Incidental Mutation 'R2857:Trmt11'
ID 252493
Institutional Source Beutler Lab
Gene Symbol Trmt11
Ensembl Gene ENSMUSG00000019792
Gene Name tRNA methyltransferase 11
Synonyms 2410075D05Rik, 3110045I18Rik
MMRRC Submission 040447-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.852) question?
Stock # R2857 (G1)
Quality Score 154
Status Not validated
Chromosome 10
Chromosomal Location 30410221-30476745 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 30423744 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Arginine at position 387 (P387R)
Ref Sequence ENSEMBL: ENSMUSP00000019927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019927] [ENSMUST00000215595]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000019927
AA Change: P387R

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000019927
Gene: ENSMUSG00000019792
AA Change: P387R

DomainStartEndE-ValueType
Pfam:UPF0020 189 324 1.9e-14 PFAM
Pfam:Methyltransf_26 216 373 1.2e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215595
Meta Mutation Damage Score 0.3309 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330087D11Rik A T 7: 29,273,303 (GRCm39) noncoding transcript Het
Amfr A T 8: 94,731,842 (GRCm39) N11K probably damaging Het
Bpifa6 G A 2: 153,831,194 (GRCm39) M253I probably benign Het
C330018D20Rik A G 18: 57,095,531 (GRCm39) L18P probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdh23 C T 10: 60,218,432 (GRCm39) probably null Het
Ceacam1 T A 7: 25,173,442 (GRCm39) I249F probably damaging Het
Cfap54 C T 10: 92,881,144 (GRCm39) R348Q probably damaging Het
Cfap91 A C 16: 38,123,075 (GRCm39) L651R probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Cuzd1 C T 7: 130,917,863 (GRCm39) V246M probably damaging Het
Ehd2 A T 7: 15,698,054 (GRCm39) V61E probably damaging Het
Erich5 C T 15: 34,471,560 (GRCm39) T263I probably damaging Het
Fbxo36 A G 1: 84,874,316 (GRCm39) K104R probably benign Het
Fibin C T 2: 110,192,542 (GRCm39) R200H probably damaging Het
Gad2 A C 2: 22,563,987 (GRCm39) M397L probably benign Het
Garin3 T C 11: 46,296,039 (GRCm39) I137T probably damaging Het
Iqgap3 C A 3: 88,014,903 (GRCm39) S873* probably null Het
Kcnh8 A G 17: 53,284,961 (GRCm39) D977G probably benign Het
Mau2 T C 8: 70,472,474 (GRCm39) M570V probably benign Het
Mrgprb4 T A 7: 47,848,084 (GRCm39) R281S possibly damaging Het
Mthfd1 T C 12: 76,335,699 (GRCm39) Y258H probably damaging Het
Nexn C T 3: 151,953,680 (GRCm39) E247K probably damaging Het
Or11g27 T A 14: 50,770,897 (GRCm39) N9K probably benign Het
Or3a10 C T 11: 73,935,653 (GRCm39) G149D possibly damaging Het
Or9e1 T A 11: 58,732,708 (GRCm39) V256E probably benign Het
Phrf1 T A 7: 140,839,593 (GRCm39) probably benign Het
Prc1 A G 7: 79,961,969 (GRCm39) N52S probably damaging Het
Psd G C 19: 46,312,859 (GRCm39) S170R probably benign Het
Riok1 T C 13: 38,233,053 (GRCm39) F229L probably damaging Het
Slco1a7 A G 6: 141,690,264 (GRCm39) V163A probably benign Het
Stat2 A G 10: 128,112,770 (GRCm39) probably null Het
Sycp3 A G 10: 88,303,234 (GRCm39) E166G probably damaging Het
Szt2 G A 4: 118,226,599 (GRCm39) T510I probably damaging Het
Trank1 A T 9: 111,196,001 (GRCm39) T1342S probably benign Het
Trav3-1 C A 14: 52,818,515 (GRCm39) A63E probably benign Het
Trim34b A T 7: 103,985,439 (GRCm39) N358I probably benign Het
Vmn2r82 T A 10: 79,217,090 (GRCm39) I474N probably damaging Het
Vrk2 C A 11: 26,433,324 (GRCm39) S286I possibly damaging Het
Wdfy3 A T 5: 102,023,796 (GRCm39) I2451N probably benign Het
Zfp326 G A 5: 106,036,395 (GRCm39) R102H probably benign Het
Other mutations in Trmt11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Trmt11 APN 10 30,442,445 (GRCm39) missense probably damaging 1.00
IGL01586:Trmt11 APN 10 30,473,747 (GRCm39) missense probably benign 0.01
IGL02307:Trmt11 APN 10 30,470,150 (GRCm39) missense possibly damaging 0.92
IGL02319:Trmt11 APN 10 30,436,869 (GRCm39) missense probably damaging 1.00
IGL02622:Trmt11 APN 10 30,435,169 (GRCm39) missense probably benign 0.00
R0047:Trmt11 UTSW 10 30,411,239 (GRCm39) missense probably benign
R0047:Trmt11 UTSW 10 30,411,239 (GRCm39) missense probably benign
R0269:Trmt11 UTSW 10 30,463,485 (GRCm39) missense probably benign 0.01
R1240:Trmt11 UTSW 10 30,466,821 (GRCm39) intron probably benign
R1694:Trmt11 UTSW 10 30,411,221 (GRCm39) missense probably benign 0.02
R1765:Trmt11 UTSW 10 30,435,184 (GRCm39) missense probably benign
R2293:Trmt11 UTSW 10 30,423,744 (GRCm39) missense probably damaging 0.98
R2295:Trmt11 UTSW 10 30,423,744 (GRCm39) missense probably damaging 0.98
R4631:Trmt11 UTSW 10 30,435,200 (GRCm39) missense probably benign 0.00
R5684:Trmt11 UTSW 10 30,423,706 (GRCm39) missense probably damaging 1.00
R5952:Trmt11 UTSW 10 30,436,838 (GRCm39) missense probably benign 0.01
R6022:Trmt11 UTSW 10 30,463,497 (GRCm39) missense possibly damaging 0.76
R7044:Trmt11 UTSW 10 30,466,930 (GRCm39) missense probably benign 0.27
R7459:Trmt11 UTSW 10 30,466,039 (GRCm39) missense probably benign 0.02
R7538:Trmt11 UTSW 10 30,436,870 (GRCm39) missense probably damaging 1.00
R7672:Trmt11 UTSW 10 30,463,520 (GRCm39) missense probably damaging 1.00
R7728:Trmt11 UTSW 10 30,463,497 (GRCm39) missense possibly damaging 0.76
R8116:Trmt11 UTSW 10 30,442,490 (GRCm39) missense possibly damaging 0.88
R8988:Trmt11 UTSW 10 30,467,027 (GRCm39) missense probably benign
R9225:Trmt11 UTSW 10 30,423,753 (GRCm39) missense probably damaging 1.00
R9507:Trmt11 UTSW 10 30,434,938 (GRCm39) nonsense probably null
R9555:Trmt11 UTSW 10 30,470,150 (GRCm39) missense possibly damaging 0.92
R9690:Trmt11 UTSW 10 30,436,938 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CCGAGTGCACCAAGTTCAAC -3'
(R):5'- AAGGGGTAAAATACTGAGCTACATC -3'

Sequencing Primer
(F):5'- GAGTGCACCAAGTTCAACATCTG -3'
(R):5'- ATACTGAGCTACATCTTTTGGTGC -3'
Posted On 2014-12-04