Incidental Mutation 'R2913:Mapk4'
ID 254779
Institutional Source Beutler Lab
Gene Symbol Mapk4
Ensembl Gene ENSMUSG00000024558
Gene Name mitogen-activated protein kinase 4
Synonyms p63Mapk, A330097D03Rik, Erk3-related
MMRRC Submission 040500-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2913 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 74061557-74198430 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 74068236 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 232 (A232T)
Ref Sequence ENSEMBL: ENSMUSP00000089462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091851] [ENSMUST00000159162] [ENSMUST00000162863]
AlphaFold Q6P5G0
Predicted Effect probably benign
Transcript: ENSMUST00000091851
AA Change: A232T

PolyPhen 2 Score 0.343 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000089462
Gene: ENSMUSG00000024558
AA Change: A232T

DomainStartEndE-ValueType
S_TKc 20 312 3.81e-79 SMART
low complexity region 462 478 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159162
SMART Domains Protein: ENSMUSP00000123922
Gene: ENSMUSG00000024558

DomainStartEndE-ValueType
Pfam:Pkinase 20 232 2.3e-58 PFAM
Pfam:Pkinase_Tyr 22 232 5.5e-30 PFAM
Predicted Effect silent
Transcript: ENSMUST00000162863
SMART Domains Protein: ENSMUSP00000124408
Gene: ENSMUSG00000024558

