Mutagenetix > Incidental Mutation

Incidental Mutation 'R2866:Clec2g'

253236

Institutional Source

Beutler Lab

Gene Symbol

Clec2g

Ensembl Gene

ENSMUSG00000000248

Gene Name

C-type lectin domain family 2, member g

Synonyms

Ocilrp1, 4632413B12Rik

MMRRC Submission

040455-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R2866 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

128911344-128961670 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 128925719 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 43 (S43P)

Ref Sequence

ENSEMBL: ENSMUSP00000000254 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000254]

AlphaFold

Q9D676

Predicted Effect

probably benign
Transcript: ENSMUST00000000254
AA Change: S43P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000000254
Gene: ENSMUSG00000000248
AA Change: S43P

Domain	Start	End	E-Value	Type
Pfam:Lectin_C	3	108	2.4e-6	PFAM
low complexity region	114	126	N/A	INTRINSIC
CLECT	143	254	9.36e-25	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141700

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146925

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atmin	T	A	8: 117,683,112 (GRCm39)	D257E	probably benign	Het
Best1	T	C	19: 9,963,585 (GRCm39)	E532G	probably benign	Het
Cenpj	T	C	14: 56,789,637 (GRCm39)	H804R	probably benign	Het
Col8a2	A	G	4: 126,204,992 (GRCm39)		probably benign	Het
Cpz	T	C	5: 35,659,705 (GRCm39)	K647E	probably benign	Het
Csmd2	T	C	4: 128,308,185 (GRCm39)		probably null	Het
Ctss	A	G	3: 95,452,717 (GRCm39)	K166R	probably benign	Het
Cyp2c23	T	C	19: 43,993,885 (GRCm39)	R494G	probably damaging	Het
Cyp2c68	A	G	19: 39,677,589 (GRCm39)	I467T	probably damaging	Het
Dcaf11	A	T	14: 55,803,202 (GRCm39)	T299S	possibly damaging	Het
Dennd1b	A	G	1: 139,098,019 (GRCm39)	S762G	possibly damaging	Het
Epb42	C	T	2: 120,856,402 (GRCm39)	A381T	possibly damaging	Het
Fhad1	A	G	4: 141,648,099 (GRCm39)	Y256H	probably benign	Het
Gfra1	C	T	19: 58,227,739 (GRCm39)	A395T	possibly damaging	Het
Gm10323	C	A	13: 67,002,574 (GRCm39)	C55F	probably benign	Het
Greb1	T	C	12: 16,749,551 (GRCm39)	S1092G	probably damaging	Het
Grid1	A	T	14: 35,284,516 (GRCm39)	D753V	probably damaging	Het
Grin2b	A	G	6: 135,710,637 (GRCm39)	F970L	probably damaging	Het
Kcnma1	A	T	14: 23,423,275 (GRCm39)	N682K	probably benign	Het
Lat2	T	A	5: 134,634,798 (GRCm39)	D114V	probably damaging	Het
Lcat	C	T	8: 106,666,511 (GRCm39)	C337Y	probably damaging	Het
Mapk10	C	T	5: 103,186,548 (GRCm39)	D25N	probably benign	Het
Mroh7	C	T	4: 106,548,287 (GRCm39)	G1064R	probably damaging	Het
Muc21	T	C	17: 35,930,599 (GRCm39)		probably benign	Het
Or10h5	T	A	17: 33,435,252 (GRCm39)	H22L	probably benign	Het
Or51ah3	A	T	7: 103,210,064 (GRCm39)	I127F	probably damaging	Het
Or5p5	T	A	7: 107,414,126 (GRCm39)	C112S	probably benign	Het
Or8k39	A	T	2: 86,563,773 (GRCm39)	F61Y	possibly damaging	Het
Polr1has	A	T	17: 37,276,052 (GRCm39)	R211S	possibly damaging	Het
Psg27	T	A	7: 18,295,818 (GRCm39)	D209V	probably benign	Het
Ptgir	A	G	7: 16,640,794 (GRCm39)	M29V	possibly damaging	Het
Pzp	A	G	6: 128,502,227 (GRCm39)	S41P	possibly damaging	Het
Rab23	A	T	1: 33,777,376 (GRCm39)	K163N	possibly damaging	Het
Rilpl2	T	C	5: 124,615,898 (GRCm39)	D84G	probably damaging	Het
Sorl1	A	G	9: 41,881,077 (GRCm39)	I2148T	probably benign	Het
Tead1	A	G	7: 112,358,694 (GRCm39)	E2G	probably damaging	Het
Tigd4	A	G	3: 84,501,259 (GRCm39)	N59D	possibly damaging	Het
Tmprss15	T	A	16: 78,832,121 (GRCm39)	D345V	possibly damaging	Het
Togaram2	T	C	17: 72,016,592 (GRCm39)	S649P	probably benign	Het
Ucp2	T	C	7: 100,146,459 (GRCm39)	V95A	probably benign	Het
Usp17lb	T	C	7: 104,489,955 (GRCm39)	D323G	probably damaging	Het
Zfp677	A	T	17: 21,617,518 (GRCm39)	K192*	probably null	Het
Zmym2	T	A	14: 57,165,705 (GRCm39)	I676K	probably damaging	Het

