Incidental Mutation 'R2982:Fabp3'
ID 257096
Institutional Source Beutler Lab
Gene Symbol Fabp3
Ensembl Gene ENSMUSG00000028773
Gene Name fatty acid binding protein 3, muscle and heart
Synonyms Fabph-1, Fabp3, Fabph4, H-FABP, Mdgi, Fabph1, Fabph-4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2982 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 130202531-130209256 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 130206180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 57 (T57I)
Ref Sequence ENSEMBL: ENSMUSP00000070709 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070532] [ENSMUST00000097865] [ENSMUST00000134159]
AlphaFold P11404
Predicted Effect probably benign
Transcript: ENSMUST00000070532
AA Change: T57I

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000070709
Gene: ENSMUSG00000028773
AA Change: T57I

DomainStartEndE-ValueType
Pfam:Lipocalin_7 3 133 3.2e-13 PFAM
Pfam:Lipocalin 6 132 4.5e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000097865
SMART Domains Protein: ENSMUSP00000095477
Gene: ENSMUSG00000073752

DomainStartEndE-ValueType
low complexity region 20 34 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000134159
SMART Domains Protein: ENSMUSP00000120807
Gene: ENSMUSG00000028772

DomainStartEndE-ValueType
S1 14 86 4.47e-11 SMART
ZnF_C2HC 132 148 4.56e-1 SMART
low complexity region 160 171 N/A INTRINSIC
low complexity region 182 211 N/A INTRINSIC
low complexity region 227 240 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141615
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149755
Meta Mutation Damage Score 0.7568 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
PHENOTYPE: Inactivation of this locus results in impaired fatty acid utilization. Homozygous null mice show exercise intolerance and cardiac hypertrophy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cd200r3 T A 16: 44,774,552 (GRCm39) D188E probably benign Het
Fgfr1 T C 8: 26,048,227 (GRCm39) F106L probably benign Het
Hpse2 T A 19: 43,373,182 (GRCm39) D149V probably null Het
Hsd3b5 T A 3: 98,527,116 (GRCm39) D110V possibly damaging Het
Klhl42 T C 6: 146,993,114 (GRCm39) Y29H probably damaging Het
Klk1 G A 7: 43,878,863 (GRCm39) C117Y probably damaging Het
Mfhas1 T C 8: 36,058,269 (GRCm39) Y915H probably benign Het
Msantd2 A G 9: 37,434,639 (GRCm39) Q293R probably damaging Het
Or1l4b G T 2: 37,036,393 (GRCm39) M56I probably damaging Het
Or7a36 T C 10: 78,820,274 (GRCm39) S217P probably damaging Het
Or9g20 T A 2: 85,629,694 (GRCm39) I307F probably benign Het
Osgin1 T G 8: 120,169,274 (GRCm39) L35R probably damaging Het
Rufy1 C T 11: 50,310,535 (GRCm39) R210K possibly damaging Het
Spats2 T C 15: 99,108,927 (GRCm39) S426P probably benign Het
Tnc T A 4: 63,938,756 (GRCm39) I28F possibly damaging Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Zfp512 C A 5: 31,634,122 (GRCm39) probably null Het
Other mutations in Fabp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
cardio UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1111:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1112:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1114:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1116:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1144:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1146:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1146:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1147:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1147:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1460:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1505:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1506:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1508:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1509:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1582:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1601:Fabp3 UTSW 4 130,202,641 (GRCm39) missense probably benign 0.24
R1612:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1641:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1664:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1670:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1686:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1690:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1709:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1854:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1855:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R1935:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2107:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2208:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2211:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2392:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2393:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2829:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2830:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2831:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2901:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2964:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2975:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2979:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2980:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2981:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R2983:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3430:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3612:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3613:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3614:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3755:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3756:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R3825:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R3842:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4012:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4280:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R4282:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R4405:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4406:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4466:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4503:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R4547:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R4548:Fabp3 UTSW 4 130,206,245 (GRCm39) splice site probably null
R4671:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4681:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4710:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4743:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4850:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R4989:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R5015:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R5133:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R5134:Fabp3 UTSW 4 130,206,180 (GRCm39) missense probably benign 0.21
R5549:Fabp3 UTSW 4 130,209,018 (GRCm39) makesense probably null
R5884:Fabp3 UTSW 4 130,206,131 (GRCm39) missense probably benign 0.01
R7170:Fabp3 UTSW 4 130,207,763 (GRCm39) missense probably benign 0.06
R7967:Fabp3 UTSW 4 130,207,781 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCCACAAACTTCTCTTTGG -3'
(R):5'- GCTTATACTTAGTCCCTGGGCC -3'

Sequencing Primer
(F):5'- GGGTCTATATAACACGTCTCTACC -3'
(R):5'- CACTGAGCAGGCTTTATGAACCTG -3'
Posted On 2015-01-11