Incidental Mutation 'R2857:Trmt11'
ID252493
Institutional Source Beutler Lab
Gene Symbol Trmt11
Ensembl Gene ENSMUSG00000019792
Gene NametRNA methyltransferase 11
Synonyms3110045I18Rik, 2410075D05Rik
MMRRC Submission 040447-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.298) question?
Stock #R2857 (G1)
Quality Score154
Status Not validated
Chromosome10
Chromosomal Location30534225-30600749 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to C at 30547748 bp
ZygosityHeterozygous
Amino Acid Change Proline to Arginine at position 387 (P387R)
Ref Sequence ENSEMBL: ENSMUSP00000019927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019927] [ENSMUST00000215595]
Predicted Effect probably damaging
Transcript: ENSMUST00000019927
AA Change: P387R

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000019927
Gene: ENSMUSG00000019792
AA Change: P387R

DomainStartEndE-ValueType
Pfam:UPF0020 189 324 1.9e-14 PFAM
Pfam:Methyltransf_26 216 373 1.2e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215595
Meta Mutation Damage Score 0.338 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330087D11Rik A T 7: 29,573,878 noncoding transcript Het
Amfr A T 8: 94,005,214 N11K probably damaging Het
Bpifa6 G A 2: 153,989,274 M253I probably benign Het
C330018D20Rik A G 18: 56,962,459 L18P probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,712,500 probably benign Het
Cdh23 C T 10: 60,382,653 probably null Het
Ceacam1 T A 7: 25,474,017 I249F probably damaging Het
Cfap54 C T 10: 93,045,282 R348Q probably damaging Het
Crygs C T 16: 22,805,551 G102D possibly damaging Het
Cuzd1 C T 7: 131,316,134 V246M probably damaging Het
Ehd2 A T 7: 15,964,129 V61E probably damaging Het
Erich5 C T 15: 34,471,414 T263I probably damaging Het
Fam71b T C 11: 46,405,212 I137T probably damaging Het
Fbxo36 A G 1: 84,896,595 K104R probably benign Het
Fibin C T 2: 110,362,197 R200H probably damaging Het
Gad2 A C 2: 22,673,975 M397L probably benign Het
Gm5724 A G 6: 141,744,538 V163A probably benign Het
Iqgap3 C A 3: 88,107,596 S873* probably null Het
Kcnh8 A G 17: 52,977,933 D977G probably benign Het
Maats1 A C 16: 38,302,713 L651R probably damaging Het
Mau2 T C 8: 70,019,824 M570V probably benign Het
Mrgprb4 T A 7: 48,198,336 R281S possibly damaging Het
Mthfd1 T C 12: 76,288,925 Y258H probably damaging Het
Nexn C T 3: 152,248,043 E247K probably damaging Het
Olfr139 C T 11: 74,044,827 G149D possibly damaging Het
Olfr311 T A 11: 58,841,882 V256E probably benign Het
Olfr743 T A 14: 50,533,440 N9K probably benign Het
Phrf1 T A 7: 141,259,680 probably benign Het
Prc1 A G 7: 80,312,221 N52S probably damaging Het
Psd G C 19: 46,324,420 S170R probably benign Het
Riok1 T C 13: 38,049,077 F229L probably damaging Het
Stat2 A G 10: 128,276,901 probably null Het
Sycp3 A G 10: 88,467,372 E166G probably damaging Het
Szt2 G A 4: 118,369,402 T510I probably damaging Het
Trank1 A T 9: 111,366,933 T1342S probably benign Het
Trav3-1 C A 14: 52,581,058 A63E probably benign Het
Trim34b A T 7: 104,336,232 N358I probably benign Het
Vmn2r82 T A 10: 79,381,256 I474N probably damaging Het
Vrk2 C A 11: 26,483,324 S286I possibly damaging Het
Wdfy3 A T 5: 101,875,930 I2451N probably benign Het
Zfp326 G A 5: 105,888,529 R102H probably benign Het
Other mutations in Trmt11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Trmt11 APN 10 30566449 missense probably damaging 1.00
IGL01586:Trmt11 APN 10 30597751 missense probably benign 0.01
IGL02307:Trmt11 APN 10 30594154 missense possibly damaging 0.92
IGL02319:Trmt11 APN 10 30560873 missense probably damaging 1.00
IGL02622:Trmt11 APN 10 30559173 missense probably benign 0.00
R0047:Trmt11 UTSW 10 30535243 missense probably benign
R0047:Trmt11 UTSW 10 30535243 missense probably benign
R0269:Trmt11 UTSW 10 30587489 missense probably benign 0.01
R1240:Trmt11 UTSW 10 30590825 intron probably benign
R1694:Trmt11 UTSW 10 30535225 missense probably benign 0.02
R1765:Trmt11 UTSW 10 30559188 missense probably benign
R2293:Trmt11 UTSW 10 30547748 missense probably damaging 0.98
R2295:Trmt11 UTSW 10 30547748 missense probably damaging 0.98
R4631:Trmt11 UTSW 10 30559204 missense probably benign 0.00
R5684:Trmt11 UTSW 10 30547710 missense probably damaging 1.00
R5952:Trmt11 UTSW 10 30560842 missense probably benign 0.01
R6022:Trmt11 UTSW 10 30587501 missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- CCGAGTGCACCAAGTTCAAC -3'
(R):5'- AAGGGGTAAAATACTGAGCTACATC -3'

Sequencing Primer
(F):5'- GAGTGCACCAAGTTCAACATCTG -3'
(R):5'- ATACTGAGCTACATCTTTTGGTGC -3'
Posted On2014-12-04