Incidental Mutation 'R2843:Zfp84'
| ID |
254387 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp84
|
| Ensembl Gene |
ENSMUSG00000046185 |
| Gene Name |
zinc finger protein 84 |
| Synonyms |
KRAB18, C86188, Zfp69, 2210410P13Rik, 4633401C23Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2843 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
29467977-29479246 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to G
at 29474758 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032802
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032802]
|
| AlphaFold |
Q9D654 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000032802
|
| SMART Domains |
Protein: ENSMUSP00000032802
Gene: ENSMUSG00000046185
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.09e-36 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
1.43e-1 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
1.58e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158514
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 16 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afm |
C |
T |
5: 90,674,324 (GRCm39) |
R279* |
probably null |
Het |
| Arhgef18 |
A |
G |
8: 3,414,634 (GRCm39) |
E4G |
possibly damaging |
Het |
| Fbxw7 |
G |
A |
3: 84,883,527 (GRCm39) |
R486Q |
probably damaging |
Het |
| Fhad1 |
G |
T |
4: 141,632,279 (GRCm39) |
Q1287K |
probably benign |
Het |
| Hmg20b |
G |
C |
10: 81,182,404 (GRCm39) |
R209G |
probably benign |
Het |
| Hydin |
T |
C |
8: 111,245,746 (GRCm39) |
V2153A |
probably benign |
Het |
| Jade1 |
T |
C |
3: 41,559,280 (GRCm39) |
Y454H |
probably damaging |
Het |
| Kcnn3 |
CGCAGCAGCAGCAGCAGCAGCAG |
CGCAGCAGCAGCAGCAGCAG |
3: 89,427,972 (GRCm39) |
|
probably benign |
Het |
| Pdlim2 |
C |
T |
14: 70,403,549 (GRCm39) |
V288I |
probably benign |
Het |
| Pknox2 |
T |
C |
9: 36,805,624 (GRCm39) |
N395S |
probably benign |
Het |
| Ppfia3 |
C |
A |
7: 45,005,852 (GRCm39) |
R348L |
probably damaging |
Het |
| Rad51 |
T |
C |
2: 118,949,114 (GRCm39) |
V38A |
probably benign |
Het |
| Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
| Slc15a4 |
A |
G |
5: 127,681,600 (GRCm39) |
|
probably null |
Het |
| Vmn2r18 |
T |
A |
5: 151,485,749 (GRCm39) |
T582S |
probably damaging |
Het |
| Zbtb8os |
A |
T |
4: 129,235,309 (GRCm39) |
E54D |
probably damaging |
Het |
|
| Other mutations in Zfp84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01768:Zfp84
|
APN |
7 |
29,476,091 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03022:Zfp84
|
APN |
7 |
29,474,759 (GRCm39) |
splice site |
probably benign |
|
|
R0666:Zfp84
|
UTSW |
7 |
29,476,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0781:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
|
R1110:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
|
R1353:Zfp84
|
UTSW |
7 |
29,475,600 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1495:Zfp84
|
UTSW |
7 |
29,476,728 (GRCm39) |
nonsense |
probably null |
|
|
R1496:Zfp84
|
UTSW |
7 |
29,476,039 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1681:Zfp84
|
UTSW |
7 |
29,476,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Zfp84
|
UTSW |
7 |
29,476,768 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1854:Zfp84
|
UTSW |
7 |
29,474,796 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2209:Zfp84
|
UTSW |
7 |
29,476,607 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2844:Zfp84
|
UTSW |
7 |
29,474,758 (GRCm39) |
splice site |
probably null |
|
|
R4691:Zfp84
|
UTSW |
7 |
29,476,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5453:Zfp84
|
UTSW |
7 |
29,475,722 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5474:Zfp84
|
UTSW |
7 |
29,476,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5578:Zfp84
|
UTSW |
7 |
29,474,856 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5646:Zfp84
|
UTSW |
7 |
29,475,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5963:Zfp84
|
UTSW |
7 |
29,476,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6830:Zfp84
|
UTSW |
7 |
29,475,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8129:Zfp84
|
UTSW |
7 |
29,475,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8138:Zfp84
|
UTSW |
7 |
29,474,797 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9180:Zfp84
|
UTSW |
7 |
29,474,873 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9401:Zfp84
|
UTSW |
7 |
29,476,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9489:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9555:Zfp84
|
UTSW |
7 |
29,476,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9605:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
V3553:Zfp84
|
UTSW |
7 |
29,476,672 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1186:Zfp84
|
UTSW |
7 |
29,470,805 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCAAGGTCTCAGGCATACAG -3'
(R):5'- TCCCTAGCCCTTACAGAGAG -3'
Sequencing Primer
(F):5'- CCTCATCAGGCTGGAAATCAAGG -3'
(R):5'- CTAGCCCTTACAGAGAGGTACAG -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation