Incidental Mutation 'R2960:Or9s14'
ID 255868
Institutional Source Beutler Lab
Gene Symbol Or9s14
Ensembl Gene ENSMUSG00000063583
Gene Name olfactory receptor family 9 subfamily S member 14
Synonyms Olfr1410, MOR208-2, GA_x6K02T2R7CC-81146179-81145211
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R2960 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 92535561-92536529 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 92536050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 164 (I164V)
Ref Sequence ENSEMBL: ENSMUSP00000149621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000079790] [ENSMUST00000216553] [ENSMUST00000217316]
AlphaFold E9PYK6
Predicted Effect probably benign
Transcript: ENSMUST00000073748
AA Change: I164V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: I164V

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079790
AA Change: I164V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000078720
Gene: ENSMUSG00000063583
AA Change: I164V

DomainStartEndE-ValueType
Pfam:7tm_4 38 314 2.6e-50 PFAM
Pfam:7tm_1 48 302 9.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216553
AA Change: I164V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217316
AA Change: I164V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl5c A G 11: 97,885,902 (GRCm39) L33P probably damaging Het
Auh A T 13: 52,993,610 (GRCm39) I268N probably damaging Het
Cimap2 A G 4: 106,470,615 (GRCm39) S186P probably damaging Het
Defa25 A T 8: 21,575,273 (GRCm39) H84L probably benign Het
Endou T C 15: 97,611,687 (GRCm39) Y317C probably damaging Het
Fmn2 C T 1: 174,437,385 (GRCm39) L1119F probably damaging Het
Glyat T A 19: 12,617,214 (GRCm39) L22H probably damaging Het
Gpd2 C T 2: 57,228,987 (GRCm39) R264* probably null Het
Grb7 C T 11: 98,343,087 (GRCm39) T268I probably damaging Het
Ints15 A T 5: 143,293,776 (GRCm39) F234I probably benign Het
Itfg2 G A 6: 128,390,515 (GRCm39) A190V probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Mdga2 G T 12: 66,676,752 (GRCm39) Y513* probably null Het
Med8 A G 4: 118,271,944 (GRCm39) T222A probably damaging Het
Nup43 T C 10: 7,546,713 (GRCm39) V111A probably benign Het
Rfx3 G A 19: 27,878,211 (GRCm39) Q29* probably null Het
Rfx8 A G 1: 39,722,112 (GRCm39) V291A probably damaging Het
Scnn1a A G 6: 125,299,256 (GRCm39) Y112C probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Tmx3 T C 18: 90,551,116 (GRCm39) V252A probably damaging Het
Vmn1r216 A G 13: 23,284,103 (GRCm39) D262G probably benign Het
Vmn1r9 A G 6: 57,048,657 (GRCm39) D244G possibly damaging Het
Xkr6 T A 14: 63,844,586 (GRCm39) M203K possibly damaging Het
Zfr G A 15: 12,162,319 (GRCm39) R823H probably benign Het
Other mutations in Or9s14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02310:Or9s14 APN 1 92,535,787 (GRCm39) missense possibly damaging 0.80
R0189:Or9s14 UTSW 1 92,535,615 (GRCm39) missense probably damaging 0.99
R0520:Or9s14 UTSW 1 92,536,471 (GRCm39) missense probably damaging 1.00
R0605:Or9s14 UTSW 1 92,535,618 (GRCm39) missense probably benign 0.02
R1568:Or9s14 UTSW 1 92,535,676 (GRCm39) missense probably damaging 1.00
R1753:Or9s14 UTSW 1 92,536,122 (GRCm39) missense probably benign 0.07
R1778:Or9s14 UTSW 1 92,535,831 (GRCm39) missense possibly damaging 0.88
R4206:Or9s14 UTSW 1 92,536,317 (GRCm39) missense possibly damaging 0.95
R7379:Or9s14 UTSW 1 92,536,189 (GRCm39) missense possibly damaging 0.76
R7868:Or9s14 UTSW 1 92,536,237 (GRCm39) missense possibly damaging 0.63
R8447:Or9s14 UTSW 1 92,535,494 (GRCm39) start gained probably benign
R8925:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R8927:Or9s14 UTSW 1 92,536,438 (GRCm39) missense probably damaging 1.00
R9512:Or9s14 UTSW 1 92,535,990 (GRCm39) missense probably benign 0.00
Z1176:Or9s14 UTSW 1 92,535,473 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- GGATGTGCCACTCAGTTCTTC -3'
(R):5'- AACGCATTCTGAGGATGGTG -3'

Sequencing Primer
(F):5'- GATGTGCCACTCAGTTCTTCTTTTTC -3'
(R):5'- TGTAACCATAAGAGATGATGACCAC -3'
Posted On 2014-12-29