Incidental Mutation 'R2859:Or1j12'
ID 252620
Institutional Source Beutler Lab
Gene Symbol Or1j12
Ensembl Gene ENSMUSG00000094266
Gene Name olfactory receptor family 1 subfamily J member 12
Synonyms MOR136-1, GA_x6K02T2NLDC-33147742-33148680, Olfr340
MMRRC Submission 040449-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R2859 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 36342599-36343537 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36343142 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 182 (S182P)
Ref Sequence ENSEMBL: ENSMUSP00000072632 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072854]
AlphaFold Q8VGL0
Predicted Effect probably benign
Transcript: ENSMUST00000072854
AA Change: S182P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000072632
Gene: ENSMUSG00000094266
AA Change: S182P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.2e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.8e-6 PFAM
Pfam:7tm_1 41 290 1.4e-23 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,500,288 (GRCm39) Y1301C possibly damaging Het
Amfr A T 8: 94,731,842 (GRCm39) N11K probably damaging Het
Cadm3 A G 1: 173,174,112 (GRCm39) S34P possibly damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdh23 C T 10: 60,218,432 (GRCm39) probably null Het
Ceacam1 T A 7: 25,173,442 (GRCm39) I249F probably damaging Het
Cuzd1 C T 7: 130,917,863 (GRCm39) V246M probably damaging Het
Ehd2 A T 7: 15,698,054 (GRCm39) V61E probably damaging Het
Fibin C T 2: 110,192,542 (GRCm39) R200H probably damaging Het
Fmo9 A C 1: 166,501,236 (GRCm39) F237C probably damaging Het
Garin3 T C 11: 46,296,039 (GRCm39) I137T probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Iqgap3 C A 3: 88,014,903 (GRCm39) S873* probably null Het
Ism2 T C 12: 87,346,437 (GRCm39) M15V unknown Het
Itk T G 11: 46,235,662 (GRCm39) probably benign Het
Mastl C A 2: 23,029,979 (GRCm39) C249F probably damaging Het
Mink1 T C 11: 70,503,334 (GRCm39) V1143A probably damaging Het
Mrgprb4 T A 7: 47,848,084 (GRCm39) R281S possibly damaging Het
Mthfd1 T C 12: 76,335,699 (GRCm39) Y258H probably damaging Het
Ntmt1 A G 2: 30,712,377 (GRCm39) H140R probably damaging Het
Or3a10 C T 11: 73,935,653 (GRCm39) G149D possibly damaging Het
Or3a1b T C 11: 74,012,808 (GRCm39) I231T probably damaging Het
Or9e1 T A 11: 58,732,708 (GRCm39) V256E probably benign Het
Parm1 A G 5: 91,742,165 (GRCm39) T178A possibly damaging Het
Patl1 T C 19: 11,901,195 (GRCm39) F282L probably damaging Het
Phospho2 T C 2: 69,626,195 (GRCm39) V117A possibly damaging Het
Ppp4r3a T C 12: 101,008,906 (GRCm39) probably null Het
Pramel29 A G 4: 143,936,192 (GRCm39) S23P probably benign Het
Rbm17 A G 2: 11,595,515 (GRCm39) F230S possibly damaging Het
Robo3 C A 9: 37,339,400 (GRCm39) G196* probably null Het
Samhd1 A G 2: 156,948,149 (GRCm39) probably null Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Thbs4 A G 13: 92,927,216 (GRCm39) F91S probably benign Het
Trim34b A T 7: 103,985,439 (GRCm39) N358I probably benign Het
Ulk1 A G 5: 110,942,495 (GRCm39) L255P probably damaging Het
Vmn2r104 T A 17: 20,268,455 (GRCm39) I5F possibly damaging Het
Vrk2 C A 11: 26,433,324 (GRCm39) S286I possibly damaging Het
Zswim3 T C 2: 164,662,309 (GRCm39) L263P probably damaging Het
Other mutations in Or1j12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01467:Or1j12 APN 2 36,342,656 (GRCm39) nonsense probably null
IGL01590:Or1j12 APN 2 36,343,004 (GRCm39) missense probably benign 0.39
IGL01614:Or1j12 APN 2 36,342,636 (GRCm39) missense probably benign 0.32
IGL02470:Or1j12 APN 2 36,342,609 (GRCm39) missense probably benign 0.00
IGL02943:Or1j12 APN 2 36,343,051 (GRCm39) missense probably benign 0.05
R0089:Or1j12 UTSW 2 36,343,107 (GRCm39) missense probably benign 0.00
R0600:Or1j12 UTSW 2 36,342,660 (GRCm39) missense probably benign 0.06
R0881:Or1j12 UTSW 2 36,343,452 (GRCm39) missense probably damaging 1.00
R1945:Or1j12 UTSW 2 36,343,043 (GRCm39) missense probably damaging 1.00
R2184:Or1j12 UTSW 2 36,343,046 (GRCm39) missense probably benign
R2196:Or1j12 UTSW 2 36,342,600 (GRCm39) start codon destroyed probably null 1.00
R2419:Or1j12 UTSW 2 36,343,338 (GRCm39) missense probably damaging 1.00
R2964:Or1j12 UTSW 2 36,342,779 (GRCm39) missense probably damaging 1.00
R4677:Or1j12 UTSW 2 36,343,062 (GRCm39) missense probably benign 0.00
R4867:Or1j12 UTSW 2 36,343,211 (GRCm39) missense probably benign
R5468:Or1j12 UTSW 2 36,343,455 (GRCm39) missense probably damaging 0.99
R5582:Or1j12 UTSW 2 36,343,233 (GRCm39) missense probably benign 0.03
R6335:Or1j12 UTSW 2 36,342,734 (GRCm39) missense probably benign 0.22
R6415:Or1j12 UTSW 2 36,342,617 (GRCm39) missense probably damaging 0.99
R6664:Or1j12 UTSW 2 36,343,110 (GRCm39) missense probably benign 0.00
R6873:Or1j12 UTSW 2 36,343,508 (GRCm39) missense probably benign 0.00
R7097:Or1j12 UTSW 2 36,342,702 (GRCm39) missense probably damaging 1.00
R7122:Or1j12 UTSW 2 36,342,702 (GRCm39) missense probably damaging 1.00
R7199:Or1j12 UTSW 2 36,342,872 (GRCm39) missense probably damaging 1.00
R7275:Or1j12 UTSW 2 36,342,851 (GRCm39) missense probably benign 0.05
R7812:Or1j12 UTSW 2 36,343,290 (GRCm39) missense probably benign 0.00
R8260:Or1j12 UTSW 2 36,342,897 (GRCm39) missense probably damaging 1.00
R9061:Or1j12 UTSW 2 36,342,897 (GRCm39) missense probably damaging 1.00
Z1088:Or1j12 UTSW 2 36,342,918 (GRCm39) missense possibly damaging 0.66
Predicted Primers PCR Primer
(F):5'- GCTGATCTTGAGAGCTTTCTTC -3'
(R):5'- CATGTGGACAAGGCTTTGCAG -3'

Sequencing Primer
(F):5'- CCTATGACAGGTATGTGGCCATC -3'
(R):5'- GACAAGGCTTTGCAGATTCC -3'
Posted On 2014-12-04