Incidental Mutation 'R0310:Abcc1'
| ID |
25257 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcc1
|
| Ensembl Gene |
ENSMUSG00000023088 |
| Gene Name |
ATP-binding cassette, sub-family C member 1 |
| Synonyms |
Mdrap, Mrp1, MRP, Abcc1b, Abcc1a |
| MMRRC Submission |
038520-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.164)
|
| Stock # |
R0310 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
14179317-14292743 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 14228791 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 346
(I346N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115627
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100167]
[ENSMUST00000130671]
[ENSMUST00000133454]
[ENSMUST00000147759]
|
| AlphaFold |
O35379 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000100167
AA Change: I346N
PolyPhen 2
Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000097743
Gene: ENSMUSG00000023088
AA Change: I346N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
7.8e-44 |
PFAM |
|
AAA
|
670 |
845 |
4.07e-8 |
SMART |
|
Pfam:ABC_membrane
|
971 |
1243 |
3e-52 |
PFAM |
|
AAA
|
1316 |
1501 |
5.8e-13 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000130671
AA Change: I346N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000116714
Gene: ENSMUSG00000023088
AA Change: I346N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000133454
AA Change: I346N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000122656
Gene: ENSMUSG00000023088
AA Change: I346N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000147759
AA Change: I346N
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000115627
Gene: ENSMUSG00000023088
AA Change: I346N
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156089
|
| Meta Mutation Damage Score |
0.8255 |
| Coding Region Coverage |
- 1x: 98.6%
- 3x: 97.3%
- 10x: 93.3%
- 20x: 82.5%
|
| Validation Efficiency |
99% (113/114) |
| MGI Phenotype |
FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930550C14Rik |
A |
C |
9: 53,336,971 (GRCm39) |
T92P |
probably damaging |
Het |
| Abca13 |
T |
C |
11: 9,243,810 (GRCm39) |
V1891A |
probably benign |
Het |
| Afdn |
G |
T |
17: 14,105,770 (GRCm39) |
|
probably null |
Het |
| Ahrr |
G |
A |
13: 74,431,143 (GRCm39) |
|
probably benign |
Het |
| Akap13 |
A |
G |
7: 75,264,678 (GRCm39) |
D507G |
probably damaging |
Het |
| Akap8 |
A |
T |
17: 32,535,234 (GRCm39) |
M260K |
possibly damaging |
Het |
| Akr1b8 |
T |
C |
6: 34,342,194 (GRCm39) |
V265A |
probably benign |
Het |
| Alpk3 |
C |
G |
7: 80,728,358 (GRCm39) |
P496R |
possibly damaging |
Het |
| Ankrd13b |
A |
G |
11: 77,363,571 (GRCm39) |
V249A |
possibly damaging |
Het |
| Arid4a |
T |
C |
12: 71,122,604 (GRCm39) |
V995A |
probably benign |
Het |
| Ascc3 |
G |
T |
10: 50,625,022 (GRCm39) |
V1637L |
probably benign |
Het |
| Atad2 |
G |
A |
15: 57,977,653 (GRCm39) |
A499V |
probably damaging |
Het |
| Barhl2 |
G |
T |
5: 106,605,253 (GRCm39) |
A152E |
possibly damaging |
Het |
| Bbs12 |
T |
A |
3: 37,375,194 (GRCm39) |
D547E |
probably damaging |
Het |
| Btaf1 |
A |
G |
19: 36,981,934 (GRCm39) |
M1655V |
probably damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,225,408 (GRCm39) |
H40Q |
probably damaging |
Het |
| Ccr9 |
A |
T |
9: 123,603,617 (GRCm39) |
|
probably benign |
Het |
| Cdh15 |
A |
G |
8: 123,592,175 (GRCm39) |
D654G |
probably damaging |
Het |
| Cebpz |
T |
C |
17: 79,233,553 (GRCm39) |
D758G |
probably damaging |
Het |
| Cgn |
C |
T |
3: 94,672,960 (GRCm39) |
R906K |
possibly damaging |
