Mutagenetix > Incidental Mutation

Incidental Mutation 'R2983:Tex264'

257124

Institutional Source

Beutler Lab

Gene Symbol

Tex264

Ensembl Gene

ENSMUSG00000040813

Gene Name

testis expressed gene 264

Synonyms

TEG-264

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.433) question?

Stock #

R2983 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

106535945-106563126 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106559296 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 10 (I10T)

Ref Sequence

ENSEMBL: ENSMUSP00000133194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046735] [ENSMUST00000163441] [ENSMUST00000169068]

AlphaFold

E9Q137

Predicted Effect

unknown
Transcript: ENSMUST00000046735
AA Change: I10T

SMART Domains

Protein: ENSMUSP00000044654
Gene: ENSMUSG00000040813
AA Change: I10T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
Pfam:GyrI-like	41	185	1e-12	PFAM
low complexity region	208	225	N/A	INTRINSIC
low complexity region	258	291	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000163441
AA Change: I10T

SMART Domains

Protein: ENSMUSP00000132247
Gene: ENSMUSG00000040813
AA Change: I10T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
SCOP:d1jyha_	46	133	7e-3	SMART
low complexity region	208	225	N/A	INTRINSIC
low complexity region	258	291	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000169068
AA Change: I10T

SMART Domains

Protein: ENSMUSP00000133194
Gene: ENSMUSG00000040813
AA Change: I10T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
Pfam:GyrI-like	41	176	4.2e-11	PFAM
low complexity region	220	253	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185257

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185645

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188120

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188892

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190948

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214885

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4	A	G	4: 144,349,784 (GRCm39)	D347G	probably damaging	Het
Brwd1	T	C	16: 95,867,774 (GRCm39)	K124E	probably damaging	Het
Ddx41	G	A	13: 55,682,293 (GRCm39)	R205W	possibly damaging	Het
Dlec1	T	C	9: 118,975,241 (GRCm39)	V1607A	probably benign	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Flnb	T	A	14: 7,882,250 (GRCm38)	V317E	probably damaging	Het
Gkn3	C	T	6: 87,360,507 (GRCm39)	A163T	probably damaging	Het
Kmt2c	AGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTG	AGCTGCTGCTGCTGCTG	5: 25,520,755 (GRCm39)		probably benign	Het
Ncs1	C	T	2: 31,174,708 (GRCm39)	T144I	probably damaging	Het
Nfix	CAAAAA	CAAAA	8: 85,442,876 (GRCm39)		probably null	Het
Or5k16	T	A	16: 58,736,930 (GRCm39)	T25S	probably benign	Het
Pira13	A	T	7: 3,824,574 (GRCm39)	S503T	probably damaging	Het
Prkcd	G	A	14: 30,321,435 (GRCm39)	S552L	probably damaging	Het
Rad54l2	A	G	9: 106,577,789 (GRCm39)	V1044A	probably benign	Het
Rasal1	A	G	5: 120,792,927 (GRCm39)	H60R	probably benign	Het
Rccd1	G	A	7: 79,970,276 (GRCm39)	Q114*	probably null	Het
Speg	T	C	1: 75,361,574 (GRCm39)	V90A	possibly damaging	Het
St8sia1	A	G	6: 142,909,355 (GRCm39)	V47A	probably damaging	Het
Ttc23l	CT	CTTGGATT	15: 10,537,648 (GRCm39)		probably benign	Het
Ttc23l	G	A	15: 10,537,652 (GRCm39)	S206L	probably benign	Het
Vmn1r81	G	A	7: 11,994,596 (GRCm39)	T4I	probably benign	Het

Other mutations in Tex264

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01308:Tex264	APN	9	106,539,607 (GRCm39)	missense	possibly damaging	0.95
IGL01533:Tex264	APN	9	106,550,798 (GRCm39)	missense	probably benign
R0712:Tex264	UTSW	9	106,536,431 (GRCm39)	missense	possibly damaging	0.88
R0737:Tex264	UTSW	9	106,536,498 (GRCm39)	missense	probably benign	0.42
R1579:Tex264	UTSW	9	106,559,116 (GRCm39)	missense	possibly damaging	0.95
R4772:Tex264	UTSW	9	106,550,901 (GRCm39)	missense	possibly damaging	0.92
R7553:Tex264	UTSW	9	106,536,335 (GRCm39)	missense	probably damaging	0.99
R9437:Tex264	UTSW	9	106,559,096 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- TGTCATAGTAGACAGCGATGG -3'
(R):5'- TGTGTAAATACCTGTGGCCC -3'

Sequencing Primer
(F):5'- GATGCTGCAGCTCTCTGTGAAAAG -3'
(R):5'- GTAAATACCTGTGGCCCCTCCC -3'

Posted On

2015-01-11