Incidental Mutation 'R0318:Or5ak25'
ID 25483
Institutional Source Beutler Lab
Gene Symbol Or5ak25
Ensembl Gene ENSMUSG00000075218
Gene Name olfactory receptor family 5 subfamily AK member 25
Synonyms MOR203-3, GA_x6K02T2Q125-46915844-46914897, Olfr995
MMRRC Submission 038528-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # R0318 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85268553-85269500 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 85268581 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Methionine at position 307 (R307M)
Ref Sequence ENSEMBL: ENSMUSP00000149952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099924] [ENSMUST00000214679] [ENSMUST00000216933] [ENSMUST00000217218]
AlphaFold Q8VF74
Predicted Effect possibly damaging
Transcript: ENSMUST00000099924
AA Change: R307M

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097508
Gene: ENSMUSG00000075218
AA Change: R307M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-50 PFAM
Pfam:7tm_1 41 290 2.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214679
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215758
Predicted Effect possibly damaging
Transcript: ENSMUST00000216933
AA Change: R307M

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000217218
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.4%
  • 20x: 86.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik A T 15: 57,892,370 (GRCm39) L79Q probably damaging Het
Add1 T C 5: 34,782,684 (GRCm39) V130A probably damaging Het
Ankrd23 G T 1: 36,573,153 (GRCm39) T73K probably benign Het
Blk A G 14: 63,611,646 (GRCm39) Y430H probably damaging Het
C3 C T 17: 57,531,709 (GRCm39) V272M probably damaging Het
Cerk C T 15: 86,035,766 (GRCm39) A254T possibly damaging Het
Ces2a G A 8: 105,467,456 (GRCm39) A494T probably damaging Het
Cfap46 T C 7: 139,234,482 (GRCm39) Y258C probably damaging Het
Chaf1a C T 17: 56,369,227 (GRCm39) T486I possibly damaging Het
Colec12 A G 18: 9,848,446 (GRCm39) N208S possibly damaging Het
Coro7 T A 16: 4,493,671 (GRCm39) H63L probably benign Het
Cps1 T A 1: 67,216,173 (GRCm39) W833R probably damaging Het
Csmd3 A T 15: 47,522,549 (GRCm39) W2707R probably damaging Het
Dbn1 C T 13: 55,622,729 (GRCm39) E585K probably damaging Het
Ddx50 A T 10: 62,478,616 (GRCm39) I190K probably damaging Het
Dnmt3l G A 10: 77,890,889 (GRCm39) V264M probably damaging Het
Dnpep A G 1: 75,293,270 (GRCm39) V33A probably damaging Het
Fam163a A G 1: 155,955,715 (GRCm39) C26R probably damaging Het
Fam83h A G 15: 75,875,478 (GRCm39) S620P probably benign Het
Fcna A G 2: 25,515,071 (GRCm39) S263P probably benign Het
Fnip2 A T 3: 79,419,685 (GRCm39) S165R probably damaging Het
Fpr-rs3 T C 17: 20,844,410 (GRCm39) T244A probably benign Het
Gpr152 T C 19: 4,193,541 (GRCm39) S361P possibly damaging Het
Grm5 A T 7: 87,252,175 (GRCm39) I142L probably damaging Het
Gucy2g A G 19: 55,226,230 (GRCm39) S229P probably benign Het
Htr7 C T 19: 35,946,886 (GRCm39) G376D probably damaging Het
Irgc T C 7: 24,131,896 (GRCm39) D307G probably benign Het
Irs1 A T 1: 82,266,381 (GRCm39) S612T probably benign Het
Maml2 C T 9: 13,531,890 (GRCm39) T368I probably damaging Het
Mapkapk2 A G 1: 131,025,072 (GRCm39) V64A probably damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Nptx1 C T 11: 119,433,367 (GRCm39) E411K probably damaging Het
Or2z8 C T 8: 72,812,244 (GRCm39) T240M probably damaging Het
Pcgf5 A T 19: 36,389,590 (GRCm39) K22N possibly damaging Het
Psmd9 C A 5: 123,372,712 (GRCm39) A65E possibly damaging Het
Sh3bp1 A G 15: 78,795,907 (GRCm39) T679A probably damaging Het
Sipa1l2 G A 8: 126,174,436 (GRCm39) P1281S possibly damaging Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
Slc25a24 A G 3: 109,064,316 (GRCm39) M222V probably benign Het
Smg9 T C 7: 24,120,313 (GRCm39) F429S possibly damaging Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Sorl1 T A 9: 41,993,250 (GRCm39) Y258F probably damaging Het
Srp72 C T 5: 77,132,047 (GRCm39) T242I probably benign Het
Stc1 A T 14: 69,275,867 (GRCm39) Q220L probably damaging Het
Tas2r122 T C 6: 132,688,795 (GRCm39) T33A possibly damaging Het
Tbc1d10b A G 7: 126,798,206 (GRCm39) L645P probably damaging Het
Thoc2l T C 5: 104,665,619 (GRCm39) F47S probably benign Het
Timd4 T A 11: 46,727,898 (GRCm39) H272Q probably benign Het
Ttll5 T G 12: 85,923,368 (GRCm39) probably null Het
Veph1 G T 3: 65,964,680 (GRCm39) S783Y probably damaging Het
Vmn1r230 T C 17: 21,067,078 (GRCm39) L89S possibly damaging Het
Xcr1 A G 9: 123,685,219 (GRCm39) V165A possibly damaging Het
Zfp286 T C 11: 62,675,788 (GRCm39) D58G probably damaging Het
Zfyve26 C T 12: 79,323,055 (GRCm39) R897H probably damaging Het
Other mutations in Or5ak25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02102:Or5ak25 APN 2 85,268,611 (GRCm39) missense probably damaging 1.00
IGL02540:Or5ak25 APN 2 85,269,259 (GRCm39) missense probably benign 0.05
IGL02687:Or5ak25 APN 2 85,268,930 (GRCm39) missense possibly damaging 0.93
IGL02713:Or5ak25 APN 2 85,268,981 (GRCm39) missense probably damaging 0.99
R0463:Or5ak25 UTSW 2 85,268,630 (GRCm39) missense probably damaging 1.00
R0638:Or5ak25 UTSW 2 85,268,845 (GRCm39) missense probably benign 0.03
R1668:Or5ak25 UTSW 2 85,269,220 (GRCm39) missense probably benign 0.00
R1718:Or5ak25 UTSW 2 85,269,149 (GRCm39) missense probably benign 0.39
R4981:Or5ak25 UTSW 2 85,268,813 (GRCm39) missense probably damaging 1.00
R5261:Or5ak25 UTSW 2 85,269,241 (GRCm39) missense probably benign
R7036:Or5ak25 UTSW 2 85,268,774 (GRCm39) missense probably damaging 1.00
R7899:Or5ak25 UTSW 2 85,268,741 (GRCm39) missense probably benign 0.39
R8209:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8226:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8803:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R9037:Or5ak25 UTSW 2 85,269,139 (GRCm39) missense possibly damaging 0.88
R9541:Or5ak25 UTSW 2 85,269,025 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- TCCATGTACCCCTCAGTGAATTTCTGTA -3'
(R):5'- CCACCTGACAGCAGTCACCATCTT -3'

Sequencing Primer
(F):5'- actccaccttctatcagcattc -3'
(R):5'- GACAGCAGTCACCATCTTCTATG -3'
Posted On 2013-04-16