39) |
Y434H |
probably benign |
Het |
| Or13a28 |
T |
C |
7: 140,218,397 (GRCm39) |
V261A |
probably benign |
Het |
| Osbpl1a |
C |
A |
18: 13,038,088 (GRCm39) |
V288L |
probably benign |
Het |
| Pan3 |
A |
G |
5: 147,463,846 (GRCm39) |
E562G |
possibly damaging |
Het |
| Pappa |
T |
A |
4: 65,099,126 (GRCm39) |
Y548* |
probably null |
Het |
| Phf3 |
A |
T |
1: 30,849,870 (GRCm39) |
L1181Q |
probably damaging |
Het |
| Phip |
T |
C |
9: 82,797,392 (GRCm39) |
H537R |
possibly damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,348,824 (GRCm39) |
I240T |
probably damaging |
Het |
| Pole |
G |
A |
5: 110,438,368 (GRCm39) |
|
probably null |
Het |
| Polq |
T |
A |
16: 36,832,304 (GRCm39) |
S15T |
unknown |
Het |
| Prrt2 |
T |
C |
7: 126,619,396 (GRCm39) |
E23G |
possibly damaging |
Het |
| Prss37 |
A |
T |
6: 40,494,760 (GRCm39) |
|
probably null |
Het |
| Prune2 |
T |
C |
19: 16,977,400 (GRCm39) |
L45P |
probably damaging |
Het |
| Psd |
A |
T |
19: 46,313,352 (GRCm39) |
M6K |
possibly damaging |
Het |
| Psmd1 |
A |
G |
1: 86,017,719 (GRCm39) |
E510G |
possibly damaging |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Pxdn |
T |
A |
12: 30,053,405 (GRCm39) |
I1194N |
probably damaging |
Het |
| Rbp3 |
C |
T |
14: 33,677,975 (GRCm39) |
T641M |
probably damaging |
Het |
| Rgmb |
C |
A |
17: 16,027,909 (GRCm39) |
R270L |
probably benign |
Het |
| Rpgrip1l |
A |
G |
8: 92,007,344 (GRCm39) |
|
probably null |
Het |
| Rps2 |
G |
A |
17: 24,939,353 (GRCm39) |
|
probably benign |
Het |
| Rsbn1l |
G |
T |
5: 21,107,364 (GRCm39) |
A550E |
probably damaging |
Het |
| S1pr4 |
C |
T |
10: 81,335,138 (GRCm39) |
R112H |
probably benign |
Het |
| Scfd2 |
T |
C |
5: 74,691,838 (GRCm39) |
N148S |
probably damaging |
Het |
| Scin |
C |
T |
12: 40,131,705 (GRCm39) |
M276I |
probably benign |
Het |
| Sec24d |
T |
C |
3: 123,147,255 (GRCm39) |
I708T |
possibly damaging |
Het |
| Skint11 |
T |
A |
4: 114,086,009 (GRCm39) |
F41I |
possibly damaging |
Het |
| Slc15a4 |
A |
T |
5: 127,694,303 (GRCm39) |
F44Y |
possibly damaging |
Het |
| Slc6a18 |
A |
G |
13: 73,823,925 (GRCm39) |
Y72H |
probably benign |
Het |
| Slc7a11 |
A |
T |
3: 50,332,195 (GRCm39) |
|
probably null |
Het |
| Slc7a14 |
G |
T |
3: 31,291,650 (GRCm39) |
N209K |
possibly damaging |
Het |
| Sstr2 |
T |
C |
11: 113,515,257 (GRCm39) |
C59R |
probably damaging |
Het |
| Stab1 |
A |
G |
14: 30,884,997 (GRCm39) |
|
probably null |
Het |
| Stag1 |
G |
T |
9: 100,748,263 (GRCm39) |
S475I |
probably damaging |
Het |
| Stxbp5l |
A |
G |
16: 36,936,029 (GRCm39) |
Y1183H |
probably damaging |
Het |
| Svep1 |
A |
T |
4: 58,135,628 (GRCm39) |
|
probably null |
Het |
| Tm9sf2 |
A |
G |
14: 122,396,096 (GRCm39) |
T653A |
probably benign |
Het |
| Tmeff1 |
T |
C |
4: 48,662,059 (GRCm39) |
S366P |
possibly damaging |
Het |
| Tnnt2 |
G |
T |
1: 135,779,803 (GRCm39) |
W300L |
probably damaging |
Het |
| Traj32 |
A |
G |
14: 54,423,560 (GRCm39) |
|
probably benign |
Het |
| Trp53bp2 |
A |
T |
1: 182,269,204 (GRCm39) |
M223L |
probably benign |
Het |
| Tsga10 |
G |
A |
1: 37,854,758 (GRCm39) |
T246M |
probably damaging |
Het |
| Txn2 |
A |
T |
15: 77,810,870 (GRCm39) |
|
probably benign |
Het |
| Usp47 |
T |
C |
7: 111,703,677 (GRCm39) |
|
probably null |
Het |
| Vars2 |
C |
T |
17: 35,975,685 (GRCm39) |
R244Q |
probably damaging |
Het |
| Xrra1 |
T |
A |
7: 99,546,803 (GRCm39) |
F251L |
probably damaging |
Het |
| Zfp804a |
G |
A |
2: 82,087,863 (GRCm39) |
R564Q |
probably benign |
Het |
| Zfp983 |
T |
C |
17: 21,877,883 (GRCm39) |
C29R |
probably damaging |
Het |
|
| Other mutations in Ubr3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Ubr3
|
APN |
2 |
69,819,154 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00985:Ubr3
|
APN |
2 |
69,833,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01061:Ubr3
|
APN |
2 |
69,813,569 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01325:Ubr3
|
APN |
2 |
69,747,441 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01398:Ubr3
|
APN |
2 |
69,789,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01484:Ubr3
|
APN |
2 |
69,851,888 (GRCm39) |
nonsense |
probably null |
|
|
IGL01599:Ubr3
|
APN |
2 |
69,768,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01616:Ubr3
|
APN |
2 |
69,850,828 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01634:Ubr3
|
APN |
2 |
69,803,916 (GRCm39) |
missense |
probably benign |
|
|
IGL01684:Ubr3
|
APN |
2 |
69,846,502 (GRCm39) |
nonsense |
probably null |
|
|
IGL01810:Ubr3
|
APN |
2 |
69,833,809 (GRCm39) |
splice site |
probably null |
|
|
IGL01813:Ubr3
|
APN |
2 |
