Incidental Mutation 'R2861:Or5p66'
ID 252722
Institutional Source Beutler Lab
Gene Symbol Or5p66
Ensembl Gene ENSMUSG00000109884
Gene Name olfactory receptor family 5 subfamily P member 66
Synonyms Olfr490, GA_x6K02T2PBJ9-10617173-10616229, MOR204-17
MMRRC Submission 040451-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R2861 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107885387-107886331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 107886169 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 55 (S55P)
Ref Sequence ENSEMBL: ENSMUSP00000147922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210114] [ENSMUST00000211345]
AlphaFold Q8VFD2
Predicted Effect probably damaging
Transcript: ENSMUST00000074550
AA Change: S55P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074137
Gene: ENSMUSG00000093808
AA Change: S55P

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4e-53 PFAM
Pfam:7tm_1 44 293 5e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000210114
AA Change: S55P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000211345
AA Change: S55P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.7344 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,259,057 (GRCm39) S2928G probably damaging Het
Abcc9 C T 6: 142,571,736 (GRCm39) V1131M probably benign Het
Abcd1 T A X: 72,781,064 (GRCm39) L713H probably damaging Het
Actg1 T C 11: 120,237,627 (GRCm39) I52V probably benign Het
Ang G T 14: 51,339,275 (GRCm39) D139Y probably damaging Het
Ano1 C T 7: 144,143,749 (GRCm39) G1011E probably damaging Het
Apoe T C 7: 19,431,479 (GRCm39) Y46C probably damaging Het
Ash1l T C 3: 88,961,785 (GRCm39) W2386R probably damaging Het
Asph T C 4: 9,598,277 (GRCm39) D250G probably damaging Het
Atr A G 9: 95,756,296 (GRCm39) N836S probably benign Het
Bltp1 G A 3: 37,019,998 (GRCm39) S2079N probably damaging Het
Btg3 A G 16: 78,161,868 (GRCm39) V114A probably damaging Het
C2 T C 17: 35,082,854 (GRCm39) T471A possibly damaging Het
C4b T A 17: 34,953,732 (GRCm39) S959C probably damaging Het
Cap1 A T 4: 122,758,518 (GRCm39) S221T probably benign Het
Capn2 A T 1: 182,300,485 (GRCm39) probably benign Het
Cd38 A G 5: 44,058,775 (GRCm39) S130G probably damaging Het
Cd8b1 A G 6: 71,311,085 (GRCm39) R202G probably damaging Het
Col22a1 A G 15: 71,687,792 (GRCm39) probably null Het
Cps1 A T 1: 67,205,534 (GRCm39) E519V probably benign Het
Cyp2c38 G A 19: 39,449,138 (GRCm39) R72W probably benign Het
Cyp3a16 A T 5: 145,392,309 (GRCm39) Y215* probably null Het
Dennd10 T C 19: 60,803,232 (GRCm39) S80P probably benign Het
F5 A T 1: 164,012,533 (GRCm39) K482N probably damaging Het
Gab1 T C 8: 81,511,382 (GRCm39) M488V probably benign Het
Gabpb1 A G 2: 126,495,494 (GRCm39) I86T probably damaging Het
Gbx2 C T 1: 89,856,853 (GRCm39) R179Q probably damaging Het
Gm11938 C A 11: 99,493,972 (GRCm39) R41L probably damaging Het
Gpn1 A G 5: 31,654,664 (GRCm39) D72G probably damaging Het
Greb1 A G 12: 16,761,746 (GRCm39) S545P probably benign Het
Hsd3b7 T G 7: 127,401,442 (GRCm39) L189R probably damaging Het
Iglc1 T C 16: 18,880,660 (GRCm39) probably benign Het
Il18r1 T C 1: 40,537,717 (GRCm39) V494A possibly damaging Het
Inka1 T C 9: 107,861,603 (GRCm39) T238A probably benign Het
Itsn2 C A 12: 4,750,315 (GRCm39) probably benign Het
Kcnn1 T C 8: 71,299,179 (GRCm39) K487R probably benign Het
Kdf1 G A 4: 133,255,852 (GRCm39) E190K probably damaging Het
Klhdc10 G A 6: 30,402,139 (GRCm39) R48H unknown Het
Lama3 G T 18: 12,586,807 (GRCm39) L723F probably damaging Het
Lama5 T C 2: 179,829,040 (GRCm39) T2034A probably benign Het
Maged1 G A X: 93,582,530 (GRCm39) P366S probably damaging Het
Med14 A G X: 12,585,936 (GRCm39) I521T probably benign Het
Mia2 A G 12: 59,201,196 (GRCm39) K841E probably damaging Het
Mrgbp G A 2: 180,225,203 (GRCm39) R53Q possibly damaging Het
Nmnat2 G A 1: 152,988,171 (GRCm39) V267I probably benign Het
Opn4 A G 14: 34,315,785 (GRCm39) probably null Het
Or2d2b T A 7: 106,705,675 (GRCm39) H131L probably benign Het
Or4f56 G T 2: 111,703,818 (GRCm39) C127* probably null Het
Or6k6 A G 1: 173,945,298 (GRCm39) Y95H probably damaging Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Parp16 G T 9: 65,141,086 (GRCm39) D219Y probably damaging Het
Pitpnm2 G C 5: 124,259,500 (GRCm39) H1224Q probably damaging Het
Pkd1 C T 17: 24,784,420 (GRCm39) T322I probably benign Het
Pkhd1l1 A C 15: 44,404,267 (GRCm39) T2299P probably damaging Het
Plin4 T C 17: 56,413,668 (GRCm39) D319G probably damaging Het
Ppp6r3 A C 19: 3,571,782 (GRCm39) S122R possibly damaging Het
Pwwp3b G A X: 138,137,429 (GRCm39) G656S possibly damaging Het
Rims1 A T 1: 22,503,227 (GRCm39) F653I probably benign Het
Rnf113a1 A G X: 36,455,736 (GRCm39) E231G probably damaging Het
Rnf41 T C 10: 128,274,023 (GRCm39) L225P possibly damaging Het
Ryr2 T C 13: 11,607,979 (GRCm39) E876G probably damaging Het
Slc25a10 G A 11: 120,386,003 (GRCm39) V115M probably damaging Het
Snx13 T A 12: 35,188,116 (GRCm39) I798N probably benign Het
Sri A T 5: 8,117,540 (GRCm39) Q178L probably benign Het
Tex14 T G 11: 87,365,243 (GRCm39) D62E probably damaging Het
Tshz1 G T 18: 84,033,105 (GRCm39) H434Q probably damaging Het
Vegfd A G X: 163,168,879 (GRCm39) E57G probably damaging Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r59 A G 7: 41,696,427 (GRCm39) I105T possibly damaging Het
Vmn2r6 G T 3: 64,454,760 (GRCm39) T513N probably benign Het
Vmn2r72 A T 7: 85,400,044 (GRCm39) I335N probably damaging Het
Wiz G T 17: 32,580,680 (GRCm39) T257K probably damaging Het
Xirp1 T C 9: 119,848,881 (GRCm39) M1V probably null Het
Xirp1 A G 9: 119,847,444 (GRCm39) S41P probably benign Het
Other mutations in Or5p66
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0395:Or5p66 UTSW 7 107,885,478 (GRCm39) missense probably benign 0.00
R0634:Or5p66 UTSW 7 107,885,503 (GRCm39) missense probably benign 0.00
R0940:Or5p66 UTSW 7 107,886,264 (GRCm39) missense probably benign 0.01
R1990:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R1991:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R2860:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R3712:Or5p66 UTSW 7 107,885,663 (GRCm39) nonsense probably null
R4735:Or5p66 UTSW 7 107,885,520 (GRCm39) missense probably benign
R4895:Or5p66 UTSW 7 107,885,802 (GRCm39) missense probably damaging 0.97
R4976:Or5p66 UTSW 7 107,885,818 (GRCm39) missense probably damaging 1.00
R5686:Or5p66 UTSW 7 107,885,949 (GRCm39) missense probably damaging 1.00
R5719:Or5p66 UTSW 7 107,885,599 (GRCm39) missense probably damaging 0.97
R5883:Or5p66 UTSW 7 107,885,451 (GRCm39) missense probably damaging 1.00
R5911:Or5p66 UTSW 7 107,885,605 (GRCm39) missense probably damaging 1.00
R6452:Or5p66 UTSW 7 107,886,100 (GRCm39) missense probably damaging 1.00
R7018:Or5p66 UTSW 7 107,885,551 (GRCm39) missense probably benign 0.34
R7233:Or5p66 UTSW 7 107,885,923 (GRCm39) missense probably benign 0.36
R8085:Or5p66 UTSW 7 107,885,620 (GRCm39) missense probably benign 0.01
R8166:Or5p66 UTSW 7 107,885,904 (GRCm39) missense probably benign 0.06
R8919:Or5p66 UTSW 7 107,886,289 (GRCm39) missense probably damaging 1.00
R9209:Or5p66 UTSW 7 107,885,526 (GRCm39) missense probably benign 0.06
R9612:Or5p66 UTSW 7 107,885,487 (GRCm39) missense probably benign
R9789:Or5p66 UTSW 7 107,885,898 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGGTTGCAGATTGCCATGAAG -3'
(R):5'- TATCCCATGGCTTTCCTGGAG -3'

Sequencing Primer
(F):5'- GGAAGCATTCAGTTGCACC -3'
(R):5'- GCTTTCCTGGAGAATGGGAAC -3'
Posted On 2014-12-04