Incidental Mutation 'R2513:Trip11'
| ID |
253676 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
040419-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2513 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 101803986 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 1632
(N1632I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134976
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000177183]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021605
AA Change: N1917I
PolyPhen 2
Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: N1917I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177183
AA Change: N1632I
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: N1632I
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
T |
C |
14: 32,383,809 (GRCm39) |
T719A |
possibly damaging |
Het |
| Abcc1 |
A |
G |
16: 14,290,873 (GRCm39) |
|
probably null |
Het |
| Aftph |
C |
T |
11: 20,658,676 (GRCm39) |
|
probably null |
Het |
| Als2 |
C |
A |
1: 59,254,276 (GRCm39) |
K360N |
probably benign |
Het |
| Atg2a |
T |
A |
19: 6,308,076 (GRCm39) |
|
probably null |
Het |
| Axl |
T |
C |
7: 25,486,941 (GRCm39) |
D22G |
probably benign |
Het |
| Baiap2 |
G |
A |
11: 119,890,052 (GRCm39) |
A438T |
probably benign |
Het |
| Bean1 |
G |
C |
8: 104,908,643 (GRCm39) |
A7P |
probably benign |
Het |
| Birc6 |
C |
G |
17: 74,954,724 (GRCm39) |
P3431R |
probably damaging |
Het |
| Camk1d |
A |
G |
2: 5,719,047 (GRCm39) |
M1T |
probably null |
Het |
| Carmil3 |
T |
C |
14: 55,741,295 (GRCm39) |
Y1027H |
probably damaging |
Het |
| Ccdc6 |
G |
A |
10: 70,023,658 (GRCm39) |
|
probably benign |
Het |
| Cemip |
C |
A |
7: 83,591,233 (GRCm39) |
V1280L |
probably benign |
Het |
| Cfap58 |
C |
A |
19: 47,950,981 (GRCm39) |
N447K |
probably benign |
Het |
| Chd3 |
A |
G |
11: 69,251,471 (GRCm39) |
L520P |
probably damaging |
Het |
| Col1a2 |
T |
A |
6: 4,531,223 (GRCm39) |
|
probably null |
Het |
| Cpne7 |
A |
C |
8: 123,844,406 (GRCm39) |
|
probably null |
Het |
| Ctla4 |
T |
C |
1: 60,951,723 (GRCm39) |
V84A |
probably damaging |
Het |
| Dap3 |
A |
G |
3: 88,835,565 (GRCm39) |
V263A |
probably benign |
Het |
| Dhx57 |
T |
A |
17: 80,549,378 (GRCm39) |
|
probably null |
Het |
| Dlg5 |
C |
A |
14: 24,214,593 (GRCm39) |
K663N |
probably damaging |
Het |
| Dsg3 |
C |
A |
18: 20,656,719 (GRCm39) |
F196L |
possibly damaging |
Het |
| Eif2ak4 |
C |
A |
2: 118,257,064 (GRCm39) |
D402E |
probably damaging |
Het |
| Fance |
T |
C |
17: 28,537,068 (GRCm39) |
V24A |
probably benign |
Het |
| Fasn |
A |
T |
11: 120,705,574 (GRCm39) |
L1149Q |
probably damaging |
Het |
| Fcgbpl1 |
C |
G |
7: 27,831,060 (GRCm39) |
S91C |
probably damaging |
Het |
| Flg |
T |
A |
3: 93,187,093 (GRCm39) |
S182T |
possibly damaging |
Het |
| Gm128 |
T |
A |
3: 95,147,293 (GRCm39) |
S334C |
possibly damaging |
Het |
| Gm3727 |
A |
C |
14: 7,264,561 (GRCm38) |
H31Q |
probably damaging |
Het |
| Gm4841 |
T |
G |
18: 60,403,977 (GRCm39) |
T39P |
probably damaging |
Het |
| Golgb1 |
G |
T |
16: 36,735,513 (GRCm39) |
V1587L |
possibly damaging |
Het |
| Golm1 |
G |
A |
13: 59,790,072 (GRCm39) |
P243S |
probably benign |
Het |
| Gstcd |
C |
A |
3: 132,788,081 (GRCm39) |
A206S |
possibly damaging |
Het |
| Gstcd |
C |
A |
3: 132,788,082 (GRCm39) |
K205N |
possibly damaging |
Het |
| Gtf3c1 |
A |
G |
7: 125,280,345 (GRCm39) |
V355A |
probably benign |
Het |
| Hhatl |
T |
C |
9: 121,618,236 (GRCm39) |
D173G |
probably benign |
Het |
| Kcnu1 |
T |
A |
8: 26,395,994 (GRCm39) |
C660S |
probably benign |
Het |
| Kctd8 |
T |
C |
5: 69,267,988 (GRCm39) |
D374G |
probably benign |
Het |
| Kif21a |
T |
C |
15: 90,878,594 (GRCm39) |
I229V |
possibly damaging |
Het |
| L3mbtl1 |
A |
T |
2: 162,809,505 (GRCm39) |
I702F |
probably benign |
Het |
| Lce1d |
T |
C |
3: 92,593,066 (GRCm39) |
|
probably benign |
Het |
| Lrig1 |
C |
T |
6: 94,594,347 (GRCm39) |
|
probably null |
Het |
| Lrp12 |
A |
T |
15: 39,739,507 (GRCm39) |
D563E |
probably damaging |
Het |
| Lrp2 |
C |
T |
2: 69,336,718 (GRCm39) |
|
probably null |
Het |
| Map3k5 |
G |
A |
10: 19,970,201 (GRCm39) |
V703I |
possibly damaging |
Het |
| Mecr |
A |
G |
4: 131,581,076 (GRCm39) |
R110G |
probably benign |
Het |
| Mtrr |
T |
A |
13: 68,715,092 (GRCm39) |
K445* |
probably null |
Het |
| Nanos1 |
T |
A |
19: 60,744,990 (GRCm39) |
L96Q |
probably benign |
Het |
| Or13a24 |
T |
G |
7: 140,154,069 (GRCm39) |
M1R |
probably null |
Het |
| Or51t4 |
T |
A |
7: 102,598,700 (GRCm39) |
F333I |
probably benign |
Het |
| Or6c214 |
T |
A |
10: 129,591,021 (GRCm39) |
L99F |
probably damaging |
Het |
| Otog |
T |
C |
7: 45,955,014 (GRCm39) |
|
probably null |
Het |
| Pcdhb3 |
G |
T |
18: 37,434,294 (GRCm39) |
V87F |
probably benign |
Het |
| Pcdhb3 |
T |
A |
18: 37,434,292 (GRCm39) |
L86* |
probably null |
Het |
| Pcdhb3 |
A |
T |
18: 37,434,293 (GRCm39) |
L86F |
probably damaging |
Het |
| Pdgfd |
A |
G |
9: 6,359,894 (GRCm39) |
K322E |
probably damaging |
Het |
| Picalm |
T |
C |
7: 89,846,217 (GRCm39) |
S648P |
probably damaging |
Het |
| Pigr |
T |
C |
1: 130,774,357 (GRCm39) |
S446P |
possibly damaging |
Het |
| Pik3cb |
A |
C |
9: 98,943,895 (GRCm39) |
L636W |
probably damaging |
Het |
| Pla2g2f |
A |
T |
4: 138,481,473 (GRCm39) |
L92Q |
probably damaging |
Het |
| Plod3 |
G |
C |
5: 137,017,000 (GRCm39) |
A50P |
probably benign |
Het |
| Prkar2b |
C |
T |
12: 32,025,928 (GRCm39) |
V191I |
possibly damaging |
Het |
| Prune1 |
C |
A |
3: 95,165,430 (GRCm39) |
A281S |
probably benign |
Het |
| Ptges3l |
A |
T |
11: 101,314,868 (GRCm39) |
C42S |
possibly damaging |
Het |
| Reg3b |
A |
T |
6: 78,348,802 (GRCm39) |
I33L |
probably benign |
Het |
| Rel |
A |
G |
11: 23,695,823 (GRCm39) |
I188T |
probably damaging |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Ripor1 |
G |
T |
8: 106,344,254 (GRCm39) |
V463L |
probably benign |
Het |
| Rrm1 |
T |
A |
7: 102,109,896 (GRCm39) |
D510E |
probably damaging |
Het |
| Setd7 |
A |
G |
3: 51,440,436 (GRCm39) |
S202P |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,432,889 (GRCm39) |
D1211E |
probably benign |
Het |
| Slc30a1 |
A |
T |
1: 191,639,674 (GRCm39) |
T186S |
possibly damaging |
Het |
| Slc4a4 |
G |
A |
5: 89,304,257 (GRCm39) |
V523I |
probably benign |
Het |
| Slc9a2 |
T |
A |
1: 40,781,768 (GRCm39) |
|
probably null |
Het |
| Smg6 |
A |
G |
11: 74,820,502 (GRCm39) |
T258A |
probably damaging |
Het |
| Sptlc1 |
C |
T |
13: 53,491,676 (GRCm39) |
D408N |
possibly damaging |
Het |
| Tasor2 |
G |
T |
13: 3,632,150 (GRCm39) |
L784I |
possibly damaging |
Het |
| Tbl3 |
T |
C |
17: 24,923,524 (GRCm39) |
|
probably null |
Het |
| Tdo2 |
T |
C |
3: 81,876,812 (GRCm39) |
D139G |
possibly damaging |
Het |
| Ticam1 |
T |
A |
17: 56,578,612 (GRCm39) |
H161L |
possibly damaging |
Het |
| Tnfaip3 |
T |
A |
10: 18,881,407 (GRCm39) |
D293V |
probably benign |
Het |
| Trim72 |
G |
A |
7: 127,603,878 (GRCm39) |
V75M |
possibly damaging |
Het |
| Tspan18 |
A |
T |
2: 93,050,440 (GRCm39) |
M61K |
possibly damaging |
Het |
| Tuba8 |
A |
T |
6: 121,202,932 (GRCm39) |
E415V |
probably damaging |
Het |
| Ung |
A |
G |
5: 114,275,253 (GRCm39) |
H214R |
probably benign |
Het |
| Uqcrc1 |
T |
C |
9: 108,765,836 (GRCm39) |
L17P |
probably damaging |
Het |
| Usp24 |
A |
G |
4: 106,236,602 (GRCm39) |
|
probably null |
Het |
| Vps39 |
A |
C |
2: 120,169,268 (GRCm39) |
Y245D |
probably damaging |
Het |
| Whrn |
T |
A |
4: 63,353,649 (GRCm39) |
T373S |
probably benign |
Het |
| Zc2hc1a |
C |
T |
3: 7,581,596 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTACCTATTGCTTTAGAAGGTC -3'
(R):5'- TTCTGCTCTCAAAGTAGAGCAG -3'
Sequencing Primer
(F):5'- GGTCTTTCAATACAACACCTGCACTG -3'
(R):5'- CTGTAAGAGGTTCATGGCCAGC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation