Incidental Mutation 'R2975:Cdca3'
ID 255343
Institutional Source Beutler Lab
Gene Symbol Cdca3
Ensembl Gene ENSMUSG00000023505
Gene Name cell division cycle associated 3
Synonyms TOME-1, Grcc8, 2410005A12Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.434) question?
Stock # R2975 (G1)
Quality Score 143
Status Not validated
Chromosome 6
Chromosomal Location 124806533-124810664 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to T at 124807616 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024206] [ENSMUST00000024270] [ENSMUST00000047510] [ENSMUST00000122110] [ENSMUST00000131847] [ENSMUST00000131847] [ENSMUST00000150120] [ENSMUST00000150120] [ENSMUST00000151674] [ENSMUST00000151674] [ENSMUST00000153306] [ENSMUST00000142058]
AlphaFold Q99M54
Predicted Effect probably benign
Transcript: ENSMUST00000024206
SMART Domains Protein: ENSMUSP00000024206
Gene: ENSMUSG00000023439

DomainStartEndE-ValueType
WD40 44 83 4.91e-8 SMART
WD40 86 125 1.61e-3 SMART
WD40 132 170 5.1e-6 SMART
WD40 173 212 3.99e-8 SMART
WD40 215 254 2.67e-9 SMART
WD40 263 298 2e-1 SMART
WD40 301 340 3.87e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000024270
Predicted Effect probably benign
Transcript: ENSMUST00000047510
SMART Domains Protein: ENSMUSP00000041299
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-19 BLAST
ZnF_UBP 198 253 6.47e-27 SMART
low complexity region 497 516 N/A INTRINSIC
UBA 656 694 3.12e-7 SMART
UBA 724 761 8.63e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000122110
SMART Domains Protein: ENSMUSP00000114000
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-19 BLAST
ZnF_UBP 198 253 6.47e-27 SMART
low complexity region 497 516 N/A INTRINSIC
UBA 633 671 3.12e-7 SMART
UBA 701 738 8.63e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129251
Predicted Effect probably null
Transcript: ENSMUST00000131847
Predicted Effect probably null
Transcript: ENSMUST00000131847
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134637
Predicted Effect probably null
Transcript: ENSMUST00000150120
Predicted Effect probably null
Transcript: ENSMUST00000150120
Predicted Effect probably null
Transcript: ENSMUST00000151674
Predicted Effect probably null
Transcript: ENSMUST00000151674
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140233
Predicted Effect probably benign
Transcript: ENSMUST00000153306
SMART Domains Protein: ENSMUSP00000118200
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
Blast:ZnF_UBP 1 32 3e-7 BLAST
ZnF_UBP 152 207 6.47e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000142058
SMART Domains Protein: ENSMUSP00000117439
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-20 BLAST
ZnF_UBP 180 235 6.47e-27 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 T C 2: 22,847,099 (GRCm39) N251D probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fut8 T C 12: 77,411,787 (GRCm39) V83A probably benign Het
Gnb1l T C 16: 18,383,016 (GRCm39) S352P probably damaging Het
Hmgxb3 A T 18: 61,296,038 (GRCm39) Y323* probably null Het
Katna1 A T 10: 7,619,473 (GRCm39) K160N probably benign Het
Kif7 C A 7: 79,360,008 (GRCm39) A410S probably damaging Het
Mrpl43 T C 19: 44,994,498 (GRCm39) probably null Het
Muc6 T A 7: 141,216,951 (GRCm39) E2574V possibly damaging Het
Naip6 A G 13: 100,424,695 (GRCm39) V1199A probably damaging Het
Ntn4 A G 10: 93,480,753 (GRCm39) Y122C probably damaging Het
Pon3 A G 6: 5,232,345 (GRCm39) I225T probably damaging Het
Rrp1b T A 17: 32,277,547 (GRCm39) V609E probably damaging Het
Scube1 T C 15: 83,543,299 (GRCm39) T180A probably damaging Het
Tas2r136 C A 6: 132,754,972 (GRCm39) V52L probably damaging Het
Tas2r138 A G 6: 40,590,198 (GRCm39) I16T probably benign Het
Traf3ip2 A C 10: 39,502,536 (GRCm39) Q228P probably benign Het
Vmn2r54 A G 7: 12,369,919 (GRCm39) M48T possibly damaging Het
Washc5 T C 15: 59,217,207 (GRCm39) N787D probably damaging Het
Zbed6 T C 1: 133,585,975 (GRCm39) Y454C probably damaging Het
Other mutations in Cdca3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02535:Cdca3 APN 6 124,807,521 (GRCm39) missense probably damaging 1.00
R0206:Cdca3 UTSW 6 124,809,514 (GRCm39) unclassified probably benign
R2193:Cdca3 UTSW 6 124,808,409 (GRCm39) missense probably damaging 1.00
R4720:Cdca3 UTSW 6 124,809,127 (GRCm39) missense probably damaging 0.97
R6275:Cdca3 UTSW 6 124,809,627 (GRCm39) splice site probably null
R6384:Cdca3 UTSW 6 124,809,382 (GRCm39) missense probably damaging 0.96
R7376:Cdca3 UTSW 6 124,809,538 (GRCm39) missense probably benign
R9716:Cdca3 UTSW 6 124,809,172 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGAGTCTCTTCTGACGGACG -3'
(R):5'- CCAGTGCAGGTTAAAGAATGC -3'

Sequencing Primer
(F):5'- TGACGGACGTCCCTTCC -3'
(R):5'- GAGAAAGTAGGGTTCCAGTG -3'
Posted On 2014-12-29