Incidental Mutation 'R0315:Or6c209'
ID 25411
Institutional Source Beutler Lab
Gene Symbol Or6c209
Ensembl Gene ENSMUSG00000094734
Gene Name olfactory receptor family 6 subfamily C member 209
Synonyms GA_x6K02T2PULF-11325750-11326685, MOR114-2, Olfr799
MMRRC Submission 038525-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R0315 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129482999-129483934 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129483366 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 123 (I123N)
Ref Sequence ENSEMBL: ENSMUSP00000150406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071126] [ENSMUST00000213820] [ENSMUST00000214182] [ENSMUST00000216446] [ENSMUST00000217364]
AlphaFold Q8VGI7
Predicted Effect probably damaging
Transcript: ENSMUST00000071126
AA Change: I123N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071126
Gene: ENSMUSG00000094734
AA Change: I123N

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 6e-46 PFAM
Pfam:7TM_GPCR_Srsx 32 302 6e-7 PFAM
Pfam:7tm_1 38 287 7.7e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213820
AA Change: I123N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214182
AA Change: I123N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216446
AA Change: I123N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217364
AA Change: I123N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.2310 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.9%
  • 20x: 88.9%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 G A 17: 45,826,378 (GRCm39) R409Q possibly damaging Het
Ank3 A T 10: 69,838,347 (GRCm39) Q825L probably damaging Het
Ap1g1 A G 8: 110,545,667 (GRCm39) I107V probably benign Het
Bub1b A T 2: 118,457,457 (GRCm39) probably benign Het
Cd86 C T 16: 36,441,306 (GRCm39) V54I possibly damaging Het
Dpys T G 15: 39,720,734 (GRCm39) I9L probably benign Het
Fbxl17 G A 17: 63,663,846 (GRCm39) R67C probably damaging Het
Flg2 G T 3: 93,122,029 (GRCm39) G1400C unknown Het
Gm28042 T C 2: 119,869,538 (GRCm39) L634P probably damaging Het
Gm6712 G A 17: 17,536,380 (GRCm39) noncoding transcript Het
Gpbp1 T G 13: 111,573,072 (GRCm39) E360A possibly damaging Het
Hmgn1 A C 16: 95,926,017 (GRCm39) I52R probably benign Het
Ing2 A C 8: 48,122,125 (GRCm39) M141R probably benign Het
Klhl2 A T 8: 65,196,053 (GRCm39) Y563* probably null Het
Lrrc9 A G 12: 72,502,802 (GRCm39) T258A probably damaging Het
Map1b A T 13: 99,567,624 (GRCm39) I1699N unknown Het
Map2k5 A T 9: 63,210,433 (GRCm39) H185Q probably damaging Het
Mpv17l A T 16: 13,758,863 (GRCm39) I96L probably benign Het
Mroh1 C T 15: 76,311,800 (GRCm39) A511V possibly damaging Het
Nop53 T C 7: 15,679,235 (GRCm39) D90G probably damaging Het
Or10k2 T C 8: 84,268,001 (GRCm39) V76A possibly damaging Het
Or5b97 A T 19: 12,878,598 (GRCm39) V182D possibly damaging Het
Or5w20 A T 2: 87,727,410 (GRCm39) Y289F probably damaging Het
Pkd2 T A 5: 104,607,716 (GRCm39) S72T possibly damaging Het
Prc1 T C 7: 79,963,284 (GRCm39) S587P probably damaging Het
Rdh7 G T 10: 127,724,265 (GRCm39) T73K possibly damaging Het
Runx1 T C 16: 92,402,655 (GRCm39) N429S probably damaging Het
Skint7 G A 4: 111,845,315 (GRCm39) A376T possibly damaging Het
Slc16a14 T C 1: 84,890,217 (GRCm39) I363V possibly damaging Het
Smarcal1 C T 1: 72,634,970 (GRCm39) Q350* probably null Het
Soat1 T A 1: 156,268,083 (GRCm39) K275* probably null Het
Speg T C 1: 75,391,780 (GRCm39) V1571A possibly damaging Het
Stat5b G C 11: 100,679,286 (GRCm39) D605E probably benign Het
Susd4 G A 1: 182,686,077 (GRCm39) R209H probably benign Het
Tlr1 T G 5: 65,084,271 (GRCm39) D102A probably damaging Het
Tm4sf5 A G 11: 70,401,462 (GRCm39) N154D probably damaging Het
Tmigd3 T A 3: 105,824,085 (GRCm39) M18K probably damaging Het
Ube2h A T 6: 30,241,412 (GRCm39) V86E probably damaging Het
Utp20 A G 10: 88,643,283 (GRCm39) L613P probably damaging Het
Vmn2r117 G A 17: 23,679,139 (GRCm39) S695L probably benign Het
Washc5 T C 15: 59,213,825 (GRCm39) D427G probably damaging Het
Zfp462 T A 4: 55,079,314 (GRCm39) F2403I probably damaging Het
Other mutations in Or6c209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Or6c209 APN 10 129,483,306 (GRCm39) missense probably benign 0.09
IGL01079:Or6c209 APN 10 129,483,243 (GRCm39) missense possibly damaging 0.79
IGL01095:Or6c209 APN 10 129,483,498 (GRCm39) missense probably benign 0.00
R0080:Or6c209 UTSW 10 129,483,522 (GRCm39) missense probably benign 0.00
R0082:Or6c209 UTSW 10 129,483,522 (GRCm39) missense probably benign 0.00
R0268:Or6c209 UTSW 10 129,483,045 (GRCm39) missense possibly damaging 0.94
R0310:Or6c209 UTSW 10 129,483,600 (GRCm39) missense probably damaging 1.00
R0545:Or6c209 UTSW 10 129,483,218 (GRCm39) missense probably damaging 1.00
R1257:Or6c209 UTSW 10 129,483,413 (GRCm39) nonsense probably null
R2355:Or6c209 UTSW 10 129,483,711 (GRCm39) missense probably benign 0.02
R4905:Or6c209 UTSW 10 129,483,792 (GRCm39) missense possibly damaging 0.88
R5706:Or6c209 UTSW 10 129,483,960 (GRCm39) splice site probably null
R5961:Or6c209 UTSW 10 129,483,723 (GRCm39) missense possibly damaging 0.58
R6233:Or6c209 UTSW 10 129,483,165 (GRCm39) missense probably benign 0.01
R6843:Or6c209 UTSW 10 129,483,048 (GRCm39) missense possibly damaging 0.86
R7426:Or6c209 UTSW 10 129,483,027 (GRCm39) missense probably damaging 1.00
R7507:Or6c209 UTSW 10 129,483,366 (GRCm39) missense probably damaging 1.00
R7871:Or6c209 UTSW 10 129,483,281 (GRCm39) missense probably benign
R8315:Or6c209 UTSW 10 129,483,522 (GRCm39) missense probably benign 0.00
R9153:Or6c209 UTSW 10 129,483,306 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GAGATTGGCACCTGACTCAACTCTG -3'
(R):5'- TGATGATGAATGTCAACACCGCACC -3'

Sequencing Primer
(F):5'- TCTGACAGATGACATTAGGCTGC -3'
(R):5'- TCAACCATGTGTCTGAACAAGAG -3'
Posted On 2013-04-16