Incidental Mutation 'R2925:Zbtb11'
ID 255728
Institutional Source Beutler Lab
Gene Symbol Zbtb11
Ensembl Gene ENSMUSG00000022601
Gene Name zinc finger and BTB domain containing 11
Synonyms 9230110G02Rik, ZNF-U69274
MMRRC Submission 040510-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.972) question?
Stock # R2925 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 55794246-55829276 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 55794447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 8 (R8Q)
Ref Sequence ENSEMBL: ENSMUSP00000056923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023269] [ENSMUST00000050248]
AlphaFold G5E8B9
Predicted Effect probably benign
Transcript: ENSMUST00000023269
SMART Domains Protein: ENSMUSP00000023269
Gene: ENSMUSG00000098274

DomainStartEndE-ValueType
TRASH 6 44 9.53e-6 SMART
low complexity region 102 142 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000050248
AA Change: R8Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000056923
Gene: ENSMUSG00000022601
AA Change: R8Q

DomainStartEndE-ValueType
low complexity region 136 158 N/A INTRINSIC
low complexity region 161 177 N/A INTRINSIC
BTB 214 312 4.77e-13 SMART
low complexity region 371 399 N/A INTRINSIC
ZnF_C2H2 566 588 1.1e-2 SMART
ZnF_C2H2 594 616 2.09e-3 SMART
low complexity region 623 640 N/A INTRINSIC
ZnF_C2H2 648 670 4.47e-3 SMART
ZnF_C2H2 676 698 8.22e-2 SMART
ZnF_C2H2 704 726 2.27e-4 SMART
ZnF_C2H2 732 754 1.28e-3 SMART
ZnF_C2H2 763 785 2.95e-3 SMART
ZnF_C2H2 791 813 7.67e-2 SMART
ZnF_C2H2 819 843 2.95e-3 SMART
ZnF_C2H2 855 877 1.67e-2 SMART
ZnF_C2H2 883 905 3.02e0 SMART
ZnF_C2H2 911 934 9.58e-3 SMART
low complexity region 979 994 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122365
SMART Domains Protein: ENSMUSP00000114135
Gene: ENSMUSG00000022601

DomainStartEndE-ValueType
TRASH 6 44 9.53e-6 SMART
coiled coil region 102 126 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126419
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128581
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137811
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186480
Meta Mutation Damage Score 0.0655 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 95% (40/42)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik T C 14: 44,407,755 (GRCm39) T93A probably damaging Het
Acte1 A T 7: 143,437,736 (GRCm39) R147* probably null Het
Akr1c21 A G 13: 4,626,349 (GRCm39) probably null Het
Alk A G 17: 72,910,202 (GRCm39) V168A probably benign Het
Ap4b1 A G 3: 103,727,997 (GRCm39) E337G probably damaging Het
Bltp1 G T 3: 37,061,271 (GRCm39) A3327S probably damaging Het
Btn2a2 A G 13: 23,665,984 (GRCm39) S283P probably damaging Het
Ctcfl C T 2: 172,936,489 (GRCm39) E628K probably damaging Het
Cul9 G A 17: 46,821,907 (GRCm39) T1856M probably benign Het
Defb41 T C 1: 18,330,857 (GRCm39) D30G probably damaging Het
Dnai1 A T 4: 41,597,919 (GRCm39) I74F probably damaging Het
Ecpas T A 4: 58,833,928 (GRCm39) K851* probably null Het
Fbln2 T A 6: 91,242,837 (GRCm39) C846S probably damaging Het
Fuom T C 7: 139,679,862 (GRCm39) T110A probably benign Het
Hsp90aa1 C A 12: 110,662,115 (GRCm39) probably null Het
Hsp90aa1 T A 12: 110,662,114 (GRCm39) M1L possibly damaging Het
Il12a TCAC TC 3: 68,605,320 (GRCm39) probably null Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Lyz3 C T 10: 117,070,336 (GRCm39) R147Q probably benign Het
Man2b2 A G 5: 36,981,446 (GRCm39) F224L probably benign Het
Mtbp G A 15: 55,483,210 (GRCm39) R429Q probably benign Het
Ncapg2 C A 12: 116,402,349 (GRCm39) T727K probably benign Het
Nek4 G A 14: 30,673,667 (GRCm39) G29S probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Nup214 A G 2: 31,888,015 (GRCm39) K15E probably damaging Het
Or5ac24 A T 16: 59,165,706 (GRCm39) Y119* probably null Het
Or5m11b T A 2: 85,806,125 (GRCm39) C179* probably null Het
Or8k32 C T 2: 86,368,891 (GRCm39) D121N probably damaging Het
Or9a4 T A 6: 40,548,342 (GRCm39) S7R probably benign Het
P2ry13 G A 3: 59,116,801 (GRCm39) H326Y probably benign Het
Plec A G 15: 76,062,452 (GRCm39) F2563S probably damaging Het
Rc3h1 A G 1: 160,782,546 (GRCm39) Y675C probably damaging Het
Samd3 T A 10: 26,127,785 (GRCm39) S288T probably benign Het
Scaf4 G T 16: 90,047,177 (GRCm39) P400Q unknown Het
Selplg T C 5: 113,958,240 (GRCm39) D22G possibly damaging Het
Slc30a6 T C 17: 74,708,999 (GRCm39) probably benign Het
Syt3 T A 7: 44,045,222 (GRCm39) V518E probably damaging Het
Tnks G A 8: 35,432,815 (GRCm39) A2V unknown Het
Upk3a A G 15: 84,902,350 (GRCm39) Y59C probably benign Het
Usp4 T C 9: 108,245,055 (GRCm39) L331P probably damaging Het
Zbed5 A G 5: 129,932,039 (GRCm39) T663A possibly damaging Het
Other mutations in Zbtb11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Zbtb11 APN 16 55,820,965 (GRCm39) nonsense probably null
IGL01107:Zbtb11 APN 16 55,826,370 (GRCm39) missense probably damaging 1.00
IGL01341:Zbtb11 APN 16 55,811,294 (GRCm39) missense possibly damaging 0.68
IGL01510:Zbtb11 APN 16 55,810,706 (GRCm39) missense probably damaging 0.99
IGL01611:Zbtb11 APN 16 55,800,973 (GRCm39) missense probably damaging 1.00
IGL01736:Zbtb11 APN 16 55,818,523 (GRCm39) missense probably damaging 1.00
IGL01834:Zbtb11 APN 16 55,811,371 (GRCm39) missense probably benign 0.35
IGL02427:Zbtb11 APN 16 55,802,713 (GRCm39) missense possibly damaging 0.95
IGL02441:Zbtb11 APN 16 55,794,552 (GRCm39) missense possibly damaging 0.94
IGL02455:Zbtb11 APN 16 55,821,038 (GRCm39) missense probably damaging 1.00
PIT4544001:Zbtb11 UTSW 16 55,818,556 (GRCm39) nonsense probably null
R0987:Zbtb11 UTSW 16 55,811,071 (GRCm39) missense probably benign 0.00
R1414:Zbtb11 UTSW 16 55,810,923 (GRCm39) nonsense probably null
R1437:Zbtb11 UTSW 16 55,811,983 (GRCm39) critical splice donor site probably null
R1570:Zbtb11 UTSW 16 55,811,178 (GRCm39) missense probably benign
R1658:Zbtb11 UTSW 16 55,794,588 (GRCm39) missense possibly damaging 0.71
R1735:Zbtb11 UTSW 16 55,811,045 (GRCm39) missense probably benign
R2048:Zbtb11 UTSW 16 55,818,372 (GRCm39) missense probably damaging 1.00
R4072:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4075:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4076:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R5023:Zbtb11 UTSW 16 55,826,428 (GRCm39) missense probably damaging 1.00
R5755:Zbtb11 UTSW 16 55,821,076 (GRCm39) missense probably benign 0.02
R5757:Zbtb11 UTSW 16 55,827,392 (GRCm39) missense probably damaging 1.00
R6218:Zbtb11 UTSW 16 55,818,436 (GRCm39) missense probably benign 0.00
R6313:Zbtb11 UTSW 16 55,810,854 (GRCm39) missense probably benign 0.03
R6461:Zbtb11 UTSW 16 55,827,234 (GRCm39) missense probably damaging 0.99
R6666:Zbtb11 UTSW 16 55,826,615 (GRCm39) missense probably damaging 1.00
R6807:Zbtb11 UTSW 16 55,810,865 (GRCm39) missense probably benign 0.03
R7194:Zbtb11 UTSW 16 55,827,551 (GRCm39) missense probably damaging 1.00
R7424:Zbtb11 UTSW 16 55,810,850 (GRCm39) missense probably benign 0.01
R8022:Zbtb11 UTSW 16 55,826,383 (GRCm39) missense probably damaging 0.99
R8436:Zbtb11 UTSW 16 55,821,022 (GRCm39) nonsense probably null
R8532:Zbtb11 UTSW 16 55,811,252 (GRCm39) missense probably benign 0.03
R8806:Zbtb11 UTSW 16 55,802,637 (GRCm39) missense probably damaging 1.00
R9033:Zbtb11 UTSW 16 55,818,492 (GRCm39) missense probably benign
R9673:Zbtb11 UTSW 16 55,827,336 (GRCm39) missense probably damaging 1.00
RF014:Zbtb11 UTSW 16 55,800,960 (GRCm39) missense probably damaging 0.97
Z1176:Zbtb11 UTSW 16 55,811,865 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCATTTTGTCAGTCGCCAGC -3'
(R):5'- AGTAGGTCTTGGACAGGTCG -3'

Sequencing Primer
(F):5'- TGCCGAAGTGCAGTTCC -3'
(R):5'- TCTTGGACAGGTCGTGCCAG -3'
Posted On 2014-12-29