Het |
| Chil3 |
T |
A |
3: 106,067,839 (GRCm39) |
M109L |
possibly damaging |
Het |
| Cntnap4 |
A |
T |
8: 113,569,148 (GRCm39) |
|
probably null |
Het |
| Cyp4f18 |
C |
T |
8: 72,754,856 (GRCm39) |
|
probably benign |
Het |
| Daam2 |
A |
G |
17: 49,770,952 (GRCm39) |
|
probably null |
Het |
| Ddost |
T |
A |
4: 138,037,922 (GRCm39) |
H220Q |
probably benign |
Het |
| Dennd2a |
C |
T |
6: 39,441,135 (GRCm39) |
|
probably benign |
Het |
| Depdc1b |
G |
A |
13: 108,510,375 (GRCm39) |
V296I |
possibly damaging |
Het |
| Dnaaf4 |
A |
T |
9: 72,879,618 (GRCm39) |
D386V |
probably damaging |
Het |
| Dnah5 |
A |
T |
15: 28,299,256 (GRCm39) |
R1539S |
probably benign |
Het |
| Dusp22 |
T |
C |
13: 30,889,641 (GRCm39) |
I74T |
probably damaging |
Het |
| Epc1 |
A |
G |
18: 6,440,202 (GRCm39) |
|
probably benign |
Het |
| Epha7 |
A |
G |
4: 28,961,301 (GRCm39) |
I845V |
probably benign |
Het |
| Fanci |
C |
T |
7: 79,057,165 (GRCm39) |
|
probably benign |
Het |
| Fbn1 |
T |
A |
2: 125,205,564 (GRCm39) |
E1104V |
probably damaging |
Het |
| Fbxo8 |
T |
A |
8: 57,043,132 (GRCm39) |
F205L |
probably damaging |
Het |
| Fcgbpl1 |
G |
T |
7: 27,841,699 (GRCm39) |
V545L |
probably benign |
Het |
| Fetub |
T |
C |
16: 22,748,506 (GRCm39) |
|
probably benign |
Het |
| Frs3 |
T |
C |
17: 48,014,747 (GRCm39) |
V480A |
probably benign |
Het |
| Gne |
C |
A |
4: 44,060,157 (GRCm39) |
E79* |
probably null |
Het |
| Hrc |
T |
A |
7: 44,985,921 (GRCm39) |
H357Q |
probably benign |
Het |
| Idh1 |
T |
C |
1: 65,201,079 (GRCm39) |
M291V |
probably damaging |
Het |
| Il22b |
T |
A |
10: 118,129,090 (GRCm39) |
H133L |
probably benign |
Het |
| Ino80b |
T |
C |
6: 83,101,072 (GRCm39) |
E165G |
probably damaging |
Het |
| Inppl1 |
A |
T |
7: 101,477,706 (GRCm39) |
|
probably benign |
Het |
| Ints15 |
G |
T |
5: 143,293,643 (GRCm39) |
T278K |
probably benign |
Het |
| Ip6k2 |
T |
C |
9: 108,676,432 (GRCm39) |
|
probably benign |
Het |
| Itga11 |
A |
T |
9: 62,667,628 (GRCm39) |
I654F |
probably damaging |
Het |
| Jag2 |
G |
T |
12: 112,876,997 (GRCm39) |
|
probably benign |
Het |
| Katna1 |
G |
T |
10: 7,619,513 (GRCm39) |
|
probably benign |
Het |
| Kcnh4 |
G |
T |
11: 100,636,995 (GRCm39) |
S707Y |
probably benign |
Het |
| Kcnn2 |
T |
G |
18: 45,693,585 (GRCm39) |
L387R |
probably damaging |
Het |
| Khnyn |
A |
G |
14: 56,125,425 (GRCm39) |
T503A |
probably damaging |
Het |
| Lama5 |
G |
T |
2: 179,823,359 (GRCm39) |
|
probably benign |
Het |
| Lmbr1l |
A |
T |
15: 98,806,654 (GRCm39) |
|
probably benign |
Het |
| Mast4 |
A |
T |
13: 102,890,669 (GRCm39) |
S870T |
possibly damaging |
Het |
| Med1 |
A |
G |
11: 98,058,400 (GRCm39) |
Y266H |
probably benign |
Het |
| Med13 |
A |
T |
11: 86,236,829 (GRCm39) |
N109K |
probably benign |
Het |
| Mgam |
T |
C |
6: 40,737,969 (GRCm39) |
|
probably benign |
Het |
| Mmp8 |
A |
G |
9: 7,561,455 (GRCm39) |
Q153R |
probably benign |
Het |
| Mpeg1 |
C |
A |
19: 12,439,055 (GRCm39) |
T171N |
probably benign |
Het |
| Mtus2 |
T |
C |
5: 148,043,829 (GRCm39) |
S806P |
probably benign |
Het |
| Naip2 |
T |
A |
13: 100,285,350 (GRCm39) |
E1226V |
probably damaging |
Het |
| Naip6 |
A |
G |
13: 100,444,721 (GRCm39) |
F246L |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,602,989 (GRCm39) |
I1187V |
possibly damaging |
Het |
| Nbeal1 |
T |
C |
1: 60,344,529 (GRCm39) |
|
probably benign |
Het |
| Nbeal2 |
C |
A |
9: 110,467,231 (GRCm39) |
V653L |
probably damaging |
Het |
| Ndufa9 |
G |
T |
6: 126,804,495 (GRCm39) |
|
probably benign |
Het |
| Nlrp5 |
G |
T |
7: 23,129,582 (GRCm39) |
C883F |
probably damaging |
Het |
| Nr0b2 |
C |
A |
4: 133,283,303 (GRCm39) |
|
probably null |
Het |
| Or1m1 |
T |
A |
9: 18,666,629 (GRCm39) |
M101L |
possibly damaging |
Het |
| Or6c209 |
T |
A |
10: 129,483,600 (GRCm39) |
V201E |
probably damaging |
Het |
| Or6c69c |
G |
A |
10: 129,910,692 (GRCm39) |
V138I |
probably benign |
Het |
| Or8b101 |
T |
A |
9: 38,020,782 (GRCm39) |
S267T |
possibly damaging |
Het |
| Pkhd1 |
A |
T |
1: 20,620,046 (GRCm39) |
|
probably null |
Het |
| Pkhd1l1 |
A |
G |
15: 44,386,134 (GRCm39) |
|
probably benign |
Het |
| Ppm1l |
A |
G |
3: 69,456,794 (GRCm39) |
K237R |
probably benign |
Het |
| Ppp1r18 |
T |
C |
17: 36,184,603 (GRCm39) |
|
probably benign |
Het |
| Ptpn3 |
A |
T |
4: 57,204,958 (GRCm39) |
D734E |
probably benign |
Het |
| Pxdn |
T |
C |
12: 30,065,528 (GRCm39) |
C1283R |
probably damaging |
Het |
| Rbm12 |
A |
G |
2: 155,937,644 (GRCm39) |
|
probably benign |
Het |
| Rttn |
A |
T |
18: 89,027,584 (GRCm39) |
|
probably benign |
Het |
| Sgsm1 |
G |
T |
5: 113,411,571 (GRCm39) |
H431Q |
probably benign |
Het |
| Siah3 |
A |
G |
14: 75,763,367 (GRCm39) |
N206S |
possibly damaging |
Het |
| Slc22a15 |
G |
T |
3: 101,767,827 (GRCm39) |
D521E |
probably benign |
Het |
| Sprr2k |
A |
T |
3: 92,340,770 (GRCm39) |
|
probably benign |
Het |
| Stab2 |
G |
A |
10: 86,803,477 (GRCm39) |
|
probably benign |
Het |
| Sval3 |
T |
A |
6: 41,945,120 (GRCm39) |
L16Q |
probably damaging |
Het |
| Sycp2 |
C |
G |
2: 178,023,648 (GRCm39) |
S456T |
probably benign |
Het |
| Tk1 |
T |
C |
11: 117,707,921 (GRCm39) |
|
probably benign |
Het |
| Tlk2 |
C |
A |
11: 105,145,799 (GRCm39) |
A335E |
probably benign |
Het |
| Tmtc1 |
T |
C |
6: 148,151,079 (GRCm39) |
K659E |
probably benign |
Het |
| Tnk2 |
C |
T |
16: 32,499,408 (GRCm39) |
P907L |
probably benign |
Het |
| Trim14 |
C |
A |
4: 46,522,043 (GRCm39) |
K211N |
probably damaging |
Het |
| Trim15 |
A |
C |
17: 37,177,878 (GRCm39) |
L39R |
probably damaging |
Het |
| Tspan15 |
T |
A |
10: 62,023,872 (GRCm39) |
T269S |
probably benign |
Het |
| Ttc7 |
T |
A |
17: 87,669,292 (GRCm39) |
D646E |
probably benign |
Het |
| Ttll6 |
A |
T |
11: 96,038,382 (GRCm39) |
Q410L |
probably benign |
Het |
| Unc79 |
A |
G |
12: 103,027,666 (GRCm39) |
Q419R |
probably damaging |
Het |
| Vcam1 |
A |
T |
3: 115,908,065 (GRCm39) |
Y666N |
possibly damaging |
Het |
| Vmn1r10 |
A |
T |
6: 57,090,486 (GRCm39) |
Y26F |
probably damaging |
Het |
| Vmn1r80 |
A |
G |
7: 11,927,775 (GRCm39) |
N295S |
probably benign |
Het |
| Vmn2r114 |
A |
T |
17: 23,509,917 (GRCm39) |
H854Q |
probably benign |
Het |
| Vmn2r2 |
A |
T |
3: 64,042,039 (GRCm39) |
D225E |
probably damaging |
Het |
| Vmn2r4 |
A |
T |
3: 64,296,855 (GRCm39) |
Y643* |
probably null |
Het |
| Vmn2r52 |
T |
A |
7: 9,893,393 (GRCm39) |
Y582F |
probably damaging |
Het |
| Vmn2r60 |
G |
T |
7: 41,844,564 (GRCm39) |
L642F |
possibly damaging |
Het |
| Zbtb20 |
T |
C |
16: 43,430,109 (GRCm39) |
S207P |
probably damaging |
Het |
| Zic2 |
CCCACCACCACCATCACCACCACCACC |
CCCACCATCACCACCACCACC |
14: 122,713,776 (GRCm39) |
|
probably benign |
Het |
| Zkscan7 |
G |
T |
9: 122,717,958 (GRCm39) |
E118* |
probably null |
Het |
|
| Other mutations in Abcc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Abcc1
|
APN |
16 |
14,278,847 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL00094:Abcc1
|
APN |
16 |
14,288,398 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL00475:Abcc1
|
APN |
16 |
14,254,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00516:Abcc1
|
APN |
16 |
14,231,176 (GRCm39) |
nonsense |
probably null |
|
|
IGL00765:Abcc1
|
APN |
16 |
14,229,372 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00792:Abcc1
|
APN |
16 |
14,228,790 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01678:Abcc1
|
APN |
16 |
14,222,883 (GRCm39) |
missense |
probably null |
0.96 |
|
IGL01683:Abcc1
|
APN |
16 |
14,214,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01955:Abcc1
|
APN |
16 |
14,228,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02048:Abcc1
|
APN |
16 |
14,229,383 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02345:Abcc1
|
APN |
16 |
14,214,215 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02366:Abcc1
|
APN |
16 |
14,285,843 (GRCm39) |
splice site |
probably benign |
|
|
IGL02431:Abcc1
|
APN |
16 |
14,237,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02480:Abcc1
|
APN |
16 |
14,221,869 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02651:Abcc1
|
APN |
16 |
14,283,990 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02902:Abcc1
|
APN |
16 |
14,240,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03101:Abcc1
|
APN |
16 |
14,207,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03230:Abcc1
|
APN |
16 |
14,275,811 (GRCm39) |
missense |
probably benign |
|
|
IGL03308:Abcc1
|
APN |
16 |
14,288,475 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
gloom
|
UTSW |
16 |
14,229,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
loom
|
UTSW |
16 |
14,290,794 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4544001:Abcc1
|
UTSW |
16 |
14,222,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Abcc1
|
UTSW |
16 |
14,207,744 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0894:Abcc1
|
UTSW |
16 |
14,283,001 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0928:Abcc1
|
UTSW |
16 |
14,207,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1367:Abcc1
|
UTSW |
16 |
14,261,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1496:Abcc1
|
UTSW |
16 |
14,266,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1643:Abcc1
|
UTSW |
16 |
14,231,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1795:Abcc1
|
UTSW |
16 |
14,283,001 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1834:Abcc1
|
UTSW |
16 |
14,240,981 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1847:Abcc1
|
UTSW |
16 |
14,263,313 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1959:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1961:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Abcc1
|
UTSW |
16 |
14,279,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Abcc1
|
UTSW |
16 |
14,289,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Abcc1
|
UTSW |
16 |
14,285,787 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2513:Abcc1
|
UTSW |
16 |
14,290,873 (GRCm39) |
splice site |
probably null |
|
|
R2876:Abcc1
|
UTSW |
16 |
14,275,824 (GRCm39) |
missense |
probably benign |
|
|
R3003:Abcc1
|
UTSW |
16 |
14,254,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3941:Abcc1
|
UTSW |
16 |
14,214,263 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4119:Abcc1
|
UTSW |
16 |
14,211,877 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4191:Abcc1
|
UTSW |
16 |
14,207,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4369:Abcc1
|
UTSW |
16 |
14,278,857 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4428:Abcc1
|
UTSW |
16 |
14,263,164 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4589:Abcc1
|
UTSW |
16 |
14,211,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4779:Abcc1
|
UTSW |
16 |
14,228,635 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5027:Abcc1
|
UTSW |
16 |
14,221,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5275:Abcc1
|
UTSW |
16 |
14,284,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5418:Abcc1
|
UTSW |
16 |
14,278,996 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5490:Abcc1
|
UTSW |
16 |
14,228,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Abcc1
|
UTSW |
16 |
14,278,842 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5641:Abcc1
|
UTSW |
16 |
14,289,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5642:Abcc1
|
UTSW |
16 |
14,261,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5875:Abcc1
|
UTSW |
16 |
14,284,901 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5916:Abcc1
|
UTSW |
16 |
14,283,006 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Abcc1
|
UTSW |
16 |
14,278,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6331:Abcc1
|
UTSW |
16 |
14,282,920 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6464:Abcc1
|
UTSW |
16 |
14,265,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6950:Abcc1
|
UTSW |
16 |
14,229,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Abcc1
|
UTSW |
16 |
14,231,247 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7115:Abcc1
|
UTSW |
16 |
14,255,589 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7187:Abcc1
|
UTSW |
16 |
14,284,861 (GRCm39) |
missense |
probably benign |
|
|
R7298:Abcc1
|
UTSW |
16 |
14,214,336 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7342:Abcc1
|
UTSW |
16 |
14,283,033 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7474:Abcc1
|
UTSW |
16 |
14,290,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7488:Abcc1
|
UTSW |
16 |
14,207,763 (GRCm39) |
nonsense |
probably null |
|
|
R7583:Abcc1
|
UTSW |
16 |
14,221,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7619:Abcc1
|
UTSW |
16 |
14,263,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7971:Abcc1
|
UTSW |
16 |
14,266,443 (GRCm39) |
missense |
probably benign |
|
|
R8048:Abcc1
|
UTSW |
16 |
14,228,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8138:Abcc1
|
UTSW |
16 |
14,290,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8159:Abcc1
|
UTSW |
16 |
14,290,794 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8319:Abcc1
|
UTSW |
16 |
14,214,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Abcc1
|
UTSW |
16 |
14,214,225 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8980:Abcc1
|
UTSW |
16 |
14,278,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9480:Abcc1
|
UTSW |
16 |
14,211,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9519:Abcc1
|
UTSW |
16 |
14,207,681 (GRCm39) |
missense |
probably benign |
|
|
R9653:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9708:Abcc1
|
UTSW |
16 |
14,254,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Abcc1
|
UTSW |
16 |
14,290,797 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9786:Abcc1
|
UTSW |
16 |
14,222,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0026:Abcc1
|
UTSW |
16 |
14,277,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1088:Abcc1
|
UTSW |
16 |
14,228,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Abcc1
|
UTSW |
16 |
14,229,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAAGCCTAAGGGAAGTTCCCAG -3'
(R):5'- CCAGCACGTCACTCAAAGGTAGTC -3'
Sequencing Primer
(F):5'- CAGTTGGATGTGAATGAGGAGG -3'
(R):5'- ctacctgcacccttgctc -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation