Incidental Mutation 'R2938:Or4d5'
ID 256113
Institutional Source Beutler Lab
Gene Symbol Or4d5
Ensembl Gene ENSMUSG00000045812
Gene Name olfactory receptor family 4 subfamily D member 5
Synonyms Olfr984, MOR239-6, GA_x6K02T2PVTD-33799484-33798540
MMRRC Submission 040515-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.201) question?
Stock # R2938 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 40011840-40012784 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 40012039 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 249 (I249K)
Ref Sequence ENSEMBL: ENSMUSP00000150287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056795] [ENSMUST00000213858] [ENSMUST00000214856] [ENSMUST00000217536]
AlphaFold Q8VFN1
Predicted Effect probably benign
Transcript: ENSMUST00000056795
AA Change: I249K

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000060787
Gene: ENSMUSG00000045812
AA Change: I249K

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7tm_1 41 287 6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213858
AA Change: I249K

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000214856
AA Change: I249K

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000217536
AA Change: I249K

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 T A 2: 166,736,653 (GRCm39) I1775K probably damaging Het
Arhgap45 T A 10: 79,864,836 (GRCm39) M933K probably damaging Het
Astn2 A T 4: 65,910,550 (GRCm39) H427Q possibly damaging Het
Bace2 T C 16: 97,213,388 (GRCm39) probably null Het
Cacna1b A G 2: 24,496,540 (GRCm39) V125A probably benign Het
Cbarp T C 10: 79,967,603 (GRCm39) D539G probably damaging Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Ccdc73 T A 2: 104,805,980 (GRCm39) L296* probably null Het
Cd40 G C 2: 164,911,622 (GRCm39) V191L probably benign Het
Cdc6 A G 11: 98,801,586 (GRCm39) I217V probably benign Het
Cdh15 G A 8: 123,588,763 (GRCm39) R279Q probably damaging Het
Cdr1 T G X: 60,228,968 (GRCm39) D66A unknown Het
Cela3b A G 4: 137,150,574 (GRCm39) I208T probably benign Het
Col1a2 A T 6: 4,520,788 (GRCm39) Q375L possibly damaging Het
Csn1s1 A T 5: 87,824,995 (GRCm39) Q221L possibly damaging Het
Cstl1 T A 2: 148,592,977 (GRCm39) I44N possibly damaging Het
Depdc5 G A 5: 33,058,965 (GRCm39) probably null Het
Dthd1 A G 5: 63,000,300 (GRCm39) I541V probably benign Het
Eml6 G A 11: 29,783,049 (GRCm39) probably benign Het
Fkbp15 T A 4: 62,222,900 (GRCm39) T1000S probably benign Het
Gimap8 A T 6: 48,635,730 (GRCm39) R498S possibly damaging Het
Glis1 A G 4: 107,489,488 (GRCm39) N692D possibly damaging Het
Gpr83 A G 9: 14,776,167 (GRCm39) T163A probably benign Het
Hmgcr G A 13: 96,799,576 (GRCm39) L173F probably damaging Het
Htr2b T A 1: 86,030,177 (GRCm39) I173F possibly damaging Het
Ifna11 T C 4: 88,738,530 (GRCm39) L112P probably damaging Het
Lmod1 A G 1: 135,291,654 (GRCm39) K170E probably benign Het
Lrrtm1 A T 6: 77,220,635 (GRCm39) M31L probably benign Het
Macf1 T C 4: 123,326,695 (GRCm39) N2815S probably damaging Het
Man1c1 A G 4: 134,430,263 (GRCm39) I173T possibly damaging Het
Man2b2 A G 5: 36,978,330 (GRCm39) I318T probably benign Het
Mib1 T A 18: 10,752,033 (GRCm39) probably benign Het
Myo10 T A 15: 25,795,803 (GRCm39) S1315T probably damaging Het
Nsun5 C T 5: 135,404,317 (GRCm39) Q375* probably null Het
Opcml A G 9: 27,702,682 (GRCm39) M1V probably null Het
Or5m3 T C 2: 85,838,357 (GRCm39) M79T probably damaging Het
Or6c66b T A 10: 129,376,484 (GRCm39) F26Y probably damaging Het
Parm1 T C 5: 91,742,328 (GRCm39) I232T possibly damaging Het
Pdss1 T A 2: 22,796,799 (GRCm39) probably null Het
Pfkfb2 G A 1: 130,633,147 (GRCm39) T202I possibly damaging Het
Postn T A 3: 54,277,731 (GRCm39) F242Y probably damaging Het
Prss12 A G 3: 123,280,625 (GRCm39) T437A probably benign Het
Rap1gap2 C A 11: 74,298,148 (GRCm39) A491S possibly damaging Het
Rbm10 T C X: 20,513,934 (GRCm39) L429P possibly damaging Het
Saraf A G 8: 34,635,735 (GRCm39) N346D probably benign Het
Sec31b T C 19: 44,524,618 (GRCm39) D93G probably damaging Het
Sgcg A T 14: 61,467,074 (GRCm39) F175L probably damaging Het
Sh3rf2 A G 18: 42,282,789 (GRCm39) D449G probably benign Het
Slc9a3 T C 13: 74,269,788 (GRCm39) I52T possibly damaging Het
Tcf7 A T 11: 52,173,610 (GRCm39) probably null Het
Tlr1 A G 5: 65,083,251 (GRCm39) V442A probably damaging Het
Tmub1 A G 5: 24,650,922 (GRCm39) *261Q probably null Het
Uck1 GCCAACACC GCC 2: 32,146,088 (GRCm39) probably benign Het
Utp4 A G 8: 107,649,561 (GRCm39) D670G probably damaging Het
Vamp5 A G 6: 72,346,323 (GRCm39) V91A probably benign Het
Vmn1r35 A T 6: 66,655,950 (GRCm39) M73K possibly damaging Het
Vmn2r12 C T 5: 109,239,397 (GRCm39) E389K probably damaging Het
Wdsub1 T C 2: 59,703,630 (GRCm39) T112A possibly damaging Het
Xpo4 G T 14: 57,841,897 (GRCm39) Q473K probably benign Het
Xpo7 A G 14: 70,909,130 (GRCm39) I797T probably damaging Het
Zfp808 G A 13: 62,319,032 (GRCm39) V67M probably benign Het
Other mutations in Or4d5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Or4d5 APN 9 40,012,450 (GRCm39) missense probably benign 0.03
IGL01402:Or4d5 APN 9 40,012,558 (GRCm39) missense probably benign 0.00
IGL01404:Or4d5 APN 9 40,012,558 (GRCm39) missense probably benign 0.00
IGL01445:Or4d5 APN 9 40,012,608 (GRCm39) missense probably benign 0.45
IGL01448:Or4d5 APN 9 40,012,378 (GRCm39) missense probably damaging 0.97
IGL02598:Or4d5 APN 9 40,011,861 (GRCm39) missense probably benign
IGL03106:Or4d5 APN 9 40,012,030 (GRCm39) missense probably damaging 1.00
R0616:Or4d5 UTSW 9 40,012,283 (GRCm39) missense probably damaging 1.00
R0712:Or4d5 UTSW 9 40,012,726 (GRCm39) missense probably benign
R2049:Or4d5 UTSW 9 40,012,415 (GRCm39) missense probably benign
R4609:Or4d5 UTSW 9 40,012,102 (GRCm39) missense possibly damaging 0.81
R4907:Or4d5 UTSW 9 40,011,955 (GRCm39) missense probably benign 0.02
R5001:Or4d5 UTSW 9 40,012,523 (GRCm39) missense probably benign 0.02
R5174:Or4d5 UTSW 9 40,012,043 (GRCm39) missense possibly damaging 0.87
R5587:Or4d5 UTSW 9 40,012,540 (GRCm39) missense probably damaging 1.00
R5880:Or4d5 UTSW 9 40,012,543 (GRCm39) missense possibly damaging 0.95
R5896:Or4d5 UTSW 9 40,012,189 (GRCm39) missense probably damaging 0.99
R6611:Or4d5 UTSW 9 40,012,316 (GRCm39) missense probably benign 0.03
R6904:Or4d5 UTSW 9 40,012,652 (GRCm39) missense probably benign 0.04
R7015:Or4d5 UTSW 9 40,012,751 (GRCm39) missense probably benign 0.30
R7870:Or4d5 UTSW 9 40,011,973 (GRCm39) missense possibly damaging 0.93
R8191:Or4d5 UTSW 9 40,012,767 (GRCm39) missense probably benign 0.13
R8739:Or4d5 UTSW 9 40,012,636 (GRCm39) missense probably benign 0.13
R8799:Or4d5 UTSW 9 40,011,985 (GRCm39) missense possibly damaging 0.84
R9307:Or4d5 UTSW 9 40,012,451 (GRCm39) missense probably benign 0.00
R9315:Or4d5 UTSW 9 40,012,270 (GRCm39) missense probably benign 0.02
R9497:Or4d5 UTSW 9 40,011,935 (GRCm39) missense probably damaging 1.00
R9554:Or4d5 UTSW 9 40,012,160 (GRCm39) missense probably benign
R9568:Or4d5 UTSW 9 40,011,864 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATGATCTGAGGAACCAAGAAAATCC -3'
(R):5'- TTCCACAGCTGATCAAATTGGC -3'

Sequencing Primer
(F):5'- AGAAAATCCTTCTTCCTCCTCCATAG -3'
(R):5'- CAGCTGATCAAATTGGCCTGTAC -3'
Posted On 2014-12-29