Incidental Mutation 'R2859:Zswim3'
ID 252627
Institutional Source Beutler Lab
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Name zinc finger SWIM-type containing 3
Synonyms 4921517A06Rik
MMRRC Submission 040449-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R2859 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 164647034-164664047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 164662309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 263 (L263P)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
AlphaFold Q8CFL8
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000052107
AA Change: L263P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: L263P

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Meta Mutation Damage Score 0.9243 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,500,288 (GRCm39) Y1301C possibly damaging Het
Amfr A T 8: 94,731,842 (GRCm39) N11K probably damaging Het
Cadm3 A G 1: 173,174,112 (GRCm39) S34P possibly damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdh23 C T 10: 60,218,432 (GRCm39) probably null Het
Ceacam1 T A 7: 25,173,442 (GRCm39) I249F probably damaging Het
Cuzd1 C T 7: 130,917,863 (GRCm39) V246M probably damaging Het
Ehd2 A T 7: 15,698,054 (GRCm39) V61E probably damaging Het
Fibin C T 2: 110,192,542 (GRCm39) R200H probably damaging Het
Fmo9 A C 1: 166,501,236 (GRCm39) F237C probably damaging Het
Garin3 T C 11: 46,296,039 (GRCm39) I137T probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Iqgap3 C A 3: 88,014,903 (GRCm39) S873* probably null Het
Ism2 T C 12: 87,346,437 (GRCm39) M15V unknown Het
Itk T G 11: 46,235,662 (GRCm39) probably benign Het
Mastl C A 2: 23,029,979 (GRCm39) C249F probably damaging Het
Mink1 T C 11: 70,503,334 (GRCm39) V1143A probably damaging Het
Mrgprb4 T A 7: 47,848,084 (GRCm39) R281S possibly damaging Het
Mthfd1 T C 12: 76,335,699 (GRCm39) Y258H probably damaging Het
Ntmt1 A G 2: 30,712,377 (GRCm39) H140R probably damaging Het
Or1j12 T C 2: 36,343,142 (GRCm39) S182P probably benign Het
Or3a10 C T 11: 73,935,653 (GRCm39) G149D possibly damaging Het
Or3a1b T C 11: 74,012,808 (GRCm39) I231T probably damaging Het
Or9e1 T A 11: 58,732,708 (GRCm39) V256E probably benign Het
Parm1 A G 5: 91,742,165 (GRCm39) T178A possibly damaging Het
Patl1 T C 19: 11,901,195 (GRCm39) F282L probably damaging Het
Phospho2 T C 2: 69,626,195 (GRCm39) V117A possibly damaging Het
Ppp4r3a T C 12: 101,008,906 (GRCm39) probably null Het
Pramel29 A G 4: 143,936,192 (GRCm39) S23P probably benign Het
Rbm17 A G 2: 11,595,515 (GRCm39) F230S possibly damaging Het
Robo3 C A 9: 37,339,400 (GRCm39) G196* probably null Het
Samhd1 A G 2: 156,948,149 (GRCm39) probably null Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Thbs4 A G 13: 92,927,216 (GRCm39) F91S probably benign Het
Trim34b A T 7: 103,985,439 (GRCm39) N358I probably benign Het
Ulk1 A G 5: 110,942,495 (GRCm39) L255P probably damaging Het
Vmn2r104 T A 17: 20,268,455 (GRCm39) I5F possibly damaging Het
Vrk2 C A 11: 26,433,324 (GRCm39) S286I possibly damaging Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164,663,011 (GRCm39) missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164,662,057 (GRCm39) missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164,661,922 (GRCm39) missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164,663,035 (GRCm39) missense possibly damaging 0.94
IGL02173:Zswim3 APN 2 164,662,759 (GRCm39) missense probably damaging 1.00
IGL02336:Zswim3 APN 2 164,662,297 (GRCm39) missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164,662,602 (GRCm39) splice site probably null
R0321:Zswim3 UTSW 2 164,662,279 (GRCm39) missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164,661,901 (GRCm39) missense probably benign 0.00
R2126:Zswim3 UTSW 2 164,661,913 (GRCm39) missense probably benign 0.31
R2176:Zswim3 UTSW 2 164,662,614 (GRCm39) missense probably benign 0.08
R3853:Zswim3 UTSW 2 164,662,777 (GRCm39) missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4435:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4436:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4438:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4805:Zswim3 UTSW 2 164,662,099 (GRCm39) missense possibly damaging 0.52
R5874:Zswim3 UTSW 2 164,662,032 (GRCm39) missense probably benign 0.06
R6417:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164,662,544 (GRCm39) splice site probably null
R6786:Zswim3 UTSW 2 164,662,771 (GRCm39) missense probably damaging 1.00
R7266:Zswim3 UTSW 2 164,662,402 (GRCm39) missense probably benign 0.41
R7467:Zswim3 UTSW 2 164,661,795 (GRCm39) missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164,662,135 (GRCm39) missense probably damaging 0.99
R7788:Zswim3 UTSW 2 164,661,699 (GRCm39) missense probably damaging 1.00
R8191:Zswim3 UTSW 2 164,662,128 (GRCm39) missense probably damaging 1.00
R8308:Zswim3 UTSW 2 164,663,566 (GRCm39) missense probably damaging 1.00
R8794:Zswim3 UTSW 2 164,662,687 (GRCm39) missense probably damaging 0.98
R9353:Zswim3 UTSW 2 164,662,261 (GRCm39) missense probably damaging 1.00
R9527:Zswim3 UTSW 2 164,662,285 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTAGACCGACTCAGCTTC -3'
(R):5'- GCAGAGCTTCTTTCATGAGCC -3'

Sequencing Primer
(F):5'- TAGACCGACTCAGCTTCCAGAG -3'
(R):5'- AGACGCATTTACTGAACTCTGGTG -3'
Posted On 2014-12-04