Incidental Mutation 'R2937:Mmp25'
ID 255101
Institutional Source Beutler Lab
Gene Symbol Mmp25
Ensembl Gene ENSMUSG00000023903
Gene Name matrix metallopeptidase 25
Synonyms MT6-MMP, Leukolysin, F730048C11Rik
MMRRC Submission 040514-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R2937 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 23847289-23864243 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 23863765 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 22 (I22F)
Ref Sequence ENSEMBL: ENSMUSP00000024696 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024696]
AlphaFold Q3U435
Predicted Effect probably benign
Transcript: ENSMUST00000024696
AA Change: I22F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000024696
Gene: ENSMUSG00000023903
AA Change: I22F

DomainStartEndE-ValueType
low complexity region 54 75 N/A INTRINSIC
Pfam:PG_binding_1 82 140 8.8e-12 PFAM
ZnMc 166 335 1.68e-47 SMART
low complexity region 343 369 N/A INTRINSIC
HX 375 419 6.35e-8 SMART
HX 424 466 1.62e-5 SMART
HX 470 516 1.64e-10 SMART
HX 518 562 2.79e-4 SMART
low complexity region 572 581 N/A INTRINSIC
low complexity region 597 607 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (73/73)
MGI Phenotype FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm1 A G 7: 119,258,350 (GRCm39) E481G probably damaging Het
Anks1b C T 10: 89,912,928 (GRCm39) T351M probably damaging Het
Arhgap45 T A 10: 79,864,836 (GRCm39) M933K probably damaging Het
Asph A C 4: 9,542,314 (GRCm39) probably benign Het
Bace2 T C 16: 97,213,388 (GRCm39) probably null Het
Cacna1b A G 2: 24,496,540 (GRCm39) V125A probably benign Het
Cbarp T C 10: 79,967,603 (GRCm39) D539G probably damaging Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Cdh15 G A 8: 123,588,763 (GRCm39) R279Q probably damaging Het
Cdr1 T G X: 60,228,968 (GRCm39) D66A unknown Het
Cela3b A G 4: 137,150,574 (GRCm39) I208T probably benign Het
Cfap91 A T 16: 38,131,400 (GRCm39) I471N possibly damaging Het
Clca3a2 T A 3: 144,519,679 (GRCm39) T232S probably benign Het
Col1a2 G A 6: 4,519,882 (GRCm39) probably benign Het
Col1a2 A T 6: 4,520,788 (GRCm39) Q375L possibly damaging Het
Cpd T C 11: 76,702,685 (GRCm39) N561S probably damaging Het
Csn1s1 A T 5: 87,824,995 (GRCm39) Q221L possibly damaging Het
Depdc5 G A 5: 33,058,965 (GRCm39) probably null Het
Dnah10 T C 5: 124,896,476 (GRCm39) probably null Het
Dsg2 T C 18: 20,712,185 (GRCm39) F107S probably damaging Het
Dthd1 A G 5: 63,000,300 (GRCm39) I541V probably benign Het
Eml6 G A 11: 29,783,049 (GRCm39) probably benign Het
Fermt2 A C 14: 45,741,948 (GRCm39) probably null Het
Gimap8 A T 6: 48,635,730 (GRCm39) R498S possibly damaging Het
Glis1 A G 4: 107,489,488 (GRCm39) N692D possibly damaging Het
Grtp1 G A 8: 13,239,755 (GRCm39) probably benign Het
Hecw1 G T 13: 14,420,421 (GRCm39) Q1001K possibly damaging Het
Hydin T C 8: 111,130,927 (GRCm39) V606A possibly damaging Het
Krt33b T A 11: 99,914,835 (GRCm39) N388I probably benign Het
Lipf T C 19: 33,950,438 (GRCm39) Y277H probably damaging Het
Lmod1 A G 1: 135,291,654 (GRCm39) K170E probably benign Het
Lrrtm1 A T 6: 77,220,635 (GRCm39) M31L probably benign Het
Man1c1 A G 4: 134,430,263 (GRCm39) I173T possibly damaging Het
Med17 T C 9: 15,187,187 (GRCm39) K196E probably damaging Het
Nrg3 T A 14: 38,092,965 (GRCm39) N540I possibly damaging Het
Nsun5 C T 5: 135,404,317 (GRCm39) Q375* probably null Het
Or52ad1 T C 7: 102,995,272 (GRCm39) M288V probably benign Het
Or52r1c T A 7: 102,735,548 (GRCm39) H269Q probably benign Het
Pcdh1 G T 18: 38,322,815 (GRCm39) A1006E probably benign Het
Pdss1 T A 2: 22,796,799 (GRCm39) probably null Het
Plaa G A 4: 94,457,696 (GRCm39) A758V probably damaging Het
Prl6a1 T A 13: 27,499,303 (GRCm39) W24R probably damaging Het
Ptk7 T C 17: 46,883,476 (GRCm39) H863R probably damaging Het
Rbm10 T C X: 20,513,934 (GRCm39) L429P possibly damaging Het
Rhou T C 8: 124,387,880 (GRCm39) I204T possibly damaging Het
Serpind1 G T 16: 17,154,972 (GRCm39) M266I probably benign Het
Sgcg A T 14: 61,467,074 (GRCm39) F175L probably damaging Het
Slc2a2 T G 3: 28,772,920 (GRCm39) C238G probably damaging Het
Slc39a8 A G 3: 135,592,584 (GRCm39) M420V probably benign Het
Slc7a9 C A 7: 35,163,167 (GRCm39) Y457* probably null Het
Smpd3 C T 8: 106,991,452 (GRCm39) R367H probably damaging Het
Sntb2 T C 8: 107,662,729 (GRCm39) V99A probably benign Het
Specc1l T G 10: 75,094,965 (GRCm39) I796R probably damaging Het
Stfa2l1 G T 16: 35,980,316 (GRCm39) V29F probably damaging Het
Synrg T C 11: 83,885,180 (GRCm39) F455S probably damaging Het
Tap2 T C 17: 34,431,328 (GRCm39) V422A possibly damaging Het
Tcf7 A T 11: 52,173,610 (GRCm39) probably null Het
Tcp10a A G 17: 7,597,173 (GRCm39) Y110C probably damaging Het
Thoc1 T A 18: 9,959,255 (GRCm39) S43R probably damaging Het
Tlr1 A G 5: 65,083,251 (GRCm39) V442A probably damaging Het
Tmub1 A G 5: 24,650,922 (GRCm39) *261Q probably null Het
Trpc3 G A 3: 36,688,532 (GRCm39) R836* probably null Het
Tsbp1 A T 17: 34,640,836 (GRCm39) H57L possibly damaging Het
Ube2u T C 4: 100,381,495 (GRCm39) S185P possibly damaging Het
Vamp5 A G 6: 72,346,323 (GRCm39) V91A probably benign Het
Vcp A G 4: 42,980,846 (GRCm39) Y755H probably damaging Het
Vmn1r35 A T 6: 66,655,950 (GRCm39) M73K possibly damaging Het
Vmn2r12 C T 5: 109,239,397 (GRCm39) E389K probably damaging Het
Wdfy3 A T 5: 102,091,988 (GRCm39) F450L probably benign Het
Xpo4 G T 14: 57,841,897 (GRCm39) Q473K probably benign Het
Xpo7 A G 14: 70,909,130 (GRCm39) I797T probably damaging Het
Xylt1 C A 7: 117,234,011 (GRCm39) Q513K probably benign Het
Zfp229 T C 17: 21,964,484 (GRCm39) F238S probably damaging Het
Other mutations in Mmp25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02814:Mmp25 APN 17 23,858,736 (GRCm39) missense probably damaging 1.00
IGL02893:Mmp25 APN 17 23,863,025 (GRCm39) missense probably damaging 1.00
R0471:Mmp25 UTSW 17 23,858,858 (GRCm39) missense possibly damaging 0.73
R0478:Mmp25 UTSW 17 23,851,756 (GRCm39) missense probably benign 0.08
R1829:Mmp25 UTSW 17 23,858,997 (GRCm39) missense probably benign 0.00
R2005:Mmp25 UTSW 17 23,859,216 (GRCm39) missense probably damaging 1.00
R2151:Mmp25 UTSW 17 23,850,048 (GRCm39) missense probably damaging 1.00
R2153:Mmp25 UTSW 17 23,850,048 (GRCm39) missense probably damaging 1.00
R2154:Mmp25 UTSW 17 23,850,048 (GRCm39) missense probably damaging 1.00
R4418:Mmp25 UTSW 17 23,863,044 (GRCm39) missense probably damaging 1.00
R4667:Mmp25 UTSW 17 23,863,581 (GRCm39) missense probably benign 0.00
R4905:Mmp25 UTSW 17 23,863,022 (GRCm39) nonsense probably null
R5535:Mmp25 UTSW 17 23,863,734 (GRCm39) missense probably benign
R5592:Mmp25 UTSW 17 23,859,176 (GRCm39) missense possibly damaging 0.95
R5888:Mmp25 UTSW 17 23,850,048 (GRCm39) missense probably damaging 1.00
R6261:Mmp25 UTSW 17 23,849,768 (GRCm39) missense possibly damaging 0.61
R6263:Mmp25 UTSW 17 23,849,768 (GRCm39) missense possibly damaging 0.61
R6264:Mmp25 UTSW 17 23,849,768 (GRCm39) missense possibly damaging 0.61
R6571:Mmp25 UTSW 17 23,858,870 (GRCm39) missense probably benign 0.17
R7172:Mmp25 UTSW 17 23,863,762 (GRCm39) missense probably benign
R7467:Mmp25 UTSW 17 23,863,756 (GRCm39) missense possibly damaging 0.53
R8109:Mmp25 UTSW 17 23,863,768 (GRCm39) missense probably benign 0.00
R9300:Mmp25 UTSW 17 23,851,728 (GRCm39) missense probably benign 0.05
R9734:Mmp25 UTSW 17 23,850,834 (GRCm39) missense possibly damaging 0.94
T0722:Mmp25 UTSW 17 23,850,192 (GRCm39) missense possibly damaging 0.94
Z1176:Mmp25 UTSW 17 23,849,633 (GRCm39) missense probably damaging 1.00
Z1177:Mmp25 UTSW 17 23,863,111 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- ACCTTCGCATCGGGATTCTG -3'
(R):5'- AGCATATTGGGCAGTTGGCG -3'

Sequencing Primer
(F):5'- CATCGGGATTCTGAGCGC -3'
(R):5'- GCTGGACCTGGAGGAGAC -3'
Posted On 2014-12-29