Mutagenetix > Incidental Mutation

Incidental Mutation 'R3009:Vmn2r91'

257468

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R3009 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18305319-18356905 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 18325717 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 112 (V112I)

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

probably benign
Transcript: ENSMUST00000172359
AA Change: V112I

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: V112I

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap12	A	G	10: 4,307,891 (GRCm39)	D1567G	probably benign	Het
Bmp3	T	C	5: 99,027,696 (GRCm39)	S439P	probably damaging	Het
Btnl2	C	T	17: 34,582,492 (GRCm39)	R353C	probably damaging	Het
Galc	T	C	12: 98,170,228 (GRCm39)	D676G	probably damaging	Het
Gpd2	C	T	2: 57,228,987 (GRCm39)	R264*	probably null	Het
Gprc6a	T	C	10: 51,504,392 (GRCm39)	T151A	probably benign	Het
Limk2	A	G	11: 3,309,046 (GRCm39)	I104T	probably benign	Het
Mei1	A	G	15: 81,996,726 (GRCm39)	H585R	probably damaging	Het
Mpp7	G	A	18: 7,461,678 (GRCm39)	P65L	possibly damaging	Het
Mtfr1	A	T	3: 19,269,750 (GRCm39)	T133S	probably benign	Het
Or12k8	T	C	2: 36,975,089 (GRCm39)	I224V	probably benign	Het
Or5h22	A	G	16: 58,895,350 (GRCm39)	V31A	probably benign	Het
Or6b13	T	C	7: 139,782,669 (GRCm39)	R5G	probably benign	Het
Or8k35	T	C	2: 86,424,714 (GRCm39)	T153A	probably benign	Het
Prkg1	G	A	19: 31,641,512 (GRCm39)	T57I	possibly damaging	Het
Sppl2c	C	T	11: 104,078,141 (GRCm39)	P314S	probably benign	Het
Tex11	C	A	X: 99,977,021 (GRCm39)	A487S	possibly damaging	Het
Urb1	A	G	16: 90,571,686 (GRCm39)	I1041T	probably benign	Het
Vmn2r72	A	T	7: 85,398,850 (GRCm39)	M501K	probably benign	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18,325,820 (GRCm39)	missense	probably benign	0.00
IGL01121:Vmn2r91	APN	17	18,356,766 (GRCm39)	missense	possibly damaging	0.94
IGL01464:Vmn2r91	APN	17	18,327,864 (GRCm39)	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18,327,921 (GRCm39)	missense	probably benign
IGL02709:Vmn2r91	APN	17	18,325,711 (GRCm39)	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18,305,539 (GRCm39)	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18,356,348 (GRCm39)	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18,356,884 (GRCm39)	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18,330,373 (GRCm39)	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18,326,399 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18,325,712 (GRCm39)	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18,356,705 (GRCm39)	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18,326,405 (GRCm39)	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18,356,142 (GRCm39)	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18,325,691 (GRCm39)	missense	possibly damaging	0.94
R2424:Vmn2r91	UTSW	17	18,356,431 (GRCm39)	nonsense	probably null
R2512:Vmn2r91	UTSW	17	18,356,048 (GRCm39)	missense	probably benign
R2885:Vmn2r91	UTSW	17	18,325,628 (GRCm39)	missense	probably benign	0.00
R2909:Vmn2r91	UTSW	17	18,356,661 (GRCm39)	missense	probably damaging	1.00
R3079:Vmn2r91	UTSW	17	18,355,973 (GRCm39)	splice site	probably null
R3080:Vmn2r91	UTSW	17	18,355,973 (GRCm39)	splice site	probably null
R3434:Vmn2r91	UTSW	17	18,330,370 (GRCm39)	splice site	probably benign
R3723:Vmn2r91	UTSW	17	18,305,540 (GRCm39)	critical splice donor site	probably null
R3829:Vmn2r91	UTSW	17	18,325,759 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18,327,860 (GRCm39)	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18,330,358 (GRCm39)	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18,356,030 (GRCm39)	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18,325,658 (GRCm39)	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18,356,751 (GRCm39)	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18,330,322 (GRCm39)	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18,356,700 (GRCm39)	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18,356,763 (GRCm39)	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18,326,464 (GRCm39)	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18,356,518 (GRCm39)	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18,326,888 (GRCm39)	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18,355,865 (GRCm39)	splice site	probably null
R6450:Vmn2r91	UTSW	17	18,305,527 (GRCm39)	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18,327,807 (GRCm39)	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18,356,271 (GRCm39)	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18,325,880 (GRCm39)	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18,356,424 (GRCm39)	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18,326,429 (GRCm39)	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18,356,838 (GRCm39)	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18,356,060 (GRCm39)	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18,325,693 (GRCm39)	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18,356,080 (GRCm39)	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18,356,540 (GRCm39)	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18,330,311 (GRCm39)	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18,327,906 (GRCm39)	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18,327,887 (GRCm39)	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18,326,762 (GRCm39)	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18,356,625 (GRCm39)	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18,305,323 (GRCm39)	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18,325,636 (GRCm39)	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18,326,296 (GRCm39)	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18,356,122 (GRCm39)	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18,327,905 (GRCm39)	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18,356,819 (GRCm39)	nonsense	probably null
R9555:Vmn2r91	UTSW	17	18,325,792 (GRCm39)	missense	possibly damaging	0.78
R9616:Vmn2r91	UTSW	17	18,356,305 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- GTGCTTGCCTAAATCTAACGTATTC -3'
(R):5'- CACAATCCAAATTTTCTCACCTGTG -3'

Sequencing Primer
(F):5'- ATCTAGTTCATCTATTGTTGGTGAAG -3'
(R):5'- CCTGTGGAAATTTAAGGAATTGAAGC -3'

Posted On

2015-01-11