Incidental Mutation 'R2471:Try10'
ID 253080
Institutional Source Beutler Lab
Gene Symbol Try10
Ensembl Gene ENSMUSG00000071521
Gene Name trypsin 10
Synonyms trypsinogen 10
MMRRC Submission 040403-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R2471 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 41331039-41334848 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41333680 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 142 (S142P)
Ref Sequence ENSEMBL: ENSMUSP00000071976 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072103]
AlphaFold Q792Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000072103
AA Change: S142P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071976
Gene: ENSMUSG00000071521
AA Change: S142P

DomainStartEndE-ValueType
low complexity region 4 16 N/A INTRINSIC
Tryp_SPc 23 239 3.38e-104 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik A T 9: 55,888,147 (GRCm39) M390K probably benign Het
Bicra A G 7: 15,706,257 (GRCm39) S1395P probably benign Het
Cacnb2 G A 2: 14,989,125 (GRCm39) D402N probably damaging Het
Csmd1 T A 8: 16,261,776 (GRCm39) D907V probably damaging Het
Cstl1 T A 2: 148,593,041 (GRCm39) Y65* probably null Het
Dnajc1 T C 2: 18,224,627 (GRCm39) I213V possibly damaging Het
Emcn C T 3: 137,109,772 (GRCm39) T138M probably damaging Het
F3 G T 3: 121,518,689 (GRCm39) W51L probably damaging Het
Far2 A G 6: 148,040,192 (GRCm39) Y41C probably damaging Het
Flrt1 A T 19: 7,073,856 (GRCm39) D230E probably damaging Het
Gimap7 G A 6: 48,700,986 (GRCm39) V191M probably damaging Het
Gm19402 A T 10: 77,526,354 (GRCm39) probably benign Het
Ipo5 A C 14: 121,159,574 (GRCm39) K134T probably benign Het
Kcnf1 T C 12: 17,225,531 (GRCm39) E230G probably damaging Het
Mad1l1 T C 5: 140,247,307 (GRCm39) E340G probably benign Het
Map4k5 T C 12: 69,903,620 (GRCm39) I62V probably benign Het
Marchf7 A G 2: 60,067,244 (GRCm39) K588R possibly damaging Het
Mctp2 T A 7: 71,810,909 (GRCm39) K52* probably null Het
Nr1h4 A T 10: 89,309,756 (GRCm39) F310L probably damaging Het
Ofcc1 G A 13: 40,250,501 (GRCm39) S605F probably damaging Het
Or2w1b A T 13: 21,300,599 (GRCm39) T246S probably damaging Het
Or5ac25 A T 16: 59,181,944 (GRCm39) S212R possibly damaging Het
Or5b97 G A 19: 12,878,679 (GRCm39) T155I probably benign Het
Pcdh20 T G 14: 88,704,672 (GRCm39) E876A probably benign Het
Plce1 C T 19: 38,768,370 (GRCm39) A2215V probably damaging Het
Ptprg T C 14: 12,210,327 (GRCm38) Y128H probably damaging Het
Sigirr A G 7: 140,672,510 (GRCm39) L204S probably damaging Het
Slc2a12 A T 10: 22,540,706 (GRCm39) Y187F probably damaging Het
Slc31a2 A T 4: 62,214,312 (GRCm39) R86W probably null Het
Smc1b T C 15: 84,976,218 (GRCm39) K830E probably damaging Het
Ssrp1 A G 2: 84,872,642 (GRCm39) N427D possibly damaging Het
Taar9 A T 10: 23,985,289 (GRCm39) F48L probably benign Het
Taok2 T C 7: 126,474,272 (GRCm39) E319G probably damaging Het
Tsc22d1 A G 14: 76,655,644 (GRCm39) T626A probably benign Het
Zfp101 T C 17: 33,599,950 (GRCm39) E602G possibly damaging Het
Other mutations in Try10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02001:Try10 APN 6 41,333,523 (GRCm39) missense probably benign 0.00
IGL02608:Try10 APN 6 41,332,421 (GRCm39) missense probably damaging 1.00
IGL03280:Try10 APN 6 41,331,154 (GRCm39) missense probably benign 0.18
R0332:Try10 UTSW 6 41,331,154 (GRCm39) missense probably benign 0.18
R1628:Try10 UTSW 6 41,334,390 (GRCm39) missense probably damaging 1.00
R2149:Try10 UTSW 6 41,333,495 (GRCm39) missense probably benign 0.02
R3764:Try10 UTSW 6 41,333,458 (GRCm39) missense probably benign 0.07
R4008:Try10 UTSW 6 41,333,608 (GRCm39) missense probably benign 0.00
R4660:Try10 UTSW 6 41,334,761 (GRCm39) missense probably damaging 1.00
R4792:Try10 UTSW 6 41,332,386 (GRCm39) missense probably benign 0.33
R5185:Try10 UTSW 6 41,333,483 (GRCm39) missense probably damaging 0.96
R6103:Try10 UTSW 6 41,333,484 (GRCm39) missense probably damaging 0.98
R6301:Try10 UTSW 6 41,332,523 (GRCm39) missense probably benign 0.30
R6692:Try10 UTSW 6 41,334,755 (GRCm39) missense probably damaging 1.00
R7786:Try10 UTSW 6 41,332,463 (GRCm39) missense possibly damaging 0.86
R8391:Try10 UTSW 6 41,334,306 (GRCm39) missense probably damaging 1.00
R9309:Try10 UTSW 6 41,333,559 (GRCm39) missense probably benign
R9636:Try10 UTSW 6 41,332,505 (GRCm39) missense probably benign 0.00
R9697:Try10 UTSW 6 41,331,041 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AACAGCCGCATCCAAGTGAG -3'
(R):5'- AAGGTCATTTTGTGTGCAACTC -3'

Sequencing Primer
(F):5'- CAACATCAACGTCCTGGAGGG -3'
(R):5'- GTGCAACTCTCTCTAATACCCACTG -3'
Posted On 2014-12-04