69,781,914 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01994:Ubr3
|
APN |
2 |
69,851,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02188:Ubr3
|
APN |
2 |
69,789,955 (GRCm39) |
nonsense |
probably null |
|
|
IGL02318:Ubr3
|
APN |
2 |
69,809,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02379:Ubr3
|
APN |
2 |
69,778,832 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02635:Ubr3
|
APN |
2 |
69,850,827 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02858:Ubr3
|
APN |
2 |
69,783,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03140:Ubr3
|
APN |
2 |
69,800,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Ubr3
|
APN |
2 |
69,803,490 (GRCm39) |
splice site |
probably benign |
|
|
Hyrax
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
manatee
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
sea_cow
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0122:Ubr3
|
UTSW |
2 |
69,809,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Ubr3
|
UTSW |
2 |
69,781,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Ubr3
|
UTSW |
2 |
69,783,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0787:Ubr3
|
UTSW |
2 |
69,781,765 (GRCm39) |
splice site |
probably benign |
|
|
R1137:Ubr3
|
UTSW |
2 |
69,768,659 (GRCm39) |
splice site |
probably benign |
|
|
R1191:Ubr3
|
UTSW |
2 |
69,851,525 (GRCm39) |
nonsense |
probably null |
|
|
R1416:Ubr3
|
UTSW |
2 |
69,775,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Ubr3
|
UTSW |
2 |
69,808,067 (GRCm39) |
nonsense |
probably null |
|
|
R1735:Ubr3
|
UTSW |
2 |
69,839,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Ubr3
|
UTSW |
2 |
69,846,711 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1793:Ubr3
|
UTSW |
2 |
69,830,895 (GRCm39) |
splice site |
probably benign |
|
|
R1932:Ubr3
|
UTSW |
2 |
69,783,820 (GRCm39) |
splice site |
probably null |
|
|
R2042:Ubr3
|
UTSW |
2 |
69,808,118 (GRCm39) |
nonsense |
probably null |
|
|
R2085:Ubr3
|
UTSW |
2 |
69,784,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2090:Ubr3
|
UTSW |
2 |
69,766,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Ubr3
|
UTSW |
2 |
69,808,136 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2173:Ubr3
|
UTSW |
2 |
69,727,743 (GRCm39) |
missense |
probably benign |
|
|
R2215:Ubr3
|
UTSW |
2 |
69,809,661 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2273:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2274:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2275:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2292:Ubr3
|
UTSW |
2 |
69,727,604 (GRCm39) |
unclassified |
probably benign |
|
|
R2447:Ubr3
|
UTSW |
2 |
69,833,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2517:Ubr3
|
UTSW |
2 |
69,766,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2901:Ubr3
|
UTSW |
2 |
69,846,536 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3109:Ubr3
|
UTSW |
2 |
69,819,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3737:Ubr3
|
UTSW |
2 |
69,801,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3793:Ubr3
|
UTSW |
2 |
69,747,525 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3821:Ubr3
|
UTSW |
2 |
69,824,157 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3918:Ubr3
|
UTSW |
2 |
69,846,474 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4157:Ubr3
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R4235:Ubr3
|
UTSW |
2 |
69,846,729 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Ubr3
|
UTSW |
2 |
69,768,731 (GRCm39) |
nonsense |
probably null |
|
|
R4544:Ubr3
|
UTSW |
2 |
69,786,437 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4678:Ubr3
|
UTSW |
2 |
69,766,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Ubr3
|
UTSW |
2 |
69,768,714 (GRCm39) |
intron |
probably benign |
|
|
R4785:Ubr3
|
UTSW |
2 |
69,789,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4872:Ubr3
|
UTSW |
2 |
69,800,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Ubr3
|
UTSW |
2 |
69,843,475 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4920:Ubr3
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4989:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5104:Ubr3
|
UTSW |
2 |
69,768,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5134:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5137:Ubr3
|
UTSW |
2 |
69,803,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Ubr3
|
UTSW |
2 |
69,839,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Ubr3
|
UTSW |
2 |
69,786,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5437:Ubr3
|
UTSW |
2 |
69,774,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5539:Ubr3
|
UTSW |
2 |
69,850,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5781:Ubr3
|
UTSW |
2 |
69,846,588 (GRCm39) |
splice site |
probably null |
|
|
R5809:Ubr3
|
UTSW |
2 |
69,795,855 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5913:Ubr3
|
UTSW |
2 |
69,851,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5969:Ubr3
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
R6136:Ubr3
|
UTSW |
2 |
69,824,107 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6140:Ubr3
|
UTSW |
2 |
69,803,673 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6185:Ubr3
|
UTSW |
2 |
69,768,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6220:Ubr3
|
UTSW |
2 |
69,850,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Ubr3
|
UTSW |
2 |
69,813,208 (GRCm39) |
splice site |
probably null |
|
|
R6319:Ubr3
|
UTSW |
2 |
69,803,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6322:Ubr3
|
UTSW |
2 |
69,786,429 (GRCm39) |
nonsense |
probably null |
|
|
R6470:Ubr3
|
UTSW |
2 |
69,795,804 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6477:Ubr3
|
UTSW |
2 |
69,809,773 (GRCm39) |
nonsense |
probably null |
|
|
R6702:Ubr3
|
UTSW |
2 |
69,786,393 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6709:Ubr3
|
UTSW |
2 |
69,843,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6803:Ubr3
|
UTSW |
2 |
69,766,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6806:Ubr3
|
UTSW |
2 |
69,786,308 (GRCm39) |
splice site |
probably benign |
|
|
R6834:Ubr3
|
UTSW |
2 |
69,830,825 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6841:Ubr3
|
UTSW |
2 |
69,850,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6847:Ubr3
|
UTSW |
2 |
69,813,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6889:Ubr3
|
UTSW |
2 |
69,774,644 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7065:Ubr3
|
UTSW |
2 |
69,784,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Ubr3
|
UTSW |
2 |
69,728,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Ubr3
|
UTSW |
2 |
69,851,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Ubr3
|
UTSW |
2 |
69,846,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7273:Ubr3
|
UTSW |
2 |
69,809,677 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7314:Ubr3
|
UTSW |
2 |
69,821,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Ubr3
|
UTSW |
2 |
69,783,886 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7584:Ubr3
|
UTSW |
2 |
69,821,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7588:Ubr3
|
UTSW |
2 |
69,801,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7597:Ubr3
|
UTSW |
2 |
69,803,812 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7697:Ubr3
|
UTSW |
2 |
69,728,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7737:Ubr3
|
UTSW |
2 |
69,821,910 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7743:Ubr3
|
UTSW |
2 |
69,774,793 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7946:Ubr3
|
UTSW |
2 |
69,781,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7991:Ubr3
|
UTSW |
2 |
69,783,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Ubr3
|
UTSW |
2 |
69,819,220 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Ubr3
|
UTSW |
2 |
69,851,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Ubr3
|
UTSW |
2 |
69,784,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R8313:Ubr3
|
UTSW |
2 |
69,775,478 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8675:Ubr3
|
UTSW |
2 |
69,850,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8834:Ubr3
|
UTSW |
2 |
69,833,785 (GRCm39) |
missense |
probably benign |
|
|
R8975:Ubr3
|
UTSW |
2 |
69,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Ubr3
|
UTSW |
2 |
69,839,489 (GRCm39) |
nonsense |
probably null |
|
|
R9153:Ubr3
|
UTSW |
2 |
69,795,822 (GRCm39) |
missense |
|
|
|
R9234:Ubr3
|
UTSW |
2 |
69,727,990 (GRCm39) |
missense |
probably benign |
|
|
R9293:Ubr3
|
UTSW |
2 |
69,727,769 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9312:Ubr3
|
UTSW |
2 |
69,784,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9710:Ubr3
|
UTSW |
2 |
69,727,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9762:Ubr3
|
UTSW |
2 |
69,839,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Ubr3
|
UTSW |
2 |
69,752,711 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,803,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,728,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,727,805 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACACAAACAGGCTTATGATGTAG -3'
(R):5'- CGGGTATTTGTGAAGGACTAAACTAGG -3'
Sequencing Primer
(F):5'- CAGGTTGCTTTTACAAAAACA -3'
(R):5'- ACAAGTGTGTTTAAAACTTGTTGCAC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation