Incidental Mutation 'R2921:Zfp507'
ID 255528
Institutional Source Beutler Lab
Gene Symbol Zfp507
Ensembl Gene ENSMUSG00000044452
Gene Name zinc finger protein 507
Synonyms A230056M16Rik, 1810022O10Rik
MMRRC Submission 040506-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.228) question?
Stock # R2921 (G1)
Quality Score 206
Status Not validated
Chromosome 7
Chromosomal Location 35471768-35502428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 35494224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 273 (E273G)
Ref Sequence ENSEMBL: ENSMUSP00000058609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061586] [ENSMUST00000187282] [ENSMUST00000205670] [ENSMUST00000206615]
AlphaFold Q6ZPY5
Predicted Effect probably damaging
Transcript: ENSMUST00000061586
AA Change: E273G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000058609
Gene: ENSMUSG00000044452
AA Change: E273G

DomainStartEndE-ValueType
ZnF_C2H2 122 144 1.56e-2 SMART
ZnF_C2H2 152 175 2.49e-1 SMART
low complexity region 178 192 N/A INTRINSIC
ZnF_C2H2 237 259 8.52e0 SMART
ZnF_C2H2 630 652 2.75e-3 SMART
ZnF_C2H2 658 680 1.26e-2 SMART
ZnF_C2H2 686 709 5.42e-2 SMART
ZnF_C2H2 746 768 4.79e-3 SMART
ZnF_C2H2 774 796 1.45e-2 SMART
ZnF_C2H2 899 921 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187282
SMART Domains Protein: ENSMUSP00000140940
Gene: ENSMUSG00000044452

DomainStartEndE-ValueType
ZnF_C2H2 107 129 1.6e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205670
Predicted Effect probably benign
Transcript: ENSMUST00000206615
Meta Mutation Damage Score 0.1471 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 90,009,393 (GRCm39) D90G possibly damaging Het
Adipor1 T C 1: 134,353,731 (GRCm39) V172A possibly damaging Het
Akt2 A G 7: 27,328,411 (GRCm39) K146R probably benign Het
Atg4a T C X: 139,941,768 (GRCm39) V284A possibly damaging Het
Atp6v0a2 C T 5: 124,794,981 (GRCm39) T656M possibly damaging Het
Baz2a AGCGGCGGTACTTGCGGG AG 10: 127,960,946 (GRCm39) probably null Het
Ccdc116 T C 16: 16,960,307 (GRCm39) H170R probably benign Het
Ccn5 G A 2: 163,674,266 (GRCm39) R222Q probably benign Het
Cemip2 A G 19: 21,795,303 (GRCm39) D732G possibly damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Dpm3 C T 3: 89,174,062 (GRCm39) L8F probably damaging Het
Fhl3 T C 4: 124,599,463 (GRCm39) S13P probably damaging Het
Fndc1 A G 17: 8,023,707 (GRCm39) S83P probably damaging Het
Gapvd1 A T 2: 34,578,875 (GRCm39) I1249N probably damaging Het
Gbp7 A T 3: 142,240,333 (GRCm39) E17V probably benign Het
Gm57858 T C 3: 36,080,077 (GRCm39) M227V probably null Het
Golga4 T A 9: 118,388,411 (GRCm39) S1844R possibly damaging Het
Grm7 T A 6: 111,472,866 (GRCm39) probably null Het
Hdc G A 2: 126,435,910 (GRCm39) P654S probably damaging Het
Hgd T C 16: 37,439,330 (GRCm39) F213L probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hoxb1 T C 11: 96,257,119 (GRCm39) L156P probably benign Het
Mboat2 T A 12: 25,004,239 (GRCm39) W347R probably damaging Het
Mlkl T C 8: 112,043,079 (GRCm39) E356G probably benign Het
Ncor2 A G 5: 125,132,855 (GRCm39) F44S probably damaging Het
Nipal3 A T 4: 135,204,776 (GRCm39) I125N probably damaging Het
Nr1h4 A T 10: 89,334,223 (GRCm39) Y42N probably damaging Het
Nup155 A C 15: 8,183,125 (GRCm39) E1228D probably damaging Het
Or4c113 A G 2: 88,884,843 (GRCm39) V309A probably benign Het
Pde4dip T C 3: 97,626,885 (GRCm39) N1218D probably benign Het
Ralgps1 A T 2: 33,033,082 (GRCm39) I449N probably damaging Het
Rdm1 T A 11: 101,521,716 (GRCm39) L157H possibly damaging Het
Rfx7 G A 9: 72,524,946 (GRCm39) G712D possibly damaging Het
Rnf151 C T 17: 24,935,235 (GRCm39) G232D possibly damaging Het
Rpl22 C A 4: 152,412,002 (GRCm39) T26N possibly damaging Het
Rptn A G 3: 93,306,015 (GRCm39) Y1116C possibly damaging Het
Safb2 A G 17: 56,875,906 (GRCm39) V89A possibly damaging Het
Setx TGTGG TG 2: 29,044,072 (GRCm39) probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slc24a2 A G 4: 86,909,591 (GRCm39) V660A possibly damaging Het
Slc26a2 T A 18: 61,335,007 (GRCm39) I149F probably damaging Het
Slc6a15 A G 10: 103,254,248 (GRCm39) D728G probably damaging Het
Slfn3 A G 11: 83,105,871 (GRCm39) M623V probably benign Het
Smim1 A G 4: 154,108,097 (GRCm39) probably benign Het
Spatc1 T C 15: 76,168,125 (GRCm39) S195P probably damaging Het
Tmx1 T A 12: 70,512,895 (GRCm39) C268S probably benign Het
Trpc6 A T 9: 8,653,034 (GRCm39) L613F possibly damaging Het
Vmn2r60 T A 7: 41,790,459 (GRCm39) V482E probably damaging Het
Zdhhc18 G T 4: 133,360,455 (GRCm39) H82Q probably benign Het
Other mutations in Zfp507
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00715:Zfp507 APN 7 35,494,137 (GRCm39) missense possibly damaging 0.93
IGL00835:Zfp507 APN 7 35,475,463 (GRCm39) missense probably damaging 1.00
IGL01083:Zfp507 APN 7 35,493,463 (GRCm39) missense probably benign 0.00
IGL01359:Zfp507 APN 7 35,493,927 (GRCm39) missense probably damaging 1.00
IGL01418:Zfp507 APN 7 35,493,237 (GRCm39) splice site probably null
IGL02122:Zfp507 APN 7 35,475,520 (GRCm39) missense probably damaging 1.00
IGL02506:Zfp507 APN 7 35,475,891 (GRCm39) missense probably damaging 1.00
IGL02601:Zfp507 APN 7 35,491,136 (GRCm39) missense probably damaging 1.00
IGL02643:Zfp507 APN 7 35,494,656 (GRCm39) missense probably damaging 0.99
IGL03129:Zfp507 APN 7 35,493,631 (GRCm39) missense probably damaging 1.00
R0400:Zfp507 UTSW 7 35,491,171 (GRCm39) missense probably damaging 1.00
R0812:Zfp507 UTSW 7 35,502,048 (GRCm39) intron probably benign
R1183:Zfp507 UTSW 7 35,494,315 (GRCm39) missense probably damaging 0.99
R1381:Zfp507 UTSW 7 35,475,435 (GRCm39) missense possibly damaging 0.91
R1542:Zfp507 UTSW 7 35,494,226 (GRCm39) missense possibly damaging 0.71
R1626:Zfp507 UTSW 7 35,494,858 (GRCm39) missense probably damaging 1.00
R1759:Zfp507 UTSW 7 35,475,403 (GRCm39) missense probably damaging 0.99
R1843:Zfp507 UTSW 7 35,493,150 (GRCm39) missense probably damaging 0.97
R1852:Zfp507 UTSW 7 35,487,176 (GRCm39) missense probably damaging 1.00
R1893:Zfp507 UTSW 7 35,502,052 (GRCm39) intron probably benign
R1923:Zfp507 UTSW 7 35,493,150 (GRCm39) missense probably damaging 0.97
R1925:Zfp507 UTSW 7 35,493,150 (GRCm39) missense probably damaging 0.97
R1927:Zfp507 UTSW 7 35,493,150 (GRCm39) missense probably damaging 0.97
R2139:Zfp507 UTSW 7 35,493,148 (GRCm39) missense probably damaging 1.00
R2191:Zfp507 UTSW 7 35,494,268 (GRCm39) missense probably damaging 1.00
R2431:Zfp507 UTSW 7 35,494,827 (GRCm39) missense probably benign 0.08
R2922:Zfp507 UTSW 7 35,494,224 (GRCm39) missense probably damaging 1.00
R3436:Zfp507 UTSW 7 35,487,195 (GRCm39) missense probably damaging 1.00
R4483:Zfp507 UTSW 7 35,487,141 (GRCm39) critical splice donor site probably null
R4751:Zfp507 UTSW 7 35,493,807 (GRCm39) missense probably damaging 0.99
R4852:Zfp507 UTSW 7 35,493,480 (GRCm39) missense probably benign 0.01
R5298:Zfp507 UTSW 7 35,475,421 (GRCm39) missense probably damaging 0.99
R5602:Zfp507 UTSW 7 35,475,663 (GRCm39) nonsense probably null
R5707:Zfp507 UTSW 7 35,493,588 (GRCm39) missense probably damaging 1.00
R5785:Zfp507 UTSW 7 35,487,167 (GRCm39) missense probably benign 0.20
R6140:Zfp507 UTSW 7 35,493,613 (GRCm39) missense probably damaging 1.00
R6674:Zfp507 UTSW 7 35,494,159 (GRCm39) missense probably damaging 0.98
R6714:Zfp507 UTSW 7 35,487,152 (GRCm39) missense probably damaging 0.99
R7045:Zfp507 UTSW 7 35,494,978 (GRCm39) missense possibly damaging 0.56
R7334:Zfp507 UTSW 7 35,475,505 (GRCm39) missense probably damaging 1.00
R7365:Zfp507 UTSW 7 35,475,843 (GRCm39) missense unknown
R7569:Zfp507 UTSW 7 35,493,969 (GRCm39) missense probably damaging 0.99
R7662:Zfp507 UTSW 7 35,487,229 (GRCm39) nonsense probably null
R7846:Zfp507 UTSW 7 35,493,963 (GRCm39) missense probably damaging 1.00
R9100:Zfp507 UTSW 7 35,494,446 (GRCm39) missense probably benign 0.39
R9136:Zfp507 UTSW 7 35,475,883 (GRCm39) missense probably damaging 0.96
R9513:Zfp507 UTSW 7 35,475,573 (GRCm39) missense probably benign 0.00
Z1088:Zfp507 UTSW 7 35,493,702 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- AGCGTGACTGCCTGGTTTAG -3'
(R):5'- AGACATCCCAGTGAACATGG -3'

Sequencing Primer
(F):5'- AGGTGTACTCCCTCCTCTGTG -3'
(R):5'- ATCCCAGTGAACATGGGCAGTC -3'
Posted On 2014-12-29