Incidental Mutation 'R2566:Mroh3'
ID 254434
Institutional Source Beutler Lab
Gene Symbol Mroh3
Ensembl Gene ENSMUSG00000087230
Gene Name maestro heat-like repeat family member 3
Synonyms 2310006M14Rik
MMRRC Submission 040425-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R2566 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 136109390-136140566 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 136125864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 343 (L343R)
Ref Sequence ENSEMBL: ENSMUSP00000148632 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168561] [ENSMUST00000212798]
AlphaFold A0A1D5RM54
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166708
Predicted Effect probably benign
Transcript: ENSMUST00000168561
SMART Domains Protein: ENSMUSP00000130772
Gene: ENSMUSG00000087230

DomainStartEndE-ValueType
SCOP:d1gw5a_ 126 669 2e-7 SMART
low complexity region 677 684 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168561
Predicted Effect probably damaging
Transcript: ENSMUST00000212798
AA Change: L343R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,055,701 (GRCm39) K408E probably damaging Het
2010315B03Rik T A 9: 124,055,783 (GRCm39) K380N probably damaging Het
9230104M06Rik C T 12: 112,964,359 (GRCm39) probably benign Het
Ahi1 T A 10: 20,846,810 (GRCm39) C413* probably null Het
Alms1 T A 6: 85,599,464 (GRCm39) M1430K possibly damaging Het
Ankrd52 G T 10: 128,225,220 (GRCm39) A894S probably benign Het
Arhgap33 C A 7: 30,226,654 (GRCm39) V494L probably damaging Het
Atic G T 1: 71,608,130 (GRCm39) V275F probably damaging Het
Atoh1 T A 6: 64,706,668 (GRCm39) V121E probably damaging Het
Atp5pd T A 11: 115,306,864 (GRCm39) probably null Het
Baiap2l2 A T 15: 79,146,174 (GRCm39) probably null Het
Brca2 A T 5: 150,465,227 (GRCm39) T1664S probably benign Het
Cdh15 G A 8: 123,588,763 (GRCm39) R279Q probably damaging Het
Celf3 ACAGCAGCAGCAGCAGCAGCAGCA ACAGCAGCAGCAGCAGCAGCA 3: 94,395,537 (GRCm39) probably benign Het
Cep350 A T 1: 155,835,464 (GRCm39) probably null Het
Ces2g T C 8: 105,692,621 (GRCm39) probably null Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Cyp2d34 A G 15: 82,500,368 (GRCm39) F457S probably damaging Het
Disp3 T A 4: 148,325,880 (GRCm39) T1293S probably damaging Het
Dock10 T A 1: 80,517,970 (GRCm39) I1348F possibly damaging Het
Dsp A T 13: 38,380,380 (GRCm39) H1776L probably damaging Het
Efhd1 A T 1: 87,237,477 (GRCm39) Q228L possibly damaging Het
Entpd2 T A 2: 25,289,295 (GRCm39) I259N probably benign Het
Fam149b A T 14: 20,425,578 (GRCm39) M138L probably damaging Het
Fastkd5 T C 2: 130,458,285 (GRCm39) K102E probably benign Het
Fzd7 C A 1: 59,523,695 (GRCm39) T526K possibly damaging Het
G6pd2 T A 5: 61,966,330 (GRCm39) I35N probably damaging Het
Gars1 T A 6: 55,042,548 (GRCm39) M427K probably damaging Het
Gimap4 C T 6: 48,667,799 (GRCm39) R57C probably damaging Het
Gm11232 C A 4: 71,676,022 (GRCm39) W41L probably benign Het
Gm15737 T A 6: 92,856,701 (GRCm39) C43* probably null Het
Gpr180 T C 14: 118,377,185 (GRCm39) V62A probably benign Het
H2-M11 C T 17: 36,859,042 (GRCm39) T194I possibly damaging Het
Jakmip3 A T 7: 138,591,197 (GRCm39) E27V possibly damaging Het
Kcnq3 T C 15: 65,903,276 (GRCm39) T145A probably damaging Het
Krt8 A G 15: 101,906,459 (GRCm39) M350T probably benign Het
Krtap4-9 T A 11: 99,676,492 (GRCm39) probably benign Het
Lbr G T 1: 181,663,692 (GRCm39) D109E probably damaging Het
Ldc1 A T 4: 130,103,681 (GRCm39) L420Q probably benign Het
Med23 A G 10: 24,764,473 (GRCm39) H42R probably damaging Het
Mgat5 A T 1: 127,234,741 (GRCm39) M77L probably benign Het
Mlf1 A T 3: 67,291,919 (GRCm39) N28I possibly damaging Het
Mrpl37 T A 4: 106,921,690 (GRCm39) I180F possibly damaging Het
Mrps27 T A 13: 99,536,836 (GRCm39) C116* probably null Het
Muc6 A G 7: 141,226,651 (GRCm39) S1354P possibly damaging Het
Myh7 A T 14: 55,220,699 (GRCm39) D1033E probably damaging Het
Myo16 A T 8: 10,644,820 (GRCm39) E1717D probably benign Het
Myo1g T A 11: 6,462,539 (GRCm39) probably null Het
Or51ag1 A G 7: 103,155,367 (GRCm39) M262T probably benign Het
Or6c217 A C 10: 129,737,964 (GRCm39) L205R probably damaging Het
Pan2 T C 10: 128,149,766 (GRCm39) L576P probably damaging Het
Parp8 A G 13: 117,032,223 (GRCm39) S278P possibly damaging Het
Pdk2 A G 11: 94,918,028 (GRCm39) probably null Het
Phf1 T C 17: 27,156,062 (GRCm39) S450P probably damaging Het
Pkd1l2 T C 8: 117,746,233 (GRCm39) Y1919C probably damaging Het
Postn T A 3: 54,284,374 (GRCm39) S614T probably damaging Het
Psmg1 A T 16: 95,783,395 (GRCm39) Y213* probably null Het
Rab11b T A 17: 33,966,692 (GRCm39) T203S probably benign Het
Rad54l2 T A 9: 106,580,825 (GRCm39) T899S possibly damaging Het
Ramp2 TTGCTGCTGCTGCTGCTGCTGCTG TTGCTGCTGCTGCTGCTGCTG 11: 101,137,371 (GRCm39) probably benign Het
Rapgef6 A G 11: 54,578,537 (GRCm39) T1028A possibly damaging Het
Rbm6 A G 9: 107,669,197 (GRCm39) S58P possibly damaging Het
Rreb1 G T 13: 38,113,768 (GRCm39) A376S possibly damaging Het
Rsbn1l T A 5: 21,124,767 (GRCm39) N345I probably benign Het
Sf3b2 A T 19: 5,325,118 (GRCm39) S785T possibly damaging Het
Sh2b1 C T 7: 126,068,098 (GRCm39) D519N probably damaging Het
Slitrk6 T C 14: 110,987,704 (GRCm39) T668A probably benign Het
Stkld1 T A 2: 26,840,650 (GRCm39) I444N probably damaging Het
Sucla2 A T 14: 73,790,244 (GRCm39) probably benign Het
Tmem67 T A 4: 12,079,918 (GRCm39) L190F probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trem2 G A 17: 48,658,863 (GRCm39) W191* probably null Het
Ube2d4 A T 15: 58,718,528 (GRCm39) noncoding transcript Het
Uimc1 G T 13: 55,223,617 (GRCm39) D218E probably damaging Het
Wdr62 A T 7: 29,973,424 (GRCm39) V95E probably damaging Het
Zfhx4 T C 3: 5,310,203 (GRCm39) V862A probably damaging Het
Zfp462 T A 4: 55,008,522 (GRCm39) S163T probably benign Het
Zfp704 T C 3: 9,674,553 (GRCm39) D76G unknown Het
Other mutations in Mroh3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0087:Mroh3 UTSW 1 136,118,541 (GRCm39) missense probably benign 0.00
R0507:Mroh3 UTSW 1 136,118,718 (GRCm39) missense probably damaging 1.00
R0638:Mroh3 UTSW 1 136,118,740 (GRCm39) missense probably damaging 1.00
R0742:Mroh3 UTSW 1 136,118,718 (GRCm39) missense probably damaging 1.00
R1728:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1729:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1730:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1739:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1762:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1783:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1784:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1785:Mroh3 UTSW 1 136,119,882 (GRCm39) missense possibly damaging 0.80
R1862:Mroh3 UTSW 1 136,113,726 (GRCm39) missense probably benign 0.01
R1883:Mroh3 UTSW 1 136,134,731 (GRCm39) missense probably damaging 1.00
R2166:Mroh3 UTSW 1 136,113,791 (GRCm39) missense probably benign 0.03
R3713:Mroh3 UTSW 1 136,113,714 (GRCm39) missense probably benign 0.01
R3788:Mroh3 UTSW 1 136,113,213 (GRCm39) missense probably damaging 1.00
R4672:Mroh3 UTSW 1 136,118,713 (GRCm39) missense probably benign 0.09
R4747:Mroh3 UTSW 1 136,113,237 (GRCm39) missense probably benign 0.00
R4855:Mroh3 UTSW 1 136,128,677 (GRCm39) critical splice donor site probably null
R5171:Mroh3 UTSW 1 136,119,394 (GRCm39) missense possibly damaging 0.82
R5296:Mroh3 UTSW 1 136,124,061 (GRCm39) missense probably damaging 0.98
R5869:Mroh3 UTSW 1 136,113,861 (GRCm39) missense probably benign
R6347:Mroh3 UTSW 1 136,128,675 (GRCm39) splice site probably null
R6531:Mroh3 UTSW 1 136,112,091 (GRCm39) missense probably benign 0.01
R6675:Mroh3 UTSW 1 136,118,550 (GRCm39) missense possibly damaging 0.65
R7015:Mroh3 UTSW 1 136,111,069 (GRCm39) missense probably damaging 1.00
R7587:Mroh3 UTSW 1 136,118,736 (GRCm39) missense probably benign 0.09
R7657:Mroh3 UTSW 1 136,109,532 (GRCm39) missense possibly damaging 0.92
R9007:Mroh3 UTSW 1 136,128,110 (GRCm39) missense probably damaging 1.00
R9059:Mroh3 UTSW 1 136,109,533 (GRCm39) missense probably benign 0.26
R9219:Mroh3 UTSW 1 136,119,377 (GRCm39) missense probably benign 0.00
R9612:Mroh3 UTSW 1 136,118,713 (GRCm39) missense probably benign 0.01
R9698:Mroh3 UTSW 1 136,114,452 (GRCm39) missense probably damaging 0.98
Z1177:Mroh3 UTSW 1 136,119,874 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- CTTCATTCTTCTCCACAGAAATAGC -3'
(R):5'- AGATGCCAGATGCTTTGGGG -3'

Sequencing Primer
(F):5'- GCTTTTGCACTATTCTGAAAACAGC -3'
(R):5'- GGGGCAGTCCTCACGTG -3'
Posted On 2014-12-04