Incidental Mutation 'R0319:Zfp759'
ID 25580
Institutional Source Beutler Lab
Gene Symbol Zfp759
Ensembl Gene ENSMUSG00000057396
Gene Name zinc finger protein 759
Synonyms Rslcan-8
MMRRC Submission 038529-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0319 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 67273040-67290468 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67288356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 636 (T636A)
Ref Sequence ENSEMBL: ENSMUSP00000049650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052716] [ENSMUST00000224346]
AlphaFold Q7M6X3
Predicted Effect probably benign
Transcript: ENSMUST00000052716
AA Change: T636A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000049650
Gene: ENSMUSG00000057396
AA Change: T636A

DomainStartEndE-ValueType
KRAB 5 65 1.6e-22 SMART
ZnF_C2H2 106 128 5.54e1 SMART
ZnF_C2H2 162 184 3.83e-2 SMART
ZnF_C2H2 190 212 1.82e-3 SMART
ZnF_C2H2 218 240 1.64e-1 SMART
ZnF_C2H2 246 268 1.67e-2 SMART
ZnF_C2H2 274 296 1.95e-3 SMART
ZnF_C2H2 302 324 1.84e-4 SMART
ZnF_C2H2 330 352 7.78e-3 SMART
ZnF_C2H2 358 380 1.6e-4 SMART
ZnF_C2H2 386 408 1.67e-2 SMART
ZnF_C2H2 414 436 4.87e-4 SMART
ZnF_C2H2 442 464 3.39e-3 SMART
ZnF_C2H2 498 520 2.57e-3 SMART
ZnF_C2H2 526 548 8.47e-4 SMART
ZnF_C2H2 554 576 2.02e-1 SMART
ZnF_C2H2 582 604 2.53e-2 SMART
ZnF_C2H2 610 632 4.79e-3 SMART
ZnF_C2H2 638 660 1.84e-4 SMART
ZnF_C2H2 666 688 1.36e-2 SMART
ZnF_C2H2 694 716 4.17e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223605
Predicted Effect probably benign
Transcript: ENSMUST00000224346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224426
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 95.0%
  • 20x: 89.1%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A C 7: 127,836,362 (GRCm39) V77G probably benign Het
Abcb1b A G 5: 8,877,428 (GRCm39) R663G probably benign Het
Acly A G 11: 100,395,808 (GRCm39) V404A probably damaging Het
Actg2 T A 6: 83,497,725 (GRCm39) I103F probably damaging Het
Anapc5 A G 5: 122,956,919 (GRCm39) V120A probably damaging Het
Ankk1 T G 9: 49,327,371 (GRCm39) T603P probably damaging Het
Ankmy2 T C 12: 36,215,898 (GRCm39) S33P possibly damaging Het
Arhgef19 A T 4: 140,983,710 (GRCm39) T748S possibly damaging Het
Atad5 T A 11: 80,011,616 (GRCm39) probably benign Het
Atxn10 T C 15: 85,249,483 (GRCm39) L105P probably damaging Het
Cacna1s T C 1: 135,998,455 (GRCm39) V161A probably damaging Het
Col6a3 T C 1: 90,735,426 (GRCm39) E741G possibly damaging Het
Cpne9 G A 6: 113,271,654 (GRCm39) G338E probably damaging Het
Cyp3a13 G A 5: 137,897,124 (GRCm39) P397S probably damaging Het
Dbn1 C T 13: 55,622,729 (GRCm39) E585K probably damaging Het
Draxin A G 4: 148,200,429 (GRCm39) L7P probably benign Het
Exosc7 T A 9: 122,960,025 (GRCm39) probably benign Het
Far2 A G 6: 148,058,968 (GRCm39) E218G probably damaging Het
Ggps1 A C 13: 14,228,462 (GRCm39) N240K possibly damaging Het
Kcnip1 T C 11: 33,601,529 (GRCm39) probably benign Het
Kcnv2 A T 19: 27,301,424 (GRCm39) Y425F probably benign Het
Kdelr2 T A 5: 143,398,272 (GRCm39) F40I probably damaging Het
Kdm1b C T 13: 47,207,195 (GRCm39) P173L probably benign Het
Kif20b G A 19: 34,925,132 (GRCm39) probably benign Het
Klhl9 A T 4: 88,638,691 (GRCm39) Y517N possibly damaging Het
Lgals3bp A G 11: 118,284,347 (GRCm39) S411P probably damaging Het
Lmo3 G A 6: 138,354,309 (GRCm39) T85M probably damaging Het
Lvrn C A 18: 46,997,820 (GRCm39) T256N probably damaging Het
Malt1 T C 18: 65,595,986 (GRCm39) probably null Het
Mgst1 A G 6: 138,133,155 (GRCm39) I157V possibly damaging Het
Mob3a A T 10: 80,525,819 (GRCm39) V164E possibly damaging Het
Mprip T A 11: 59,587,864 (GRCm39) probably benign Het
Mst1 A G 9: 107,959,712 (GRCm39) N276S probably benign Het
Or5an1b A T 19: 12,299,680 (GRCm39) C170* probably null Het
P3h2 T A 16: 25,789,681 (GRCm39) I529F possibly damaging Het
Pikfyve T A 1: 65,285,490 (GRCm39) S865T probably benign Het
Rcbtb2 G A 14: 73,415,909 (GRCm39) R474Q probably benign Het
Rpl27 G A 11: 101,334,321 (GRCm39) probably benign Het
Rtp1 G A 16: 23,250,210 (GRCm39) E192K probably damaging Het
Sgk2 T C 2: 162,837,592 (GRCm39) probably benign Het
Slc17a3 C T 13: 24,039,841 (GRCm39) S293F probably damaging Het
Slc49a4 T C 16: 35,570,884 (GRCm39) D140G probably benign Het
Spdl1 T C 11: 34,714,347 (GRCm39) N114S possibly damaging Het
Syne2 C T 12: 76,110,936 (GRCm39) R5756W probably damaging Het
Tor1aip1 T C 1: 155,882,927 (GRCm39) E307G probably damaging Het
Tpd52 T C 3: 9,018,749 (GRCm39) T44A probably benign Het
Trim67 A T 8: 125,549,966 (GRCm39) Y532F probably damaging Het
Ttll9 C A 2: 152,842,018 (GRCm39) probably null Het
Ush2a T C 1: 188,680,571 (GRCm39) probably benign Het
Vcam1 T C 3: 115,909,709 (GRCm39) I539M probably benign Het
Vmn1r19 T A 6: 57,381,600 (GRCm39) M51K possibly damaging Het
Vmn2r61 T A 7: 41,949,941 (GRCm39) M787K probably damaging Het
Xdh T A 17: 74,213,096 (GRCm39) probably benign Het
Zfp109 A T 7: 23,933,895 (GRCm39) V8E probably damaging Het
Zfp595 G A 13: 67,464,577 (GRCm39) A562V possibly damaging Het
Other mutations in Zfp759
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01509:Zfp759 APN 13 67,287,658 (GRCm39) missense probably benign 0.25
IGL03131:Zfp759 APN 13 67,286,728 (GRCm39) missense probably damaging 1.00
IGL03218:Zfp759 APN 13 67,287,480 (GRCm39) missense probably benign 0.00
R0243:Zfp759 UTSW 13 67,286,877 (GRCm39) missense possibly damaging 0.66
R0520:Zfp759 UTSW 13 67,285,419 (GRCm39) missense probably benign 0.29
R0961:Zfp759 UTSW 13 67,287,927 (GRCm39) missense probably benign 0.32
R1435:Zfp759 UTSW 13 67,286,830 (GRCm39) missense possibly damaging 0.73
R1649:Zfp759 UTSW 13 67,287,668 (GRCm39) missense probably benign 0.00
R1880:Zfp759 UTSW 13 67,287,276 (GRCm39) missense probably damaging 1.00
R2118:Zfp759 UTSW 13 67,287,578 (GRCm39) unclassified probably benign
R2170:Zfp759 UTSW 13 67,284,812 (GRCm39) missense possibly damaging 0.88
R3154:Zfp759 UTSW 13 67,286,719 (GRCm39) missense probably benign 0.20
R3551:Zfp759 UTSW 13 67,287,031 (GRCm39) missense probably benign 0.24
R4392:Zfp759 UTSW 13 67,287,707 (GRCm39) nonsense probably null
R4495:Zfp759 UTSW 13 67,286,989 (GRCm39) splice site probably null
R4736:Zfp759 UTSW 13 67,287,408 (GRCm39) missense probably damaging 1.00
R4882:Zfp759 UTSW 13 67,287,354 (GRCm39) missense probably damaging 1.00
R5717:Zfp759 UTSW 13 67,286,772 (GRCm39) missense probably damaging 1.00
R5921:Zfp759 UTSW 13 67,288,558 (GRCm39) missense probably damaging 1.00
R6247:Zfp759 UTSW 13 67,288,524 (GRCm39) missense probably benign 0.00
R6381:Zfp759 UTSW 13 67,286,969 (GRCm39) nonsense probably null
R6427:Zfp759 UTSW 13 67,287,162 (GRCm39) splice site probably null
R6567:Zfp759 UTSW 13 67,287,150 (GRCm39) missense probably benign 0.34
R7140:Zfp759 UTSW 13 67,288,177 (GRCm39) missense possibly damaging 0.92
R7731:Zfp759 UTSW 13 67,287,690 (GRCm39) missense possibly damaging 0.82
R8504:Zfp759 UTSW 13 67,286,947 (GRCm39) missense probably benign 0.00
R8770:Zfp759 UTSW 13 67,288,417 (GRCm39) missense probably damaging 1.00
R9250:Zfp759 UTSW 13 67,288,461 (GRCm39) missense probably damaging 1.00
R9695:Zfp759 UTSW 13 67,287,198 (GRCm39) missense possibly damaging 0.94
Z1176:Zfp759 UTSW 13 67,284,872 (GRCm39) missense probably damaging 0.98
Z1177:Zfp759 UTSW 13 67,288,212 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCTCCAAGTGTAAAGTAGGTAGAAAGGT -3'
(R):5'- GTGTATATGAAGTGATGATGTAGTGCGGAA -3'

Sequencing Primer
(F):5'- catacaagagagaaaccctacaac -3'
(R):5'- GGCCTTTCCACACACTTtacac -3'
Posted On 2013-04-16