Incidental Mutation 'R2853:Scgb1b20'
ID 252391
Institutional Source Beutler Lab
Gene Symbol Scgb1b20
Ensembl Gene ENSMUSG00000094978
Gene Name secretoglobin, family 1B, member 20
Synonyms Gm7147, Gm5895, Abpa20
MMRRC Submission 040446-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2853 (G1)
Quality Score 156
Status Not validated
Chromosome 7
Chromosomal Location 33072659-33073984 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 33072949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 52 (K52N)
Ref Sequence ENSEMBL: ENSMUSP00000129326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166714]
AlphaFold E9PWZ2
Predicted Effect possibly damaging
Transcript: ENSMUST00000166714
AA Change: K52N

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000129326
Gene: ENSMUSG00000094978
AA Change: K52N

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
UTG 24 93 5.06e-21 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat A C 16: 8,418,832 (GRCm39) K142T probably damaging Het
Als2cl T C 9: 110,723,203 (GRCm39) S636P probably damaging Het
Angptl7 T C 4: 148,584,736 (GRCm39) E4G probably benign Het
Aph1c T C 9: 66,741,764 (GRCm39) probably null Het
Arhgap23 T C 11: 97,383,420 (GRCm39) probably null Het
Arhgef4 A C 1: 34,763,129 (GRCm39) D795A unknown Het
Atosb A G 4: 43,036,293 (GRCm39) L146P probably benign Het
Ccdc85a A G 11: 28,342,942 (GRCm39) probably benign Het
Chchd1 T C 14: 20,754,288 (GRCm39) S67P probably benign Het
Cubn C T 2: 13,435,645 (GRCm39) V1104I probably benign Het
Dennd5a A T 7: 109,532,878 (GRCm39) N297K probably damaging Het
Dnai4 T C 4: 102,907,355 (GRCm39) I644V possibly damaging Het
Egflam A T 15: 7,249,182 (GRCm39) W879R probably damaging Het
Far1 T C 7: 113,152,944 (GRCm39) Y351H possibly damaging Het
Gpr62 T C 9: 106,341,911 (GRCm39) E339G probably benign Het
Hspd1 A T 1: 55,120,256 (GRCm39) D315E probably damaging Het
Ids G T X: 69,396,776 (GRCm39) T329K probably damaging Het
Itga9 G A 9: 118,465,604 (GRCm39) E153K probably damaging Het
Krt82 T C 15: 101,456,870 (GRCm39) Y170C probably damaging Het
Megf10 T C 18: 57,427,003 (GRCm39) I1107T probably damaging Het
Mre11a A G 9: 14,737,843 (GRCm39) E599G probably benign Het
Mtm1 T G X: 70,345,389 (GRCm39) I437S probably damaging Het
Ncoa2 C T 1: 13,257,113 (GRCm39) V129I probably damaging Het
Ncs1 T C 2: 31,177,329 (GRCm39) F169L probably damaging Het
Ndst2 T C 14: 20,779,964 (GRCm39) E92G probably damaging Het
Parm1 T C 5: 91,742,124 (GRCm39) V164A probably benign Het
Pkhd1 T C 1: 20,128,526 (GRCm39) Q4059R probably benign Het
Setbp1 T A 18: 78,967,211 (GRCm39) Q171L probably benign Het
Sik2 A T 9: 50,809,597 (GRCm39) L612Q probably damaging Het
Srprb G A 9: 103,076,038 (GRCm39) Q800* probably null Het
Ss18l1 A G 2: 179,699,914 (GRCm39) Y258C probably damaging Het
Togaram1 A G 12: 65,063,386 (GRCm39) K1567R probably benign Het
Ttc6 T C 12: 57,622,967 (GRCm39) F122S probably damaging Het
Vmn2r85 T A 10: 130,255,035 (GRCm39) M550L probably benign Het
Other mutations in Scgb1b20
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0189:Scgb1b20 UTSW 7 33,072,935 (GRCm39) missense probably benign 0.08
R0513:Scgb1b20 UTSW 7 33,072,739 (GRCm39) critical splice donor site probably null
R5047:Scgb1b20 UTSW 7 33,072,737 (GRCm39) splice site probably null
R5402:Scgb1b20 UTSW 7 33,072,656 (GRCm39) splice site probably null
R7710:Scgb1b20 UTSW 7 33,072,867 (GRCm39) missense probably damaging 0.99
R9277:Scgb1b20 UTSW 7 33,072,998 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAAGCTATCCAGGCTCTCAC -3'
(R):5'- AGTCTGAGAGTTCCTTCCTGC -3'

Sequencing Primer
(F):5'- CACCCTCTAACCCCTGGG -3'
(R):5'- ACATCCTCAATCCGGTGTG -3'
Posted On 2014-12-04