Incidental Mutation 'R2994:Fpr3'
| ID |
257159 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fpr3
|
| Ensembl Gene |
ENSMUSG00000079700 |
| Gene Name |
formyl peptide receptor 3 |
| Synonyms |
Fprl1, LXA4-R, Lxa4r, Fpr-rs1 |
| MMRRC Submission |
040529-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2994 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18190720-18191939 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 18191130 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 134
(Q134*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111227
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054871]
[ENSMUST00000115565]
|
| AlphaFold |
O08790 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000054871
AA Change: Q134*
|
| SMART Domains |
Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
AA Change: Q134*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
43 |
302 |
2.2e-43 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115565
AA Change: Q134*
|
| SMART Domains |
Protein: ENSMUSP00000111227
Gene: ENSMUSG00000079700
AA Change: Q134*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
43 |
302 |
1.5e-36 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 94.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca3 |
T |
C |
17: 24,603,538 (GRCm39) |
S577P |
probably damaging |
Het |
| Agrn |
T |
C |
4: 156,251,785 (GRCm39) |
T1826A |
possibly damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Btnl6 |
C |
A |
17: 34,734,498 (GRCm39) |
R88I |
possibly damaging |
Het |
| Cfap52 |
T |
A |
11: 67,830,617 (GRCm39) |
Y281F |
probably benign |
Het |
| CK137956 |
T |
C |
4: 127,845,300 (GRCm39) |
T148A |
probably benign |
Het |
| Gbp4 |
A |
T |
5: 105,284,886 (GRCm39) |
M1K |
probably null |
Het |
| Gpsm1 |
G |
A |
2: 26,209,843 (GRCm39) |
|
probably benign |
Het |
| Nedd4 |
A |
G |
9: 72,638,185 (GRCm39) |
D440G |
probably benign |
Het |
| Nlgn1 |
C |
T |
3: 25,490,162 (GRCm39) |
D522N |
probably damaging |
Het |
| Oprk1 |
T |
C |
1: 5,672,955 (GRCm39) |
V364A |
probably benign |
Het |
| Or1e35 |
T |
C |
11: 73,797,541 (GRCm39) |
Y259C |
probably damaging |
Het |
| Or5d18 |
A |
G |
2: 87,865,301 (GRCm39) |
Y61H |
probably damaging |
Het |
| Polr1e |
T |
C |
4: 45,027,473 (GRCm39) |
|
probably null |
Het |
| Psmd11 |
T |
C |
11: 80,351,493 (GRCm39) |
Y239H |
probably damaging |
Het |
| Ripor2 |
A |
T |
13: 24,885,610 (GRCm39) |
D576V |
probably damaging |
Het |
| Rundc3a |
C |
T |
11: 102,291,489 (GRCm39) |
T327I |
probably damaging |
Het |
| Sh3rf1 |
A |
G |
8: 61,825,609 (GRCm39) |
T535A |
probably benign |
Het |
| Slc13a2 |
T |
A |
11: 78,295,563 (GRCm39) |
E101V |
probably damaging |
Het |
| Tg |
A |
T |
15: 66,553,802 (GRCm39) |
T406S |
probably benign |
Het |
| Tjp2 |
T |
C |
19: 24,090,215 (GRCm39) |
E609G |
probably damaging |
Het |
| Zfp459 |
G |
A |
13: 67,556,853 (GRCm39) |
P77S |
possibly damaging |
Het |
| Zfp612 |
A |
G |
8: 110,816,049 (GRCm39) |
K380E |
probably damaging |
Het |
| Zfp629 |
T |
C |
7: 127,210,228 (GRCm39) |
E527G |
probably damaging |
Het |
|
| Other mutations in Fpr3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01067:Fpr3
|
APN |
17 |
18,190,828 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01520:Fpr3
|
APN |
17 |
18,191,325 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02166:Fpr3
|
APN |
17 |
18,190,726 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL02380:Fpr3
|
APN |
17 |
18,191,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02587:Fpr3
|
APN |
17 |
18,190,953 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1521:Fpr3
|
UTSW |
17 |
18,191,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Fpr3
|
UTSW |
17 |
18,190,922 (GRCm39) |
nonsense |
probably null |
|
|
R1913:Fpr3
|
UTSW |
17 |
18,191,670 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2099:Fpr3
|
UTSW |
17 |
18,191,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Fpr3
|
UTSW |
17 |
18,190,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Fpr3
|
UTSW |
17 |
18,190,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Fpr3
|
UTSW |
17 |
18,191,644 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2224:Fpr3
|
UTSW |
17 |
18,191,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2244:Fpr3
|
UTSW |
17 |
18,191,449 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5364:Fpr3
|
UTSW |
17 |
18,190,806 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6179:Fpr3
|
UTSW |
17 |
18,190,919 (GRCm39) |
nonsense |
probably null |
|
|
R6781:Fpr3
|
UTSW |
17 |
18,190,978 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6909:Fpr3
|
UTSW |
17 |
18,191,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7565:Fpr3
|
UTSW |
17 |
18,191,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8008:Fpr3
|
UTSW |
17 |
18,191,715 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8097:Fpr3
|
UTSW |
17 |
18,191,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8351:Fpr3
|
UTSW |
17 |
18,191,436 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8732:Fpr3
|
UTSW |
17 |
18,191,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8994:Fpr3
|
UTSW |
17 |
18,191,341 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9076:Fpr3
|
UTSW |
17 |
18,191,725 (GRCm39) |
missense |
probably benign |
|
|
R9206:Fpr3
|
UTSW |
17 |
18,191,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Fpr3
|
UTSW |
17 |
18,191,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9327:Fpr3
|
UTSW |
17 |
18,191,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9553:Fpr3
|
UTSW |
17 |
18,191,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0021:Fpr3
|
UTSW |
17 |
18,191,500 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1176:Fpr3
|
UTSW |
17 |
18,191,255 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCCGGATGCCACACACTG -3'
(R):5'- TTCCTCAACAGAGTTGCCC -3'
Sequencing Primer
(F):5'- ATCTGGTATCTGAATCTAGCATTGGC -3'
(R):5'- CAGAGTTGCCCCAGGATAC -3'
|
| Posted On |
2015-01-11 |
Incidental Mutation