Other mutations in Clec2g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00825:Clec2g	APN	6	128,957,144 (GRCm39)	splice site	probably null
IGL00901:Clec2g	APN	6	128,925,655 (GRCm39)	splice site	probably benign
IGL01367:Clec2g	APN	6	128,925,699 (GRCm39)	missense	unknown
IGL01514:Clec2g	APN	6	128,925,736 (GRCm39)	missense	probably benign	0.02
IGL02742:Clec2g	APN	6	128,957,224 (GRCm39)	missense	possibly damaging	0.95
R0069:Clec2g	UTSW	6	128,957,274 (GRCm39)	critical splice donor site	probably null
R0069:Clec2g	UTSW	6	128,925,716 (GRCm39)	missense	probably benign	0.02
R0368:Clec2g	UTSW	6	128,957,224 (GRCm39)	missense	possibly damaging	0.95
R1809:Clec2g	UTSW	6	128,957,273 (GRCm39)	critical splice donor site	probably null
R1813:Clec2g	UTSW	6	128,925,660 (GRCm39)	missense	unknown
R4080:Clec2g	UTSW	6	128,958,287 (GRCm39)	missense	probably damaging	0.96
R4732:Clec2g	UTSW	6	128,958,842 (GRCm39)	nonsense	probably null
R4733:Clec2g	UTSW	6	128,958,842 (GRCm39)	nonsense	probably null
R4906:Clec2g	UTSW	6	128,956,411 (GRCm39)	missense	probably benign
R5014:Clec2g	UTSW	6	128,925,765 (GRCm39)	missense	probably benign	0.00
R5220:Clec2g	UTSW	6	128,958,269 (GRCm39)	missense	probably benign	0.00
R5342:Clec2g	UTSW	6	128,925,714 (GRCm39)	missense	probably benign	0.04
R6155:Clec2g	UTSW	6	128,957,236 (GRCm39)	missense	probably damaging	1.00
R6353:Clec2g	UTSW	6	128,959,895 (GRCm39)	splice site	probably null
R6372:Clec2g	UTSW	6	128,925,726 (GRCm39)	missense	probably benign	0.00
R7678:Clec2g	UTSW	6	128,956,400 (GRCm39)	missense	probably damaging	0.96
R7821:Clec2g	UTSW	6	128,925,740 (GRCm39)	missense	probably benign	0.00
R8252:Clec2g	UTSW	6	128,958,335 (GRCm39)	missense	probably benign	0.09
R8909:Clec2g	UTSW	6	128,958,195 (GRCm39)	missense	probably benign	0.09
R9010:Clec2g	UTSW	6	128,925,688 (GRCm39)	missense	unknown
R9781:Clec2g	UTSW	6	128,960,012 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- AATTCTGTGACCCTCAGTTACAC -3'
(R):5'- GGCTATTTTATGAGGCACAGAACC -3'

Sequencing Primer
(F):5'- GACCCTCAGTTACACCCTCCTG -3'
(R):5'- TTTTATGAGGCACAGAACCTAAGCC -3'

Posted On

2014-12-04