Mutagenetix > Incidental Mutation

Incidental Mutation 'R3003:Vmn2r98'

257379

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

040532-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

R3003 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19273755-19301573 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19286125 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 208 (M208V)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: M208V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: M208V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc1	T	C	16: 14,254,393 (GRCm39)	V568A	probably damaging	Het
Acd	C	T	8: 106,426,913 (GRCm39)		probably null	Het
Acly	T	C	11: 100,395,053 (GRCm39)	K469E	possibly damaging	Het
Adh6b	G	T	3: 138,063,532 (GRCm39)	L248F	possibly damaging	Het
Atg9b	G	T	5: 24,596,217 (GRCm39)	D192E	probably damaging	Het
Ccdc180	A	G	4: 45,899,988 (GRCm39)	D182G	probably benign	Het
Cep112	A	G	11: 108,331,329 (GRCm39)	E178G	probably damaging	Het
Clptm1l	C	T	13: 73,765,875 (GRCm39)	T471I	possibly damaging	Het
Csmd1	A	G	8: 16,246,184 (GRCm39)	F1072L	probably damaging	Het
Eprs1	T	C	1: 185,156,588 (GRCm39)		probably null	Het
Il27ra	G	T	8: 84,758,660 (GRCm39)	S499*	probably null	Het
Klk1b11	T	C	7: 43,426,419 (GRCm39)	I51T	probably damaging	Het
Lct	T	C	1: 128,231,963 (GRCm39)	M629V	probably damaging	Het
Mprip	A	G	11: 59,618,381 (GRCm39)	T91A	possibly damaging	Het
Pfpl	T	C	19: 12,407,690 (GRCm39)	I647T	possibly damaging	Het
Plxnc1	A	T	10: 94,629,080 (GRCm39)	F1565I	probably damaging	Het
Prr5	G	T	15: 84,656,031 (GRCm39)	C344F	probably damaging	Het
Rnf17	T	C	14: 56,738,004 (GRCm39)	W1262R	probably damaging	Het
Rptor	G	A	11: 119,763,197 (GRCm39)	R927Q	possibly damaging	Het
Slitrk5	A	G	14: 111,917,014 (GRCm39)	K213E	probably damaging	Het
Smarcd1	C	A	15: 99,610,065 (GRCm39)	P432Q	probably damaging	Het
Stat4	A	G	1: 52,142,145 (GRCm39)	D664G	probably damaging	Het
Suz12	T	A	11: 79,910,587 (GRCm39)	W313R	probably damaging	Het
Sycp2	T	C	2: 177,999,916 (GRCm39)	Y1020C	probably benign	Het
Tmem181a	T	A	17: 6,346,061 (GRCm39)	L185H	probably damaging	Het
Tmem81	A	G	1: 132,435,752 (GRCm39)	N186S	probably benign	Het
Tut4	G	A	4: 108,370,125 (GRCm39)	E714K	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,286,007 (GRCm39)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,285,447 (GRCm39)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,286,020 (GRCm39)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,286,713 (GRCm39)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,286,548 (GRCm39)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,300,941 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,286,113 (GRCm39)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,286,083 (GRCm39)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,301,223 (GRCm39)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,286,275 (GRCm39)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,301,283 (GRCm39)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,286,242 (GRCm39)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,290,107 (GRCm39)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,301,223 (GRCm39)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,286,662 (GRCm39)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,286,089 (GRCm39)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,273,875 (GRCm39)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,300,759 (GRCm39)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,300,782 (GRCm39)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,301,011 (GRCm39)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,286,210 (GRCm39)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,285,440 (GRCm39)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,301,170 (GRCm39)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,286,680 (GRCm39)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,285,595 (GRCm39)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,301,553 (GRCm39)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,286,213 (GRCm39)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,300,698 (GRCm39)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,286,081 (GRCm39)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,301,439 (GRCm39)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,287,664 (GRCm39)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,300,887 (GRCm39)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,286,354 (GRCm39)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,290,007 (GRCm39)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,286,602 (GRCm39)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,286,419 (GRCm39)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,286,306 (GRCm39)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,273,815 (GRCm39)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,300,981 (GRCm39)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,290,016 (GRCm39)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,290,015 (GRCm39)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,301,161 (GRCm39)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,286,260 (GRCm39)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,286,336 (GRCm39)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,286,143 (GRCm39)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,286,063 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,285,510 (GRCm39)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,286,530 (GRCm39)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,301,184 (GRCm39)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,285,575 (GRCm39)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,287,570 (GRCm39)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,300,797 (GRCm39)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,287,460 (GRCm39)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,287,493 (GRCm39)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,273,912 (GRCm39)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,301,425 (GRCm39)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,301,031 (GRCm39)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,286,532 (GRCm39)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,285,531 (GRCm39)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,301,481 (GRCm39)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,286,777 (GRCm39)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,287,517 (GRCm39)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,301,496 (GRCm39)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,285,665 (GRCm39)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,287,685 (GRCm39)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,285,398 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- CTTGAAACTTGCAGGCCTAAC -3'
(R):5'- CATCCATATTTTCCCAGAATTTGGC -3'

Sequencing Primer
(F):5'- GCAGGCCTAACAAAAATTTCTGTTG -3'
(R):5'- TGGCAACATATGAAGTCCATGTG -3'

Posted On

2015-01-11