Incidental Mutation 'R2517:Vmn2r19'
ID 253925
Institutional Source Beutler Lab
Gene Symbol Vmn2r19
Ensembl Gene ENSMUSG00000091260
Gene Name vomeronasal 2, receptor 19
Synonyms EG232358
MMRRC Submission 040421-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R2517 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 123285292-123313496 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 123306937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 482 (T482A)
Ref Sequence ENSEMBL: ENSMUSP00000073604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073948]
AlphaFold G5E8G4
Predicted Effect probably benign
Transcript: ENSMUST00000073948
AA Change: T482A

PolyPhen 2 Score 0.186 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: T482A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 476 2.9e-35 PFAM
Pfam:NCD3G 518 571 8.3e-23 PFAM
Pfam:7tm_3 603 839 7.2e-52 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy4 C A 14: 56,019,403 (GRCm39) E82D probably damaging Het
Ago1 G A 4: 126,333,732 (GRCm39) R486* probably null Het
Ago2 T A 15: 72,996,091 (GRCm39) N346I possibly damaging Het
Apol11a A T 15: 77,401,395 (GRCm39) D294V probably benign Het
Atp13a5 A G 16: 29,116,215 (GRCm39) F634L possibly damaging Het
Atp2a2 G A 5: 122,595,576 (GRCm39) P953L probably damaging Het
Brca2 A G 5: 150,463,137 (GRCm39) D967G probably benign Het
Bud13 A T 9: 46,199,446 (GRCm39) H269L probably benign Het
Cachd1 A T 4: 100,838,079 (GRCm39) probably null Het
Cog3 T C 14: 75,979,182 (GRCm39) D188G probably benign Het
Col15a1 T C 4: 47,208,492 (GRCm39) S20P probably damaging Het
Col4a3 A G 1: 82,658,431 (GRCm39) D838G unknown Het
Cwh43 A T 5: 73,578,886 (GRCm39) T298S probably benign Het
Dip2c A G 13: 9,659,041 (GRCm39) R847G probably damaging Het
Dnah2 C T 11: 69,407,470 (GRCm39) D438N probably damaging Het
Drg2 T C 11: 60,358,954 (GRCm39) V358A probably damaging Het
Eif4enif1 T A 11: 3,171,168 (GRCm39) W220R probably damaging Het
Enpp2 A T 15: 54,783,090 (GRCm39) I75K probably damaging Het
Fam110c T C 12: 31,125,238 (GRCm39) I400T probably damaging Het
Fam193b C A 13: 55,690,629 (GRCm39) R711L probably damaging Het
Fgfr1 T C 8: 26,053,462 (GRCm39) Y246H probably damaging Het
Frs3 G A 17: 48,013,997 (GRCm39) R230Q probably benign Het
Galnt5 A G 2: 57,889,425 (GRCm39) K342E probably benign Het
Glrb A T 3: 80,769,054 (GRCm39) L189Q probably damaging Het
Gmeb2 T C 2: 180,900,819 (GRCm39) T193A probably benign Het
Gnl3 A G 14: 30,736,120 (GRCm39) S307P probably damaging Het
Golim4 A T 3: 75,800,166 (GRCm39) F443I probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Klf10 A C 15: 38,297,357 (GRCm39) Y228D probably benign Het
Klrc3 A T 6: 129,616,520 (GRCm39) W166R probably damaging Het
Kng2 A T 16: 22,807,065 (GRCm39) I378N probably benign Het
Map3k10 T C 7: 27,362,688 (GRCm39) K466R possibly damaging Het
Mrrf C T 2: 36,079,109 (GRCm39) T245M probably benign Het
Msi1 A G 5: 115,583,517 (GRCm39) Y239C probably damaging Het
Nfasc A G 1: 132,525,501 (GRCm39) probably null Het
Or1x6 T A 11: 50,939,300 (GRCm39) L122Q probably damaging Het
Or7g25 A T 9: 19,160,357 (GRCm39) C113S probably benign Het
P3r3urf A G 4: 116,030,791 (GRCm39) D65G probably benign Het
Pkd1l1 T C 11: 8,908,900 (GRCm39) E368G unknown Het
Polq G A 16: 36,909,687 (GRCm39) G2078D probably damaging Het
Ppfibp1 A C 6: 146,893,942 (GRCm39) I134L probably damaging Het
Rasip1 A T 7: 45,284,247 (GRCm39) I608F probably damaging Het
Ripk3 A T 14: 56,025,492 (GRCm39) V24E probably damaging Het
Rtkn T A 6: 83,124,526 (GRCm39) I110N probably damaging Het
Scn1a C T 2: 66,104,176 (GRCm39) V1695I probably damaging Het
Shank2 A G 7: 143,606,042 (GRCm39) N75S possibly damaging Het
Snu13 C A 15: 81,928,182 (GRCm39) A14S probably benign Het
Snx27 A C 3: 94,438,541 (GRCm39) D231E probably damaging Het
Spef2 A G 15: 9,725,283 (GRCm39) I158T possibly damaging Het
Sptb A G 12: 76,696,643 (GRCm39) I19T possibly damaging Het
Ssu72 T C 4: 155,817,970 (GRCm39) L175P probably damaging Het
Tcstv2a T A 13: 120,725,475 (GRCm39) C46* probably null Het
Tecr C T 8: 84,299,204 (GRCm39) V248I probably benign Het
Tnfrsf13b T G 11: 61,032,302 (GRCm39) S59A probably benign Het
Tom1l1 T C 11: 90,561,951 (GRCm39) T150A possibly damaging Het
Ubr3 A T 2: 69,766,362 (GRCm39) Y410F probably damaging Het
Vmn2r108 A G 17: 20,692,577 (GRCm39) I93T probably damaging Het
Vstm4 T A 14: 32,585,664 (GRCm39) M77K probably benign Het
Zbtb17 C T 4: 141,191,896 (GRCm39) T309I probably damaging Het
Zfp957 T C 14: 79,451,494 (GRCm39) T102A probably damaging Het
Other mutations in Vmn2r19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Vmn2r19 APN 6 123,306,826 (GRCm39) missense possibly damaging 0.92
IGL02294:Vmn2r19 APN 6 123,306,937 (GRCm39) missense probably benign 0.19
IGL02442:Vmn2r19 APN 6 123,286,621 (GRCm39) missense possibly damaging 0.94
IGL02871:Vmn2r19 APN 6 123,313,042 (GRCm39) missense probably damaging 1.00
H8562:Vmn2r19 UTSW 6 123,292,861 (GRCm39) missense possibly damaging 0.82
R0025:Vmn2r19 UTSW 6 123,308,506 (GRCm39) missense probably benign 0.01
R0389:Vmn2r19 UTSW 6 123,312,945 (GRCm39) missense possibly damaging 0.53
R0402:Vmn2r19 UTSW 6 123,313,141 (GRCm39) missense probably damaging 1.00
R0411:Vmn2r19 UTSW 6 123,286,703 (GRCm39) missense probably damaging 0.98
R0554:Vmn2r19 UTSW 6 123,313,102 (GRCm39) missense probably damaging 0.99
R0578:Vmn2r19 UTSW 6 123,312,931 (GRCm39) missense probably damaging 1.00
R1102:Vmn2r19 UTSW 6 123,313,132 (GRCm39) missense probably benign 0.28
R1652:Vmn2r19 UTSW 6 123,292,656 (GRCm39) missense possibly damaging 0.68
R1663:Vmn2r19 UTSW 6 123,313,411 (GRCm39) missense probably benign 0.11
R1817:Vmn2r19 UTSW 6 123,307,011 (GRCm39) missense possibly damaging 0.80
R1866:Vmn2r19 UTSW 6 123,308,597 (GRCm39) critical splice donor site probably null
R1928:Vmn2r19 UTSW 6 123,308,589 (GRCm39) missense probably damaging 1.00
R1997:Vmn2r19 UTSW 6 123,292,880 (GRCm39) missense probably damaging 0.98
R2013:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2015:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2088:Vmn2r19 UTSW 6 123,312,795 (GRCm39) missense probably damaging 1.00
R2126:Vmn2r19 UTSW 6 123,293,033 (GRCm39) missense possibly damaging 0.82
R2128:Vmn2r19 UTSW 6 123,285,289 (GRCm39) splice site probably null
R2256:Vmn2r19 UTSW 6 123,306,845 (GRCm39) missense probably benign 0.20
R3753:Vmn2r19 UTSW 6 123,292,548 (GRCm39) missense possibly damaging 0.80
R3817:Vmn2r19 UTSW 6 123,286,601 (GRCm39) missense probably damaging 1.00
R3929:Vmn2r19 UTSW 6 123,292,587 (GRCm39) missense probably benign 0.01
R3934:Vmn2r19 UTSW 6 123,292,628 (GRCm39) missense probably damaging 1.00
R4232:Vmn2r19 UTSW 6 123,306,871 (GRCm39) missense probably benign
R4574:Vmn2r19 UTSW 6 123,292,939 (GRCm39) missense probably benign 0.01
R4886:Vmn2r19 UTSW 6 123,286,800 (GRCm39) missense probably benign 0.05
R4995:Vmn2r19 UTSW 6 123,306,869 (GRCm39) missense probably benign 0.00
R5107:Vmn2r19 UTSW 6 123,286,602 (GRCm39) nonsense probably null
R5232:Vmn2r19 UTSW 6 123,312,916 (GRCm39) missense probably benign
R6102:Vmn2r19 UTSW 6 123,306,907 (GRCm39) missense probably damaging 1.00
R6105:Vmn2r19 UTSW 6 123,293,054 (GRCm39) missense possibly damaging 0.70
R6280:Vmn2r19 UTSW 6 123,313,212 (GRCm39) missense probably benign
R6393:Vmn2r19 UTSW 6 123,293,112 (GRCm39) missense possibly damaging 0.80
R6502:Vmn2r19 UTSW 6 123,293,067 (GRCm39) missense possibly damaging 0.68
R6617:Vmn2r19 UTSW 6 123,313,494 (GRCm39) makesense probably null
R6742:Vmn2r19 UTSW 6 123,306,917 (GRCm39) missense possibly damaging 0.90
R7662:Vmn2r19 UTSW 6 123,308,521 (GRCm39) missense probably benign 0.33
R8041:Vmn2r19 UTSW 6 123,312,750 (GRCm39) missense possibly damaging 0.94
R8054:Vmn2r19 UTSW 6 123,292,998 (GRCm39) missense probably damaging 1.00
R8074:Vmn2r19 UTSW 6 123,312,904 (GRCm39) missense probably damaging 0.96
R8267:Vmn2r19 UTSW 6 123,313,221 (GRCm39) missense possibly damaging 0.50
R8287:Vmn2r19 UTSW 6 123,308,588 (GRCm39) missense probably damaging 1.00
R8937:Vmn2r19 UTSW 6 123,293,283 (GRCm39) critical splice donor site probably null
R9058:Vmn2r19 UTSW 6 123,313,021 (GRCm39) missense possibly damaging 0.53
R9119:Vmn2r19 UTSW 6 123,292,527 (GRCm39) missense possibly damaging 0.68
R9384:Vmn2r19 UTSW 6 123,292,923 (GRCm39) missense probably benign 0.00
X0058:Vmn2r19 UTSW 6 123,285,308 (GRCm39) missense probably benign 0.00
Z1088:Vmn2r19 UTSW 6 123,285,298 (GRCm39) missense probably benign 0.02
Z1177:Vmn2r19 UTSW 6 123,313,036 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CCAGGTTTATTTACATCTCAGTGAC -3'
(R):5'- ACATGCTGGGATCCAACAC -3'

Sequencing Primer
(F):5'- CACCAATGAGGAGAACGT -3'
(R):5'- ACCCAGAAGCTGATGGATTCCTG -3'
Posted On 2014-12-04