Incidental Mutation 'R2863:Ifna6'
ID |
253017 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ifna6
|
Ensembl Gene |
ENSMUSG00000101252 |
Gene Name |
interferon alpha 6 |
Synonyms |
Ifa6, Ifna8 |
MMRRC Submission |
040453-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.069)
|
Stock # |
R2863 (G1)
|
Quality Score |
207 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
88745653-88746222 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to C
at 88746099 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Serine
at position 149
(R149S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000100777
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071378]
[ENSMUST00000105146]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000071378
AA Change: R149S
PolyPhen 2
Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000071333 Gene: ENSMUSG00000100079 AA Change: R149S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
IFabd
|
58 |
175 |
1.43e-70 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000105146
AA Change: R149S
PolyPhen 2
Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000100777 Gene: ENSMUSG00000101252 AA Change: R149S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
IFabd
|
58 |
175 |
5.8e-71 |
SMART |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.7%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection. [provided by MGI curators]
|
Allele List at MGI |
All alleles(1) : Targeted(1)
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Armh3 |
A |
T |
19: 45,874,396 (GRCm39) |
N592K |
probably damaging |
Het |
Bag5 |
T |
C |
12: 111,677,029 (GRCm39) |
T265A |
probably benign |
Het |
Bmper |
A |
G |
9: 23,395,237 (GRCm39) |
N656S |
probably benign |
Het |
Boc |
A |
G |
16: 44,313,323 (GRCm39) |
S514P |
probably benign |
Het |
Ddx6 |
G |
T |
9: 44,525,553 (GRCm39) |
L103F |
probably damaging |
Het |
Epb41l3 |
C |
T |
17: 69,517,316 (GRCm39) |
P115S |
probably benign |
Het |
Exoc6 |
T |
C |
19: 37,641,861 (GRCm39) |
F709S |
probably benign |
Het |
Fnip1 |
T |
C |
11: 54,393,250 (GRCm39) |
I562T |
probably damaging |
Het |
Fxr2 |
T |
A |
11: 69,530,253 (GRCm39) |
I40N |
probably damaging |
Het |
Ldb2 |
T |
C |
5: 44,637,666 (GRCm39) |
Q214R |
probably damaging |
Het |
Mus81 |
T |
G |
19: 5,536,528 (GRCm39) |
Y146S |
probably damaging |
Het |
Myh11 |
T |
C |
16: 14,057,290 (GRCm39) |
I335V |
probably benign |
Het |
Nid2 |
G |
A |
14: 19,818,471 (GRCm39) |
E322K |
possibly damaging |
Het |
Odad1 |
T |
C |
7: 45,597,736 (GRCm39) |
S549P |
probably benign |
Het |
Ofcc1 |
A |
T |
13: 40,226,236 (GRCm39) |
S765R |
probably damaging |
Het |
Ofcc1 |
T |
A |
13: 40,241,414 (GRCm39) |
H698L |
possibly damaging |
Het |
Or8b56 |
T |
A |
9: 38,739,835 (GRCm39) |
F283I |
possibly damaging |
Het |
Otog |
T |
G |
7: 45,918,730 (GRCm39) |
C935W |
probably damaging |
Het |
Pcdhga3 |
T |
C |
18: 37,807,643 (GRCm39) |
V32A |
probably damaging |
Het |
Phc3 |
C |
T |
3: 30,968,277 (GRCm39) |
D920N |
probably damaging |
Het |
Pou6f1 |
A |
G |
15: 100,478,689 (GRCm39) |
|
probably null |
Het |
Ppp4c |
A |
T |
7: 126,391,272 (GRCm39) |
I20N |
probably damaging |
Het |
Prkag2 |
T |
A |
5: 25,226,790 (GRCm39) |
T156S |
probably benign |
Het |
Psd |
T |
C |
19: 46,303,201 (GRCm39) |
D95G |
probably damaging |
Het |
Riox2 |
A |
G |
16: 59,309,756 (GRCm39) |
D370G |
probably damaging |
Het |
Spink14 |
T |
A |
18: 44,163,948 (GRCm39) |
C39S |
probably damaging |
Het |
Tdrd9 |
T |
C |
12: 111,997,695 (GRCm39) |
V728A |
probably benign |
Het |
Tgm2 |
T |
C |
2: 157,985,019 (GRCm39) |
E29G |
probably benign |
Het |
Wdr35 |
T |
A |
12: 9,078,060 (GRCm39) |
Y1139* |
probably null |
Het |
Wdr95 |
T |
A |
5: 149,505,321 (GRCm39) |
C367* |
probably null |
Het |
Zfp35 |
T |
A |
18: 24,137,352 (GRCm39) |
D565E |
probably damaging |
Het |
|
Other mutations in Ifna6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL03403:Ifna6
|
APN |
4 |
88,745,695 (GRCm39) |
missense |
possibly damaging |
0.69 |
R0336:Ifna6
|
UTSW |
4 |
88,746,178 (GRCm39) |
missense |
probably damaging |
0.97 |
R0521:Ifna6
|
UTSW |
4 |
88,745,887 (GRCm39) |
missense |
probably benign |
0.30 |
R2863:Ifna6
|
UTSW |
4 |
88,746,086 (GRCm39) |
missense |
probably benign |
|
R2865:Ifna6
|
UTSW |
4 |
88,746,086 (GRCm39) |
missense |
probably benign |
|
R2865:Ifna6
|
UTSW |
4 |
88,746,099 (GRCm39) |
missense |
probably benign |
0.36 |
R4171:Ifna6
|
UTSW |
4 |
88,746,038 (GRCm39) |
missense |
probably benign |
0.06 |
R4534:Ifna6
|
UTSW |
4 |
88,746,099 (GRCm39) |
missense |
probably benign |
0.36 |
R4534:Ifna6
|
UTSW |
4 |
88,746,086 (GRCm39) |
missense |
probably benign |
|
R4992:Ifna6
|
UTSW |
4 |
88,745,777 (GRCm39) |
missense |
probably benign |
0.00 |
R5667:Ifna6
|
UTSW |
4 |
88,745,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R5671:Ifna6
|
UTSW |
4 |
88,745,906 (GRCm39) |
missense |
probably damaging |
1.00 |
R5677:Ifna6
|
UTSW |
4 |
88,745,956 (GRCm39) |
missense |
probably benign |
0.00 |
R6487:Ifna6
|
UTSW |
4 |
88,745,743 (GRCm39) |
missense |
probably damaging |
1.00 |
R6751:Ifna6
|
UTSW |
4 |
88,745,987 (GRCm39) |
missense |
probably damaging |
1.00 |
R7424:Ifna6
|
UTSW |
4 |
88,746,044 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7711:Ifna6
|
UTSW |
4 |
88,745,971 (GRCm39) |
missense |
probably benign |
0.06 |
R8850:Ifna6
|
UTSW |
4 |
88,746,222 (GRCm39) |
makesense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AAGGACTCATCTGCTGCATG -3'
(R):5'- AGGTTGATTGTGTTCACACTGAAG -3'
Sequencing Primer
(F):5'- ACTCATCTGCTGCATGGAATG -3'
(R):5'- TGTGTTCACACTGAAGGTAATGAG -3'
|
Posted On |
2014-12-04 |