DomainStartEndE-ValueType
Pfam:Pkinase 20 192 1.7e-41 PFAM
Pfam:Pkinase_Tyr 22 189 5.9e-25 PFAM
Meta Mutation Damage Score 0.0794 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viabel and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 T C 16: 30,934,887 (GRCm39) Q357R probably damaging Het
Adap1 C T 5: 139,260,576 (GRCm39) probably null Het
Adgrf3 A G 5: 30,401,992 (GRCm39) S679P probably damaging Het
Aldh3b1 T C 19: 3,971,275 (GRCm39) probably benign Het
Arih2 A G 9: 108,521,275 (GRCm39) S68P probably damaging Het
Cdcp3 T C 7: 130,783,753 (GRCm39) S49P possibly damaging Het
Col1a2 C T 6: 4,519,923 (GRCm39) probably benign Het
Cplane1 T C 15: 8,300,169 (GRCm39) S3159P unknown Het
Crocc C T 4: 140,747,661 (GRCm39) R1496H probably damaging Het
Cryl1 T C 14: 57,513,375 (GRCm39) E282G probably benign Het
Cyp11b1 T C 15: 74,708,270 (GRCm39) T402A probably damaging Het
Etfa C A 9: 55,389,613 (GRCm39) A254S probably damaging Het
Fcgbpl1 A T 7: 27,863,732 (GRCm39) L2501F probably damaging Het
Fdxacb1 C T 9: 50,679,699 (GRCm39) A39V probably benign Het
Fras1 G A 5: 96,881,774 (GRCm39) R2502K probably benign Het
Gpr157 G A 4: 150,183,222 (GRCm39) V131I probably benign Het
Hbb-bh1 C T 7: 103,492,254 (GRCm39) E22K possibly damaging Het
Hmcn2 A G 2: 31,350,222 (GRCm39) T5040A possibly damaging Het
Hprt1 T C X: 52,109,016 (GRCm39) Y174H probably damaging Het
Igsf10 T A 3: 59,239,157 (GRCm39) L341F possibly damaging Het
Ints1 A G 5: 139,743,668 (GRCm39) S1592P possibly damaging Het
Itgam T C 7: 127,711,578 (GRCm39) I641T probably damaging Het
Macf1 T A 4: 123,369,704 (GRCm39) I121F probably damaging Het
Mapk3 T A 7: 126,359,978 (GRCm39) C19* probably null Het
Med26 T G 8: 73,249,956 (GRCm39) K381T possibly damaging Het
Mki67 T C 7: 135,302,415 (GRCm39) E873G possibly damaging Het
Mrgpra9 T C 7: 46,884,828 (GRCm39) I280V probably benign Het
Mroh9 T C 1: 162,871,572 (GRCm39) Y637C probably damaging Het
Nktr T C 9: 121,578,670 (GRCm39) probably benign Het
Or4c11 A T 2: 88,695,458 (GRCm39) N170Y probably benign Het
Or5j3 A G 2: 86,128,733 (GRCm39) D191G probably damaging Het
Pam A C 1: 97,850,854 (GRCm39) L168R probably damaging Het
Pikfyve G A 1: 65,292,676 (GRCm39) V1376M probably damaging Het
Pomt2 A T 12: 87,175,743 (GRCm39) N400K probably damaging Het
Pramel13 T C 4: 144,119,304 (GRCm39) E421G probably damaging Het
Rbm45 C T 2: 76,205,798 (GRCm39) P217S probably benign Het
Rc3h2 A G 2: 37,268,971 (GRCm39) S832P possibly damaging Het
Ric3 A G 7: 108,653,660 (GRCm39) F144L possibly damaging Het
Rrh G T 3: 129,609,258 (GRCm39) A83E probably damaging Het
Rspo2 T A 15: 42,941,510 (GRCm39) T138S probably benign Het
Skint5 A G 4: 113,381,289 (GRCm39) probably benign Het
Snx29 C T 16: 11,265,317 (GRCm39) R516W probably damaging Het
Spata31d1d T C 13: 59,874,769 (GRCm39) E922G possibly damaging Het
Spc25 T C 2: 69,030,331 (GRCm39) H104R probably benign Het
Sptssa A T 12: 54,703,267 (GRCm39) M1K probably null Het
Srrm2 G T 17: 24,034,658 (GRCm39) probably benign Het
Tcof1 T C 18: 60,949,156 (GRCm39) D1253G possibly damaging Het
Tmem181c-ps A G 17: 6,888,608 (GRCm39) noncoding transcript Het
Tmprss15 T C 16: 78,759,078 (GRCm39) N880S probably benign Het
Trio T A 15: 27,854,998 (GRCm39) Q728L probably damaging Het
Txk T C 5: 72,881,794 (GRCm39) N154S probably damaging Het
Vwf T A 6: 125,662,809 (GRCm39) V2731E probably benign Het
Yes1 T C 5: 32,797,926 (GRCm39) S82P probably benign Het
Zgrf1 T C 3: 127,392,356 (GRCm39) V1292A possibly damaging Het
Other mutations in Mapk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02396:Mapk4 APN 18 74,067,068 (GRCm39) splice site probably null
IGL02621:Mapk4 APN 18 74,103,346 (GRCm39) missense probably damaging 1.00
IGL03068:Mapk4 APN 18 74,103,415 (GRCm39) missense probably damaging 1.00
R0041:Mapk4 UTSW 18 74,068,109 (GRCm39) missense probably damaging 1.00
R0519:Mapk4 UTSW 18 74,103,392 (GRCm39) missense probably damaging 1.00
R0636:Mapk4 UTSW 18 74,063,525 (GRCm39) missense probably benign
R0918:Mapk4 UTSW 18 74,103,408 (GRCm39) missense probably damaging 1.00
R1654:Mapk4 UTSW 18 74,064,010 (GRCm39) missense probably damaging 1.00
R2914:Mapk4 UTSW 18 74,068,236 (GRCm39) missense probably benign 0.34
R4089:Mapk4 UTSW 18 74,063,530 (GRCm39) missense probably damaging 1.00
R4414:Mapk4 UTSW 18 74,063,609 (GRCm39) missense possibly damaging 0.76
R4487:Mapk4 UTSW 18 74,064,046 (GRCm39) missense probably damaging 1.00
R4792:Mapk4 UTSW 18 74,070,321 (GRCm39) missense probably damaging 0.98
R5445:Mapk4 UTSW 18 74,064,073 (GRCm39) missense probably benign 0.00
R5597:Mapk4 UTSW 18 74,070,341 (GRCm39) missense probably benign 0.12
R5654:Mapk4 UTSW 18 74,103,365 (GRCm39) missense probably damaging 1.00
R6700:Mapk4 UTSW 18 74,063,882 (GRCm39) missense probably damaging 1.00
R6793:Mapk4 UTSW 18 74,063,539 (GRCm39) missense probably damaging 1.00
R7200:Mapk4 UTSW 18 74,063,990 (GRCm39) missense possibly damaging 0.92
R7335:Mapk4 UTSW 18 74,070,338 (GRCm39) missense possibly damaging 0.75
R8010:Mapk4 UTSW 18 74,063,647 (GRCm39) missense probably benign 0.04
R8269:Mapk4 UTSW 18 74,063,622 (GRCm39) missense probably damaging 0.99
R8736:Mapk4 UTSW 18 74,103,396 (GRCm39) missense probably benign 0.01
Z1176:Mapk4 UTSW 18 74,070,255 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTGCCTGACATTAAAGCCAG -3'
(R):5'- CCCAGAAGCAAATCAGTGGTG -3'

Sequencing Primer
(F):5'- TGACATTAAAGCCAGAGCCCAG -3'
(R):5'- TGGAGTGAATATTAGACCCCCAGTC -3'
Posted On 2014-12-29